BRPI0609704B8 - compostos derivados de fosforamidato, seus usos, composições farmacêuticas que os compreendem, métodos de preparação das referidas composições e processo para preparação de um composto - Google Patents

compostos derivados de fosforamidato, seus usos, composições farmacêuticas que os compreendem, métodos de preparação das referidas composições e processo para preparação de um composto

Info

Publication number
BRPI0609704B8
BRPI0609704B8 BRPI0609704A BRPI0609704A BRPI0609704B8 BR PI0609704 B8 BRPI0609704 B8 BR PI0609704B8 BR PI0609704 A BRPI0609704 A BR PI0609704A BR PI0609704 A BRPI0609704 A BR PI0609704A BR PI0609704 B8 BRPI0609704 B8 BR PI0609704B8
Authority
BR
Brazil
Prior art keywords
preparing
phosphoramidate
compositions
compound
derived compounds
Prior art date
Application number
BRPI0609704A
Other languages
English (en)
Portuguese (pt)
Inventor
Christopher Mcguigan
Costantino Congiatu
Kenneth Mills
Original Assignee
Cardiff Protides Ltd
Nucana Biomed Ltd
Univ College Cardiff Consultants Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiff Protides Ltd, Nucana Biomed Ltd, Univ College Cardiff Consultants Ltd filed Critical Cardiff Protides Ltd
Publication of BRPI0609704A2 publication Critical patent/BRPI0609704A2/pt
Publication of BRPI0609704B1 publication Critical patent/BRPI0609704B1/pt
Publication of BRPI0609704B8 publication Critical patent/BRPI0609704B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0609704A 2005-03-21 2006-03-16 compostos derivados de fosforamidato, seus usos, composições farmacêuticas que os compreendem, métodos de preparação das referidas composições e processo para preparação de um composto BRPI0609704B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0505781.5 2005-03-21
GBGB0505781.5A GB0505781D0 (en) 2005-03-21 2005-03-21 Chemical compounds
PCT/GB2006/000932 WO2006100439A1 (en) 2005-03-21 2006-03-16 Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer

Publications (3)

Publication Number Publication Date
BRPI0609704A2 BRPI0609704A2 (pt) 2010-04-20
BRPI0609704B1 BRPI0609704B1 (pt) 2020-12-01
BRPI0609704B8 true BRPI0609704B8 (pt) 2021-09-28

Family

ID=34531603

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0609704A BRPI0609704B8 (pt) 2005-03-21 2006-03-16 compostos derivados de fosforamidato, seus usos, composições farmacêuticas que os compreendem, métodos de preparação das referidas composições e processo para preparação de um composto

Country Status (20)

Country Link
US (1) US8263575B2 (2)
EP (1) EP1866324B1 (2)
JP (2) JP5345381B2 (2)
CN (2) CN103936807A (2)
AT (1) ATE471334T1 (2)
AU (1) AU2006226182C1 (2)
BR (1) BRPI0609704B8 (2)
CA (1) CA2602324C (2)
CY (1) CY1111538T1 (2)
DE (1) DE602006014949D1 (2)
DK (1) DK1866324T3 (2)
ES (1) ES2348741T3 (2)
GB (1) GB0505781D0 (2)
IL (1) IL186104A (2)
MX (1) MX2007011666A (2)
PL (1) PL1866324T3 (2)
PT (1) PT1866324E (2)
SI (1) SI1866324T1 (2)
WO (1) WO2006100439A1 (2)
ZA (1) ZA200709011B (2)

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GB0623493D0 (en) * 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
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KR20110098849A (ko) 2008-12-23 2011-09-01 파마셋 인코포레이티드 뉴클레오시드 유사체
PT2376088T (pt) 2008-12-23 2017-05-02 Gilead Pharmasset Llc Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída
SG194404A1 (en) 2008-12-23 2013-11-29 Gilead Pharmasset Llc Synthesis of purine nucleosides
SG172921A1 (en) 2009-01-09 2011-08-29 Univ Cardiff Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections
PT2609923T (pt) 2010-03-31 2017-08-30 Gilead Pharmasset Llc Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo
GB201016855D0 (en) * 2010-10-06 2010-11-17 Nucana Biomed Ltd Chemical compounds
US9351989B2 (en) 2010-12-29 2016-05-31 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
US9095599B2 (en) 2011-01-03 2015-08-04 Nanjing Molecular Research, Inc. O-(substituted benzyl) phosphoramidate compounds and therapeutic use
HUE029022T2 (en) 2011-03-01 2017-02-28 Nucana Biomed Ltd Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine for use in the treatment of cancer
WO2012125900A1 (en) 2011-03-16 2012-09-20 Enanta Pharmaceuticals, Inc. 2'-allene-substituted nucleoside derivatives
SG11201503750YA (en) * 2012-11-16 2015-06-29 Univ Cardiff Process for preparing nucleoside prodrugs
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
RU2016125213A (ru) * 2013-11-27 2017-12-29 АЙДЕНИКС ФАРМАСЬЮТИКАЛЗ ЭлЭлСи Нуклеотиды для лечения рака печени
JP2017516779A (ja) * 2014-05-28 2017-06-22 アイデニクス・ファーマシューティカルズ・エルエルシー 癌治療のためのヌクレオシド誘導体
CN106459127A (zh) * 2014-05-28 2017-02-22 艾登尼克斯药业有限公司 用于治疗癌症的核苷衍生物
IL291927A (en) 2014-11-28 2022-06-01 NuCana plc Oligonucleotides containing modified nucleosides
CA3182565A1 (en) 2015-03-06 2016-09-15 Atea Pharmaceuticals, Inc. .beta.-d-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment
US10745435B2 (en) * 2015-11-16 2020-08-18 Cerecor, Inc. Nucleic acid prodrugs
GB201522764D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609601D0 (en) * 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201609602D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Chemical compounds
GB201609600D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
US10711029B2 (en) 2016-07-14 2020-07-14 Atea Pharmaceuticals, Inc. Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
DK3512863T3 (da) 2016-09-07 2022-03-07 Atea Pharmaceuticals Inc 2¿-substituerede-N6-substituerede purinnukleotider til behandling af RNA-virus
US11202792B2 (en) 2016-10-12 2021-12-21 Georgetown University CD99 inhibitors and their uses
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
GB201720279D0 (en) 2017-12-05 2018-01-17 Nucana Biomed Ltd Anticancer compounds
JP2020164521A (ja) * 2019-03-29 2020-10-08 国立大学法人 長崎大学 抗ウィルス薬
GB201904544D0 (en) 2019-04-01 2019-05-15 NuCana plc Anticancer compounds
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2021173713A1 (en) 2020-02-27 2021-09-02 Atea Pharmaceuticals, Inc. Highly active compounds against covid-19
CN113549076B (zh) * 2021-07-23 2022-12-06 中国药科大学 一种多取代嘌呤类化合物及其制备方法和应用

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EP1773355B1 (en) * 2004-06-24 2014-06-25 Merck Sharp & Dohme Corp. Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
WO2007020193A2 (en) * 2005-08-15 2007-02-22 F. Hoffmann-La Roche Ag Antiviral phosphoramidates of 4 ' -substituted pronucleotides

Also Published As

Publication number Publication date
BRPI0609704A2 (pt) 2010-04-20
JP2013173786A (ja) 2013-09-05
IL186104A0 (en) 2008-01-20
BRPI0609704B1 (pt) 2020-12-01
CN101175763A (zh) 2008-05-07
EP1866324A1 (en) 2007-12-19
CY1111538T1 (el) 2015-08-05
PT1866324E (pt) 2010-09-16
EP1866324B1 (en) 2010-06-16
IL186104A (en) 2013-06-27
ES2348741T3 (es) 2010-12-13
US8263575B2 (en) 2012-09-11
WO2006100439A1 (en) 2006-09-28
ATE471334T1 (de) 2010-07-15
AU2006226182A1 (en) 2006-09-28
DE602006014949D1 (de) 2010-07-29
AU2006226182B2 (en) 2011-09-01
MX2007011666A (es) 2007-11-14
DK1866324T3 (da) 2010-09-27
JP5345381B2 (ja) 2013-11-20
AU2006226182C1 (en) 2012-06-14
JP5863702B2 (ja) 2016-02-17
GB0505781D0 (en) 2005-04-27
CA2602324A1 (en) 2006-09-28
ZA200709011B (en) 2009-01-28
US20090215715A1 (en) 2009-08-27
JP2008533191A (ja) 2008-08-21
CA2602324C (en) 2015-02-24
SI1866324T1 (sl) 2010-10-29
PL1866324T3 (pl) 2010-12-31
CN103936807A (zh) 2014-07-23

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: CARDIFF PROTIDES LIMITED (GB)

B25A Requested transfer of rights approved

Owner name: NUCANA BIOMED LIMITED (GB)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 01/12/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/03/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REF. RPI 2604 DE 01/12/2020 QUANTO AO TITULAR (ITEM 73).

B25D Requested change of name of applicant approved

Owner name: NUCANA PLC (GB)

B25G Requested change of headquarter approved

Owner name: NUCANA PLC (GB)

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 19A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2822 DE 04-02-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.