BRPI0607490A2 - anticorpos monoclonais antiinterferon alfa e métodos para uso - Google Patents

anticorpos monoclonais antiinterferon alfa e métodos para uso

Info

Publication number
BRPI0607490A2
BRPI0607490A2 BRPI0607490-1A BRPI0607490A BRPI0607490A2 BR PI0607490 A2 BRPI0607490 A2 BR PI0607490A2 BR PI0607490 A BRPI0607490 A BR PI0607490A BR PI0607490 A2 BRPI0607490 A2 BR PI0607490A2
Authority
BR
Brazil
Prior art keywords
bioactivity
methods
subtypes
monoclonal antibodies
protein
Prior art date
Application number
BRPI0607490-1A
Other languages
English (en)
Inventor
Jacques Banchereau
Kiley Prilliman
Virginia Pascual
Anna Karolina Palucka
Original Assignee
Baylor Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor Res Inst filed Critical Baylor Res Inst
Publication of BRPI0607490A2 publication Critical patent/BRPI0607490A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ANTICORPOS MONOCLONAIS ANTIINTERFERON ALFA E MéTODOS PARA USO. A presente invenção refere-se a composições e métodos que incluem anticorpos que neutralizam seletivamente uma bioatividade de pelo menos dois subtipos de proteínas do interferon alfa ("IFN<244>") para os subtipos de proteínas A, 2, B2, O, F, G, H2, 1, Ji, K, 4a, 4b e WA, porém não neutraliza pelo menos uma bioatividade do subtipo de proteína do lFN<244> D. Os exemplos de bioatividade para a medição incluem a ativação do promotor de MxA ou a atividade antiviral, e variantes, derivados e fragmentos dos mesmos. A invenção também inclui as células hospedeiras, os hibridomas e os píasmacitomas que produzem anticorpos. Por causa de sua seletividade e afinidade únicas, os anticorpos da presente invenção são úteis para detectar os subtipos do IFN<244> em amostra ou tecido e/ou para aplicações terapêuticas que incluem, porém não estão limitadas ao tratamento e/ou à melhora de um distúrbio relacionado ao lFN<244>, tal como SLE, lúpus, diabete do tipo 1, psoríase, AIDS e Doença do Enxerto versus Hospedeiro.
BRPI0607490-1A 2005-02-10 2006-02-09 anticorpos monoclonais antiinterferon alfa e métodos para uso BRPI0607490A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65223305P 2005-02-10 2005-02-10
PCT/US2006/004643 WO2006086586A2 (en) 2005-02-10 2006-02-09 Anti-interferon alpha monoclonal antibodies and methods for use

Publications (1)

Publication Number Publication Date
BRPI0607490A2 true BRPI0607490A2 (pt) 2009-09-08

Family

ID=36694481

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607490-1A BRPI0607490A2 (pt) 2005-02-10 2006-02-09 anticorpos monoclonais antiinterferon alfa e métodos para uso

Country Status (14)

Country Link
US (2) US8080638B2 (pt)
EP (1) EP1851248B1 (pt)
JP (2) JP5837730B2 (pt)
KR (1) KR101363120B1 (pt)
CN (1) CN101155831B (pt)
AU (1) AU2006213800B2 (pt)
BR (1) BRPI0607490A2 (pt)
CA (1) CA2597265C (pt)
IL (1) IL184808A0 (pt)
MX (1) MX2007009466A (pt)
NO (1) NO343054B1 (pt)
RU (1) RU2431638C2 (pt)
WO (1) WO2006086586A2 (pt)
ZA (1) ZA200706425B (pt)

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Also Published As

Publication number Publication date
US8333965B2 (en) 2012-12-18
MX2007009466A (es) 2007-12-07
CA2597265A1 (en) 2006-08-17
NO343054B1 (no) 2018-10-22
JP2014111644A (ja) 2014-06-19
WO2006086586A3 (en) 2006-10-12
US20080160030A1 (en) 2008-07-03
AU2006213800B2 (en) 2012-02-09
JP5837730B2 (ja) 2015-12-24
ZA200706425B (en) 2014-07-30
RU2007133608A (ru) 2009-03-20
CN101155831B (zh) 2015-08-19
KR101363120B1 (ko) 2014-02-13
IL184808A0 (en) 2007-12-03
US20120020963A1 (en) 2012-01-26
JP2008529529A (ja) 2008-08-07
KR20070107753A (ko) 2007-11-07
RU2431638C2 (ru) 2011-10-20
NO20074512L (no) 2007-10-31
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