BRPI0607537A2 - nanoparticulate quinazoline derivative formulations - Google Patents

nanoparticulate quinazoline derivative formulations

Info

Publication number
BRPI0607537A2
BRPI0607537A2 BRPI0607537-1A BRPI0607537A BRPI0607537A2 BR PI0607537 A2 BRPI0607537 A2 BR PI0607537A2 BR PI0607537 A BRPI0607537 A BR PI0607537A BR PI0607537 A2 BRPI0607537 A2 BR PI0607537A2
Authority
BR
Brazil
Prior art keywords
quinazoline derivative
nanoparticulate quinazoline
compositions
nanoparticulate
derivative formulations
Prior art date
Application number
BRPI0607537-1A
Other languages
Portuguese (pt)
Inventor
Gary Liversidge
Scott Jenkins
Original Assignee
Elan Pharma Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharma Int Ltd filed Critical Elan Pharma Int Ltd
Publication of BRPI0607537A2 publication Critical patent/BRPI0607537A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

FORMULAçõES DE DERIVADO DE QUINAZOLINA NANOPARTICULADO. A presente invenção refere-se a composições de derivado de quinazolina nanoparticuladas tendo perfis farmacocinéticos melhorados e variabilidade alimentado/em jejum reduzida. As partículas do derivado de quinazolina nanoparticulado de uma composição têm um tamanho de partícula médio eficaz menor do que cerca de 2000 nm e são úteis no tratamento de distúrbios hiperproliferativos, tais como câncer e outras doenças neoplásicas. As composições podem incluir derivados de quinazolinamina tal como erlotinib ou um sal do mesmo.NANOPARTICULATED QUINAZOLIN DERIVATIVE FORMULATIONS. The present invention relates to nanoparticulate quinazoline derivative compositions having improved pharmacokinetic profiles and reduced fasted / fed variability. The nanoparticulate quinazoline derivative particles of a composition have an effective mean particle size less than about 2000 nm and are useful in treating hyperproliferative disorders such as cancer and other neoplastic diseases. Compositions may include quinazolinamine derivatives such as erlotinib or a salt thereof.

BRPI0607537-1A 2005-04-12 2006-04-12 nanoparticulate quinazoline derivative formulations BRPI0607537A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67042905P 2005-04-12 2005-04-12
PCT/US2006/013641 WO2006110811A1 (en) 2005-04-12 2006-04-12 Nanoparticulate quinazoline derivative formulations

Publications (1)

Publication Number Publication Date
BRPI0607537A2 true BRPI0607537A2 (en) 2009-09-15

Family

ID=36659858

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607537-1A BRPI0607537A2 (en) 2005-04-12 2006-04-12 nanoparticulate quinazoline derivative formulations

Country Status (14)

Country Link
US (1) US8309133B2 (en)
EP (1) EP1871345B1 (en)
JP (1) JP2008535924A (en)
KR (1) KR20080002939A (en)
CN (1) CN101198314A (en)
AU (1) AU2006235487B2 (en)
BR (1) BRPI0607537A2 (en)
CA (1) CA2604735A1 (en)
EA (1) EA014611B1 (en)
IL (1) IL186609A (en)
MX (1) MX2007012778A (en)
NO (1) NO20075774L (en)
WO (1) WO2006110811A1 (en)
ZA (1) ZA200708702B (en)

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US20060246142A1 (en) 2006-11-02
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JP2008535924A (en) 2008-09-04
WO2006110811A1 (en) 2006-10-19
EA200702214A1 (en) 2008-04-28
KR20080002939A (en) 2008-01-04
CN101198314A (en) 2008-06-11
EA014611B1 (en) 2010-12-30
IL186609A (en) 2012-12-31
EP1871345A1 (en) 2008-01-02
EP1871345B1 (en) 2012-08-01
AU2006235487B2 (en) 2011-12-22
MX2007012778A (en) 2008-01-11
US8309133B2 (en) 2012-11-13
ZA200708702B (en) 2008-11-26
CA2604735A1 (en) 2006-10-19

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