BRPI0518266A2 - medicamento oral de libertaÇço modificada de pelo menos um princÍpio ativo sob a forma multimicrocapsular - Google Patents

medicamento oral de libertaÇço modificada de pelo menos um princÍpio ativo sob a forma multimicrocapsular

Info

Publication number
BRPI0518266A2
BRPI0518266A2 BRPI0518266-2A BRPI0518266A BRPI0518266A2 BR PI0518266 A2 BRPI0518266 A2 BR PI0518266A2 BR PI0518266 A BRPI0518266 A BR PI0518266A BR PI0518266 A2 BRPI0518266 A2 BR PI0518266A2
Authority
BR
Brazil
Prior art keywords
active ingredient
release
modified
oral
medicinal product
Prior art date
Application number
BRPI0518266-2A
Other languages
English (en)
Inventor
Florence Guimberteau
Catherine Castan
Remi Meyrueix
Gerard G Soula
Original Assignee
Flamel Tech Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Tech Sa filed Critical Flamel Tech Sa
Publication of BRPI0518266A2 publication Critical patent/BRPI0518266A2/pt
Publication of BRPI0518266A8 publication Critical patent/BRPI0518266A8/pt
Publication of BRPI0518266B1 publication Critical patent/BRPI0518266B1/pt
Publication of BRPI0518266B8 publication Critical patent/BRPI0518266B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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Abstract

MEDICAMENTO ORAL DE LIBERAÇAO MODIFICADA DE PELO MENOS UM PRINCÍPIO ATIVO SOB A FORMA MULTIMICROCAPSULAR. O campo da invenção é aquele dos medicamentos ou composições farmacêuticas orais, mais particularmente do tipo daquelas que compreendem um ou vários princípios ativos. A finalidade da invenção é fornecer um medicamento oral aperfeiçoado administrável em uma ou várias ingestões diárias, de liberação modificada de princípio ativo (em particular um princípio ativo), permitindo melhorar a eficácia profilática e terapêutica desse medicamento. Essa finalidade é atingida pela forma galênica oral multímicrocapsular, de acordo com a invenção, na qual a liberação do PA é regida por um duplo mecanismo de acionamento da liberação: "tempo de acionamento" e "pH de acionamento". Esse medicamento compreende mícrocápsulas de liberação modificada de princípio ativo, comportando, cada uma, um núcleo que compreende o princípio ativo e um ou vários agentes intumescedores e pelo menos um revestimento que permite a liberação modificada do princípio ativo.
BRPI0518266A 2004-11-24 2005-11-02 medicamento oral de liberação modificada de pelo menos um princípio ativo sob a forma multimicrocapsular BRPI0518266B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0452748A FR2878159B1 (fr) 2004-11-24 2004-11-24 Medicament oral a liberation modifiee d'au moins un principe actif sous forme multimicrocapsulaire
FR0452748 2004-11-24
PCT/FR2005/050922 WO2006056711A2 (fr) 2004-11-24 2005-11-02 Medicament oral a liberation modifiee d'au moins un principe actif sous forme multimicrocapsulaire

Publications (4)

Publication Number Publication Date
BRPI0518266A2 true BRPI0518266A2 (pt) 2008-11-11
BRPI0518266A8 BRPI0518266A8 (pt) 2016-03-29
BRPI0518266B1 BRPI0518266B1 (pt) 2020-07-07
BRPI0518266B8 BRPI0518266B8 (pt) 2021-05-25

Family

ID=34953830

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518266A BRPI0518266B8 (pt) 2004-11-24 2005-11-02 medicamento oral de liberação modificada de pelo menos um princípio ativo sob a forma multimicrocapsular

Country Status (18)

Country Link
US (1) US20080305160A1 (pt)
EP (1) EP1827396B1 (pt)
JP (1) JP5619342B2 (pt)
KR (1) KR101391287B1 (pt)
CN (1) CN101094658B (pt)
AU (1) AU2005308639B2 (pt)
BR (1) BRPI0518266B8 (pt)
CA (1) CA2589137C (pt)
ES (1) ES2588160T3 (pt)
FR (1) FR2878159B1 (pt)
HU (1) HUE029440T2 (pt)
IL (1) IL183357A (pt)
MX (1) MX2007006212A (pt)
PT (1) PT1827396T (pt)
SG (1) SG157406A1 (pt)
TW (1) TW200630123A (pt)
WO (1) WO2006056711A2 (pt)
ZA (1) ZA200704163B (pt)

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US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
KR102810926B1 (ko) 2017-12-20 2025-05-22 퍼듀 퍼머 엘피 남용 억제 황산모르핀 제형
CN108558690B (zh) * 2018-03-28 2021-04-20 浙江海正药业股份有限公司 环丝氨酸酯化物盐酸盐的晶型及其制备方法
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KR102546722B1 (ko) * 2020-04-21 2023-06-23 주식회사 바이오스탠다드 바이오코폴리머 마이크로 캡슐 포함 안정화 조성물, 그의 제조방법 및 이를 이용한 피부상태 개선용 화장료 조성물
GB202116589D0 (en) 2021-11-17 2021-12-29 Rb Health Us Llc Novel composition
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EP1827396B1 (fr) 2016-06-01
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BRPI0518266B8 (pt) 2021-05-25
IL183357A0 (en) 2007-09-20
TW200630123A (en) 2006-09-01
EP1827396A2 (fr) 2007-09-05
MX2007006212A (es) 2007-07-09
CA2589137C (fr) 2014-08-26
CA2589137A1 (fr) 2006-06-01
ES2588160T3 (es) 2016-10-31
FR2878159B1 (fr) 2008-10-17
BRPI0518266B1 (pt) 2020-07-07
BRPI0518266A8 (pt) 2016-03-29
HUE029440T2 (en) 2017-02-28
CN101094658B (zh) 2016-10-05
FR2878159A1 (fr) 2006-05-26
AU2005308639A1 (en) 2006-06-01
AU2005308639B2 (en) 2011-05-26
IL183357A (en) 2014-12-31
JP5619342B2 (ja) 2014-11-05
SG157406A1 (en) 2009-12-29
PT1827396T (pt) 2016-08-31
US20080305160A1 (en) 2008-12-11
KR101391287B1 (ko) 2014-05-19
WO2006056711A2 (fr) 2006-06-01
WO2006056711A3 (fr) 2006-08-31
CN101094658A (zh) 2007-12-26
JP2008520633A (ja) 2008-06-19

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