BRPI0607235A2 - mutações do receptor do fator de crescimento epidérmico - Google Patents

mutações do receptor do fator de crescimento epidérmico

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Publication number
BRPI0607235A2
BRPI0607235A2 BRPI0607235-6A BRPI0607235A BRPI0607235A2 BR PI0607235 A2 BRPI0607235 A2 BR PI0607235A2 BR PI0607235 A BRPI0607235 A BR PI0607235A BR PI0607235 A2 BRPI0607235 A2 BR PI0607235A2
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BR
Brazil
Prior art keywords
mutant
egfr
growth factor
raf
pi3k
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BRPI0607235-6A
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English (en)
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Daniel Freeman
Todd Juan
Robert Radinsky
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Amgen Inc
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Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BRPI0607235A2 publication Critical patent/BRPI0607235A2/pt

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Abstract

MUTAçõES DO RECEPTOR DO FATOR DE CRESCIMENTO EPIDéRMICO. A presente invenção refere-se a mutações do receptor do fator de crescimento epidérmico (EGFr), de fosfatidilinositol 3'-quinase ("PI3K"), e de B-Raf. Métodos de tratar tumores que contêm EGFr mutado com anticorpos monoclonais contra EGFr são descritos. Métodos e kits para determinar a presença de um ou mais EGFr mutantes, PI3K mutantes e/ou B-Raf mutantes em uma amostra e para tratar distúrbios e condições relacionadas com a presença de EGFr mutante, PI3K mutante e/ou B-Raf mutante também são descritos. Métodos de tratar tumores que contêm EGFr mutante, PI3K mutante, e/ou B-Raf mutante também são descritas.
BRPI0607235-6A 2005-02-24 2006-02-23 mutações do receptor do fator de crescimento epidérmico BRPI0607235A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65626305P 2005-02-24 2005-02-24
PCT/US2006/006751 WO2006091899A2 (en) 2005-02-24 2006-02-23 Epidermal growth factor receptor mutations

Publications (1)

Publication Number Publication Date
BRPI0607235A2 true BRPI0607235A2 (pt) 2009-08-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607235-6A BRPI0607235A2 (pt) 2005-02-24 2006-02-23 mutações do receptor do fator de crescimento epidérmico

Country Status (15)

Country Link
US (2) US7981605B2 (pt)
EP (1) EP1851243A2 (pt)
JP (2) JP2008535477A (pt)
KR (1) KR20070106029A (pt)
CN (1) CN101208354A (pt)
AU (2) AU2006216477A1 (pt)
BR (1) BRPI0607235A2 (pt)
CA (1) CA2601936C (pt)
CR (1) CR9390A (pt)
EA (1) EA013617B1 (pt)
IL (1) IL185210A0 (pt)
MX (1) MX2007009963A (pt)
NO (1) NO20074826L (pt)
WO (1) WO2006091899A2 (pt)
ZA (1) ZA200707379B (pt)

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SI1913157T2 (sl) 2005-06-28 2017-02-28 Genentech, Inc. EGFR in KRAS mutacije za napoved bolnikovega odziva na zdravljenje z EGFR inhibitorjem

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US8546107B2 (en) 2013-10-01
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US20120328620A1 (en) 2012-12-27
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