BRPI0517463A - inibidores da protease do vìrus da hepatite c, composições e tratamentos usando os mesmos - Google Patents

inibidores da protease do vìrus da hepatite c, composições e tratamentos usando os mesmos

Info

Publication number
BRPI0517463A
BRPI0517463A BRPI0517463-5A BRPI0517463A BRPI0517463A BR PI0517463 A BRPI0517463 A BR PI0517463A BR PI0517463 A BRPI0517463 A BR PI0517463A BR PI0517463 A BRPI0517463 A BR PI0517463A
Authority
BR
Brazil
Prior art keywords
hepatitis
compositions
treatments
compounds
same
Prior art date
Application number
BRPI0517463-5A
Other languages
English (en)
Inventor
Michael Raymond Collins
Vijayalakshmi Natarajan
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0517463A publication Critical patent/BRPI0517463A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

INIBIDORES DA PROTEASE DO VìRUS DA HEPATITE C,COMPOSIçõES E TRATAMENTOS USANDO OS MESMO. A presente invenção fornece compostos de fórmula (I) , (II) ou (IV) , ou sais e solvatos farmaceuticamente aceitáveis dos mesmos, que são úteis como inibidores da enzima protease do vírus da Hepatite C (HCV) são também úteis para o tratamento de infecções por HCV em mamíferos infectados por HCV, incluindo seres humanos. A presente invenção também fornece composições farmacêuticas compreendendo os compostos de fórmula (I), (II) ou (IV), seus saís e solvatos farmaceutícamente aceitáveis. Além disso, a presente invenção fornece compostos intermediários e métodos úteis na preparação de compostos de fórmulas (I), (II) e (IV).
BRPI0517463-5A 2004-10-21 2005-10-10 inibidores da protease do vìrus da hepatite c, composições e tratamentos usando os mesmos BRPI0517463A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62130204P 2004-10-21 2004-10-21
US65015005P 2005-02-03 2005-02-03
US70555805P 2005-08-03 2005-08-03
PCT/IB2005/003085 WO2006043145A1 (en) 2004-10-21 2005-10-10 Inhibitors of hepatitis c virus protease, and compositions and treatments using the same

Publications (1)

Publication Number Publication Date
BRPI0517463A true BRPI0517463A (pt) 2008-10-07

Family

ID=35587566

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517463-5A BRPI0517463A (pt) 2004-10-21 2005-10-10 inibidores da protease do vìrus da hepatite c, composições e tratamentos usando os mesmos

Country Status (7)

Country Link
US (1) US20070249637A1 (pt)
EP (1) EP1805187A1 (pt)
JP (1) JP2008517896A (pt)
BR (1) BRPI0517463A (pt)
CA (1) CA2583152A1 (pt)
MX (1) MX2007004783A (pt)
WO (1) WO2006043145A1 (pt)

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Also Published As

Publication number Publication date
EP1805187A1 (en) 2007-07-11
US20070249637A1 (en) 2007-10-25
MX2007004783A (es) 2007-05-11
JP2008517896A (ja) 2008-05-29
CA2583152A1 (en) 2006-04-27
WO2006043145A1 (en) 2006-04-27

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Legal Events

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]