BRPI0516377A - inibição de rnai de ctgf para tratamento de distúrbios oculares - Google Patents

inibição de rnai de ctgf para tratamento de distúrbios oculares

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Publication number
BRPI0516377A
BRPI0516377A BRPI0516377-3A BRPI0516377A BRPI0516377A BR PI0516377 A BRPI0516377 A BR PI0516377A BR PI0516377 A BRPI0516377 A BR PI0516377A BR PI0516377 A BRPI0516377 A BR PI0516377A
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BR
Brazil
Prior art keywords
treatment
disorders
eye disorders
ctgf
inhibition
Prior art date
Application number
BRPI0516377-3A
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English (en)
Inventor
Allan R Shepard
Iok-Hou Pang
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Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of BRPI0516377A publication Critical patent/BRPI0516377A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

INIBIçãO DE RNAi DE CTGF PARA TRATAMENTO DE DISTúRBIOS OCULARES. A presente invenção refere-se a interferência de RNA provida para inibição de expressão de mRNA de fator de crescimento de tecido conectivo em distúrbios oculares envolvendo expressão de CTGF. Distúrbios oculares, envolvendo expressão de CTGF aberrante, incluem glaucoma, degeneração macular, retinopatia diabética, neovascularização coroidal, vitreorretinopatia proliferativa e cicatrização de ferida. Tais distúrbios são tratados através da administração de RNAs de interferência da presente invenção.
BRPI0516377-3A 2004-12-23 2005-12-19 inibição de rnai de ctgf para tratamento de distúrbios oculares BRPI0516377A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63870504P 2004-12-23 2004-12-23
PCT/US2005/046064 WO2006069037A1 (en) 2004-12-23 2005-12-19 Rnai inhibition of ctgf for treatment of ocular disorders

Publications (1)

Publication Number Publication Date
BRPI0516377A true BRPI0516377A (pt) 2008-09-02

Family

ID=36218404

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516377-3A BRPI0516377A (pt) 2004-12-23 2005-12-19 inibição de rnai de ctgf para tratamento de distúrbios oculares

Country Status (13)

Country Link
US (4) US7622454B2 (pt)
EP (2) EP1827503A1 (pt)
JP (2) JP5095414B2 (pt)
KR (1) KR20070091337A (pt)
CN (1) CN101160138B (pt)
AR (1) AR052172A1 (pt)
AU (1) AU2005319279B2 (pt)
BR (1) BRPI0516377A (pt)
CA (1) CA2591611A1 (pt)
MX (1) MX2007007654A (pt)
TW (1) TWI386225B (pt)
WO (1) WO2006069037A1 (pt)
ZA (1) ZA200704932B (pt)

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JP2008525460A (ja) 2008-07-17
WO2006069037A1 (en) 2006-06-29
CN101160138A (zh) 2008-04-09
US7622454B2 (en) 2009-11-24
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CA2591611A1 (en) 2006-06-29
AU2005319279A1 (en) 2006-06-29
US20110028534A1 (en) 2011-02-03
AR052172A1 (es) 2007-03-07
CN101160138B (zh) 2013-05-15
JP5095414B2 (ja) 2012-12-12
US20100035969A1 (en) 2010-02-11
US20140094502A1 (en) 2014-04-03
US20060166919A1 (en) 2006-07-27
AU2005319279B2 (en) 2011-08-18
EP1827503A1 (en) 2007-09-05
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US7838507B2 (en) 2010-11-23
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MX2007007654A (es) 2007-11-09
TWI386225B (zh) 2013-02-21

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