BRPI0601773A - compostos de fenilpiridilpiperazina, um processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos - Google Patents

compostos de fenilpiridilpiperazina, um processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos

Info

Publication number
BRPI0601773A
BRPI0601773A BRPI0601773-8A BRPI0601773A BRPI0601773A BR PI0601773 A BRPI0601773 A BR PI0601773A BR PI0601773 A BRPI0601773 A BR PI0601773A BR PI0601773 A BRPI0601773 A BR PI0601773A
Authority
BR
Brazil
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
compounds
phenylpyridylpiperazine
Prior art date
Application number
BRPI0601773-8A
Other languages
English (en)
Inventor
Patrice Desos
Alexis Cordi
Pierre Lestage
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0601773A publication Critical patent/BRPI0601773A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

COMPOSTOS DE FENILPIRIDILPIPERAZINA, UM PROCESSO PARA A PREPARAçãO DOS MESMOS E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS. Compostos da fórmula (I): em que: - X representa um grupo C(O) ou SO~ 2~, - R~ 1~ representa um grupo arila ou um grupo NR~ 3~R~ 4~em que R~ 3~ e R~ 4~ são como definidos na descrição, - R~ 2~ representa um grupo alquila, (C~ 3~-C~ 8~) cicloalquil-(~ 1~-C~ 6~), seus isómeros e ainda sais de adição dos mesmos. Medicamentos.
BRPI0601773-8A 2005-05-12 2006-05-12 compostos de fenilpiridilpiperazina, um processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos BRPI0601773A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0504758A FR2885616B1 (fr) 2005-05-12 2005-05-12 Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BRPI0601773A true BRPI0601773A (pt) 2007-05-15

Family

ID=35668833

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0601773-8A BRPI0601773A (pt) 2005-05-12 2006-05-12 compostos de fenilpiridilpiperazina, um processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos

Country Status (25)

Country Link
US (1) US7494994B2 (pt)
EP (1) EP1721897A1 (pt)
JP (1) JP2006316061A (pt)
KR (1) KR100807481B1 (pt)
CN (1) CN100569767C (pt)
AP (1) AP2007004223A0 (pt)
AR (1) AR054121A1 (pt)
AU (1) AU2006201994A1 (pt)
BR (1) BRPI0601773A (pt)
CA (1) CA2546392A1 (pt)
CR (1) CR9499A (pt)
EA (1) EA011155B1 (pt)
FR (1) FR2885616B1 (pt)
GE (1) GEP20084470B (pt)
GT (1) GT200700097A (pt)
IL (1) IL186862A0 (pt)
MA (1) MA28326A1 (pt)
MY (1) MY141784A (pt)
NO (1) NO20062083L (pt)
NZ (1) NZ547122A (pt)
SG (1) SG127801A1 (pt)
TN (1) TNSN07395A1 (pt)
UA (1) UA87284C2 (pt)
WO (1) WO2006120349A1 (pt)
ZA (1) ZA200603810B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
MX2007015675A (es) * 2005-07-04 2008-02-20 Novo Nordisk As Antagonistas del receptor de histamina h3.
KR20090040259A (ko) * 2006-05-29 2009-04-23 하이 포인트 파마슈티칼스, 엘엘씨 3-(1,3-벤조디옥솔-5-일)-6-(4-시클로프로필피페라진-1-일)-피리다진, 그것의 염과 용매화합물 및 그것의 히스타민 ｈ3 수용체 안타고니스트로서의 용도
MY147320A (en) * 2006-12-14 2012-11-30 Janssen Pharmaceutica Nv Process for the preparation of piperazinyl and diazepanyl benzamide derivatives
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
AP3649A (en) 2011-02-23 2016-03-18 Lupin Ltd Heteroaryl derivatives as alpha7 nachr modulators
IN2014MN01756A (pt) 2012-03-06 2015-07-03 Lupin Ltd
WO2017083216A1 (en) * 2015-11-12 2017-05-18 Merck Sharp & Dohme Corp. Cyanopyridine derivatives as liver x receptor beta agonists, compositions, and their use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019574A (en) * 1988-09-30 1991-05-28 Chugai Seiyaku Kabushiki Kaisha 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function
KR930702304A (ko) * 1990-09-13 1993-09-08 스튜어트 알. 슈터 피리딜티오 또는 피리딜옥시 알칸산
CN1088459C (zh) * 1996-10-04 2002-07-31 诺沃挪第克公司 1,4－二取代的哌嗪
WO1999018077A1 (en) * 1997-10-02 1999-04-15 Eisai Co., Ltd. Fused pyridine derivatives
JP4570773B2 (ja) * 1997-10-27 2010-10-27 ニューロサーチ、アクティーゼルスカブ ニコチン性アセチルコリンレセプターに於けるコリン作動性リガンドとしてのヘテロアリールジアザシクロアルカン
GB9919776D0 (en) * 1998-08-31 1999-10-27 Zeneca Ltd Compoujnds
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines

Also Published As

Publication number Publication date
KR100807481B1 (ko) 2008-02-25
KR20060117263A (ko) 2006-11-16
CR9499A (es) 2008-02-20
CN1896073A (zh) 2007-01-17
EP1721897A1 (fr) 2006-11-15
AR054121A1 (es) 2007-06-06
SG127801A1 (en) 2006-12-29
NO20062083L (no) 2006-11-13
US7494994B2 (en) 2009-02-24
MA28326A1 (fr) 2006-12-01
EA200600760A1 (ru) 2006-12-29
GEP20084470B (en) 2008-08-25
NZ547122A (en) 2007-05-31
TNSN07395A1 (en) 2009-03-17
WO2006120349A1 (fr) 2006-11-16
AP2007004223A0 (en) 2007-10-31
CN100569767C (zh) 2009-12-16
US20060258670A1 (en) 2006-11-16
GT200700097A (es) 2009-06-04
ZA200603810B (en) 2007-08-29
FR2885616B1 (fr) 2007-06-22
JP2006316061A (ja) 2006-11-24
UA87284C2 (ru) 2009-07-10
CA2546392A1 (fr) 2006-11-12
FR2885616A1 (fr) 2006-11-17
MY141784A (en) 2010-06-30
AU2006201994A1 (en) 2006-11-30
EA011155B1 (ru) 2009-02-27
IL186862A0 (en) 2008-02-09

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.