BRPI0519072A2 - mÉtodo para preparar uma fosforamidita, uso de um ativador, mistura, e, usos da mistura e de cetonas - Google Patents

mÉtodo para preparar uma fosforamidita, uso de um ativador, mistura, e, usos da mistura e de cetonas

Info

Publication number
BRPI0519072A2
BRPI0519072A2 BRPI0519072-0A BRPI0519072A BRPI0519072A2 BR PI0519072 A2 BRPI0519072 A2 BR PI0519072A2 BR PI0519072 A BRPI0519072 A BR PI0519072A BR PI0519072 A2 BRPI0519072 A2 BR PI0519072A2
Authority
BR
Brazil
Prior art keywords
activator
preparing
mixture
phosphoramidite
ketones
Prior art date
Application number
BRPI0519072-0A
Other languages
English (en)
Inventor
Meinolf Lange
Andreas Schoenberger
Christina Kirchhoff
Olaf Groessel
Nadja Omelcenko
Andreas Hohlfeld
Fritz Link
Original Assignee
Girindus Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34930059&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0519072(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Girindus Ag filed Critical Girindus Ag
Publication of BRPI0519072A2 publication Critical patent/BRPI0519072A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0271—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds also containing elements or functional groups covered by B01J31/0201 - B01J31/0231
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)

Abstract

MÉTODO PARA PREPARAR UMA FOSFORAMIDITA, USO DE UM ATIVADOR, MISTURA, E, USOS DA MISTURA E DE CETONAS. Um método para preparar um composto fosfitilado, compreendendo as etapas de: -reagir um composto contendo hidroxila com um agente de fosfitilação, na presença de um ativador tendo a fórmula (I), em que R alquila, cicloalquila, arila, aralquila, heteroalquila, heteroarila, R~ 1~, R~ 2~ = H ou formam juntos um anel de 5 a 6 membros. X~ 1~, X~ 2~ = independentemente N ou CH, Y = H ou Si(R~ 4~)~ 3~, com R~ 4~ alquila, cicloalquila, arila, aralquila, heteroalquila, heteroarila B = ácido desprotonado. O composto contendo hidroxila é preferivelmente uma porção de açúcar ou um nucleosídeo ou um oligômero derivado dele.
BRPI0519072-0A 2004-12-15 2005-12-15 mÉtodo para preparar uma fosforamidita, uso de um ativador, mistura, e, usos da mistura e de cetonas BRPI0519072A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63615204P 2004-12-15 2004-12-15
EP04106599 2004-12-15
PCT/EP2005/056815 WO2006064039A1 (en) 2004-12-15 2005-12-15 Synthesis of phosphitylated compounds using a quaternary heterocyclic activator

Publications (1)

Publication Number Publication Date
BRPI0519072A2 true BRPI0519072A2 (pt) 2008-12-23

Family

ID=34930059

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519072-0A BRPI0519072A2 (pt) 2004-12-15 2005-12-15 mÉtodo para preparar uma fosforamidita, uso de um ativador, mistura, e, usos da mistura e de cetonas

Country Status (13)

Country Link
US (3) US20100081802A1 (pt)
EP (1) EP1828218B1 (pt)
JP (1) JP2008524163A (pt)
KR (1) KR20070090019A (pt)
CN (1) CN101103040B (pt)
AU (1) AU2005315631A1 (pt)
BR (1) BRPI0519072A2 (pt)
CA (1) CA2590221A1 (pt)
DE (2) DE202005021489U1 (pt)
IL (1) IL183738A (pt)
MX (1) MX2007007298A (pt)
RU (1) RU2440364C2 (pt)
WO (1) WO2006064039A1 (pt)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4973679A (en) * 1981-03-27 1990-11-27 University Patents, Inc. Process for oligonucleo tide synthesis using phosphormidite intermediates
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
JPH1180185A (ja) * 1997-09-05 1999-03-26 Res Dev Corp Of Japan オリゴヌクレオチドの化学合成法
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
JP4709959B2 (ja) * 2001-06-14 2011-06-29 国立大学法人東京工業大学 ヌクレオシドホスホロアミダイト化合物
JP2003012690A (ja) * 2001-07-03 2003-01-15 Mitsui Chemicals Inc 置換イミダゾール誘導体又は置換ベンズイミダゾール誘導体を用いたヌクレオチドの製造法
GB0224316D0 (en) * 2002-10-18 2002-11-27 Syngenta Participations Ag Chemical compounds

Also Published As

Publication number Publication date
IL183738A0 (en) 2007-09-20
US20100081802A1 (en) 2010-04-01
DE202005021488U1 (de) 2008-05-08
RU2007126807A (ru) 2009-01-27
KR20070090019A (ko) 2007-09-04
US20120316328A1 (en) 2012-12-13
JP2008524163A (ja) 2008-07-10
WO2006064039A1 (en) 2006-06-22
DE202005021489U1 (de) 2008-05-08
US20130281682A1 (en) 2013-10-24
CN101103040A (zh) 2008-01-09
CN101103040B (zh) 2012-06-13
MX2007007298A (es) 2007-10-19
CA2590221A1 (en) 2006-06-22
RU2440364C2 (ru) 2012-01-20
AU2005315631A1 (en) 2006-06-22
EP1828218B1 (en) 2014-04-30
EP1828218A1 (en) 2007-09-05
IL183738A (en) 2012-12-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.