BRPI0607097B8 - uso de um peptídeo imunogênico para a fabricação de um medicamento para o tratamento, prevenção ou redução de infecção por papilomavírus - Google Patents

uso de um peptídeo imunogênico para a fabricação de um medicamento para o tratamento, prevenção ou redução de infecção por papilomavírus

Info

Publication number
BRPI0607097B8
BRPI0607097B8 BRPI0607097A BRPI0607097A BRPI0607097B8 BR PI0607097 B8 BRPI0607097 B8 BR PI0607097B8 BR PI0607097 A BRPI0607097 A BR PI0607097A BR PI0607097 A BRPI0607097 A BR PI0607097A BR PI0607097 B8 BRPI0607097 B8 BR PI0607097B8
Authority
BR
Brazil
Prior art keywords
protein
peptide
papillomavirus
amino acids
neutralizing antibodies
Prior art date
Application number
BRPI0607097A
Other languages
English (en)
Inventor
V Pastrana Diana
R Lowy Douglas
T Schiller John
Gambhira Ratish
B S Roden Richard
Original Assignee
The Gorvernment Of The United States Of America Repres By The Secretary Depart Of Health And Human S
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Gorvernment Of The United States Of America Repres By The Secretary Depart Of Health And Human S, Univ Johns Hopkins filed Critical The Gorvernment Of The United States Of America Repres By The Secretary Depart Of Health And Human S
Publication of BRPI0607097A2 publication Critical patent/BRPI0607097A2/pt
Publication of BRPI0607097B1 publication Critical patent/BRPI0607097B1/pt
Publication of BRPI0607097B8 publication Critical patent/BRPI0607097B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

peptídeos de papiloma vírus l2 n-terminais para a indução de anticorpos de neutralização amplamente cruzada. a invenção compreende um método para induzir anticorpos de neutralização amplamente cruzada contra papiloma vírus tipos mucosa e cutâneo ou contra papiloma vírus tipos heterólogos em humanos, compreendendo administrar a um humano em necessidade do mesmo um peptídeo ou proteína imunogênicos (ou polinucleotídeo de codificação por essa razão), onde o peptídeo ou proteína imunogênícos é: (a) um peptídeo ou proteína de pelo menos 10 aminoácidos sobrando em comprimento tendo uma seqüência correspondente a tanto uma seqüência a partir dos aminoácidos n-terminal 1-200 de proteína l2 de papiloma vírus (para anticorpos de neutralização cruzada contra papiloma vírus tipos mucosa e cutâneo) quanto uma seqüência a partir de aminoácidos n-termínal 1-88 de proteína l2 papiloma vírus (para anticorpos de neutralização cruzada contra papiloma vírus tipos heterólogos), (b) um peptídeo ou proteína de pelo menos 10 aminoácidos sobrando em comprimento com pelo menos identidade de 55% com a seqüência a apartir de (a), ou (c) um peptídeo ou proteína como definido em tanto (a) quanto (b), o qual é conjugado ou fundido a uma proteína ou peptídeo diferente de peptídeo ou proteína l2 de papiloma vírus.
BRPI0607097A 2005-02-01 2006-02-01 uso de um peptídeo imunogênico para a fabricação de um medicamento para o tratamento, prevenção ou redução de infecção por papilomavírus BRPI0607097B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US64924905P 2005-02-01 2005-02-01
US60/649,249 2005-02-01
US69765505P 2005-07-07 2005-07-07
US60/697,655 2005-07-07
US75226805P 2005-12-21 2005-12-21
US60/752,268 2005-12-21
PCT/US2006/003601 WO2006083984A1 (en) 2005-02-01 2006-02-01 Papillomavirus l2 n-terminal peptides for the induction of broadly cross-neutralizing antibodies

Publications (3)

Publication Number Publication Date
BRPI0607097A2 BRPI0607097A2 (pt) 2009-08-04
BRPI0607097B1 BRPI0607097B1 (pt) 2020-09-24
BRPI0607097B8 true BRPI0607097B8 (pt) 2021-05-25

Family

ID=36590144

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607097A BRPI0607097B8 (pt) 2005-02-01 2006-02-01 uso de um peptídeo imunogênico para a fabricação de um medicamento para o tratamento, prevenção ou redução de infecção por papilomavírus

Country Status (8)

Country Link
US (2) US8404244B2 (pt)
EP (1) EP1853307B1 (pt)
JP (1) JP5224821B2 (pt)
CN (1) CN101193653B (pt)
AU (1) AU2006210792B2 (pt)
BR (1) BRPI0607097B8 (pt)
CA (1) CA2596698C (pt)
WO (1) WO2006083984A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006083984A1 (en) 2005-02-01 2006-08-10 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Papillomavirus l2 n-terminal peptides for the induction of broadly cross-neutralizing antibodies
AU2007297801A1 (en) 2006-07-14 2008-03-27 Sanofi Pasteur Biologics Co. Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins
EP2069483A4 (en) 2006-09-29 2010-10-27 Sanofi Pasteur Biologics Co RECOMBINANT RHINOVIRAL VECTORS
US20100272753A1 (en) * 2006-10-26 2010-10-28 The Johns Hopkins University Recombinant Adenovirus Vaccines
WO2010129821A1 (en) 2009-05-07 2010-11-11 Oncohealth Corporation Identification of high grade or ≥cin2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (hpv) and hpv-associated cancers
US8968995B2 (en) 2008-11-12 2015-03-03 Oncohealth Corp. Detection, screening, and diagnosis of HPV-associated cancers
US8278056B2 (en) * 2008-06-13 2012-10-02 Oncohealth Corp. Detection of early stages and late stages HPV infection
US8501907B2 (en) 2007-08-10 2013-08-06 Janssen Biotech, Inc. Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such
US9149517B2 (en) * 2007-11-02 2015-10-06 The Johns Hopkins University Multitype HPV peptide compositions and methods for treatment or prevention of human papillomavirus infection
CN107080833A (zh) * 2009-04-10 2017-08-22 约翰·霍普金斯大学 作为广谱人类乳头状瘤病毒（hpv）疫苗的乳头状瘤病毒样颗粒（vlp）
CA2768172A1 (en) 2009-06-25 2010-12-29 Glaxosmithkline Biologicals S.A. Novel compositions
ES2641892T3 (es) * 2009-08-26 2017-11-14 Selecta Biosciences, Inc. Composiciones que inducen la ayuda de las células T
JP5819851B2 (ja) 2010-01-08 2015-11-24 オンコヘルス コーポレーション Ｈｐｖ関連の癌の治療及びスクリーニングのための細胞に基づいた高処理能力ｈｐｖ免疫アッセイ
US9533057B2 (en) * 2010-02-09 2017-01-03 Stc.Unm Immunogenic HPV L2-containing VLPs and related compositions, constructs, and therapeutic methods
US9717783B2 (en) 2010-02-09 2017-08-01 Stc.Unm Immunogenic HPV L2-containing VLPs and related compositions, constructs, and therapeutic methods
CA2818245A1 (en) * 2010-11-19 2012-05-24 Janssen Biotech, Inc. Immunoglobulin cleavage fragments vaccine compositions
WO2015068101A1 (en) * 2013-11-06 2015-05-14 Shantha Biotechnics Private Limited Papillomavirus vaccine formulations
CN107188967B (zh) * 2016-03-15 2020-03-31 中国医学科学院基础医学研究所 一种乳头瘤病毒嵌合蛋白及其用途
CN107188966B (zh) * 2016-03-15 2020-03-31 中国医学科学院基础医学研究所 一种乳头瘤病毒嵌合蛋白及其用途
AU2020212577A1 (en) * 2019-01-25 2021-09-09 Psomagen Inc. Antibody-DNA conjugates and HPV detection and treatment
CN114716560B (zh) * 2021-01-04 2024-02-02 中国医学科学院基础医学研究所 一种人乳头瘤病毒18型嵌合蛋白及其用途
CN115838401A (zh) * 2022-10-27 2023-03-24 武汉博沃生物科技有限公司 一种hpv重组蛋白及其应用

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ATE76429T1 (de) * 1986-03-21 1992-06-15 Pasteur Institut Bestimmte, von einem papillomavirus-genom abgeleitete dns-sequenzen, deren anwendungen fuer in vitro-diagnostische zwecke und die herstellung von antigenzusammensetzungen.
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GB9306731D0 (en) 1993-03-31 1993-05-26 Cancer Res Campaign Tech Vaccines
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Also Published As

Publication number Publication date
WO2006083984A1 (en) 2006-08-10
US20130177585A1 (en) 2013-07-11
AU2006210792B2 (en) 2012-07-26
EP1853307A1 (en) 2007-11-14
CN101193653B (zh) 2013-03-27
JP2008530010A (ja) 2008-08-07
BRPI0607097B1 (pt) 2020-09-24
US9388221B2 (en) 2016-07-12
CA2596698C (en) 2017-05-16
JP5224821B2 (ja) 2013-07-03
WO2006083984A9 (en) 2006-10-26
US8404244B2 (en) 2013-03-26
BRPI0607097A2 (pt) 2009-08-04
EP1853307B1 (en) 2016-12-14
CA2596698A1 (en) 2006-08-10
US20090047301A1 (en) 2009-02-19
AU2006210792A1 (en) 2006-08-10
CN101193653A (zh) 2008-06-04

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