BRPI0517672A - modalidades de formação de imagens para seleção terapêutica de doença de alzheimer - Google Patents

modalidades de formação de imagens para seleção terapêutica de doença de alzheimer

Info

Publication number
BRPI0517672A
BRPI0517672A BRPI0517672-7A BRPI0517672A BRPI0517672A BR PI0517672 A BRPI0517672 A BR PI0517672A BR PI0517672 A BRPI0517672 A BR PI0517672A BR PI0517672 A BRPI0517672 A BR PI0517672A
Authority
BR
Brazil
Prior art keywords
alzheimer
disease
imaging modalities
therapeutic selection
therapeutic
Prior art date
Application number
BRPI0517672-7A
Other languages
English (en)
Inventor
Julia L Rutkowski
Jack Steven Jacobsen
Orest Hurko
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0517672A publication Critical patent/BRPI0517672A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

MODALIDADES DE FORMAçãO DE IMAGENS PARA SELEçãO TERAPêUTICA DE DOENçA DE ALZHEIMER. A presente invenção refere-se a uso de modelos animais de distúrbios neurodegenerativos para estabelecimento de índices diagnósticos pré-clínicos e terapêuticos, e para métodos de seleção para identificar terapias pré-clínicas eficazes.
BRPI0517672-7A 2004-11-05 2005-11-03 modalidades de formação de imagens para seleção terapêutica de doença de alzheimer BRPI0517672A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62516204P 2004-11-05 2004-11-05
PCT/US2005/039865 WO2006052691A2 (en) 2004-11-05 2005-11-03 Pet and magnetic resonance for screening alzheimer's disease therapeutics

Publications (1)

Publication Number Publication Date
BRPI0517672A true BRPI0517672A (pt) 2008-10-14

Family

ID=36129750

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517672-7A BRPI0517672A (pt) 2004-11-05 2005-11-03 modalidades de formação de imagens para seleção terapêutica de doença de alzheimer

Country Status (9)

Country Link
US (1) US20060117397A1 (pt)
EP (1) EP1807119A2 (pt)
JP (1) JP2008519282A (pt)
CN (1) CN101072591A (pt)
AU (1) AU2005304931A1 (pt)
BR (1) BRPI0517672A (pt)
CA (1) CA2586220A1 (pt)
MX (1) MX2007005317A (pt)
WO (1) WO2006052691A2 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
RU2440367C2 (ru) * 2005-05-17 2012-01-20 Сатори Фармасеутикалс, Инк. Соединения, полезные для лечения нейродегенеративных нарушений
WO2007094830A1 (en) * 2005-11-10 2007-08-23 In Silico Biosciences, Inc. Method and apparatus for computer modeling the human brain for predicting drug effects
JP5153114B2 (ja) * 2006-10-12 2013-02-27 知宏 千葉 新規のアルツハイマー病検出方法
JP5319121B2 (ja) * 2007-01-30 2013-10-16 株式会社東芝 診療支援システム及び診療支援装置
CA2680762A1 (en) * 2007-03-12 2008-09-25 National Institute Of Radiological Sciences Pet visualization of amyloid-associated neuroinflammation in the brain
JP2010526999A (ja) * 2007-05-10 2010-08-05 トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク Ｐｅｔを用いた疾患の診断法及びその治療の評価法
WO2008154415A1 (en) * 2007-06-08 2008-12-18 New York University Stage specific prognostic in vivo markers of brain aging and dementia
CL2007002908A1 (es) 2007-10-09 2008-05-30 Univ Concepcion Procedimiento electroquimico in vitro para evaluar capacidad neurotoxica de estructuras, principios activos y/o compuestos de interes en celulas vivas y que comprende medir y cuantificar los parametros electricos en membranas expuestas a dichos agreg
US8450466B2 (en) * 2008-03-21 2013-05-28 The General Hosptial Corporation Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders
WO2009123734A1 (en) * 2008-04-04 2009-10-08 The Regents Of The University Of California Functionalized magnetic nanoparticles and methods of use thereof
US8593141B1 (en) 2009-11-24 2013-11-26 Hypres, Inc. Magnetic resonance system and method employing a digital squid
EP2451348A4 (en) * 2010-04-13 2013-07-31 Baxter Int USE OF THE VENTRICULAR MAGNITUDE RATE IN INTRAVENOUS IMMUNOGLOBULIN TREATMENT OF MORBUS ALZHEIMER
US8970217B1 (en) 2010-04-14 2015-03-03 Hypres, Inc. System and method for noise reduction in magnetic resonance imaging
DE102012209059B4 (de) * 2012-05-30 2024-05-02 Siemens Healthineers Ag Verfahren und Vorrichtung zur Bestimmung einer zeitlichen Änderung eines Biomarkers in einem Untersuchungsgebiet
US10203388B2 (en) 2016-01-04 2019-02-12 Toshiba Medical Systems Corporation Magnetic resonance imaging apparatus and magnetic resonance imaging method
CN114587323A (zh) * 2020-12-04 2022-06-07 安影科技（北京）有限公司 一种阿尔茨海默病脑血流灌注异常的测量方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2101774C (en) * 1991-01-21 2011-01-04 John A. Hardy Test and model for alzheimer's disease
EP1001019A1 (en) * 1993-10-27 2000-05-17 Athena Neurosciences, Inc. Transgenic animals harboring APP Allele having Swedish mutation
JPH07132033A (ja) * 1993-11-12 1995-05-23 Hoechst Japan Ltd アルツハイマー病モデルトランスジェニック動物
US5877399A (en) * 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
US6717031B2 (en) * 1995-06-07 2004-04-06 Kate Dora Games Method for selecting a transgenic mouse model of alzheimer's disease
US5894078A (en) * 1996-02-26 1999-04-13 Advanced Bioconcept, Inc. Transgenic mouse expressing C-100 app
US5849999A (en) * 1996-10-16 1998-12-15 The Mclean Hospital Corporation Transgenic non-human mice expressing Flag-APP-C100 protein develop alzheimer's disease brain morphology and behavior
US5898094A (en) * 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
US6284944B1 (en) * 1997-08-29 2001-09-04 Cephalon, Inc, Gene-targeted non-human mammal with a human fad presenilin mutation and generational offspring
US6175057B1 (en) * 1997-10-08 2001-01-16 The Regents Of The University Of California Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy
US5846197A (en) * 1998-03-16 1998-12-08 Beth Israel Deaconess Medical Center Compensating for magnetization transfer effects in multislice and three-dimensional MRI blood flow mapping studies
US6664443B1 (en) * 1998-05-01 2003-12-16 Mayo Foundation For Medical Education And Research Pathogenic Tau mutations in transgenic mice
JP3980833B2 (ja) * 1998-08-20 2007-09-26 リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア βアミロイド斑及び神経原線維変化の標識方法
AU4078900A (en) * 1999-04-06 2000-10-23 Harrington Arthritis Research Center Methods for tracking the progression of alzheimer's disease and identifying treatments using transgenic mice
US7371920B2 (en) * 2000-06-20 2008-05-13 The Governing Council Of The University Of Toronto Transgenic mouse model of neurodegenerative disorders
US6593516B1 (en) * 2002-10-03 2003-07-15 Rico Corp. Holder for a musical instrument reed
CA2518407A1 (en) * 2003-03-12 2004-09-23 Samaritan Pharmaceuticals, Inc. Animal model simulating neurologic disease

Also Published As

Publication number Publication date
WO2006052691A2 (en) 2006-05-18
JP2008519282A (ja) 2008-06-05
WO2006052691A3 (en) 2007-05-10
CA2586220A1 (en) 2006-05-18
EP1807119A2 (en) 2007-07-18
US20060117397A1 (en) 2006-06-01
CN101072591A (zh) 2007-11-14
AU2005304931A1 (en) 2006-05-18
MX2007005317A (es) 2007-06-11

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Legal Events

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.