BRPI0516009A - processo para a produção da 2-cloro-4-nitroimidazol - Google Patents
processo para a produção da 2-cloro-4-nitroimidazolInfo
- Publication number
- BRPI0516009A BRPI0516009A BRPI0516009-0A BRPI0516009A BRPI0516009A BR PI0516009 A BRPI0516009 A BR PI0516009A BR PI0516009 A BRPI0516009 A BR PI0516009A BR PI0516009 A BRPI0516009 A BR PI0516009A
- Authority
- BR
- Brazil
- Prior art keywords
- production
- nitroimidazole
- chloro
- provides
- present
- Prior art date
Links
- BOJZBRDIZUHTCE-UHFFFAOYSA-N 2-chloro-5-nitro-1h-imidazole Chemical compound [O-][N+](=O)C1=CN=C(Cl)N1 BOJZBRDIZUHTCE-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000004880 explosion Methods 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"PROCESSO PARA A PRODUçAO DA 2-CLORO-4-NITROIMIDAZOL". A invenção atual apresenta um processo para a produção de 2cloro-4-nitroimidazol com um rendimento elevado e uma pureza elevada, através de uma operação simples de uma forma segura envolvendo um baixo risco de explosão ou semelhante. A invenção atual apresenta um processo para a produção de 2-cloro-4-nitroimidazol representada pela fórmula (1): compreendendo uma reação de composto 1-alcoxialquil-2-bromo-4nitroimidazol representado pela fórmula geral (7): onde R1 representa um grupo alquila inferior, e n representa um número inteiro de 1 a 3, com cloreto de hidrogênio.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004278974 | 2004-09-27 | ||
| PCT/JP2005/018230 WO2006035960A2 (en) | 2004-09-27 | 2005-09-27 | Process for production of 2-chloro-4-nitroimidazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0516009A true BRPI0516009A (pt) | 2008-08-19 |
Family
ID=35967026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0516009-0A BRPI0516009A (pt) | 2004-09-27 | 2005-09-27 | processo para a produção da 2-cloro-4-nitroimidazol |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090082575A1 (pt) |
| EP (1) | EP1794132A2 (pt) |
| KR (1) | KR20070056105A (pt) |
| CN (1) | CN101027287A (pt) |
| AR (1) | AR053972A1 (pt) |
| AU (1) | AU2005288086A1 (pt) |
| BR (1) | BRPI0516009A (pt) |
| CA (1) | CA2580139A1 (pt) |
| IL (1) | IL182134A0 (pt) |
| MX (1) | MX2007003257A (pt) |
| RU (1) | RU2007115892A (pt) |
| TW (1) | TW200624422A (pt) |
| WO (1) | WO2006035960A2 (pt) |
| ZA (1) | ZA200702426B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2323990B1 (en) * | 2008-08-21 | 2014-06-18 | Dynamit Nobel GmbH Explosivstoff- und Systemtechnik | Methods for the production of 2-halo-4-nitroimidazole and intermediates thereof |
| CN103396369B (zh) * | 2013-08-14 | 2016-03-23 | 盐城工学院 | 一种制备2-氯-4-硝基咪唑的方法 |
| US11104650B2 (en) | 2018-01-29 | 2021-08-31 | Otsuka Pharmaceutical Co., Ltd. | Process for production of 2-chloro-4-nitroimidazole derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2494710C (en) * | 2002-10-15 | 2011-05-03 | Otsuka Pharmaceutical Co., Ltd. | 1-substituted-4-nitroimidazole compound and method for preparing the same |
| TWI300409B (en) * | 2004-02-18 | 2008-09-01 | Otsuka Pharma Co Ltd | Method for producing 4-nitroimidazole compound |
-
2005
- 2005-09-16 TW TW094132159A patent/TW200624422A/zh unknown
- 2005-09-26 AR ARP050103983A patent/AR053972A1/es not_active Application Discontinuation
- 2005-09-27 BR BRPI0516009-0A patent/BRPI0516009A/pt not_active IP Right Cessation
- 2005-09-27 KR KR1020077006460A patent/KR20070056105A/ko not_active Withdrawn
- 2005-09-27 WO PCT/JP2005/018230 patent/WO2006035960A2/en not_active Ceased
- 2005-09-27 CN CNA2005800326128A patent/CN101027287A/zh active Pending
- 2005-09-27 EP EP05787645A patent/EP1794132A2/en not_active Withdrawn
- 2005-09-27 AU AU2005288086A patent/AU2005288086A1/en not_active Abandoned
- 2005-09-27 RU RU2007115892/04A patent/RU2007115892A/ru not_active Application Discontinuation
- 2005-09-27 MX MX2007003257A patent/MX2007003257A/es not_active Application Discontinuation
- 2005-09-27 US US11/663,724 patent/US20090082575A1/en not_active Abandoned
- 2005-09-27 CA CA002580139A patent/CA2580139A1/en not_active Abandoned
- 2005-09-27 ZA ZA200702426A patent/ZA200702426B/xx unknown
-
2007
- 2007-03-22 IL IL182134A patent/IL182134A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200702426B (en) | 2008-08-27 |
| AR053972A1 (es) | 2007-05-30 |
| EP1794132A2 (en) | 2007-06-13 |
| RU2007115892A (ru) | 2008-11-10 |
| IL182134A0 (en) | 2007-07-24 |
| US20090082575A1 (en) | 2009-03-26 |
| TW200624422A (en) | 2006-07-16 |
| WO2006035960A3 (en) | 2006-05-11 |
| CA2580139A1 (en) | 2006-04-06 |
| KR20070056105A (ko) | 2007-05-31 |
| MX2007003257A (es) | 2007-05-23 |
| WO2006035960A2 (en) | 2006-04-06 |
| CN101027287A (zh) | 2007-08-29 |
| AU2005288086A1 (en) | 2006-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |