BRPI0607773A2 - método para produção de um oligÈmero de proantocianidina - Google Patents

método para produção de um oligÈmero de proantocianidina

Info

Publication number
BRPI0607773A2
BRPI0607773A2 BRPI0607773-0A BRPI0607773A BRPI0607773A2 BR PI0607773 A2 BRPI0607773 A2 BR PI0607773A2 BR PI0607773 A BRPI0607773 A BR PI0607773A BR PI0607773 A2 BRPI0607773 A2 BR PI0607773A2
Authority
BR
Brazil
Prior art keywords
ring structure
oligomer
substance
composition
resorcinol
Prior art date
Application number
BRPI0607773-0A
Other languages
English (en)
Inventor
Takashi Tanaka
Gen-Ichiro Nonaka
Isao Kohno
Hajime Fujii
Takashi Nakagawa
Hiroshi Nishioka
Original Assignee
Univ Nagasaki
Usaien Pharmaceutical Co Ltd
Amino Up Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nagasaki, Usaien Pharmaceutical Co Ltd, Amino Up Chemical Co Ltd filed Critical Univ Nagasaki
Publication of BRPI0607773A2 publication Critical patent/BRPI0607773A2/pt
Publication of BRPI0607773B1 publication Critical patent/BRPI0607773B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/04—Rhodophycota or rhodophyta (red algae), e.g. Porphyra
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/485—Gueldenstaedtia
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/734—Crataegus (hawthorn)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • A61Q19/08—Anti-ageing preparations
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

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Abstract

MéTODO PARA PRODUçãO DE UM OLIGÈMERO DE PROANTOCIANIDINA. A presente invenção refere-se a uma composição contendo como seu principal componente um oligómero de proantocianidina, ao qual se liga uma substância apresentando uma estrutura de anel de floroglicinol ou estrutura de anel de resorcinol, a qual reduz o peso molecular e que é obtida através do aquecimento de materiais de plantas contendo o polímero de proantocianidina ou extrato do mesmo, com uma substância apresentando uma estrutura de anel de floroglicinol ou estrutura de anel de resorcinol em uma solução aquosa acídica, a um método de produção da dita composição, e ao uso da dita composição em produtos para preservação da saúde e produtos farmacêuticos. De acordo com a invenção, o oligómero de proantocianidina tendo atividade fisiológica, ao qual uma substância apresentando uma estrutura de anel de floroglicinol ou estrutura de anel de resorcinol, se liga e tem peso molecular reduzido em um tal nível que o oligómero possa ser absorvido no corpo humano, o que foi convencionalmente difícil de se obter com alta produção de matérias-primas de plantas, pode ser eficiente e facilmente produzido.
BRPI0607773-0A 2005-02-25 2006-02-24 Método para produção de um oligômero de proantocianidina BRPI0607773B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005-051070 2005-02-25
JP2005051070 2005-02-25
PCT/JP2006/303402 WO2006090830A1 (ja) 2005-02-25 2006-02-24 プロアントシアニジンオリゴマーの製造方法

Publications (2)

Publication Number Publication Date
BRPI0607773A2 true BRPI0607773A2 (pt) 2009-10-06
BRPI0607773B1 BRPI0607773B1 (pt) 2019-07-23

Family

ID=36927463

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607773-0A BRPI0607773B1 (pt) 2005-02-25 2006-02-24 Método para produção de um oligômero de proantocianidina

Country Status (14)

Country Link
US (2) US20090047305A1 (pt)
EP (1) EP1852430B1 (pt)
JP (1) JP4941991B2 (pt)
KR (2) KR20130128017A (pt)
CN (1) CN101133043B (pt)
AU (1) AU2006216182A1 (pt)
BR (1) BRPI0607773B1 (pt)
CA (1) CA2599295C (pt)
DK (1) DK1852430T3 (pt)
ES (1) ES2746955T3 (pt)
NZ (1) NZ560436A (pt)
PL (1) PL1852430T3 (pt)
RU (1) RU2435579C2 (pt)
WO (1) WO2006090830A1 (pt)

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JP5160149B2 (ja) * 2007-06-22 2013-03-13 明治薬品株式会社 柿ポリフェノールオリゴマー
FR2923718B1 (fr) * 2007-11-15 2009-12-18 Caudalie Compositions de derives polyphenoliques flavonoidiques et leurs applications pour lutter contre les pathologies et le vieillissement des organismes vivants
CA2719358C (en) * 2008-03-31 2017-10-24 Altan Co., Ltd. Antiviral agent and antiviral composition
JP5738755B2 (ja) * 2008-05-09 2015-06-24 アイカーン スクール オブ メディシン アット マウント シナイ 神経変性疾患を予防および治療するための方法
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EP2714085B1 (en) 2011-05-27 2016-06-01 Unilever PLC Anti-inflammatory composition
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JP5437537B1 (ja) * 2012-10-05 2014-03-12 フジッコ株式会社 低重合度プロアントシアニジンの製法
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KR102766105B1 (ko) 2022-01-24 2025-02-13 경희대학교 산학협력단 저분자 페놀 화합물을 포함하는 수소화 분해된 적송수피 추출물을 유효성분으로 함유하는 알츠하이머병 예방 또는 치료용 조성물 및 이의 제조방법
CN116120336B (zh) * 2023-02-17 2024-11-19 江南大学 一种木瓜原花青素及其制备方法和应用
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WO2006090830A1 (ja) 2006-08-31
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JPWO2006090830A1 (ja) 2008-07-24
EP1852430B1 (en) 2019-07-03
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JP4941991B2 (ja) 2012-05-30
RU2435579C2 (ru) 2011-12-10
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US20160151329A1 (en) 2016-06-02
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