BRPI0518607A2 - derivados de pirrol tendo atividade antagonista de receptor crth2 - Google Patents

derivados de pirrol tendo atividade antagonista de receptor crth2

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Publication number
BRPI0518607A2
BRPI0518607A2 BRPI0518607-2A BRPI0518607A BRPI0518607A2 BR PI0518607 A2 BRPI0518607 A2 BR PI0518607A2 BR PI0518607 A BRPI0518607 A BR PI0518607A BR PI0518607 A2 BRPI0518607 A2 BR PI0518607A2
Authority
BR
Brazil
Prior art keywords
antagonist activity
receptor antagonist
crth2 receptor
pyrrol derivatives
crth2
Prior art date
Application number
BRPI0518607-2A
Other languages
English (en)
Inventor
Claire Adcock
Catherine Leblanc
David Andrew Sandham
Simon James Watson
Kamlesh Jagdis Bala
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34090028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0518607(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0518607A2 publication Critical patent/BRPI0518607A2/pt

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
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  • Hematology (AREA)
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  • Cardiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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Abstract

DERIVADOS DE PIRROL TENDO ATIVIDADE ANTAGONISTA DE RECEPTOR CRTH2. A presente invenção refere-se a fornecer de acordo com a invenção compostos de fórmula (I) como antagonistas de CRTh2. Em forma de sal ou livre, em que Rü, R^ 4^, R^ 5^, R^ 6^, Q, W e n são como descritos na especificação, processo para preparação deles, e seu uso como produtos farmacêuticos.
BRPI0518607-2A 2004-12-14 2005-12-12 derivados de pirrol tendo atividade antagonista de receptor crth2 BRPI0518607A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0427381.9A GB0427381D0 (en) 2004-12-14 2004-12-14 Organic compounds
PCT/EP2005/013297 WO2006063763A1 (en) 2004-12-14 2005-12-12 Pyrrole derivatives having crth2 receptor antagonist activity

Publications (1)

Publication Number Publication Date
BRPI0518607A2 true BRPI0518607A2 (pt) 2008-11-25

Family

ID=34090028

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518607-2A BRPI0518607A2 (pt) 2004-12-14 2005-12-12 derivados de pirrol tendo atividade antagonista de receptor crth2

Country Status (21)

Country Link
US (1) US20100087432A1 (pt)
EP (1) EP1828172B1 (pt)
JP (1) JP2008523130A (pt)
KR (1) KR20070087605A (pt)
CN (1) CN101072773B (pt)
AR (1) AR052266A1 (pt)
AT (1) ATE449772T1 (pt)
AU (1) AU2005315881C1 (pt)
BR (1) BRPI0518607A2 (pt)
CA (1) CA2587934A1 (pt)
DE (1) DE602005017935D1 (pt)
ES (1) ES2335519T3 (pt)
GB (1) GB0427381D0 (pt)
GT (1) GT200500360A (pt)
MX (1) MX2007007098A (pt)
PE (1) PE20060736A1 (pt)
PL (1) PL1828172T3 (pt)
PT (1) PT1828172E (pt)
RU (1) RU2007126761A (pt)
TW (1) TW200635921A (pt)
WO (1) WO2006063763A1 (pt)

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CA2790139C (en) 2010-03-22 2018-03-13 Actelion Pharmaceuticals Ltd 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
WO2011117184A1 (de) 2010-03-24 2011-09-29 Bayer Cropscience Ag Fludioxonil-derivate
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
US20140187795A1 (en) * 2010-12-08 2014-07-03 Ironwood Pharmaceuticals, Inc. Crth2 modulators and preparation thereof
JP5964945B2 (ja) 2011-04-14 2016-08-03 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ７−（ヘテロアリ−ル−アミノ）−６，７，８，９−テトラヒドロピリド［１，２−ａ］インド−ル酢酸誘導体及びプロスタグランジンＤ２受容体調節剤としてのそれらの使用
KR20140113667A (ko) 2011-12-16 2014-09-24 아토픽스 테라퓨릭스 리미티드 호산구성 식도염의 치료를 위한 ｃｒｔｈ2 길항제 및 양성자 펌프 저해제의 조합
CN104011021B (zh) 2011-12-21 2016-08-24 埃科特莱茵药品有限公司 杂环衍生物及其作为前列腺素d2受体调节剂的用途
US20150080381A1 (en) * 2012-04-12 2015-03-19 Ironwood Pharmaceuticals, Inc. Methods of treating alopecia and acne
US9169270B2 (en) 2012-07-05 2015-10-27 Actelion Pharmaceuticals Ltd. 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
ES2461415B1 (es) * 2012-10-16 2015-03-16 Consejo Superior De Investigaciones Científicas (Csic) Derivados funcionalizados e inmunorreactivos para el fungicida fludioxonil
CN103588686B (zh) * 2013-11-08 2016-01-20 苏州诚和医药化学有限公司 一种用卤素卤化制备2－甲氧基－4－氨基－5－乙砜基苯甲酸甲酯的方法
CN103553990B (zh) * 2013-11-08 2016-01-20 苏州诚和医药化学有限公司 用卤素卤化合成2－甲氧基－4－氨基－5－乙砜基苯甲酸甲酯的方法
CN103553991B (zh) * 2013-11-08 2016-01-20 苏州诚和医药化学有限公司 一种制备2－甲氧基－4－氨基－5－乙砜基苯甲酸甲酯的方法
CA2939892C (en) 2014-03-17 2020-03-31 Idorsia Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
CN106103437A (zh) 2014-03-18 2016-11-09 埃科特莱茵药品有限公司 氮杂吲哚乙酸衍生物及其作为前列腺素d2受体调节剂的用途
CN108026093B (zh) 2015-09-15 2021-11-16 爱杜西亚药品有限公司 结晶形式
CN108164502B (zh) * 2018-03-06 2021-04-13 苏州华一新能源科技有限公司 1,3-丙烷磺酸内酯的制备方法
CN112602714B (zh) * 2020-12-23 2021-11-16 华南农业大学 一类咯菌腈羧酸衍生物在用于植物维管组织靶向药剂中的应用

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JP4316232B2 (ja) * 2001-12-28 2009-08-19 武田薬品工業株式会社 アンドロゲン受容体拮抗剤
TW200307542A (en) * 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0301010D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
AU2005247610A1 (en) * 2004-05-29 2005-12-08 7Tm Pharma A/S Substituted thiazoleacetic as crth2 ligands

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EP1828172A1 (en) 2007-09-05
RU2007126761A (ru) 2009-01-27
CN101072773B (zh) 2011-01-19
DE602005017935D1 (de) 2010-01-07
MX2007007098A (es) 2007-06-22
AR052266A1 (es) 2007-03-07
ATE449772T1 (de) 2009-12-15
JP2008523130A (ja) 2008-07-03
WO2006063763A1 (en) 2006-06-22
EP1828172B1 (en) 2009-11-25
KR20070087605A (ko) 2007-08-28
CN101072773A (zh) 2007-11-14
AU2005315881B2 (en) 2009-09-24
GB0427381D0 (en) 2005-01-19
PE20060736A1 (es) 2006-09-08
PT1828172E (pt) 2010-02-17
ES2335519T3 (es) 2010-03-29
CA2587934A1 (en) 2006-06-22
AU2005315881A1 (en) 2006-06-22
AU2005315881C1 (en) 2010-03-11
TW200635921A (en) 2006-10-16
PL1828172T3 (pl) 2010-05-31
US20100087432A1 (en) 2010-04-08

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