BRPI0606117A2 - método de geração de ácido l-ascórbico, levedura recombinante e método para aumentar a produção, a produtividade, ou o rendimento de um produto produzido por um microorganismo durante a fermentação - Google Patents

método de geração de ácido l-ascórbico, levedura recombinante e método para aumentar a produção, a produtividade, ou o rendimento de um produto produzido por um microorganismo durante a fermentação

Info

Publication number
BRPI0606117A2
BRPI0606117A2 BRPI0606117-6A BRPI0606117A BRPI0606117A2 BR PI0606117 A2 BRPI0606117 A2 BR PI0606117A2 BR PI0606117 A BRPI0606117 A BR PI0606117A BR PI0606117 A2 BRPI0606117 A2 BR PI0606117A2
Authority
BR
Brazil
Prior art keywords
ascorbic acid
yeast
productivity
increasing
production
Prior art date
Application number
BRPI0606117-6A
Other languages
English (en)
Inventor
Paola Branduardi
Danilo Porro
Michael Sauer
Diethard Mattanovich
Original Assignee
Tate & Lyle Ingredients
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tate & Lyle Ingredients filed Critical Tate & Lyle Ingredients
Publication of BRPI0606117A2 publication Critical patent/BRPI0606117A2/pt
Publication of BRPI0606117C1 publication Critical patent/BRPI0606117C1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

MéTODO DE GERAçãO DE áCIDO L-ASCóRBICO, LEVEDURA RECOMBINANTE E MéTODO PARA AUMENTAR A PRODUçãO, A PRODUTIVIDADE, OU O RENDIMENTO DE UM PRODUTO PRODUZIDO POR UM MICROORGANISMO DURANTE A FERMENTAçãO. Trata-se de um método de geração de ácido ascórbico a partir de levedura transformada com uma epimerase de manose. Em uma realização adicional, a levedura também pode ser transformada com uma fosfatase de mioinositol. No método, a levedura transformada pode produzir o ácido L-ascórbico a partir da D-glicose. Foi observado que a levedura transformada tem uma maior taxa de crescimento, densidade da célula ou sobrevivência quando cultivada em meios apropriados.
BRC10606117-6A 2005-04-13 2006-04-07 método para aumentar a toleráncia ao stress em um organismo recombinante que é projetado por engenharia genética para a produção industrial de pelo menos um produto e método para aumentar a toleráncia ao stress em um organismo que produz ácido láctico BRPI0606117C1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/105,162 US20060234360A1 (en) 2005-04-13 2005-04-13 Ascorbic acid production from D-glucose in yeast
PCT/US2006/012854 WO2006113147A2 (en) 2005-04-13 2006-04-07 Ascorbic acid production from d-glucose in yeast

Publications (2)

Publication Number Publication Date
BRPI0606117A2 true BRPI0606117A2 (pt) 2009-10-06
BRPI0606117C1 BRPI0606117C1 (pt) 2009-12-29

Family

ID=37108990

Family Applications (1)

Application Number Title Priority Date Filing Date
BRC10606117-6A BRPI0606117C1 (pt) 2005-04-13 2006-04-07 método para aumentar a toleráncia ao stress em um organismo recombinante que é projetado por engenharia genética para a produção industrial de pelo menos um produto e método para aumentar a toleráncia ao stress em um organismo que produz ácido láctico

Country Status (6)

Country Link
US (2) US20060234360A1 (pt)
EP (1) EP1874947A2 (pt)
JP (1) JP2008536497A (pt)
CN (1) CN101171340A (pt)
BR (1) BRPI0606117C1 (pt)
WO (1) WO2006113147A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102477446B (zh) * 2010-11-25 2014-03-19 花王株式会社 神经酰胺和/或葡萄糖神经酰胺产生促进剂的制造方法
EP2540170A1 (de) * 2011-06-29 2013-01-02 Evonik Degussa GmbH Dermatologisch wirksamer Hefeextrakt
ITTO20120870A1 (it) 2012-10-05 2014-04-06 Chemtex Italia Spa Organismo microbico resistente allo stress biochimico
JP6171598B2 (ja) * 2013-06-11 2017-08-02 国立大学法人 新潟大学 β−マンノシドの製造方法
KR102144998B1 (ko) 2013-08-30 2020-08-14 삼성전자주식회사 효모에 내산성을 부여하는 폴리펩티드, 그를 코딩하는 폴리뉴클레오티드, 그 양이 증가되어 있는 효모 세포, 상기 효모 세포를 이용한 산물의 생산 방법 및 내산성 효모 세포를 생산하는 방법
AR101479A1 (es) * 2014-08-11 2016-12-21 Boehringer Ingelheim Int Derivados de 6-alquinil-piridina
EA038950B1 (ru) 2016-05-19 2021-11-12 Бёрингер Ингельхайм Интернациональ Гмбх Способ получения производных 6-алкинил-пиридина
US11028146B2 (en) * 2017-09-22 2021-06-08 Modern Meadow, Inc. Recombinant yeast strains
CN111518185B (zh) * 2020-05-18 2022-02-08 山东农业大学 调控番茄果实品质的转录因子及其应用
EP4286515A4 (en) * 2021-01-27 2026-02-25 Korea Advanced Inst Sci & Tech VARIANTS OF C-GLYCOSYLTRANSFERASE AND THEIR USE
CN116083260B (zh) * 2022-12-26 2024-12-27 暨南大学 生产l-抗坏血酸的基因工程菌及其构建方法与应用

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
US2265121A (en) * 1933-10-25 1941-12-02 Hoffmann La Roche Process for the manufacture of levoascorbic acid
US4595659A (en) * 1983-10-20 1986-06-17 Kraft, Inc. Fermentation production of ascorbic acid from L-galactonic substrate
US4916068A (en) * 1983-10-20 1990-04-10 Kraft, Inc. Bioconversion production of ascorbic acid with L-galactono-1,4-oxidase
DE3901681A1 (de) * 1989-01-21 1990-07-26 Behringwerke Ag Signalpeptid fuer die sekretion von peptiden in escherichia coli, verfahren zu seiner gewinnung und seine verwendung
US5789210A (en) * 1993-11-08 1998-08-04 Purdue Research Foundation Recombinant yeasts for effective fermentation of glucose and xylose
CA2287542A1 (en) * 1997-04-22 1998-10-29 Invitrogen Corporation Methods for the production of aslv reverse transcriptases composed of multiple subunits
IT1294728B1 (it) * 1997-09-12 1999-04-12 Biopolo S C A R L Ceppi di lievito per la riproduzione di acido lattico
US7074608B1 (en) * 1998-05-12 2006-07-11 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for coenzyme B12 synthesis
US20020012979A1 (en) * 1998-06-08 2002-01-31 Alan Berry Vitamin c production in microorganisms and plants
US6358715B1 (en) * 1998-12-04 2002-03-19 Genencor International, Inc. Production of ascorbic acid
US7115730B1 (en) * 1999-04-27 2006-10-03 Chiron Srl Immunogenic detoxified mutant E. coli LT-A-toxin
US6630330B1 (en) * 2000-08-02 2003-10-07 Biopolo S.C.A.R.L. Ascorbic acid production from yeast
TWI220675B (en) * 2000-10-07 2004-09-01 Nat Science Council Yeast with high biotin-productivity and the preparation method thereof
AR035868A1 (es) * 2001-04-24 2004-07-21 Innogenetics Nv Un acido nucleico recombinante que codifica una proteina de un peptido lider de lisozima de ave o equivalente funcional, un vector que lo comprende, una celula huesped, un metodo para producir una proteina de envoltura del hcv o una parte de la misma.
WO2002103001A1 (en) * 2001-06-15 2002-12-27 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Gdp-mannose-3',5'-epimerase and methods of use thereof
WO2004000233A2 (en) * 2002-06-25 2003-12-31 Arkion Life Sciences Llc Algal gdp-mannose-3',5'-epimerases and methods of use thereof
WO2006011815A2 (en) * 2004-07-26 2006-02-02 The Horticulture And Food Research Institute Of New Zealand Limited Phosphatases, polynucleotides encoding these and uses thereof

Also Published As

Publication number Publication date
EP1874947A2 (en) 2008-01-09
BRPI0606117C1 (pt) 2009-12-29
JP2008536497A (ja) 2008-09-11
US20060234360A1 (en) 2006-10-19
US20070141687A1 (en) 2007-06-21
CN101171340A (zh) 2008-04-30
WO2006113147A2 (en) 2006-10-26
WO2006113147B1 (en) 2007-08-09
WO2006113147A3 (en) 2007-05-10

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