BRPI0518622A2 - usos de antagonistas de receptor do tipo 1 de interleucina-1(il-1r1) para a fabricaÇço de um medicamento para o tratamento de uma doenÇa respiratària; composiÇço farmacÊutica que compreende um antagonista do il-1r1 e um veÍculo fisiologicamente aceitÁvel e dispositivo de liberaÇço de medicamento - Google Patents
usos de antagonistas de receptor do tipo 1 de interleucina-1(il-1r1) para a fabricaÇço de um medicamento para o tratamento de uma doenÇa respiratària; composiÇço farmacÊutica que compreende um antagonista do il-1r1 e um veÍculo fisiologicamente aceitÁvel e dispositivo de liberaÇço de medicamentoInfo
- Publication number
- BRPI0518622A2 BRPI0518622A2 BRPI0518622-6A BRPI0518622A BRPI0518622A2 BR PI0518622 A2 BRPI0518622 A2 BR PI0518622A2 BR PI0518622 A BRPI0518622 A BR PI0518622A BR PI0518622 A2 BRPI0518622 A2 BR PI0518622A2
- Authority
- BR
- Brazil
- Prior art keywords
- respiratory disease
- medicament
- manufacture
- treatment
- antagonist
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
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- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Peptides Or Proteins (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
USOS DE ANTAGONISTAS DE RECEPTOR DO TIPO 1DE INTERLEUCINA 1 (IL-1R1) PARA A FABRICAÇçO DE UM MEDICAMENTO PARA O TRATAMENTO DE UMA DOENÇA RESPIRATORIA; COMPOSIÇçO FARMACÊUTICA QUE COMPREENDE UM ANTAGONISTA DO IL-1R1 E UM VEÍCULO FISIOLOGICAMENTE ACEITÁVEL E DISPOSITIVO DE LIBERAÇçO DE MEDICAMENTO. Trata-se do uso de um antagonista de receptor do tipo 1 de Interleucina 1 (IL-iRi) para a fabricação de um medicamento para o tratamento, prevenção ou supressão de inflamação do pulmão ou de uma doença respiratória. Em algumas concretizações da invenção descrita, o medicamento é para a administração local ao tecido pulmonar. Também são revelados métodos para o tratamento de inflamação do pulmão ou de uma doença respiratórla.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63236104P | 2004-12-02 | 2004-12-02 | |
| PCT/GB2005/002163 WO2005118642A2 (en) | 2004-06-01 | 2005-05-31 | Bispecific fusion antibodies with enhanced serum half-life |
| GBGB0521621.3A GB0521621D0 (en) | 2005-10-24 | 2005-10-24 | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
| PCT/GB2005/004601 WO2006059108A2 (en) | 2004-12-02 | 2005-12-01 | ANTI-IL-IRl SINGLE DOMAIN ANTIBODIES AND THERAPEUTIC USES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0518622A2 true BRPI0518622A2 (pt) | 2008-12-02 |
Family
ID=38792215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518622-6A BRPI0518622A2 (pt) | 2004-12-02 | 2005-12-01 | usos de antagonistas de receptor do tipo 1 de interleucina-1(il-1r1) para a fabricaÇço de um medicamento para o tratamento de uma doenÇa respiratària; composiÇço farmacÊutica que compreende um antagonista do il-1r1 e um veÍculo fisiologicamente aceitÁvel e dispositivo de liberaÇço de medicamento |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090191217A1 (pt) |
| EP (1) | EP1863847A2 (pt) |
| JP (1) | JP2008521870A (pt) |
| KR (1) | KR20070086896A (pt) |
| CN (1) | CN101133084A (pt) |
| AU (2) | AU2005311101B8 (pt) |
| BR (1) | BRPI0518622A2 (pt) |
| CA (1) | CA2588892A1 (pt) |
| IL (1) | IL183458A0 (pt) |
| MA (1) | MA29669B1 (pt) |
| MX (1) | MX2007006593A (pt) |
| NO (1) | NO20073337L (pt) |
| WO (1) | WO2006059108A2 (pt) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9028822B2 (en) | 2002-06-28 | 2015-05-12 | Domantis Limited | Antagonists against TNFR1 and methods of use therefor |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
| EP1558647B1 (en) * | 2002-11-08 | 2015-06-10 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
| EP2284192A3 (en) | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Camelidae antibodies for sublingual administration |
| GB0521621D0 (en) * | 2005-10-24 | 2005-11-30 | Domantis Ltd | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
| KR20080077237A (ko) * | 2005-12-01 | 2008-08-21 | 도만티스 리미티드 | 인터루킨 1 수용체 타입 1에 결합하는 경쟁적 도메인 항체포맷 |
| CN101454344A (zh) * | 2005-12-01 | 2009-06-10 | 杜门蒂斯有限公司 | 与白细胞介素-1受体1型结合的非竞争性域抗体形式 |
| US8940683B2 (en) * | 2006-08-10 | 2015-01-27 | Roy C. Levitt | Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors |
| AU2013270447B2 (en) * | 2006-08-10 | 2016-10-13 | Onspira Therapeutics, Inc. | Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors |
| GB0621513D0 (en) * | 2006-10-30 | 2006-12-06 | Domantis Ltd | Novel polypeptides and uses thereof |
| AU2008259590A1 (en) * | 2007-06-06 | 2008-12-11 | Domantis Limited | Methods for selecting protease resistant polypeptides |
| GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
| AU2008303955A1 (en) * | 2007-09-11 | 2009-04-02 | Mondobiotech Laboratories Ag | Use of melanocyte-stimulating hormone release-inhibiting factor as a therapeutic agent in the treatment of Pseudomonas aeruginosa infection |
| CA2710406A1 (en) * | 2007-09-11 | 2009-04-09 | Dorian Bevec | Use of a peptide as a therapeutic agent |
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-
2005
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- 2005-12-01 KR KR1020077015202A patent/KR20070086896A/ko not_active Ceased
- 2005-12-01 EP EP05818379A patent/EP1863847A2/en not_active Ceased
- 2005-12-01 US US11/791,781 patent/US20090191217A1/en not_active Abandoned
- 2005-12-01 AU AU2005311101A patent/AU2005311101B8/en not_active Ceased
- 2005-12-01 JP JP2007543910A patent/JP2008521870A/ja active Pending
- 2005-12-01 WO PCT/GB2005/004601 patent/WO2006059108A2/en not_active Ceased
- 2005-12-01 CN CNA2005800476534A patent/CN101133084A/zh active Pending
- 2005-12-01 BR BRPI0518622-6A patent/BRPI0518622A2/pt not_active Application Discontinuation
- 2005-12-01 MX MX2007006593A patent/MX2007006593A/es unknown
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2007
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- 2007-06-29 MA MA30043A patent/MA29669B1/fr unknown
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2011
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| AU2005311101B2 (en) | 2010-11-11 |
| AU2011200544A1 (en) | 2011-03-03 |
| EP1863847A2 (en) | 2007-12-12 |
| MX2007006593A (es) | 2008-03-04 |
| NO20073337L (no) | 2007-08-28 |
| IL183458A0 (en) | 2007-09-20 |
| KR20070086896A (ko) | 2007-08-27 |
| CN101133084A (zh) | 2008-02-27 |
| CA2588892A1 (en) | 2006-06-08 |
| WO2006059108A3 (en) | 2007-02-22 |
| JP2008521870A (ja) | 2008-06-26 |
| MA29669B1 (fr) | 2008-08-01 |
| AU2005311101B8 (en) | 2011-03-03 |
| US20090191217A1 (en) | 2009-07-30 |
| WO2006059108A2 (en) | 2006-06-08 |
| AU2005311101A1 (en) | 2006-06-08 |
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