BRPI0601885A - antiinflammatory and analgesic pharmaceutical composition containing n-acylhydrazenic derivatives of safrol, use, and process for their preparation - Google Patents

antiinflammatory and analgesic pharmaceutical composition containing n-acylhydrazenic derivatives of safrol, use, and process for their preparation

Info

Publication number
BRPI0601885A
BRPI0601885A BRPI0601885-8A BRPI0601885A BRPI0601885A BR PI0601885 A BRPI0601885 A BR PI0601885A BR PI0601885 A BRPI0601885 A BR PI0601885A BR PI0601885 A BRPI0601885 A BR PI0601885A
Authority
BR
Brazil
Prior art keywords
preparation
derivatives
safrol
antiinflammatory
pharmaceutical composition
Prior art date
Application number
BRPI0601885-8A
Other languages
Portuguese (pt)
Inventor
Carlos Alberto Manssour Fraga
Eliezer Jesus De Lace Barreiro
Carolina Mattos Duarte
Jorge Luiz Mendonca Tributino
Ana Luisa Palhares Miranda
Original Assignee
Univ Rio De Janeiro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rio De Janeiro filed Critical Univ Rio De Janeiro
Priority to BRPI0601885-8A priority Critical patent/BRPI0601885A/en
Priority to PCT/BR2007/000114 priority patent/WO2007131310A1/en
Publication of BRPI0601885A publication Critical patent/BRPI0601885A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSIçãO FARMACêUTICA ANTIINFLAMATóRIA E ANALGéSICA CONTENDO DERIVADOS N-ACILIDRAZÈNICOS DO SAFROL, USO, E PROCESSO PARA SUA PREPARAçãO. São descritas novos derivados do núcleo 6-nitro-N-arilmetilideno-1,3-benzodioxola-5-carboidrazida que atuam como antiinflamatórios e analgésicos com ação no sistema nervoso central, sendo, portanto, úteis no tratamento doenças inflamatórias agudas e crónicas e hiperalgesia central em mamíferos; também são descritas composições farmacêuticas contendo os referidos compostos e processos para sua preparação.ANTI-INFLAMMATORY AND ANALGESIC PHARMACEUTICAL COMPOSITION CONTAINING N-ACYLIDRAZENIC SAFROL DERIVATIVES, USE, AND PROCESS FOR THEIR PREPARATION. New derivatives of the 6-nitro-N-arylmethylidene-1,3-benzodioxola-5-carbohydrazide nucleus that act as antiinflammatory and analgesic agents acting on the central nervous system are therefore useful in the treatment of acute and chronic inflammatory diseases and hyperalgesia. central in mammals; Also disclosed are pharmaceutical compositions containing said compounds and processes for their preparation.

BRPI0601885-8A 2006-05-15 2006-05-15 antiinflammatory and analgesic pharmaceutical composition containing n-acylhydrazenic derivatives of safrol, use, and process for their preparation BRPI0601885A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI0601885-8A BRPI0601885A (en) 2006-05-15 2006-05-15 antiinflammatory and analgesic pharmaceutical composition containing n-acylhydrazenic derivatives of safrol, use, and process for their preparation
PCT/BR2007/000114 WO2007131310A1 (en) 2006-05-15 2007-05-14 Anti-inflammatory and analgesic pharmaceutical composition containing safrole n-acylhydrazone derivatives, use, and method of preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0601885-8A BRPI0601885A (en) 2006-05-15 2006-05-15 antiinflammatory and analgesic pharmaceutical composition containing n-acylhydrazenic derivatives of safrol, use, and process for their preparation

Publications (1)

Publication Number Publication Date
BRPI0601885A true BRPI0601885A (en) 2008-03-25

Family

ID=38693471

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0601885-8A BRPI0601885A (en) 2006-05-15 2006-05-15 antiinflammatory and analgesic pharmaceutical composition containing n-acylhydrazenic derivatives of safrol, use, and process for their preparation

Country Status (2)

Country Link
BR (1) BRPI0601885A (en)
WO (1) WO2007131310A1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB921322A (en) * 1960-05-23 1963-03-20 Charles E Frosst & Company Substituted hydrazide compounds
WO1986004582A1 (en) * 1985-02-11 1986-08-14 The Upjohn Company Anthelmintic pyridinyl acylhydrazones, method of use and compositions
CA2384525C (en) * 1999-06-21 2007-03-06 University Of Maryland, Baltimore Thienylhydrazon with digitalis-like properties (positive inotropic effects)
EP1392219A4 (en) * 2001-05-10 2007-01-24 Cytovia Inc SUBSTITUTED N '- (ARYLCARBONYL) -BENZHYDRAZIDE, N' - (ARYLCARBONYL) -BENZYLIDENE HYDRAZIDE AND ANALOGA AS ACTIVATORS OF CASPASES AND INDUCTORS OF APOTOSIS AND THEIR APPLICATION
WO2006121684A2 (en) * 2005-05-06 2006-11-16 Boehringer Ingelheim International, Gmbh Acyl hydrazones for treating cardiovascular diseases

Also Published As

Publication number Publication date
WO2007131310B1 (en) 2008-01-31
WO2007131310A1 (en) 2007-11-22

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 9A ANUIDADE.

B08H Application fees: decision cancelled

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2308 DE 31/03/2015.

B07D Technical examination (opinion) related to article 229 of industrial property law

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B07E Notice of approval relating to section 229 industrial property law

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B06V Preliminary requirement: requests without searches performed by other patent offices: suspension of the patent application procedure
B07A Technical examination (opinion): publication of technical examination (opinion)
B09B Decision: refusal
B09B Decision: refusal

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