BRPI0518884A2 - mÉtodo para medir a resistÊncia ou sensibilidade ao docetaxel - Google Patents

mÉtodo para medir a resistÊncia ou sensibilidade ao docetaxel

Info

Publication number
BRPI0518884A2
BRPI0518884A2 BRPI0518884-9A BRPI0518884A BRPI0518884A2 BR PI0518884 A2 BRPI0518884 A2 BR PI0518884A2 BR PI0518884 A BRPI0518884 A BR PI0518884A BR PI0518884 A2 BRPI0518884 A2 BR PI0518884A2
Authority
BR
Brazil
Prior art keywords
sensitivity
measuring
docetaxel
predict
controls
Prior art date
Application number
BRPI0518884-9A
Other languages
English (en)
Inventor
Dorre Grueneberg
Xi Huang
Sridaran Natesan
Paul August
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of BRPI0518884A2 publication Critical patent/BRPI0518884A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

MÉTODO PARA MEDIR A RESISTÊNCIA OU SENSIBILIDADE AO DOCETAXEL. A presente invenção refere-se aos métodos novos e úteis que prognosticam ou monitoram uma resposta do paciente a uma molécula da família de taxóide medindo-se o aumento ou diminuição de marcadores genéticos específicos quando comparados aos controles. A presente invenção também fornece kits que prognosticam ou monitoram resposta de pacientes a uma molécula da família de taxóide medindo-se os níveis de ácido nucléico ou proteína de marcadores genéticos particulares e comparando seus níveis aos controles ou marcadores de referência.
BRPI0518884-9A 2004-12-08 2005-12-01 mÉtodo para medir a resistÊncia ou sensibilidade ao docetaxel BRPI0518884A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63429804P 2004-12-08 2004-12-08
PCT/US2005/043578 WO2006062811A2 (en) 2004-12-08 2005-12-01 Method for measuring resistance or sensitivity to docetaxel

Publications (1)

Publication Number Publication Date
BRPI0518884A2 true BRPI0518884A2 (pt) 2008-12-30

Family

ID=36512512

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518884-9A BRPI0518884A2 (pt) 2004-12-08 2005-12-01 mÉtodo para medir a resistÊncia ou sensibilidade ao docetaxel

Country Status (15)

Country Link
US (2) US20090226894A1 (pt)
EP (10) EP2395107A1 (pt)
JP (5) JP5139811B2 (pt)
KR (10) KR101323574B1 (pt)
CN (10) CN101072883B (pt)
AR (1) AR051523A1 (pt)
AU (1) AU2005314335C1 (pt)
BR (1) BRPI0518884A2 (pt)
CA (1) CA2589918A1 (pt)
IL (9) IL183718A (pt)
MX (1) MX2007006867A (pt)
RU (2) RU2403574C2 (pt)
SG (2) SG156625A1 (pt)
TW (10) TW201241176A (pt)
WO (1) WO2006062811A2 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0606096D0 (en) 2006-03-27 2006-05-03 Cbmm Sa Screening method
EP2468887A1 (en) * 2006-12-13 2012-06-27 Oncotherapy Science, Inc. TTK as tumor marker and therapeutic target for lung cancer
JP5832721B2 (ja) * 2007-03-14 2015-12-16 バイオンシル・エス．アール．エル．Ｂｉｏｎｓｉｌ Ｓ．Ｒ．Ｌ． 上皮腫瘍細胞における薬剤耐性のモジュレータ化合物
GB2460769C (en) * 2007-11-30 2011-09-07 Applied Genomics Inc TLE3 as a marker for chemotherapy
EP2177630A1 (en) 2008-10-02 2010-04-21 Institut Gustave Roussy Methods for predicting or monitoring whether a patient affected by a cancer is responsive to a treatment with a molecule of the taxoid family
TW201102081A (en) 2009-05-11 2011-01-16 Oncotherapy Science Inc TTK peptides and vaccines including the same
CN102770131A (zh) 2009-10-29 2012-11-07 安万特医药股份有限公司 卡巴他赛的新颖抗肿瘤用途
WO2011124669A1 (en) 2010-04-08 2011-10-13 Institut Gustave Roussy Methods for predicting or monitoring whether a patient affected by a cancer is responsive to a treatment with a molecule of the taxoid family
JP2012005479A (ja) * 2010-05-26 2012-01-12 Japanese Foundation For Cancer Research 抗癌剤のスクリーニング方法
CA2822491C (en) * 2011-01-21 2023-02-14 Basilea Pharmaceutica Ag Bubr1 as a biomarker for furazanobenzimidazoles
ES2736999T3 (es) * 2011-11-21 2020-01-09 Taivex Therapeutics Corp Biomarcadores para cánceres que responden a moduladores de la actividad de Hec1
CA2857191A1 (en) * 2011-11-28 2013-06-06 National Research Council Of Canada Paclitaxel response markers for cancer
CN102621325B (zh) * 2012-04-06 2014-11-12 上海蓝怡科技有限公司 用于检测血液中多西他赛浓度的试剂盒
WO2014049702A1 (ja) * 2012-09-26 2014-04-03 大和ハウス工業株式会社 スイッチ制御システム
CN105803053B (zh) * 2014-12-31 2021-03-16 上海吉凯基因科技有限公司 人rbm17基因的用途及其相关药物
CN105925611A (zh) * 2016-04-23 2016-09-07 同济大学苏州研究院 靶向hsp70基因rna干扰重组慢病毒载体及其构建方法
CN107447028A (zh) * 2017-09-13 2017-12-08 赵小刚 检测rb1基因i680t位点突变的试剂盒
CN113855675A (zh) * 2018-05-22 2021-12-31 郑州大学第一附属医院 基于胆囊癌标志物的试剂盒及药物
CN111944905B (zh) * 2020-08-20 2023-06-02 武汉凯德维斯医学检验实验室有限公司 人类基因组合及其在制备评估宫颈癌新辅助化疗药物敏感性试剂盒中的应用
KR102605155B1 (ko) 2022-03-04 2023-11-23 우순 다기능 표적 이송장치
KR102596893B1 (ko) 2022-03-04 2023-11-01 우순 표적지 이송장치
CN115078034B (zh) * 2022-06-30 2025-06-24 江南大学 一种适用于有机质谱的单细胞周期标记方法及其在单细胞周期鉴定中的应用
CN115869402A (zh) * 2022-07-29 2023-03-31 上海交通大学医学院附属第九人民医院 Itgb1在制备用于提高头颈鳞癌对多西他赛敏感性的药物中的应用

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7807532A (nl) 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
NL8000173A (nl) 1980-01-11 1981-08-03 Akzo Nv Toepassing van in water dispergeerbare, hydrofobe kleurstoffen als label in immunochemische testen.
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4703017C1 (en) 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
JPS61231031A (ja) * 1985-04-08 1986-10-15 Agency Of Ind Science & Technol 二硫化炭素重合体の製造方法
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
EP0280559B1 (en) 1987-02-27 1993-10-20 EASTMAN KODAK COMPANY (a New Jersey corporation) Agglutination immunoassay and kit for determination of a multivalent immune species using a buffered salt wash solution
DE3882058T2 (de) 1987-02-27 1994-01-13 Eastman Kodak Co Immunoreaktives Reagens, Verfahren zu seiner Herstellung und seine Verwendung zur Bestimmung einer immunoreaktiven Spezies.
US4857453A (en) 1987-04-07 1989-08-15 Syntex (U.S.A.) Inc. Immunoassay device
ATE195022T1 (de) 1987-04-27 2000-08-15 Unilever Nv Spezifische bindungstestverfahren
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5834298A (en) * 1995-08-01 1998-11-10 Sloan-Kettering Institute For Cancer Research Gene encoding the human homolog of MAD2
US6410312B1 (en) * 1997-12-19 2002-06-25 Chiron Corporation huBUB3 gene involved in human cancers
US6489137B2 (en) * 1997-06-11 2002-12-03 Chiron Corporation Detection of loss of the wild-type huBUB1 gene
CA2311414A1 (en) * 1997-11-27 1999-06-10 Chugai Research Institute For Molecular Medicine, Inc. Diagnostic method, diagnostic reagent and therapeutic preparation for diseases caused by variation in lkb1 gene
CA2321480A1 (en) * 1998-02-18 1999-08-26 Laurence Anthony Seabra Treating cancer
US6350452B1 (en) * 1998-09-24 2002-02-26 Promega Corporation Apoptosis marker antibodies and methods of use
AU2055300A (en) * 1998-12-18 2000-07-03 Scios Inc. Methods for detection and use of differentially expressed genes in disease states
WO2001061048A2 (en) * 2000-02-17 2001-08-23 Millennium Pharmaceuticals, Inc. Methods and compositions for the identification, assessment, prevention and therapy of human cancers
AU2001245295A1 (en) * 2000-02-17 2001-08-27 Millennum Pharmaceuticals, Inc. Methods and compositions for the identification, assessment, prevention and therapy of human cancers
CA2438092C (en) * 2001-02-21 2011-08-09 Chiron Corporation Ttk in diagnosis and as a therapeutic target in cancer
US6783597B2 (en) * 2001-03-13 2004-08-31 3M Innovative Properties Company Filament recoating apparatus and method
US7229774B2 (en) * 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
DE10139283A1 (de) * 2001-08-09 2003-03-13 Epigenomics Ag Verfahren und Nukleinsäuren zur Analyse von Colon-Krebs
US20030235581A1 (en) * 2002-06-20 2003-12-25 George Pieczenik Ligands for Reproductive Science
ATE494296T1 (de) * 2002-09-11 2011-01-15 Genentech Inc Zusammensetzungen und verfahren für die tumordiagnose und behandlung
AU2003300899A1 (en) * 2002-12-12 2004-06-30 Oncotech, Inc. Genes related to sensitivity and resistance to chemotherapeutic drug treatment
DE10260264A1 (de) * 2002-12-20 2004-07-01 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Verfahren und Zelllinie zur Identifizierung proliferationshemmender, anti-inflammatorischer oder proliferationsfördender Wirkstoffe
EP1661991A4 (en) * 2003-08-24 2007-10-10 Univ Nihon WITH HEPATOCELLULAR CARCINOMA ASSOCIATED GEN
US20050136177A1 (en) * 2003-08-25 2005-06-23 Anthony Hesse Method for coloring landscaping materials using foamable dry colorant
CA2563074C (en) * 2004-04-09 2014-05-20 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
JP2006014722A (ja) * 2004-06-02 2006-01-19 Keio Gijuku 遺伝子マーカー及びその利用
GB0426393D0 (en) * 2004-12-01 2005-01-05 Cancer Rec Tech Ltd Materials and methods relating to modulators of spindle checkpoint kinases
US7957910B2 (en) * 2005-01-31 2011-06-07 Sysmex Corporation Method for predicting effectiveness of chemotherapy
EP2177630A1 (en) * 2008-10-02 2010-04-21 Institut Gustave Roussy Methods for predicting or monitoring whether a patient affected by a cancer is responsive to a treatment with a molecule of the taxoid family

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Publication number Publication date
JP5530999B2 (ja) 2014-06-25
IL225469A0 (en) 2013-06-27
AU2005314335A1 (en) 2006-06-15
JP2012100666A (ja) 2012-05-31
IL205636A (en) 2012-08-30
CN102747141A (zh) 2012-10-24
WO2006062811A2 (en) 2006-06-15
CN102747140A (zh) 2012-10-24
EP2395107A1 (en) 2011-12-14
JP5531002B2 (ja) 2014-06-25
KR20130105760A (ko) 2013-09-25
JP5531000B2 (ja) 2014-06-25
CN102605066A (zh) 2012-07-25
CN102618641B (zh) 2014-08-13
JP2012100665A (ja) 2012-05-31
KR101357035B1 (ko) 2014-02-03
MX2007006867A (es) 2007-08-06
RU2007125722A (ru) 2009-01-20
IL221772A0 (en) 2012-10-31
CN102618641A (zh) 2012-08-01
KR20070085986A (ko) 2007-08-27
KR20130113527A (ko) 2013-10-15
KR20130105758A (ko) 2013-09-25
EP2395106A1 (en) 2011-12-14
IL221772A (en) 2014-06-30
EP2395108A1 (en) 2011-12-14
IL210298A0 (en) 2011-03-31
IL210299A (en) 2012-12-31
KR101323574B1 (ko) 2013-10-30
TW201237179A (en) 2012-09-16
CN101072883B (zh) 2012-05-23
KR101357033B1 (ko) 2014-02-03
US20130252837A1 (en) 2013-09-26
IL210299A0 (en) 2011-03-31
CN102618642B (zh) 2014-12-31
CN102634574A (zh) 2012-08-15
CN102605067A (zh) 2012-07-25
AU2005314335B2 (en) 2012-02-02
EP2395109A1 (en) 2011-12-14
RU2010122759A (ru) 2011-12-10
KR101357032B1 (ko) 2014-02-03
IL205702A0 (en) 2011-07-31
KR20130099246A (ko) 2013-09-05
KR101357038B1 (ko) 2014-02-03
KR101357040B1 (ko) 2014-02-03
KR101347106B1 (ko) 2014-01-02
EP2395102A1 (en) 2011-12-14
CN101072883A (zh) 2007-11-14
WO2006062811A3 (en) 2006-09-14
TW200636076A (en) 2006-10-16
SG194337A1 (en) 2013-11-29
IL183718A0 (en) 2007-09-20
EP2395105A1 (en) 2011-12-14
KR101357039B1 (ko) 2014-02-03
HK1153786A1 (en) 2012-04-05
KR20130004381A (ko) 2013-01-09
EP1831398A2 (en) 2007-09-12
TW201237178A (en) 2012-09-16
CN101974619A (zh) 2011-02-16
HK1111441A1 (en) 2008-08-08
JP2012115267A (ja) 2012-06-21
KR20130105761A (ko) 2013-09-25
CN102634574B (zh) 2014-11-12
JP5139811B2 (ja) 2013-02-06
SG156625A1 (en) 2009-11-26
US20090226894A1 (en) 2009-09-10
TW201237176A (en) 2012-09-16
TW201237175A (en) 2012-09-16
TW201237174A (en) 2012-09-16
CN102618642A (zh) 2012-08-01
KR20130105762A (ko) 2013-09-25
IL225468A0 (en) 2013-06-27
RU2403574C2 (ru) 2010-11-10
EP2395104A1 (en) 2011-12-14
AR051523A1 (es) 2007-01-17
JP5531001B2 (ja) 2014-06-25
KR101357037B1 (ko) 2014-02-03
TW201241176A (en) 2012-10-16
JP2008522615A (ja) 2008-07-03
CN101974619B (zh) 2012-11-21
KR20130105759A (ko) 2013-09-25
KR20130113526A (ko) 2013-10-15
AU2005314335C1 (en) 2012-08-16
IL205635A (en) 2013-02-28
CA2589918A1 (en) 2006-06-15
TW201241177A (en) 2012-10-16
TW201237177A (en) 2012-09-16
KR101347107B1 (ko) 2014-01-02
TW201241178A (en) 2012-10-16
JP2012120532A (ja) 2012-06-28
IL210298A (en) 2012-12-31
IL183718A (en) 2013-04-30
EP1831398B1 (en) 2014-10-29
EP2395103A1 (en) 2011-12-14
EP2395110A1 (en) 2011-12-14
CN102747142A (zh) 2012-10-24

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