BRPI0607784A2 - método para produzir produtos metabólicos secundários de fungos ou bactérias e produto metabólico secundário de fungos ou bactérias, marcado de forma isotópica - Google Patents

método para produzir produtos metabólicos secundários de fungos ou bactérias e produto metabólico secundário de fungos ou bactérias, marcado de forma isotópica

Info

Publication number
BRPI0607784A2
BRPI0607784A2 BRPI0607784-6A BRPI0607784A BRPI0607784A2 BR PI0607784 A2 BRPI0607784 A2 BR PI0607784A2 BR PI0607784 A BRPI0607784 A BR PI0607784A BR PI0607784 A2 BRPI0607784 A2 BR PI0607784A2
Authority
BR
Brazil
Prior art keywords
fungal
secondary metabolic
bacterial
producing
products
Prior art date
Application number
BRPI0607784-6A
Other languages
English (en)
Inventor
Martin Freudenschuss
Georg Haubl
Rudolf Krslka
Guenther Jaunecker
Eva Binder
Original Assignee
Erber Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erber Ag filed Critical Erber Ag
Publication of BRPI0607784A2 publication Critical patent/BRPI0607784A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

MéTODO PARA PRODUZIR PRODUTOS METABóLICOS SECUNDáRIOS DE FUNGOS OU BACTéRIAS E PRODUTO METABóLICO SECUNDáRIO DE FUNGOS OU BACTéRIAS, MARCADO DE FORMA ISOTóPICA. A presente invenção refere-se a um método para produzir produtos metabólicos secundários de fungos ou bactérias, altamente marcados de forma isotópica, em um meio de cultura liquido sintético. De acordo com o dito método, a síntese é conduzida imobilizando os fungos ou bactérias sobre um veículo inerte, adicionando um meio de cultura líquido sintético no qual essencialmente todos átomos de carbono, átomos de nitrogênio e/ou átomos de enxofre são substituidos por isótopos estáveis.
BRPI0607784-6A 2005-04-05 2006-03-31 método para produzir produtos metabólicos secundários de fungos ou bactérias e produto metabólico secundário de fungos ou bactérias, marcado de forma isotópica BRPI0607784A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0057405A AT501629B1 (de) 2005-04-05 2005-04-05 Herstellung von hochgradig isotopenmarkierten, sekundären, mikrobiellen stoffwechselprodukten sowie stoffwechselprodukte
PCT/AT2006/000129 WO2006105563A2 (de) 2005-04-05 2006-03-31 Herstellung von hochgradig isotopenmarkierten, sekundären, mikrobiellen stoffwechselprodukten sowie stoffwechselprodukte

Publications (1)

Publication Number Publication Date
BRPI0607784A2 true BRPI0607784A2 (pt) 2009-06-13

Family

ID=36699043

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607784-6A BRPI0607784A2 (pt) 2005-04-05 2006-03-31 método para produzir produtos metabólicos secundários de fungos ou bactérias e produto metabólico secundário de fungos ou bactérias, marcado de forma isotópica

Country Status (20)

Country Link
US (1) US20090068706A1 (pt)
EP (1) EP1866423B1 (pt)
JP (1) JP5231212B2 (pt)
KR (2) KR101215023B1 (pt)
CN (1) CN101155924A (pt)
AT (2) AT501629B1 (pt)
AU (1) AU2006230781B2 (pt)
BR (1) BRPI0607784A2 (pt)
CA (1) CA2602415C (pt)
DK (1) DK1866423T3 (pt)
ES (1) ES2381275T3 (pt)
IL (1) IL186043A (pt)
MX (1) MX2007012315A (pt)
PL (1) PL1866423T3 (pt)
PT (1) PT1866423E (pt)
RU (1) RU2407797C2 (pt)
SG (1) SG160414A1 (pt)
SI (1) SI1866423T1 (pt)
WO (1) WO2006105563A2 (pt)
ZA (1) ZA200708207B (pt)

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* Cited by examiner, † Cited by third party
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DE102010019869B4 (de) 2010-05-07 2012-04-05 Bruker Daltonik Gmbh Massenspektrometrischer Schnellnachweis von Salmonellen
CN101914586B (zh) * 2010-07-14 2012-05-30 江苏省农业科学院 Don毒素的制备纯化方法
EP2687854A1 (en) 2012-07-19 2014-01-22 Chiron AS Test kit for the quantitative determination of narcotic drugs
CN103421019B (zh) * 2012-11-02 2015-08-26 华中农业大学 氚标记脱氧镰刀菌烯醇的微量制备方法
EA201201654A1 (ru) * 2012-12-28 2014-06-30 Ооо "Эн.Си.Фарм" Противоопухолевое средство (варианты)
DE102013011509A1 (de) 2013-07-11 2015-01-15 Martin-Luther-Universität Halle-Wittenberg, Körperschaft des öffentlichen Rechts Verfahren zur Biosynthese von spezifisch isotopenmarkierten Sekundermetaboliten
CN103351371B (zh) * 2013-07-23 2015-03-04 江苏省农业科学院 通过麦粒培养基制备纯化zen毒素的方法
EP3266874A1 (en) 2016-07-08 2018-01-10 Universität Wien Fermentative production and isolation of stable isotope labeled metabolites from microbial cell walls and/or cell membranes
CN108593753B (zh) * 2016-11-25 2020-06-05 北京毅新博创生物科技有限公司 通过内部标准物质谱检测微生物的内标校正方法
CN108760929A (zh) * 2018-06-13 2018-11-06 广东省药品检验所（广东省药品质量研究所、广东省口岸药品检验所） 一种检测广佛手8种真菌毒素的方法
CN109593676B (zh) * 2018-12-21 2023-04-07 江苏大学 一种用于酸菜发酵液中微生物分离的培养基及其制备方法
CN111849796B (zh) * 2019-04-26 2023-01-13 姚瑞莲 稳定同位素标记的细胞内中间代谢物及其制备方法
CN112979605A (zh) * 2021-03-03 2021-06-18 上海海关动植物与食品检验检疫技术中心 一种稳定同位素标记的玉米赤霉烯酮及其合成方法
CN115290739B (zh) * 2022-08-12 2024-04-26 中国科学技术大学 细菌代谢物分析方法
CN115927014A (zh) * 2022-12-27 2023-04-07 青岛普瑞邦生物工程有限公司 一种产毒培养基及碳13标记的链格孢霉毒素的制备方法
CN119506374A (zh) * 2024-11-28 2025-02-25 青岛普瑞邦生物工程有限公司 一种碳13标记的呕吐毒素的制备方法及采用的产毒培养基

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WO1997018321A1 (en) * 1995-11-15 1997-05-22 Martek Corporation Photosynthetic production of stable isotopically labeled recombinant proteins
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JP4780815B2 (ja) * 1999-08-26 2011-09-28 三洋電機株式会社 エレクトロルミネッセンス表示装置の駆動方法
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Also Published As

Publication number Publication date
ATE542914T1 (de) 2012-02-15
KR101215023B1 (ko) 2012-12-24
ES2381275T3 (es) 2012-05-24
CN101155924A (zh) 2008-04-02
MX2007012315A (es) 2007-12-11
PL1866423T3 (pl) 2012-07-31
CA2602415A1 (en) 2006-10-12
WO2006105563A2 (de) 2006-10-12
KR20100110400A (ko) 2010-10-12
AT501629A1 (de) 2006-10-15
EP1866423A2 (de) 2007-12-19
PT1866423E (pt) 2012-04-03
EP1866423B1 (de) 2012-01-25
KR101013706B1 (ko) 2011-02-10
AU2006230781B2 (en) 2011-04-07
AT501629B1 (de) 2007-10-15
US20090068706A1 (en) 2009-03-12
ZA200708207B (en) 2008-11-26
RU2007140982A (ru) 2009-05-20
SG160414A1 (en) 2010-04-29
WO2006105563A3 (de) 2006-12-14
CA2602415C (en) 2013-10-01
JP2008534027A (ja) 2008-08-28
SI1866423T1 (sl) 2012-05-31
IL186043A0 (en) 2008-02-09
RU2407797C2 (ru) 2010-12-27
DK1866423T3 (da) 2012-04-16
KR20070118675A (ko) 2007-12-17
IL186043A (en) 2015-04-30
JP5231212B2 (ja) 2013-07-10
AU2006230781A1 (en) 2006-10-12

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C12P 1/02 , C12P 1/04

Ipc: C12P 1/02 (2006.01), C12P 1/04 (2006.01), C12P 11/

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]