BRPI0604377A - microemulsão óleo/água de propofol estável e pronta-para-uso - Google Patents

microemulsão óleo/água de propofol estável e pronta-para-uso

Info

Publication number
BRPI0604377A
BRPI0604377A BRPI0604377-1A BRPI0604377A BRPI0604377A BR PI0604377 A BRPI0604377 A BR PI0604377A BR PI0604377 A BRPI0604377 A BR PI0604377A BR PI0604377 A BRPI0604377 A BR PI0604377A
Authority
BR
Brazil
Prior art keywords
propofol
water microemulsion
oil
ready
coo
Prior art date
Application number
BRPI0604377-1A
Other languages
English (en)
Inventor
Ogari De Castro Pacheco
Roberto Debom Moreira
Marisa Dutra Rodrigues Rizzi
Original Assignee
Cristalia Prod Quimicos Farm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cristalia Prod Quimicos Farm filed Critical Cristalia Prod Quimicos Farm
Priority to BRPI0604377-1A priority Critical patent/BRPI0604377A/pt
Priority to PY200700735799A priority patent/PY0735799A/es
Priority to US12/447,247 priority patent/US20100041769A1/en
Priority to EP07815724.5A priority patent/EP2097073A4/en
Priority to HK10101737.4A priority patent/HK1135029B/xx
Priority to PCT/BR2007/000283 priority patent/WO2008049178A1/en
Priority to CN2007800427185A priority patent/CN101553215B/zh
Priority to ARP070104732A priority patent/AR063397A1/es
Priority to CL200703075A priority patent/CL2007003075A1/es
Priority to UY30676A priority patent/UY30676A1/es
Publication of BRPI0604377A publication Critical patent/BRPI0604377A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

MICROEMULSãO óLEO/áGUA DE PROPOFOL ESTáVEL E PRONTA-PARA-USO A presente invenção descreve uma nova composição farmacêutica anestésica contendo propofol para administração parenteral, estando na forma de microemulsão óleo/água na qual a fase oleosa é constituída pelo propofol sob a forma de partículas com diâmetro compreendido entre 1 e 100 nm utilizando um único surfactante selecionado do grupo constituído por estearatos de polietilenoglicol possuindo a fórmula geral C~ 17~H~ 35~COO. (O.CH~ 2~CH~ 2~)~ nH~ ou C~ 17~H~ 35~COO (OCH~ 2~CH~ 2~)~ n~. COOC~ 17~H~ 35~. A composição farmacêutica anestésica da presente invenção é mais potente para a indução de hipnose e anestesia, está na forma pronta-para-uso e é altamente estável quanto ás dimensões de partículas, apresentando melhores propriedades físico-químicas, e previne os potenciais riscos de efeitos indesejáveis encontrados nas formulações de propofol conhecidas no estado da arte.
BRPI0604377-1A 2006-10-27 2006-10-27 microemulsão óleo/água de propofol estável e pronta-para-uso BRPI0604377A (pt)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BRPI0604377-1A BRPI0604377A (pt) 2006-10-27 2006-10-27 microemulsão óleo/água de propofol estável e pronta-para-uso
PY200700735799A PY0735799A (es) 2006-10-27 2007-10-19 Microemulsión aceite/agua de propofol estable y lista para uso. para administración parenteral y de uso como anestésico
US12/447,247 US20100041769A1 (en) 2006-10-27 2007-10-23 Stable and ready-to-use oil-in-water propofol microemulsion
EP07815724.5A EP2097073A4 (en) 2006-10-27 2007-10-23 STABLE AND APPLICABLE OIL-IN-WATER MICROEMULSION FROM PROPOFOL
HK10101737.4A HK1135029B (en) 2006-10-27 2007-10-23 Stable and ready-to-use oil-in-water propofol microemulsion
PCT/BR2007/000283 WO2008049178A1 (en) 2006-10-27 2007-10-23 Stable and ready-to-use oil-in-water propofol microemulsion
CN2007800427185A CN101553215B (zh) 2006-10-27 2007-10-23 稳定的即用型水包油丙泊酚微乳液
ARP070104732A AR063397A1 (es) 2006-10-27 2007-10-25 Microemulsion aceite/agua de propofol estable y lista para uso
CL200703075A CL2007003075A1 (es) 2006-10-27 2007-10-25 Microemulsion oleo/agua de propofol, donde la fase oleosa esta constituida por propofol en forma de particulas con diametro entre 1 y 100 nm y por un surfactante del grupo constituido por estearatos de polietileno glicol; proceso de preparacion; y us
UY30676A UY30676A1 (es) 2006-10-27 2007-10-30 Microemulsion aceite/agua de propofol estable y lista para uso

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0604377-1A BRPI0604377A (pt) 2006-10-27 2006-10-27 microemulsão óleo/água de propofol estável e pronta-para-uso

Publications (1)

Publication Number Publication Date
BRPI0604377A true BRPI0604377A (pt) 2008-06-24

Family

ID=39324037

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0604377-1A BRPI0604377A (pt) 2006-10-27 2006-10-27 microemulsão óleo/água de propofol estável e pronta-para-uso

Country Status (9)

Country Link
US (1) US20100041769A1 (pt)
EP (1) EP2097073A4 (pt)
CN (1) CN101553215B (pt)
AR (1) AR063397A1 (pt)
BR (1) BRPI0604377A (pt)
CL (1) CL2007003075A1 (pt)
PY (1) PY0735799A (pt)
UY (1) UY30676A1 (pt)
WO (1) WO2008049178A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
WO2014033751A2 (en) * 2012-08-16 2014-03-06 Emcure Pharmaceuticals Limited Pharmaceutical composition of propofol
WO2017002117A1 (en) * 2015-07-01 2017-01-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Delivery systems for propofol

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8912391D0 (en) * 1989-05-30 1989-07-12 Unilever Plc Shampoo composition
DE4039602A1 (de) * 1990-12-12 1992-06-17 Bauer Kurt Heinz Prof Dr Pharmazeutische formulierungen
US5962536A (en) * 1998-07-31 1999-10-05 Komer; Gene Injectable propofol formulations
AU5574200A (en) * 1999-06-21 2001-01-09 Kuhnil Pharm. Co., Ltd. Anesthetic composition for intravenous injection comprising propofol
KR20010055736A (ko) * 1999-12-13 2001-07-04 이규현 프로포폴의 마이크로에멀젼 주사제 조성물
IN188917B (pt) * 2000-12-07 2002-11-23 Bharat Surums & Vaccines Ltd
US20040220283A1 (en) * 2002-07-29 2004-11-04 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
NZ526347A (en) * 2003-04-30 2005-07-29 Parnell Lab Aust Pty Ltd Formulations containing propofol for anaesthetic use
US7326735B2 (en) * 2003-04-30 2008-02-05 Parnell Laboratories (Aust) Pty Limited Formulations for anaesthetic use
BRPI0506812B8 (pt) * 2004-02-13 2021-05-25 Bioavailability Inc composição base anidra auto-microemulsificável, microemulsão e método de preparação da composição base automicroemulsificável
ATE420625T1 (de) * 2005-08-05 2009-01-15 Bharat Serums & Vaccines Ltd Intravenöse propofol-emulsionszusammensetzungen mit konservierendem effekt

Also Published As

Publication number Publication date
WO2008049178A1 (en) 2008-05-02
AR063397A1 (es) 2009-01-28
US20100041769A1 (en) 2010-02-18
PY0735799A (es) 2012-08-01
EP2097073A4 (en) 2013-09-18
UY30676A1 (es) 2008-05-31
HK1135029A1 (en) 2010-05-28
CL2007003075A1 (es) 2008-03-14
CN101553215B (zh) 2013-04-10
EP2097073A1 (en) 2009-09-09
WO2008049178A8 (en) 2008-06-12
CN101553215A (zh) 2009-10-07

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements