BRPI0612219A2 - macrociclos amida v antibacterianos - Google Patents

macrociclos amida v antibacterianos

Info

Publication number
BRPI0612219A2
BRPI0612219A2 BRPI0612219-1A BRPI0612219A BRPI0612219A2 BR PI0612219 A2 BRPI0612219 A2 BR PI0612219A2 BR PI0612219 A BRPI0612219 A BR PI0612219A BR PI0612219 A2 BRPI0612219 A2 BR PI0612219A2
Authority
BR
Brazil
Prior art keywords
macrocycles
represents hydrogen
antibacterial amide
antibacterial
prophylaxis
Prior art date
Application number
BRPI0612219-1A
Other languages
English (en)
Inventor
Rainer Endermann
Kerstin Ehlert
Siegfried Raddatz
Martin Michels
Yolanda Cancho-Grande
Stefan Weigand
Karin Fischer
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of BRPI0612219A2 publication Critical patent/BRPI0612219A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Macrociclos amida V antibacterianos. O presente invento se refere a macrociclos amida antibacterianos de fórmula (I) em que R^ 26^ representa hidrogênio, halogênio, amina ou metila, R^ 7^ representa um grupo de fórmula (II), (III), (IV) ou (V), em que R¹ representa hidrogénio ou hidroxila e * é o sítio de união ao átomo de carbono, R² representa hidrogênio ou metila e métodos para sua produção, seu uso para o tratamento e/ou profilaxia de enfermidades assim como seu uso na produção de medicamentos para o tratamento e/ou profilaxia de enfermidades, em particular de infecções bacterianas.
BRPI0612219-1A 2005-03-30 2006-03-22 macrociclos amida v antibacterianos BRPI0612219A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005014245A DE102005014245A1 (de) 2005-03-30 2005-03-30 Antibakterielle Amid-Makrozyklen V
PCT/EP2006/002617 WO2006103015A1 (de) 2005-03-30 2006-03-22 Antibakterielle amid-makrozyklen v

Publications (1)

Publication Number Publication Date
BRPI0612219A2 true BRPI0612219A2 (pt) 2009-01-13

Family

ID=36572224

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0612219-1A BRPI0612219A2 (pt) 2005-03-30 2006-03-22 macrociclos amida v antibacterianos

Country Status (17)

Country Link
US (1) US20080275018A1 (pt)
EP (1) EP1869068A1 (pt)
JP (1) JP2008534540A (pt)
KR (1) KR20070116169A (pt)
CN (1) CN101228182A (pt)
AU (1) AU2006228751A1 (pt)
BR (1) BRPI0612219A2 (pt)
CA (1) CA2602755A1 (pt)
DE (1) DE102005014245A1 (pt)
IL (1) IL185899A0 (pt)
MX (1) MX2007012146A (pt)
NO (1) NO20075270L (pt)
NZ (1) NZ562003A (pt)
RU (1) RU2409588C2 (pt)
UA (1) UA91541C2 (pt)
WO (1) WO2006103015A1 (pt)
ZA (1) ZA200709336B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
BR112013006265A2 (pt) 2010-09-15 2016-06-07 Scripps Research Inst espectros antibióticos gerais análogos a arilomicina
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
WO2012166665A2 (en) * 2011-05-27 2012-12-06 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
JP6437443B2 (ja) 2012-11-21 2018-12-12 アールキューエックス ファーマシューティカルズ，インク． 大環状広域抗生物質
US10392422B2 (en) 2014-05-20 2019-08-27 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
HRP20201273T1 (hr) 2015-10-27 2020-11-13 F. Hoffmann - La Roche Ag Peptidni makrocikli protiv bakterije acinetobacter baumannii
RU2761476C2 (ru) 2015-11-20 2021-12-08 АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. Макроциклические антибиотики широкого спектра действия
EP3388444A1 (en) * 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
WO2019040109A1 (en) 2017-08-21 2019-02-28 Celgene Corporation PROCESSES FOR THE PREPARATION OF (S) -TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
PT3968983T (pt) 2019-05-28 2023-10-04 Hoffmann La Roche Antibióticos macrocíclicos de largo espectro
WO2024262518A1 (ja) * 2023-06-20 2024-12-26 国立大学法人北海道大学 スキャニング用アミノ酸化合物、スキャニング用改変ペプチド、スキャニング用キット及びペプチドの活性部位のスキャニング方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452136A (en) * 1968-04-17 1969-06-24 American Cyanamid Co Antibiotic af283 and production thereof
FR2720066B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Peptides antagonistes de la neurotensine.
DE10226921A1 (de) * 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
DE10234422A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Antibakterielle Ester-Makrozyklen
JP2008502583A (ja) * 2003-10-01 2008-01-31 バイエル・ヘルスケア・アクチェンゲゼルシャフト 抗細菌性アミド大員環
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV

Also Published As

Publication number Publication date
CN101228182A (zh) 2008-07-23
NZ562003A (en) 2010-11-26
RU2409588C2 (ru) 2011-01-20
JP2008534540A (ja) 2008-08-28
EP1869068A1 (de) 2007-12-26
IL185899A0 (en) 2008-12-29
US20080275018A1 (en) 2008-11-06
MX2007012146A (es) 2007-12-10
UA91541C2 (ru) 2010-08-10
RU2007139760A (ru) 2009-05-10
CA2602755A1 (en) 2006-10-05
KR20070116169A (ko) 2007-12-06
WO2006103015A1 (de) 2006-10-05
NO20075270L (no) 2007-12-18
ZA200709336B (en) 2009-09-30
AU2006228751A1 (en) 2006-10-05
DE102005014245A1 (de) 2006-10-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 7A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2213 DE 04/06/2013.