BRPI0607549A2 - sistemas de distribuição farmacêutica para fármacos hidrófobos e composições compreendendo os mesmos - Google Patents

sistemas de distribuição farmacêutica para fármacos hidrófobos e composições compreendendo os mesmos

Info

Publication number
BRPI0607549A2
BRPI0607549A2 BRPI0607549-5A BRPI0607549A BRPI0607549A2 BR PI0607549 A2 BRPI0607549 A2 BR PI0607549A2 BR PI0607549 A BRPI0607549 A BR PI0607549A BR PI0607549 A2 BRPI0607549 A2 BR PI0607549A2
Authority
BR
Brazil
Prior art keywords
same
compositions
hydrophobic drugs
delivery systems
pharmaceutical delivery
Prior art date
Application number
BRPI0607549-5A
Other languages
English (en)
Inventor
Robert E Dudley
Pannayiotis P Constantinides
Original Assignee
Clarus Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37115755&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0607549(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Clarus Therapeutics Inc filed Critical Clarus Therapeutics Inc
Publication of BRPI0607549A2 publication Critical patent/BRPI0607549A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

SISTEMAS DE DISTRIBUIçãO FARMACêUTICA PARA FáRMACOS HIDRóFOBOS E COMPOSIçõES COMPRENDENDO OS MESMOS. A presente invenção refere-se a um sistema de distribuição de fármaco para administração oral de fármacos hidrófobos com absorção aumentada e prolongada e farmacocinética melhorada. Em uma modalidade, estão descritas formulações compreendendo testosterona e ésteres de testosterona, por exemplo, palmitato de testosterona. Também são fornecidos métodos para o tratamento de uma deficiência hormonal ou para contracepção masculina com as formulações da invenção.
BRPI0607549-5A 2005-04-15 2006-04-14 sistemas de distribuição farmacêutica para fármacos hidrófobos e composições compreendendo os mesmos BRPI0607549A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67145405P 2005-04-15 2005-04-15
US72197105P 2005-09-30 2005-09-30
PCT/US2006/014207 WO2006113505A2 (en) 2005-04-15 2006-04-14 Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same

Publications (1)

Publication Number Publication Date
BRPI0607549A2 true BRPI0607549A2 (pt) 2009-09-15

Family

ID=37115755

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607549-5A BRPI0607549A2 (pt) 2005-04-15 2006-04-14 sistemas de distribuição farmacêutica para fármacos hidrófobos e composições compreendendo os mesmos

Country Status (14)

Country Link
US (18) US8241664B2 (pt)
EP (3) EP1871384A4 (pt)
JP (3) JP5887044B2 (pt)
KR (3) KR101382725B1 (pt)
AU (2) AU2006236564B2 (pt)
BR (1) BRPI0607549A2 (pt)
CA (1) CA2604943C (pt)
DK (1) DK2985026T3 (pt)
ES (1) ES2930658T3 (pt)
HU (1) HUE061300T2 (pt)
PL (1) PL2985026T3 (pt)
PT (1) PT2985026T (pt)
RU (2) RU2429850C2 (pt)
WO (1) WO2006113505A2 (pt)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20040259852A1 (en) 2003-06-18 2004-12-23 White Hillary D. Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome
US8883769B2 (en) 2003-06-18 2014-11-11 White Mountain Pharma, Inc. Methods for the treatment of fibromyalgia and chronic fatigue syndrome
EP1871384A4 (en) 2005-04-15 2012-01-25 Clarus Therapeutics Inc SYSTEMS FOR THE PHARMACEUTICAL ADMINISTRATION OF HYDROPHOUS ACTIVE SUBSTANCES AND COMPOSITIONS THEREWITH
US8492369B2 (en) 2010-04-12 2013-07-23 Clarus Therapeutics Inc Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
DK2450041T3 (en) 2005-10-12 2018-11-19 Unimed Pharmaceuticals Llc Enhanced testosterone gel for use in the treatment of hypogonadism
SI1993559T1 (sl) 2006-02-03 2017-01-31 Opko Renal, Llc Zdravljenje nezadostnosti in pomanjkanja vitamina D s 25-hidroksivitaminon D2 in 25-hidroksivitaminom D3
PT3357496T (pt) 2006-06-21 2020-05-12 Opko Ireland Global Holdings Ltd Terapia utilizando um agente de repleção de vitamina d e um agente de substituição hormonal de vitamina d
CN101668532B (zh) 2007-04-25 2014-08-20 赛特克罗公司 治疗维生素d不足和缺乏、继发性甲状旁腺功能亢进症和维生素d-响应疾病的组合物及其相应的制药用途
PL3225243T3 (pl) 2007-04-25 2025-12-22 Opko Renal, Llc Sposób bezpiecznego i skutecznego leczenia i zapobiegania wtórnej nadczynności przytarczyc w przewlekłej chorobie nerek
KR20190141269A (ko) 2007-04-25 2019-12-23 사이토크로마 인코포레이티드 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물
EP2164518B1 (en) 2007-05-25 2019-04-24 The University Of British Columbia Formulations for the oral administration of therapeutic agents and related methods
WO2009042114A2 (en) 2007-09-21 2009-04-02 The Johns Hopkins University Phenazine derivatives and uses thereof
CN102046812A (zh) 2008-04-02 2011-05-04 赛特克罗公司 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒
GB0807605D0 (en) 2008-04-28 2008-06-04 Diurnal Ltd Lipid composition
US20140288039A1 (en) * 2009-01-08 2014-09-25 Lipocine Inc. Lipobalanced long chain testosterone prodrugs for oral delivery
US20130225544A1 (en) * 2009-01-08 2013-08-29 Lipocine Inc. Lipobalanced long chain testosterone esters for oral delivery
US11304960B2 (en) * 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
WO2011050457A1 (en) 2009-10-26 2011-05-05 The University Of British Columbia Stabilized formulation for oral administration of therapeutic agents and related methods
WO2011055269A1 (en) * 2009-11-09 2011-05-12 Pfizer Inc. Delivery carrier
WO2011087867A1 (en) * 2009-12-22 2011-07-21 Talima Therapeutics, Inc. Antifungal therapy
EP2519230B1 (en) 2009-12-31 2018-10-10 Marius Pharmaceuticals LLC Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols
US20130303495A1 (en) * 2009-12-31 2013-11-14 Sov Therapeutics Emulsion formulations
CA2797537C (en) 2010-03-29 2021-11-23 Cytochroma Inc. Use of 25-hydroxyvitamin d compound for reducing parathyroid levels
AU2014265072B2 (en) * 2010-04-12 2016-09-15 Besins Healthcare Luxembourg S.A.R.L. Oral testosterone ester formulations and methods of treating testoterone deficiency comprising same
RU2642244C2 (ru) * 2010-04-12 2018-01-24 Кларус Терапеутикс, Инк. Оральные фармацевтические композиции сложных эфиров тестостерона и способы лечения недостатка тестостерона с их использованием
ES2525520T3 (es) * 2010-04-12 2014-12-26 Clarus Therapeutics, Inc. Formulaciones orales de éster de testosterona y métodos para tratar la deficiencia de testosterona con las mismas
AU2011329782A1 (en) 2010-11-18 2013-06-20 White Mountain Pharma, Inc. Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and pharmaceutical compositions for use therein
US9358241B2 (en) * 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120135074A1 (en) * 2010-11-30 2012-05-31 Chandrashekar Giliyar High-Strength Testosterone Undecanoate Compositions
US20120148675A1 (en) * 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US11850451B2 (en) 2011-01-31 2023-12-26 Lucolas-M.D. Ltd. Cosmetic compositions and methods for improving skin conditions
RU2631483C2 (ru) * 2011-01-31 2017-09-22 Луколас-М.Д. Лтд Косметическое применение
US8951996B2 (en) 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
PH12014501000A1 (en) * 2011-11-04 2014-06-09 Agile Therapeutics Inc Dermal delivery compositions and methods
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
ES2885523T3 (es) 2011-11-23 2021-12-14 Therapeuticsmd Inc Formulaciones y terapias de reposición hormonal de combinación naturales
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
DE102013111531A1 (de) 2012-10-18 2014-04-24 Electronics And Telecommunications Research Institute Vorrichtung zur raumfilterung unter verwendung eines sendeverzögerungsunterschieds von signalen und verfahren für selbiges
EP2934591B1 (en) 2012-12-20 2017-08-09 Solural Pharma Aps Solid oral dosage form of testosterone derivative
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
KR102213143B1 (ko) * 2013-02-28 2021-02-08 바스프 에이에스 지방질 화합물, 트리글리세리드 및 계면활성제를 포함하는 조성물 및 이를 이용하는 방법
CN105377355A (zh) 2013-03-14 2016-03-02 拇趾公司 治疗甲单元的感染、疾病或病症的方法
CN105188670B (zh) 2013-03-15 2018-11-02 马留斯医药有限责任公司 乳液制剂
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
TW201521731A (zh) * 2013-03-15 2015-06-16 利波辛股份有限公司 用於口服之脂平衡的長鏈睪固酮酯
US9040034B2 (en) 2013-04-09 2015-05-26 International Business Machines Corporation Vitamin functionalized gel-forming block copolymers for biomedical applications
WO2015100406A1 (en) * 2013-12-26 2015-07-02 Clarus Therapeutics, Inc. Use of oral pharmaceutical products combining testosterone esters with hypolipidemic agents
PT3096625T (pt) 2014-01-20 2020-05-20 Xeda International Composições anti-germinativas para revestir bolbos e tubérculos e sua utilização para tratamento anti-germinativo
MX2016014281A (es) 2014-05-22 2017-02-22 Therapeuticsmd Inc Formulaciones y terapias de reemplazo de combinación de hormonas naturales.
US9925200B2 (en) 2014-06-17 2018-03-27 Merck Sharp & Dohme B.V. Stable formulations of testosterone undecanoate
AU2015276202B2 (en) 2014-06-19 2020-09-17 Pebean Pharma Aps Solid oral dosage form of lipophilic compounds
MX2016013693A (es) 2014-07-29 2017-10-31 Therapeuticsmd Inc Crema transdermica.
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
ES2877107T3 (es) 2014-08-28 2021-11-16 Univ Texas Formulaciones de testosterona y procedimientos de tratamiento con ellas
RU2017110076A (ru) * 2014-08-28 2018-09-28 Липосин Инк. Фармацевтическая композиция и способы
JP6948660B2 (ja) 2014-11-13 2021-10-13 東亞合成株式会社 外来物質の細胞内への導入方法ならびに該方法に用いる材料
US20160361322A1 (en) 2015-06-15 2016-12-15 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
EP3331495B1 (en) 2015-08-03 2020-11-04 Tolmar International Limited Liquid polymer delivery system for extended administration of drugs
KR101679380B1 (ko) 2015-09-10 2016-11-25 주식회사 유유제약 두타스테리드를 포함하는 약학적 조성물 및 이를 포함하는 캡슐 제형
JP6097803B2 (ja) * 2015-09-17 2017-03-15 クラルス セラピューティクス，インク． 経口テストステロンエステル配合剤およびそれを含むテストステロン欠損を処置する方法
KR101679992B1 (ko) * 2015-12-31 2016-11-28 주식회사 유유제약 프로필렌글리콜 모노라우레이트를 포함하는 두타스테리드의 약학적 조성물 및 이의 제조 방법
JP2019506443A (ja) * 2016-02-24 2019-03-07 イースタン バージニア メディカル スクール 改良された持効性注射用デポ型ブタン酸レボノルゲストレル懸濁製剤
CA3016542A1 (en) * 2016-03-02 2017-09-08 Board Of Regents, The University Of Texas System Formulations of testosterone and methods of treatment therewith
EP4596045A3 (en) 2016-03-28 2025-10-15 EirGen Pharma Ltd. Methods of vitamin d treatment
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
AU2017239645A1 (en) 2016-04-01 2018-10-18 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US11559530B2 (en) 2016-11-28 2023-01-24 Lipocine Inc. Oral testosterone undecanoate therapy
WO2019046582A1 (en) 2017-08-30 2019-03-07 Antares Pharma, Inc. TESTOSTERONE ESTER TRIGLYCERIDE FORMULATIONS
MX2020002730A (es) * 2017-09-12 2022-10-27 Jina Pharmaceuticals Inc Metodos de preparacion de composiciones que contienen timoquinona.
US11389451B2 (en) 2017-09-12 2022-07-19 Hyloris Developments S.A. Metolazone emulsion formulation
WO2019087696A1 (ja) * 2017-11-01 2019-05-09 富士フイルム株式会社 経口医薬組成物
EP3824296A4 (en) 2018-07-20 2022-04-27 Lipocine Inc. LIVER DISEASE
KR102051808B1 (ko) * 2018-07-23 2019-12-04 주식회사 종근당 테스토스테론 운데카노에이트를 포함하는 안정한 약제학적 조성물
TW202027725A (zh) * 2018-09-25 2020-08-01 愛爾蘭商托爾瑪國際有限公司 供藥物之延長投予之液體聚合物輸送系統
WO2020210501A1 (en) * 2019-04-12 2020-10-15 Clarus Therapeutics, Inc. Oral pharmaceutical products and methods of use combining testosterone esters with anti-hypertensive agents
US12403146B2 (en) 2019-10-30 2025-09-02 Marius Pharmaceuticals, Inc. Preferred oral testosterone undecanoate therapy to achieve testosterone replacement treatment
JP7822939B2 (ja) 2020-02-05 2026-03-03 ニューロクライン ユーケー リミテッド テストステロン含有医薬組成物
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
CA3091554A1 (en) * 2020-08-28 2022-02-28 Triple Hair Inc. Formulations for reducing hair loss and/or increasing hair regrowth
WO2022094817A1 (en) * 2020-11-04 2022-05-12 Janssen Pharmaceuticals, Inc. Pharmaceutical formulation
IL303509A (en) * 2020-12-19 2023-08-01 Avaca Pharma Private Ltd A pharmaceutical composition comprising fexofenadine, famotidine and melatonin
KR20230161551A (ko) * 2022-05-18 2023-11-28 부광약품 주식회사 제제학적으로 안정성이 향상된 연질 캡슐

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH399447A (de) * 1961-04-14 1965-09-30 Ciba Geigy Verfahren zur Herstellung eines neuen Steroid-Hormon-Esters
US3164520A (en) * 1962-10-29 1965-01-05 Olin Mathieson Injectable steroid compositions containing at least 75% benzyl benzoate
FR1578974A (pt) 1968-05-16 1969-08-22
US4147783A (en) * 1974-02-28 1979-04-03 Akzona Incorporated Oral pharmaceutical preparation
NL189235C (nl) 1974-02-28 1993-02-16 Akzo Nv Werkwijze voor de bereiding van een oraal toe te dienen farmaceutisch preparaat met androgene werking.
DE3406497A1 (de) * 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4572915A (en) * 1984-05-01 1986-02-25 Bioglan Laboratories Clear micellized solutions of fat soluble essential nutrients
GB8903804D0 (en) 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
US4874795A (en) 1985-04-02 1989-10-17 Yesair David W Composition for delivery of orally administered drugs and other substances
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
CA2108266C (en) 1991-04-19 2003-06-03 Albert J. Owen Convertible microemulsion formulations
EP0597007B1 (en) 1991-07-26 1996-10-16 Smithkline Beecham Corporation W/o microemulsions
US5605929A (en) * 1992-05-27 1997-02-25 Arch Development Corp. Methods and compositions for inhibiting 5α-reductase activity
WO1994008610A1 (en) 1992-10-16 1994-04-28 Smithkline Beecham Corporation Pharmaceutical emulsion compositions
US6191105B1 (en) 1993-05-10 2001-02-20 Protein Delivery, Inc. Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin
US6312704B1 (en) 1993-09-30 2001-11-06 Gattefosse, S.A. Orally administrable composition capable of providing enhanced bioavailability when ingested
US6054136A (en) 1993-09-30 2000-04-25 Gattefosse S.A. Orally administrable composition capable of providing enhanced bioavailability when ingested
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
CN1140058A (zh) * 1996-03-29 1997-01-15 中国科学院成都有机化学研究所 一种雄性激素缓释微球粉针剂及其制备方法和用途
GB9608719D0 (en) * 1996-04-26 1996-07-03 Scherer Ltd R P Pharmaceutical compositions
JP4142742B2 (ja) 1996-05-23 2008-09-03 大正製薬株式会社 マイクロエマルション
US5891469A (en) * 1997-04-02 1999-04-06 Pharmos Corporation Solid Coprecipitates for enhanced bioavailability of lipophilic substances
GB9700878D0 (en) * 1997-01-17 1997-03-05 Scherer Ltd R P Dosage forms and method for ameliorating male erectile dysfunction
CN1250373A (zh) 1997-02-07 2000-04-12 瑟垃技术有限公司 用于在具有睾酮缺乏症状的妇女中补充睾酮的组合物和方法
WO1999027946A1 (en) 1997-12-02 1999-06-10 Chong Kun Dang Corp. Pharmaceutical composition comprising cyclosporin solid-state microemulsion
CN1252711A (zh) 1997-04-18 2000-05-10 大正制药株式会社 微乳
US20030044434A1 (en) * 1997-07-29 2003-03-06 Ping Gao Self-emulsifying formulation for lipophilic compounds
US20050070516A1 (en) * 1997-10-28 2005-03-31 Vivus Inc. As-needed administration of an androgenic agent to enhance female desire and responsiveness
US6013665A (en) * 1997-12-16 2000-01-11 Abbott Laboratories Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides
CA2268211A1 (en) * 1998-04-13 1999-10-13 Medical College Of Hampton Roads Control of selective estrogen receptor modulators
FR2782006B1 (fr) 1998-08-07 2002-04-19 Gattefosse Ets Sa Composition a liberation prolongee apte a former une micro-emulsion
EP2127642A3 (en) 1998-08-13 2010-02-24 Cima Labs, Inc. Microemulsions as solid dosage forms for oral administration
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US20030104048A1 (en) * 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
PL195163B1 (pl) * 1999-04-01 2007-08-31 Organon Nv Kompozycja farmaceutyczna zawierająca undekanian testosteronu, zastosowanie undekanianu testosteronu i zastosowanie zawierającej go kompozycji farmaceutycznej
US6652880B1 (en) * 1999-04-01 2003-11-25 R.P. Scherer Technologies, Inc. Oral pharmaceutical compositions containing long-chain triglycerides and liphophilic surfactants
GB9907715D0 (en) * 1999-04-01 1999-05-26 Scherer Corp R P Pharmaceutical compositions
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6982281B1 (en) * 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US20030236236A1 (en) 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US20030235595A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Oil-containing, orally administrable pharmaceutical composition for improved delivery of a therapeutic agent
US6458383B2 (en) * 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6309663B1 (en) * 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
AR025587A1 (es) * 1999-09-13 2002-12-04 Hoffmann La Roche Formulaciones en dispersion que contienen inhibidores de lipasa
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20060034937A1 (en) * 1999-11-23 2006-02-16 Mahesh Patel Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20020102301A1 (en) 2000-01-13 2002-08-01 Joseph Schwarz Pharmaceutical solid self-emulsifying composition for sustained delivery of biologically active compounds and the process for preparation thereof
US7025979B2 (en) * 2000-02-15 2006-04-11 Schering Ag Male contraceptive formulation comprising norethisterone
AU2001261513A1 (en) 2000-05-15 2001-11-26 Braswell, Glenn A. Composition and method for increasing testosterone levels
KR20030023878A (ko) * 2000-06-26 2003-03-20 몬산토 테크놀로지 엘엘씨 소마토트로핀의 지속적인 방출을 위한 계면활성제 함유비수성 제제들
US6623765B1 (en) 2000-08-01 2003-09-23 University Of Florida, Research Foundation, Incorporated Microemulsion and micelle systems for solubilizing drugs
AU9177501A (en) 2000-08-23 2002-03-04 Akzo Nobel Nv Novel testosterone ester formulation for human use
US20030022875A1 (en) 2001-07-27 2003-01-30 Wilson Leland F. As-needed administration of orally active androgenic agents to enhance female sexual desire and responsiveness
US20040198799A1 (en) 2001-09-27 2004-10-07 Brondyk William H. Methods of increasing endogenous testosterone levels
US6665880B2 (en) * 2001-11-01 2003-12-23 Kimberly-Clark Worldwide, Inc. Protective garments with glove flaps
WO2003053404A1 (en) 2001-12-20 2003-07-03 Bernard Charles Sherman Pharmaceutical compositions comprising a cyclosporin, a hydrophilic surfactant and a lipophilic surfactant
US20030186892A1 (en) * 2002-03-28 2003-10-02 Rajneesh Taneja Enhancement of endogenous gonadotropin production
US20040002445A1 (en) * 2002-03-28 2004-01-01 Rajneesh Taneja Enhancement of endogenous gonadotropin production
US20050287203A1 (en) * 2002-05-08 2005-12-29 Nijs De H Formulation comprising testosteron undecanoate and castor oil
RU2359698C2 (ru) * 2002-09-13 2009-06-27 Сайдекс, Инк. Капсулы, содержащие водные наполняющие композиции, стабилизированные производным циклодекстрина
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
WO2004043434A1 (en) * 2002-11-14 2004-05-27 Shear/Kershman Laboratories, Inc. Oral testosterone delivery system with improved sustained release
US20040115287A1 (en) 2002-12-17 2004-06-17 Lipocine, Inc. Hydrophobic active agent compositions and methods
US20050100608A1 (en) 2003-02-21 2005-05-12 Watson Pharmaceuticals, Inc. Testosterone oral dosage formulations and associated methods
JO2505B1 (en) * 2003-03-14 2009-10-05 باير شيرنغ فارما اكتنجيسيلشافت Pharmacy methods and formulations for obtaining acceptable serum testosterone levels
EP1648537B1 (en) 2003-07-31 2011-04-20 Debiotech S.A. A system for performing fluid administration in peritoneal dialysis
JP2007001865A (ja) * 2003-09-16 2007-01-11 Ltt Bio-Pharma Co Ltd 脂溶性薬物封入微粒子、その製造法およびそれを含有する製剤
US20060003002A1 (en) 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
US20050096365A1 (en) * 2003-11-03 2005-05-05 David Fikstad Pharmaceutical compositions with synchronized solubilizer release
US7138389B2 (en) * 2004-02-09 2006-11-21 University Of Washington Oral androgen therapy using modulators of testosterone bioavailability
US20050233970A1 (en) 2004-03-23 2005-10-20 Praecis Pharmaceuticals, Inc. Methods for treating long QT syndrome
EP1778187B1 (en) 2004-08-04 2012-05-23 Camurus Ab Compositions forming non-lamellar dispersions
US20060134210A1 (en) * 2004-12-22 2006-06-22 Astrazeneca Ab Solid dosage form comprising proton pump inhibitor and suspension made thereof
DE102005015128B4 (de) 2005-03-31 2008-12-11 Bayer Schering Pharma Aktiengesellschaft Wafer enthaltend Steroidhormone
CN1686143A (zh) 2005-04-04 2005-10-26 浙江大学 十一酸睾酮自乳化软胶囊组合物及制备方法
RU2406480C2 (ru) * 2005-04-08 2010-12-20 Озфарма Пти Лтд Трансбуккальная система доставки
EP1871384A4 (en) 2005-04-15 2012-01-25 Clarus Therapeutics Inc SYSTEMS FOR THE PHARMACEUTICAL ADMINISTRATION OF HYDROPHOUS ACTIVE SUBSTANCES AND COMPOSITIONS THEREWITH
US8492369B2 (en) 2010-04-12 2013-07-23 Clarus Therapeutics Inc Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
US7400031B2 (en) * 2005-09-19 2008-07-15 International Business Machines Corporation Asymmetrically stressed CMOS FinFET
GB0807605D0 (en) 2008-04-28 2008-06-04 Diurnal Ltd Lipid composition
JPWO2010070799A1 (ja) 2008-12-16 2012-05-24 パナソニック株式会社 薬剤投与装置
US20140288039A1 (en) 2009-01-08 2014-09-25 Lipocine Inc. Lipobalanced long chain testosterone prodrugs for oral delivery
US20130225544A1 (en) 2009-01-08 2013-08-29 Lipocine Inc. Lipobalanced long chain testosterone esters for oral delivery
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
EP2229936B1 (en) 2009-03-09 2015-05-06 PharmaSol GmbH Nanonized testosterone formulations for improved bioavailability
US20110263552A1 (en) 2009-12-31 2011-10-27 Sov Therapeutics Modulation of side effect profile of 5-alpha reductase inhibitor therapy
US20130303495A1 (en) 2009-12-31 2013-11-14 Sov Therapeutics Emulsion formulations
EP2519230B1 (en) 2009-12-31 2018-10-10 Marius Pharmaceuticals LLC Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols
ES2525520T3 (es) 2010-04-12 2014-12-26 Clarus Therapeutics, Inc. Formulaciones orales de éster de testosterona y métodos para tratar la deficiencia de testosterona con las mismas
US8367103B2 (en) 2010-09-27 2013-02-05 Bardani Frank M Oral testosterone composition
US20140309202A1 (en) 2010-11-30 2014-10-16 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120135074A1 (en) 2010-11-30 2012-05-31 Chandrashekar Giliyar High-Strength Testosterone Undecanoate Compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
WO2013026002A1 (en) 2011-08-18 2013-02-21 Monosol Rx, Llc Steroid hormone delivery systems and methods of preparing the same
WO2014080282A2 (en) 2012-11-22 2014-05-30 Trimel Biopharma Srl One-and two-point titration methods to determine daily treatment regimens to treat hypogonadism or male testosterone deficiency with an intranasal testosterone bio-adhesive gel, and primary and secondary efficacy and safety endpoints
WO2014145518A2 (en) 2013-03-15 2014-09-18 Clarus Therapeutics, Inc. Methods of treating testosterone deficiency
AU2015276202B2 (en) 2014-06-19 2020-09-17 Pebean Pharma Aps Solid oral dosage form of lipophilic compounds
ES2877107T3 (es) 2014-08-28 2021-11-16 Univ Texas Formulaciones de testosterona y procedimientos de tratamiento con ellas
US20160184321A1 (en) 2014-09-24 2016-06-30 Lipocine Inc. Compositions and their use in oral dosing regimens
US20160361322A1 (en) 2015-06-15 2016-12-15 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
US20170319596A1 (en) 2015-11-10 2017-11-09 Lipocine Inc. Methods for improving quality of life or sexual domain function and composition useful in the methods
EP3399965A4 (en) 2016-01-08 2019-08-21 Western University Of Health Sciences PROLIPOSOMAL TESTOSTERONE ANDECANOATE FORMULATIONS
CA3016542A1 (en) 2016-03-02 2017-09-08 Board Of Regents, The University Of Texas System Formulations of testosterone and methods of treatment therewith
US11559530B2 (en) 2016-11-28 2023-01-24 Lipocine Inc. Oral testosterone undecanoate therapy
WO2018102618A1 (en) 2016-11-30 2018-06-07 Lipocine Inc. Oral testosterone tridecanoate therapy
US20180333423A1 (en) 2017-05-18 2018-11-22 Clarus Therapeutics, Inc. Methods of treating testosterone deficiency
AU2018282905B2 (en) 2017-06-12 2022-06-02 Lakewood Amedex, Inc Bisphosphocin gel formulations and uses thereof
US11311554B2 (en) 2018-04-04 2022-04-26 Slayback Pharma Llc Pharmaceutical compositions of testosterone
WO2020059512A1 (ja) 2018-09-18 2020-03-26 パナソニックＩｐマネジメント株式会社 扁平型ブラシ付コアレスモータ
WO2020132163A1 (en) 2018-12-20 2020-06-25 Clarus Therapeutics, Inc. Methods of treating testosterone deficiency

Also Published As

Publication number Publication date
KR20130119518A (ko) 2013-10-31
US20200046733A1 (en) 2020-02-13
US8828428B1 (en) 2014-09-09
AU2006236564A1 (en) 2006-10-26
JP6251713B2 (ja) 2017-12-20
EP2979699A1 (en) 2016-02-03
US20180021351A1 (en) 2018-01-25
US20250120983A1 (en) 2025-04-17
US11331325B2 (en) 2022-05-17
US20150343072A1 (en) 2015-12-03
US20140249124A1 (en) 2014-09-04
CA2604943A1 (en) 2006-10-26
RU2007142204A (ru) 2009-05-20
HUE061300T2 (hu) 2023-06-28
KR101432466B1 (ko) 2014-08-21
CA2604943C (en) 2013-09-17
US20150343073A1 (en) 2015-12-03
JP2016074677A (ja) 2016-05-12
PT2985026T (pt) 2022-11-03
US20180028542A1 (en) 2018-02-01
RU2623206C2 (ru) 2017-06-22
RU2011119796A (ru) 2012-11-27
US20130022674A1 (en) 2013-01-24
US11179402B2 (en) 2021-11-23
WO2006113505A3 (en) 2008-01-17
WO2006113505A2 (en) 2006-10-26
KR101382725B1 (ko) 2014-04-08
US20230165878A1 (en) 2023-06-01
JP5887044B2 (ja) 2016-03-16
AU2006236564A2 (en) 2006-10-26
KR20080009201A (ko) 2008-01-25
US8241664B2 (en) 2012-08-14
EP1871384A4 (en) 2012-01-25
EP2985026A1 (en) 2016-02-17
PL2985026T3 (pl) 2023-02-20
AU2011201422B2 (en) 2012-02-09
US20160000806A1 (en) 2016-01-07
JP2013121986A (ja) 2013-06-20
JP2008537960A (ja) 2008-10-02
US20140296199A1 (en) 2014-10-02
US20180071311A1 (en) 2018-03-15
AU2006236564B2 (en) 2011-02-17
US20140011789A1 (en) 2014-01-09
EP1871384A2 (en) 2008-01-02
US20150343074A1 (en) 2015-12-03
US20190070196A1 (en) 2019-03-07
RU2429850C2 (ru) 2011-09-27
ES2930658T3 (es) 2022-12-20
EP2985026B1 (en) 2022-08-03
US8778917B2 (en) 2014-07-15
US20180021350A1 (en) 2018-01-25
US20180078566A1 (en) 2018-03-22
KR20130124414A (ko) 2013-11-13
DK2985026T3 (da) 2022-10-31
US20080317844A1 (en) 2008-12-25
JP5778705B2 (ja) 2015-09-16
AU2011201422A1 (en) 2011-04-14

Similar Documents

Publication Publication Date Title
BRPI0607549A2 (pt) sistemas de distribuição farmacêutica para fármacos hidrófobos e composições compreendendo os mesmos
CY1119140T1 (el) Συνθεσεις αντικωδικευσης και μεθοδοι κατασκευης και χρησης τους
BRPI0717509B8 (pt) sistema de liberação controlada para aplicação nasal de neurotransmissores
BRPI0820308B8 (pt) composição farmacêutica compreendendo oxi-hidróxido de ferro em alta carga, seus usos e seus processos de preparação, e comprimido
MY149623A (en) Sprayable gel-type skin/mucosa-adhesive preparation and administration system using the preparation
MX2009007742A (es) Formulaciones farmaceuticas multi-fasicas de farmacos pobremente solubles en agua para una biodisponibilidad oral de variabilidad alimentada/en ayunas reducida y mejorada.
EA200900264A1 (ru) Композиции флибансерина и способ их приготовления
WO2004105694A3 (en) Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
DE602006014990D1 (de) Intranasale verabreichung von schnell wirkendem insulin
EA200801275A1 (ru) Стабилизированные составы карбоната лантана
CY1107906T1 (el) Φαρμακευτικη συνθεση που περιλαμβανει παραγωγα οιστετρολης για χρηση στην θεραπεια κατα του καρκινου
CY1108700T1 (el) Συνθεσεις απελευθερωσης φαρμακου εστερα αλφα-υδροξυ οξεος και μεθοδοι χρησης
AR053680A1 (es) Composicion
BR112012026596A2 (pt) método para preparar composições farmacêuticas pretendidas para administração oral compreendendo um ou mais ingredientes ativos e as composições que compreendem as mesmas
DE60216305D1 (de) Zusammensetzungen zur verabreichung von arzneimittelkombinationen
BR112017027985A2 (pt) peptídeos terapêuticos e métodos de uso dos mesmos
BR112012030641A2 (pt) métodos e composições para terapia farmacêutica oral
BR0211198A (pt) Composições farmacêuticas e seu uso
WO2008023362A3 (en) Use of a combination of methotrexate and an a3ar agonist for the treatment of cancer
MY157187A (en) Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance
CO7101247A2 (es) Formulaciones de ácido poliinosínico-policitidílico (poli(i:c)) para el tratamiento de infecciones de las vías respiratorias altas
BR9812553A (pt) Formulação medicamentosa com liberação de substância ativa controlada
BRPI0510034A (pt) forma de dosagem para distribuição de múltiplas formas de fármacos
MX2010004556A (es) Formulacion farmaceutica de acido clavulanico.
DE60205905D1 (de) Pharmazeutische zusammensetzung zur orale verabreichung mit verbesserter bioverfügbarkeit

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08G Application fees: restoration [chapter 8.7 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]