BRPI0609426B8 - naftiridonas e quinolonas de alquilidenil-heterocíclicas de 7-amino - Google Patents

naftiridonas e quinolonas de alquilidenil-heterocíclicas de 7-amino

Info

Publication number
BRPI0609426B8
BRPI0609426B8 BRPI0609426A BRPI0609426A BRPI0609426B8 BR PI0609426 B8 BRPI0609426 B8 BR PI0609426B8 BR PI0609426 A BRPI0609426 A BR PI0609426A BR PI0609426 A BRPI0609426 A BR PI0609426A BR PI0609426 B8 BRPI0609426 B8 BR PI0609426B8
Authority
BR
Brazil
Prior art keywords
naphthyridones
quinolones
heterocyclic
amino alkylidenyl
amino
Prior art date
Application number
BRPI0609426A
Other languages
English (en)
Inventor
Bowers Grant Eugene Iii
Joseph Macielag Mark
Ann Weidner-Wells Michele
David Paget Steven
Xu Xiaodong
Xu Xiaoqing
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0609426A2 publication Critical patent/BRPI0609426A2/pt
Publication of BRPI0609426B1 publication Critical patent/BRPI0609426B1/pt
Publication of BRPI0609426B8 publication Critical patent/BRPI0609426B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

naftiridonas e quinolonas de alquilide-nil-heterocíclicas de 7-amino. a presente invenção refere-se a composto tendo uma estrutura de acordo com a fórmula i em que n, m, z, r, r2, r3, r4, r5, r6, a, e, x, y, a e b são como definidos acima; ou um enantiômero, diastereômero ou isômero óptico destes; um fármaco, hidrato, ou sal farmaceuticamente aceitáveis destes.
BRPI0609426A 2005-03-21 2006-02-02 naftiridonas e quinolonas de alquilidenil-heterocíclicas de 7-amino BRPI0609426B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/084,987 US7732612B2 (en) 2004-09-09 2005-03-21 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US11/084,987 2005-03-21
PCT/US2006/003657 WO2006101603A1 (en) 2005-03-21 2006-02-02 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones

Publications (3)

Publication Number Publication Date
BRPI0609426A2 BRPI0609426A2 (pt) 2010-04-06
BRPI0609426B1 BRPI0609426B1 (pt) 2020-09-24
BRPI0609426B8 true BRPI0609426B8 (pt) 2021-05-25

Family

ID=36648281

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0609426A BRPI0609426B8 (pt) 2005-03-21 2006-02-02 naftiridonas e quinolonas de alquilidenil-heterocíclicas de 7-amino

Country Status (22)

Country Link
US (1) US7732612B2 (pt)
EP (1) EP1861401B1 (pt)
JP (1) JP4977684B2 (pt)
KR (1) KR101323665B1 (pt)
CN (1) CN101248070B (pt)
AR (1) AR053342A1 (pt)
AU (1) AU2006227984A1 (pt)
BR (1) BRPI0609426B8 (pt)
CA (1) CA2602140C (pt)
CR (1) CR9458A (pt)
DK (1) DK1861401T3 (pt)
EA (1) EA014554B1 (pt)
ES (1) ES2561834T3 (pt)
IL (1) IL186041A (pt)
MX (1) MX2007011774A (pt)
MY (1) MY147638A (pt)
NO (1) NO340833B1 (pt)
NZ (1) NZ561651A (pt)
TW (1) TWI444380B (pt)
UA (1) UA93672C2 (pt)
WO (1) WO2006101603A1 (pt)
ZA (1) ZA200708868B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7913302B2 (en) * 2004-05-02 2011-03-22 Markmonitor, Inc. Advanced responses to online fraud
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
HRP20100194T8 (hr) * 2005-10-21 2010-06-30 Glaxo Group Limited Perikondenzirani triciklički spojevi, korisni kao antibakterijska sredstva
WO2007071936A1 (en) 2005-12-22 2007-06-28 Glaxo Group Limited Heterocyclic compounds, their preparation and their use as antibacterials
ES2366150T3 (es) * 2006-03-28 2011-10-17 Warner Chilcott Company, Llc Malatos de polimorfos de ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinocarboxílico.
CA2647454A1 (en) * 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
EP2297254B1 (fr) 2008-05-29 2014-08-20 Bluestar Silicones France Article presentant des proprietes antisalissures et destine a etre utilise dans des applications aquatiques en particulier marines
JO3611B1 (ar) 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
WO2013021052A1 (en) 2011-08-10 2013-02-14 Janssen R&D Ireland Antibacterial piperidinyl substituted 3,4-dihydro-1h-[1,8]naphthyridinones
AU2012314409B2 (en) 2011-09-30 2016-11-03 Janssen Pharmaceutica Nv Improved process for preparing 2-[(2E)-2-fluoro-2-(3-piperidinylidene)ethyl]-1H-isoindole-1,3(2H)-dione
WO2014087292A1 (en) * 2012-12-04 2014-06-12 Mankind Research Centre An improved process for the preparation of moxifloxacin hydrochloride
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK164287A (da) 1986-03-31 1987-10-01 Sankyo Co Quinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf og deres anvendelse
JPH0262875A (ja) * 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
CA1332605C (en) 1988-10-03 1994-10-18 Yasuhiro Nishitani Pyridonecarboxylic acids
US5580872A (en) * 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
FR2692577B1 (fr) 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
JPH07300472A (ja) * 1992-12-28 1995-11-14 Korea Res Inst Chem Technol 新規キノロンカルボン酸誘導体およびその製造方法
JPH06263754A (ja) 1993-03-12 1994-09-20 Hokuriku Seiyaku Co Ltd ７−アミノピロリジニルキノリン−３−カルボン酸誘導体
CN1264837C (zh) 1997-09-15 2006-07-19 普罗克特和甘保尔公司 喹诺酮抗微生物剂、其组合物和应用
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
WO2005033108A1 (en) * 2003-09-22 2005-04-14 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones

Also Published As

Publication number Publication date
NO340833B1 (no) 2017-06-26
EP1861401A1 (en) 2007-12-05
ZA200708868B (en) 2009-01-28
JP4977684B2 (ja) 2012-07-18
KR101323665B1 (ko) 2013-10-31
TW200700418A (en) 2007-01-01
KR20070113304A (ko) 2007-11-28
CA2602140A1 (en) 2006-09-28
UA93672C2 (en) 2011-03-10
MY147638A (en) 2012-12-31
MX2007011774A (es) 2008-03-10
EA014554B1 (ru) 2010-12-30
CN101248070A (zh) 2008-08-20
EP1861401B1 (en) 2015-11-18
JP2008538110A (ja) 2008-10-09
DK1861401T3 (en) 2015-12-07
NO20075385L (no) 2007-12-14
US20060052359A1 (en) 2006-03-09
US7732612B2 (en) 2010-06-08
NZ561651A (en) 2011-09-30
AU2006227984A1 (en) 2006-09-28
WO2006101603A1 (en) 2006-09-28
CR9458A (es) 2008-09-09
IL186041A0 (en) 2008-02-09
CN101248070B (zh) 2011-12-14
EA200702039A1 (ru) 2008-02-28
CA2602140C (en) 2015-04-14
IL186041A (en) 2016-05-31
AR053342A1 (es) 2007-05-02
BRPI0609426A2 (pt) 2010-04-06
ES2561834T3 (es) 2016-03-01
BRPI0609426B1 (pt) 2020-09-24
TWI444380B (zh) 2014-07-11

Similar Documents

Publication Publication Date Title
BRPI0414573A (pt) 7-amino alquilidenil-quinolonas e naftiridonas heterocìclicas
BRPI0412347A (pt) 2-aminofenil-4-fenilpiridinas como inibidores de quinase
ATE479687T1 (de) Kinaseinhibitoren
MY160424A (en) Substituted pyrrolidine-2-carboxyamides.
TW200738655A (en) Novel bicyclic sulfonamide derivatives
HRP20120323T1 (en) Diarylhydantoin compounds
BRPI0616393B8 (pt) compostos heterocíclicos fundidos úteis como moduladores de quinase, composição farmacêutica e usos dos mesmos
MY146491A (en) Fused pyrrole derivatives
DK1881967T3 (da) Substituerede benzo (D) isoaxol-3-yl-amin-forbindelser som analgetika
BRPI0821255A2 (pt) Derivados de espiroindolinona
TW200745032A (en) Novel heterobicyclic derivatives
TW200600494A (en) Bisphenyl compounds useful as vitamin d3 receptor agonists
EA200970372A1 (ru) Ингибитор развития болезни альцгеймера, содержащий гетероциклическое соединение
BRPI0518169A (pt) tiazolil-dihidro-indazóis
NO20075385L (no) 7-aminoalkylidenyl-heterocykliske kinoloner og naftyridoner
ATE404536T1 (de) Substituierte chinolinderivate als inhibitoren von mitotischem kinesin
EA200900631A1 (ru) Замещённые пиразолы и триазолы, как ингибиторы кбв (кинезин-белок веретена)
BRPI0516981A (pt) inibidores de mif
ATE553106T1 (de) Heteroarylpyrrolopyridinone als kinaseinhibitoren
EA200801199A1 (ru) Ингибиторы киназы
CY1113484T1 (el) Ενωση 3-φαινυλπυραζολο[5,1-b]θειαζολιου
DOP2006000233A (es) Inhibidores de cinasa
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate
MA32834B1 (fr) 3-aminocyclopentanecarboxamides servant de modulateurs de recepteurs de chimiokines
TW200634013A (en) Quinoline derivative, its use, production and pharmaceutical agents containing the derivative

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PANTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. TENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESE

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/09/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/02/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 17A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2708 DE 29-11-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.