BRPI0517416A - inibidores de pi3 quinase gama para o tratamento de anemia - Google Patents
inibidores de pi3 quinase gama para o tratamento de anemiaInfo
- Publication number
- BRPI0517416A BRPI0517416A BRPI0517416-3A BRPI0517416A BRPI0517416A BR PI0517416 A BRPI0517416 A BR PI0517416A BR PI0517416 A BRPI0517416 A BR PI0517416A BR PI0517416 A BRPI0517416 A BR PI0517416A
- Authority
- BR
- Brazil
- Prior art keywords
- anemia
- treatment
- gamma
- kinase inhibitors
- selective
- Prior art date
Links
- 208000007502 anemia Diseases 0.000 title abstract 4
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 title abstract 3
- 208000032467 Aplastic anaemia Diseases 0.000 abstract 1
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 abstract 1
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 208000007475 hemolytic anemia Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
INIBIDORES DE PI3 QUINASE GAMA PARA O TRATAMENTO DE ANEMIA. A presente invenção refere-se ao uso de inibidores de PI3 Quinase gama seletivos para a produção de medicamento para o tratamento de distúrbios relacionados com deficiência de eritrócitos. Especificamente, a presente invenção refere-se ao uso de inibidores de PI3 Quinase gama seletivos, por exemplo, derivados benzênicos fundidos com azolidinona-vinila substituidas para o tratamento de anemia, incluindo anemia hemolitica, anemia aplásica e anemia eritrocítica pura. em que A, X, Y~ 1~, Y~ 2~, Z, n, e R são descritos em detalhes na descrição.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104997 | 2004-10-12 | ||
| PCT/EP2005/055156 WO2006040318A2 (en) | 2004-10-12 | 2005-10-11 | Pi3 kinase gamma inhibitors for the treatment of anaemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0517416A true BRPI0517416A (pt) | 2008-10-07 |
Family
ID=34929693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0517416-3A BRPI0517416A (pt) | 2004-10-12 | 2005-10-11 | inibidores de pi3 quinase gama para o tratamento de anemia |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090042773A1 (pt) |
| EP (1) | EP1807075A2 (pt) |
| JP (1) | JP2008515955A (pt) |
| KR (1) | KR20070073857A (pt) |
| CN (1) | CN101056633A (pt) |
| AU (1) | AU2005293556A1 (pt) |
| BR (1) | BRPI0517416A (pt) |
| CA (1) | CA2580480A1 (pt) |
| EA (1) | EA200700848A1 (pt) |
| IL (1) | IL182110A0 (pt) |
| MX (1) | MX2007004302A (pt) |
| NO (1) | NO20072393L (pt) |
| WO (1) | WO2006040318A2 (pt) |
| ZA (1) | ZA200702435B (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101052640B (zh) * | 2004-09-03 | 2011-05-11 | 默克雪兰诺有限公司 | 吡啶亚甲基唑烷酮类及其作为磷酸肌醇抑制剂的用途 |
| EP2046333A4 (en) * | 2006-07-24 | 2010-09-15 | Glaxosmithkline Llc | THIOZOLIDINEDIONE DERIVATIVES AS INHIBITORS OF P13-KINASE |
| TW200911798A (en) | 2007-08-02 | 2009-03-16 | Amgen Inc | PI3 kinase modulators and methods of use |
| AU2008343813B2 (en) | 2007-12-19 | 2012-04-12 | Amgen Inc. | Inhibitors of PI3 kinase |
| US8268834B2 (en) | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
| US20110172217A1 (en) * | 2008-09-05 | 2011-07-14 | Shionogi & Co., Ltd. | Ring-fused morpholine derivative having pi3k-inhibiting activity |
| WO2010110380A1 (ja) * | 2009-03-27 | 2010-09-30 | 興和株式会社 | 縮合ピペリジン化合物及びこれを含有する医薬 |
| EP2440556A1 (en) * | 2009-06-10 | 2012-04-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of phosphatidylinositol 3-kinase |
| US8633183B2 (en) * | 2010-01-26 | 2014-01-21 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyrimidines |
| US8609672B2 (en) | 2010-08-27 | 2013-12-17 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| CN102584809B (zh) * | 2011-01-14 | 2014-12-24 | 湘北威尔曼制药股份有限公司 | 胺基噻唑烷酮化合物及其制备方法与在制备抗肿瘤药物中的应用 |
| EP2699569B1 (en) | 2011-04-22 | 2017-08-30 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
| KR101990605B1 (ko) | 2011-11-04 | 2019-06-18 | 자스코 파머수티컬스, 엘엘씨 | 아미노피리미딘 키나아제 억제제 |
| JO3398B1 (ar) | 2011-12-22 | 2019-10-20 | Novartis Ag | مشتقات 2،3- ثانى هيدرو- بنزو[1,4] أوكسازين والمركبات المتعلقة بها كمثبطات كيناز فسفواينوسيتيد-3 (pi3k) لمعالجة على سبيل المثال التهاب المفاصل الروماتيدي |
| US9862711B2 (en) | 2014-04-24 | 2018-01-09 | Novartis Ag | Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
| BR112016024484A2 (pt) | 2014-04-24 | 2017-08-15 | Novartis Ag | derivados de aminopiridina como inibidores de fosfatidilinositol 3-quinase |
| CA2945212A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
| HRP20240793T1 (hr) | 2018-04-18 | 2024-09-13 | Constellation Pharmaceuticals, Inc. | Modulatori enzima koji modificiraju metil, njihovi pripravci i upotreba |
| EP3797108B1 (en) | 2018-05-21 | 2022-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| LT4003532T (lt) | 2019-07-24 | 2024-11-11 | Constellation Pharmaceuticals, Inc. | 7-chlor-2- (4-(3-metoksiazetidin-1-il)cikloheksil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-okso-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioksol-5-karboksamido kristalinės formos |
| JPWO2022163843A1 (pt) * | 2021-02-01 | 2022-08-04 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW518219B (en) * | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| JP4782564B2 (ja) * | 2002-07-10 | 2011-09-28 | メルク セローノ ソシエテ アノニム | アゾリジノン−ビニル縮合−ベンゼン誘導体 |
| CN100579978C (zh) * | 2002-11-22 | 2010-01-13 | 史密丝克莱恩比彻姆公司 | 化合物 |
-
2005
- 2005-10-11 ZA ZA200702435A patent/ZA200702435B/en unknown
- 2005-10-11 EP EP05801722A patent/EP1807075A2/en not_active Withdrawn
- 2005-10-11 EA EA200700848A patent/EA200700848A1/ru unknown
- 2005-10-11 KR KR1020077010007A patent/KR20070073857A/ko not_active Withdrawn
- 2005-10-11 BR BRPI0517416-3A patent/BRPI0517416A/pt not_active IP Right Cessation
- 2005-10-11 CA CA002580480A patent/CA2580480A1/en not_active Abandoned
- 2005-10-11 US US11/664,969 patent/US20090042773A1/en not_active Abandoned
- 2005-10-11 JP JP2007536166A patent/JP2008515955A/ja active Pending
- 2005-10-11 CN CNA200580038804XA patent/CN101056633A/zh active Pending
- 2005-10-11 MX MX2007004302A patent/MX2007004302A/es not_active Application Discontinuation
- 2005-10-11 AU AU2005293556A patent/AU2005293556A1/en not_active Abandoned
- 2005-10-11 WO PCT/EP2005/055156 patent/WO2006040318A2/en not_active Ceased
-
2007
- 2007-03-22 IL IL182110A patent/IL182110A0/en unknown
- 2007-05-09 NO NO20072393A patent/NO20072393L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20090042773A1 (en) | 2009-02-12 |
| CN101056633A (zh) | 2007-10-17 |
| WO2006040318A2 (en) | 2006-04-20 |
| KR20070073857A (ko) | 2007-07-10 |
| CA2580480A1 (en) | 2006-04-20 |
| ZA200702435B (en) | 2008-06-25 |
| EP1807075A2 (en) | 2007-07-18 |
| JP2008515955A (ja) | 2008-05-15 |
| IL182110A0 (en) | 2007-07-24 |
| NO20072393L (no) | 2007-05-09 |
| MX2007004302A (es) | 2007-06-07 |
| WO2006040318A3 (en) | 2006-08-10 |
| EA200700848A1 (ru) | 2007-10-26 |
| AU2005293556A1 (en) | 2006-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: LABORATOIRES SERONO S.A. (CH) Free format text: TRANSFERIDO DE: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |