BRPI0606844A2 - derivados de pirido(2,3-d)pirimidina substituida e composição farmacêuticas úteis como remédios para o tratamento de distúrbios auto-imunes - Google Patents
derivados de pirido(2,3-d)pirimidina substituida e composição farmacêuticas úteis como remédios para o tratamento de distúrbios auto-imunesInfo
- Publication number
- BRPI0606844A2 BRPI0606844A2 BRPI0606844-8A BRPI0606844A BRPI0606844A2 BR PI0606844 A2 BRPI0606844 A2 BR PI0606844A2 BR PI0606844 A BRPI0606844 A BR PI0606844A BR PI0606844 A2 BRPI0606844 A2 BR PI0606844A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- disorders
- pyrimidine derivatives
- remedies
- pharmaceutical compositions
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Chemical class 0.000 title abstract 2
- 159000000018 pyrido[2,3-d]pyrimidines Chemical class 0.000 title abstract 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 208000035269 cancer or benign tumor Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
Abstract
DERIVADOS DE PIRIDO(2,3-d)PIRIMIDINA SUBSTITUìDA E COMPOSIçõES FARMACêUTICAS úTEIS COMO REMéDIOS PARA O TRATAMENTO DE DISTúRBIOS AUTO-IMUNES. A presente invenção refere-se a um grupo de derivados de pirido(2,3-d)pirimidina trissubstitu ido, seus sais farmaceuticamente aceitáveis, N-óxidos, solvatos e enantiómeros, que possuem propriedades farmacêuticas desejáveis inesperadas, em particular que são agentes altamente imunossupressores, e como tal são úteis no tratamento da rejeição a transplantes e 1 ou no tratamento de certas doenças inflamatórias. Esses derivados são também úteis na prevenção e tratamento de distúrbios cardiovasculares, distúrbios do sistema nervoso central, distúrbios relacionados à TNF-<244> e distúrbios de proliferação de células.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0503506.8A GB0503506D0 (en) | 2005-02-21 | 2005-02-21 | Substituted pyrido(2,3-d) pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
| PCT/EP2006/001539 WO2006087229A1 (en) | 2005-02-21 | 2006-02-21 | Substituted pyrido (2 , 3-d) pyrimidine derivatives useful as medicines for the treatment of autoimmune disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0606844A2 true BRPI0606844A2 (pt) | 2009-07-21 |
Family
ID=34401023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0606844-8A BRPI0606844A2 (pt) | 2005-02-21 | 2006-02-21 | derivados de pirido(2,3-d)pirimidina substituida e composição farmacêuticas úteis como remédios para o tratamento de distúrbios auto-imunes |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20080312227A1 (pt) |
| EP (1) | EP1851217B1 (pt) |
| JP (1) | JP2008530167A (pt) |
| KR (1) | KR20070112174A (pt) |
| CN (1) | CN101203514A (pt) |
| AT (1) | ATE422496T1 (pt) |
| AU (1) | AU2006215700A1 (pt) |
| BR (1) | BRPI0606844A2 (pt) |
| CA (1) | CA2598465A1 (pt) |
| DE (1) | DE602006005136D1 (pt) |
| DK (1) | DK1851217T3 (pt) |
| ES (1) | ES2318723T3 (pt) |
| GB (1) | GB0503506D0 (pt) |
| HR (1) | HRP20090208T1 (pt) |
| IL (1) | IL185289A0 (pt) |
| MX (1) | MX2007010156A (pt) |
| NO (1) | NO20074207L (pt) |
| PL (1) | PL1851217T3 (pt) |
| PT (1) | PT1851217E (pt) |
| RU (1) | RU2007135053A (pt) |
| SI (1) | SI1851217T1 (pt) |
| WO (1) | WO2006087229A1 (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2612788A1 (en) | 2005-06-24 | 2006-12-28 | Steven Cesar Alfons De Jonghe | Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis c |
| US9259426B2 (en) * | 2006-07-20 | 2016-02-16 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US8338435B2 (en) | 2006-07-20 | 2012-12-25 | Gilead Sciences, Inc. | Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections |
| US10144736B2 (en) * | 2006-07-20 | 2018-12-04 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| WO2008009077A2 (en) * | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
| US8637531B2 (en) * | 2006-12-26 | 2014-01-28 | Gilead Sciences, Inc. | Pyrido(3,2-d)pyridmidines useful for treating viral infections |
| TW200840584A (en) * | 2006-12-26 | 2008-10-16 | Gilead Sciences Inc | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
| CN102388041B (zh) | 2009-02-12 | 2014-12-24 | 默克雪兰诺有限公司 | 2-吗啉代-吡啶并[3,2-d]嘧啶 |
| RU2015148359A (ru) | 2013-04-12 | 2017-05-15 | Асана Биосайенсис, Ллк | Хиназолины и азахиназолины - двойные ингибиторы путей ras/raf/mek/erk и pi3k/akt/pten/mtor |
| CN103694255A (zh) * | 2014-01-09 | 2014-04-02 | 华中师范大学 | 吡啶并噁嗪酮和吡啶并嘧啶酮类化合物及其制备方法与应用 |
| GB201416186D0 (en) | 2014-09-12 | 2014-10-29 | Redx Pharma Ltd | Compounds |
| CU20180011A7 (es) | 2015-03-04 | 2018-06-05 | Gilead Sciences Inc | Composiciones farmacéuticas que comprenden compuestos derivados de diaminopirido (3,2-d) como moduladores de receptor de tipo toll |
| US10640499B2 (en) | 2016-09-02 | 2020-05-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| PL3507276T3 (pl) | 2016-09-02 | 2022-02-21 | Gilead Sciences, Inc. | Związki modulatory receptorów toll-podobnych |
| GB201809460D0 (en) | 2018-06-08 | 2018-07-25 | Crt Pioneer Fund Lp | Salt form |
| GB201809458D0 (en) | 2018-06-08 | 2018-07-25 | Crt Pioneer Fund Lp | Salt form |
| WO2020057604A1 (zh) | 2018-09-19 | 2020-03-26 | 正大天晴药业集团股份有限公司 | Tlr8激动剂 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI879779B (zh) | 2019-06-28 | 2025-04-11 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
| CN113801114B (zh) * | 2020-06-11 | 2022-11-18 | 江苏恒瑞医药股份有限公司 | 稠合二环杂芳基类衍生物、其制备方法及其在医药上的应用 |
| IL300113A (en) | 2020-07-28 | 2023-03-01 | Jazz Pharmaceuticals Ireland Ltd | Compressed cyclic RAF inhibitors and methods of using them |
| KR102487604B1 (ko) * | 2020-11-06 | 2023-01-12 | 에스케이케미칼 주식회사 | 히드로플루메티아지드를 유효성분으로 포함하는 TNF-α 관련 질환 예방 또는 치료용 조성물 |
| WO2022161461A1 (zh) * | 2021-01-29 | 2022-08-04 | 江苏先声药业有限公司 | Sos1抑制剂及其制备方法和应用 |
| CN118146134A (zh) * | 2024-02-07 | 2024-06-07 | 南方海洋科学与工程广东省实验室(湛江) | 一种3-羟基吡咯烷衍生物及其制备方法与应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4818819A (en) * | 1986-10-20 | 1989-04-04 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
| US5223503A (en) * | 1991-04-29 | 1993-06-29 | Eli Lilly And Company | 6-substituted pyrido[2,3-d]pyrimidines as antineoplastic agents |
-
2005
- 2005-02-21 GB GBGB0503506.8A patent/GB0503506D0/en not_active Ceased
-
2006
- 2006-02-21 HR HR20090208T patent/HRP20090208T1/xx unknown
- 2006-02-21 CN CNA2006800054787A patent/CN101203514A/zh active Pending
- 2006-02-21 ES ES06707117T patent/ES2318723T3/es not_active Expired - Lifetime
- 2006-02-21 PL PL06707117T patent/PL1851217T3/pl unknown
- 2006-02-21 JP JP2007555544A patent/JP2008530167A/ja not_active Withdrawn
- 2006-02-21 EP EP06707117A patent/EP1851217B1/en not_active Expired - Lifetime
- 2006-02-21 WO PCT/EP2006/001539 patent/WO2006087229A1/en not_active Ceased
- 2006-02-21 AU AU2006215700A patent/AU2006215700A1/en not_active Abandoned
- 2006-02-21 AT AT06707117T patent/ATE422496T1/de not_active IP Right Cessation
- 2006-02-21 RU RU2007135053/04A patent/RU2007135053A/ru not_active Application Discontinuation
- 2006-02-21 KR KR1020077020966A patent/KR20070112174A/ko not_active Withdrawn
- 2006-02-21 US US11/816,086 patent/US20080312227A1/en not_active Abandoned
- 2006-02-21 BR BRPI0606844-8A patent/BRPI0606844A2/pt not_active Application Discontinuation
- 2006-02-21 PT PT06707117T patent/PT1851217E/pt unknown
- 2006-02-21 CA CA002598465A patent/CA2598465A1/en not_active Abandoned
- 2006-02-21 DE DE602006005136T patent/DE602006005136D1/de not_active Expired - Fee Related
- 2006-02-21 DK DK06707117T patent/DK1851217T3/da active
- 2006-02-21 SI SI200630255T patent/SI1851217T1/sl unknown
- 2006-02-21 MX MX2007010156A patent/MX2007010156A/es not_active Application Discontinuation
-
2007
- 2007-08-15 IL IL185289A patent/IL185289A0/en unknown
- 2007-08-16 NO NO20074207A patent/NO20074207L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006087229A1 (en) | 2006-08-24 |
| MX2007010156A (es) | 2008-02-19 |
| AU2006215700A1 (en) | 2006-08-24 |
| ATE422496T1 (de) | 2009-02-15 |
| HRP20090208T1 (hr) | 2009-05-31 |
| IL185289A0 (en) | 2008-02-09 |
| DE602006005136D1 (de) | 2009-03-26 |
| PL1851217T3 (pl) | 2009-07-31 |
| DK1851217T3 (da) | 2009-03-23 |
| GB0503506D0 (en) | 2005-03-30 |
| PT1851217E (pt) | 2009-05-14 |
| SI1851217T1 (sl) | 2009-06-30 |
| ES2318723T3 (es) | 2009-05-01 |
| CN101203514A (zh) | 2008-06-18 |
| EP1851217A1 (en) | 2007-11-07 |
| JP2008530167A (ja) | 2008-08-07 |
| EP1851217B1 (en) | 2009-02-11 |
| NO20074207L (no) | 2007-10-26 |
| CA2598465A1 (en) | 2006-08-24 |
| RU2007135053A (ru) | 2009-03-27 |
| US20080312227A1 (en) | 2008-12-18 |
| KR20070112174A (ko) | 2007-11-22 |
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