BRPI0607883A2 - método para obter material celular prontamente disponìvel derivado de sangue periférico e uma composição do referido material celular - Google Patents

método para obter material celular prontamente disponìvel derivado de sangue periférico e uma composição do referido material celular

Info

Publication number
BRPI0607883A2
BRPI0607883A2 BRPI0607883-4A BRPI0607883A BRPI0607883A2 BR PI0607883 A2 BRPI0607883 A2 BR PI0607883A2 BR PI0607883 A BRPI0607883 A BR PI0607883A BR PI0607883 A2 BRPI0607883 A2 BR PI0607883A2
Authority
BR
Brazil
Prior art keywords
cellular material
peripheral blood
composition
readily available
available peripheral
Prior art date
Application number
BRPI0607883-4A
Other languages
English (en)
Inventor
Donnie Rudd
David Wolf
Original Assignee
Regenetech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regenetech Inc filed Critical Regenetech Inc
Publication of BRPI0607883A2 publication Critical patent/BRPI0607883A2/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

MéTODO PARA OBTER MATERIAL CELULAR PRONTAMENTE DISPONìVEL DERIVADO DE SANGUE PERIFéRICO E UMA COMPOSIçãO DO REFERIDO MATERIAL CELULAR. A presente invenção está voltada para a expansão por TVEMF de células tronco de sangue periférico de mamíferos, de preferência células CD34+/CD3 8-, para composições resultantes das células expandidas por TVEMIF e para um método de tratamento de doenças ou reparo de tecidos com as composições.
BRPI0607883-4A 2005-02-28 2006-02-27 método para obter material celular prontamente disponìvel derivado de sangue periférico e uma composição do referido material celular BRPI0607883A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65730605P 2005-02-28 2005-02-28
US65727105P 2005-02-28 2005-02-28
PCT/US2006/006816 WO2006093857A2 (en) 2005-02-28 2006-02-27 Method of providing readily available cellular material derived from peripheral blood and a composition thereof

Publications (1)

Publication Number Publication Date
BRPI0607883A2 true BRPI0607883A2 (pt) 2009-12-22

Family

ID=36941683

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607883-4A BRPI0607883A2 (pt) 2005-02-28 2006-02-27 método para obter material celular prontamente disponìvel derivado de sangue periférico e uma composição do referido material celular

Country Status (9)

Country Link
US (5) US20060193839A1 (pt)
EP (1) EP1853110A4 (pt)
JP (1) JP2008531051A (pt)
KR (1) KR20070114378A (pt)
BR (1) BRPI0607883A2 (pt)
CA (1) CA2599274A1 (pt)
EA (1) EA200701600A1 (pt)
IL (1) IL185437A0 (pt)
WO (1) WO2006093857A2 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807458B2 (en) 2003-01-30 2010-10-05 The United States Of America As Represented By The Secretary Of The Department Of Veterans Affairs Multilineage-inducible cells and uses thereof
ATE470199T1 (de) * 2003-04-24 2010-06-15 Koninkl Philips Electronics Nv Eingriffsfreie links-herzkammervolumenbestimmung
WO2006033429A1 (ja) * 2004-09-24 2006-03-30 Seiren Kabushiki Kaisha 細胞凍結保存用組成物
US20060193839A1 (en) * 2005-02-28 2006-08-31 Donnie Rudd Method of providing readily available cellular material derived from peripheral blood, and a composition thereof
US20080075704A1 (en) * 2005-02-28 2008-03-27 Wolf David A Method of providing readily available cellular material derived from peripheral blood, and a composition thereof
US20090081752A1 (en) * 2007-09-24 2009-03-26 Dennis Robert G Bioreactor, kit and method of using same
US8993231B2 (en) * 2008-03-18 2015-03-31 Marshall University Research Corporation Methods for stem cell production and therapy
US8844298B2 (en) 2008-11-18 2014-09-30 S2 Corporation Vibration reducing sample mount with thermal coupling
US8307666B2 (en) * 2009-03-27 2012-11-13 S2 Corporation Methods and apparatus for providing rotational movement and thermal stability to a cooled sample
US20140377228A1 (en) * 2009-10-30 2014-12-25 National Institute Of Immunology Bone Marrow-Derived Cells Ameliorates The Pathological Consequences Of The Liver In Case Of Alpha1-Antitrypsin Deficiency
RU2495683C1 (ru) * 2012-02-17 2013-10-20 Владимир Михайлович Музалевский Способ лечения внутренних органов
CN102669087A (zh) * 2012-05-15 2012-09-19 深圳市博泰生物医疗机构管理有限公司 一种外周血单个核细胞的冻存液及冻存方法
KR101290062B1 (ko) * 2012-07-06 2013-07-26 김홍승 말초 혈액으로부터 활성화 ｔ 임파구 세포를 유도하기 위한 배양 조성물, 이를 포함하는 배양 키트 및 이를 이용하여 말초 혈액으로부터 활성화 ｔ 임파구 세포를 유도하는 방법
KR101290061B1 (ko) * 2012-07-06 2013-07-26 김홍승 말초 혈액으로부터 수지상 세포를 유도하기 위한 배양 조성물, 이를 포함하는 배양 키트 및 이를 이용하여 말초 혈액으로부터 수지상 세포를 유도하는 방법
US9943545B2 (en) * 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
JP2016518415A (ja) * 2013-10-21 2016-06-23 アドバンスド ニューロリジェネレイティブ セラピーズ エルエルシー 加齢と疾患免疫機能障害と細胞老化とをリンパ球系幹細胞で修復する方法、及び治療使用のためのそれらの再適用する方法
ES2747951T3 (es) 2013-10-24 2020-03-12 Ospedale San Raffaele Srl Método
US9410143B1 (en) 2014-06-10 2016-08-09 Endonovo Therapeutics, Inc. Biological molecules produced by electromagnetically stimulating living mammalian cells
WO2016076428A1 (ja) 2014-11-14 2016-05-19 日本赤十字社 臍帯血および末梢血の凍結保存方法および凍結保存用溶液
CN106665560B (zh) * 2017-01-16 2021-02-05 哈尔滨医科大学 一种直接静脉回输的免疫细胞冻存液及其应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US209357A (en) * 1878-10-29 Improvement in boots
US3485963A (en) * 1967-02-20 1969-12-23 Sanjiro Murata Ultraminiature tape recorder with two-way gravity-operated control switch actuated by change in vertical orientation of recorder
US4762705A (en) * 1981-11-10 1988-08-09 Adolf W. Schwimmer Cancer therapy with interferon
US4844818A (en) * 1987-10-23 1989-07-04 Becton Dickinson & Company Method for separating the cellular components of blood samples
US5192553A (en) * 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
US5004681B1 (en) * 1987-11-12 2000-04-11 Biocyte Corp Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
US6007978A (en) * 1988-05-18 1999-12-28 Cobe Laboratories, Inc. Method of freezing cells and cell-like materials
US5635387A (en) * 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
SE9100142L (sv) * 1991-01-17 1992-07-18 Bengt Sandberg En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US6436387B1 (en) * 1992-11-24 2002-08-20 G.D. Searle & Co. Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins
DE4240635C2 (de) * 1992-12-03 1997-07-10 Lothar Prof Dr Kanz Vermehrung hämatopoetischer Vorläuferzellen ex vivo sowieZusammensetzungen hämatopoetischer Wachstumsfaktoren
US5599705A (en) * 1993-11-16 1997-02-04 Cameron; Robert B. In vitro method for producing differentiated universally compatible mature human blood cells
ES2180665T3 (es) * 1994-11-16 2003-02-16 Amgen Inc Uso de factor de celulas madre y de receptor soluble de interleuquina-6 para la expansion ex-vivo de celulas hematopoyeticas multipotenciales.
US5925567A (en) * 1995-05-19 1999-07-20 T. Breeders, Inc. Selective expansion of target cell populations
WO1997018298A1 (en) * 1995-11-14 1997-05-22 Regents Of The University Of Minnesota Ex vivo culture of stem cells
CA2294944A1 (en) * 1997-07-03 1999-01-14 Osiris Therapeutics, Inc. Human mesenchymal stem cells from peripheral blood
US6962698B1 (en) * 1998-02-17 2005-11-08 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
CA2358949A1 (en) * 1999-01-22 2000-07-27 Robert M. Strom Surface modified divinylbenzene resin having a hemocompatible coating
US6673318B1 (en) * 1999-05-31 2004-01-06 Bridgestone Corporation Pipette
US6541249B2 (en) * 1999-12-22 2003-04-01 Human Genome Sciences, Inc. Immortalized human stromal cell lines
US6485963B1 (en) * 2000-06-02 2002-11-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Growth stimulation of biological cells and tissue by electromagnetic fields and uses thereof
US6455306B1 (en) * 2000-06-09 2002-09-24 Transcyte, Inc. Transfusable oxygenating composition
US20030190689A1 (en) * 2002-04-05 2003-10-09 Cell Signaling Technology,Inc. Molecular profiling of disease and therapeutic response using phospho-specific antibodies
WO2004011631A2 (en) * 2002-07-26 2004-02-05 Ebi, L.P. Methods and compositions for treating tissue defects using pulsed electromagnetic field stimulus
US20040076620A1 (en) * 2002-09-03 2004-04-22 Donnie Rudd Method of repairing primate mammalian tissue
US20040258670A1 (en) * 2002-12-05 2004-12-23 Case Western Reserve University Cell-based therapies for ischemia
US7332334B2 (en) * 2003-04-18 2008-02-19 Oklahoma Medical Research Foundation Hematopoietic stem cells treated by in vitro fucosylation and methods of use
US20050084962A1 (en) * 2003-08-20 2005-04-21 Bruce Simon Methods of treatment using electromagnetic field stimulated stem cells
US20080057042A1 (en) * 2005-01-27 2008-03-06 Donnie Rudd Method of providing readily available cellular material derived from cord blood, and a composition thereof
CN101142310A (zh) * 2005-01-27 2008-03-12 雷格内泰克公司 提供容易获得的源于脐带血的细胞材料的方法及其组合物
CA2599275A1 (en) * 2005-02-28 2006-09-08 Regenetech, Inc. Method and composition for treating diabetes
US20060193839A1 (en) * 2005-02-28 2006-08-31 Donnie Rudd Method of providing readily available cellular material derived from peripheral blood, and a composition thereof
JP2008531698A (ja) * 2005-02-28 2008-08-14 リジェネテック，インコーポレイテッド 上皮及び他の細胞及び組織を治療するための方法及び組成物
WO2006093860A2 (en) * 2005-02-28 2006-09-08 Regenetech, Inc. Method and composition for repairing heart tissue
US20080075700A1 (en) * 2006-02-27 2008-03-27 Wolf David A Method and composition for treating diabetes
US20080050348A1 (en) * 2006-02-27 2008-02-28 Donnie Rudd Method and composition for repairing heart tissue

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US20070087324A1 (en) 2007-04-19
US20060193839A1 (en) 2006-08-31
CA2599274A1 (en) 2006-09-08
WO2006093857A2 (en) 2006-09-08
US20070098704A1 (en) 2007-05-03
WO2006093857A3 (en) 2007-06-07
US20070098699A1 (en) 2007-05-03
KR20070114378A (ko) 2007-12-03
EP1853110A2 (en) 2007-11-14
EA200701600A1 (ru) 2008-02-28
EP1853110A4 (en) 2009-01-14
IL185437A0 (en) 2008-01-06
US20070117087A1 (en) 2007-05-24
JP2008531051A (ja) 2008-08-14

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