BRPI0614434B8 - composição líquida oral compreendendo arginina e ácido r-alfa-lipóico - Google Patents
composição líquida oral compreendendo arginina e ácido r-alfa-lipóicoInfo
- Publication number
- BRPI0614434B8 BRPI0614434B8 BRPI0614434A BRPI0614434A BRPI0614434B8 BR PI0614434 B8 BRPI0614434 B8 BR PI0614434B8 BR PI0614434 A BRPI0614434 A BR PI0614434A BR PI0614434 A BRPI0614434 A BR PI0614434A BR PI0614434 B8 BRPI0614434 B8 BR PI0614434B8
- Authority
- BR
- Brazil
- Prior art keywords
- arginine
- lipoic acid
- liquid composition
- oral liquid
- donor
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000004475 Arginine Substances 0.000 title abstract 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 title abstract 2
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 title 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 title 1
- 239000007788 liquid Substances 0.000 title 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 8
- 239000002840 nitric oxide donor Substances 0.000 abstract 3
- 239000002243 precursor Substances 0.000 abstract 3
- IMLSAISZLJGWPP-UHFFFAOYSA-N 1,3-dithiolane Chemical compound C1CSCS1 IMLSAISZLJGWPP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000036299 sexual function Effects 0.000 abstract 2
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 239000008247 solid mixture Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229960002663 thioctic acid Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
composições compreendendo um doador de no e um ditiolano e o uso das mesmas para o melhoramento da função sexual. a presente invenção refere-se à composições sólidas compreendendo uma substância que aumenta a capacidade de disponibilidade do óxido nítrico (no), re. um doador do no ou um precursor da biosíntese do óxido nítrico ou um agonista direto ou indireto de no, com arginina sendo um composto de preferência, em combinação com um ditiolano, com o ácido (alfa)lipólico como um composto de preferência, e o seu uso para o melhoramento da função sexual. as composições de acordo com a invenção compreendem o doador de no ou o seu precursor em excesso, com base na quantidade molar dos constituintes. as composições também são adequadas para o melhoramento da função sexual. especificamente, a presente invenção refere-se ao uso de um ditiolano em combinação com um doador de no ou um precursor do mesmo para a preparação de uma medicação para o tratamento de disfunção sexual.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05107206A EP1754478B1 (en) | 2005-08-04 | 2005-08-04 | Liquid Composition comprising arginine and alpha-lipoic acid and its use for improvement of sexual function |
| EP05107206.4 | 2005-08-04 | ||
| PCT/EP2006/007733 WO2007017191A2 (en) | 2005-08-04 | 2006-08-04 | Compositions comprising an no donor and a dithiolane and their use for improvement of sexual function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0614434A2 BRPI0614434A2 (pt) | 2011-03-29 |
| BRPI0614434B1 BRPI0614434B1 (pt) | 2020-04-28 |
| BRPI0614434B8 true BRPI0614434B8 (pt) | 2021-05-25 |
Family
ID=35502745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0614434A BRPI0614434B8 (pt) | 2005-08-04 | 2006-08-04 | composição líquida oral compreendendo arginina e ácido r-alfa-lipóico |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9107889B2 (pt) |
| EP (2) | EP1754478B1 (pt) |
| JP (3) | JP5295766B2 (pt) |
| CN (2) | CN101237862B (pt) |
| AT (1) | ATE418976T1 (pt) |
| BR (1) | BRPI0614434B8 (pt) |
| CY (2) | CY1109430T1 (pt) |
| DE (1) | DE602005012089D1 (pt) |
| DK (2) | DK1754478T3 (pt) |
| ES (2) | ES2320560T3 (pt) |
| MX (1) | MX2008001554A (pt) |
| PL (2) | PL1754478T3 (pt) |
| PT (2) | PT1754478E (pt) |
| RU (1) | RU2423120C2 (pt) |
| SI (2) | SI1754478T1 (pt) |
| UA (1) | UA95917C2 (pt) |
| WO (1) | WO2007017191A2 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE418976T1 (de) * | 2005-08-04 | 2009-01-15 | Extarma Ag | Flüssige zusammensetzung enthaltend arginine und alpha-liponsäure zur verbesserung der sexuellen funktion |
| FR2939042B1 (fr) * | 2008-11-28 | 2010-11-26 | Oreal | PROCEDE DE DEPIGMENTATION DES MATIERES KERATINIQUES A l'AIDE DE COMPOSES DITHIOLANNES. |
| RU2458537C1 (ru) * | 2011-03-14 | 2012-08-20 | Общество С Ограниченной Ответственностью "Парафарм" | Биологически активная добавка к пище для профилактики эректильной дисфункции у мужчин |
| FR3012039A1 (fr) * | 2013-10-22 | 2015-04-24 | Philippe Olivier Gorny | Medicament ou produit dietetique et son utilisation pour prevenir ou traiter les dysfonctionnements sexuels de l'homme et de la femme |
| DK180173B1 (en) * | 2018-12-07 | 2020-07-14 | Inxo Ivs | Compositions for improving sexual function |
| US11571405B2 (en) | 2018-12-07 | 2023-02-07 | Inxo A/S | Compositions for improving sexual function |
| CN109876194B (zh) * | 2019-04-11 | 2021-04-02 | 湖北大学 | 一种可调节降解速率的poss-peg杂化水凝胶及其制备方法和其应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3364822D1 (en) | 1982-03-15 | 1986-09-04 | Ici Plc | Process of oxidising hydrocarbons |
| DE3629116A1 (de) * | 1986-08-27 | 1988-03-10 | Asta Pharma Ag | Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer |
| EP0318891B1 (de) | 1987-12-04 | 1992-01-02 | ASTA Medica Aktiengesellschaft | Injizierbare Lösung des Thioctsäuresalzes mit Trometamol und/oder basischen Aminosäuren |
| DE3840076A1 (de) | 1987-12-04 | 1989-06-15 | Asta Pharma Ag | Injizierbare loesung des thioctsaeuresalzes mit trometamol und/oder basischen aminosaeuren |
| DE59010810D1 (de) | 1989-11-09 | 1998-04-16 | Asta Medica Ag | Arzneimittel enthaltend als Wirkstoff R-alpha-Liponsäure oder S-alpha-Liponsäure |
| DE4137773A1 (de) | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
| JP2684287B2 (ja) * | 1991-12-20 | 1997-12-03 | 株式会社河合楽器製作所 | 楽器自動演奏装置 |
| US5223285A (en) * | 1992-03-31 | 1993-06-29 | Abbott Laboratories | Nutritional product for pulmonary patients |
| DE4317646A1 (de) | 1993-05-27 | 1994-12-01 | Asta Medica Ag | Tabletten mit Thioctsäure und mindestens einer basischen Komponente |
| DE4433764A1 (de) | 1994-09-22 | 1996-03-28 | Asta Medica Ag | Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit |
| US6234176B1 (en) | 1996-06-21 | 2001-05-22 | Integrated Medical Systems, Inc. | Data logger for transportable life support system |
| US7504376B2 (en) * | 1996-08-12 | 2009-03-17 | Natural Alternatives International | Methods and compositions for increasing the anaerobic working capacity in tissues |
| US6387645B1 (en) * | 1998-07-16 | 2002-05-14 | Hyseq, Inc. | Methods and materials relating to novel CD39-like polypeptides |
| US20020068365A1 (en) * | 1998-07-28 | 2002-06-06 | Eric H. Kuhrts | Controlled release nitric oxide producing agents |
| US6207190B1 (en) * | 1998-08-13 | 2001-03-27 | Chronorx, Llc | Dosage forms for the treatment of the chronic glaucomas |
| FR2791571B1 (fr) | 1999-04-02 | 2002-10-04 | Sod Conseils Rech Applic | Association inhibiteur(s) de no synthase et antioxydant(s) metabolique(s) |
| AR042572A1 (es) | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos |
| ES2162586B1 (es) | 1999-11-25 | 2002-07-01 | Moraleda Manuel Gomez | Composicion que comprende aceites ozonizados y/o otros productos naturales y/o sinteticos ozonizados, y su empleo en composiciones farmaceuticas, cosmeticas, dieteticas o de suplementos alimentarios, en los campos humano y veterinario |
| CZ20022927A3 (cs) * | 2000-02-01 | 2003-06-18 | Muscletech Research And Development Inc. | Doplňky stravy založené na alfa-lipoové kyselině pro zvýšení čisté svalové hmoty a síly |
| US6387945B2 (en) | 2000-04-11 | 2002-05-14 | The Regents Of The University Of California | Lipoic acid analogs |
| US6420342B1 (en) * | 2000-05-08 | 2002-07-16 | N.V. Nutricia | Nutritional preparation comprising ribose and medical use thereof |
| US7128930B1 (en) * | 2000-09-01 | 2006-10-31 | Meir S. Sacks | Compositions and methods for treating sexual dysfunction |
| US6923960B2 (en) | 2001-10-03 | 2005-08-02 | Vsl Pharmaceuticals Inc. | Antioxidant combination composition and use thereof |
| ITRM20010621A1 (it) | 2001-10-18 | 2003-04-18 | Aldo Fassi | Sali metallici non igroscopici e idrosolubili di alcanoil l-carnitine, integratori dietetici che li contengono e kit dietetici, per contrast |
| AU2002254546A1 (en) * | 2002-04-03 | 2003-10-20 | Mitchell A. Avery | Lipoic acid analogs useful as provitamins and antioxidants |
| NL1022153C2 (nl) * | 2002-12-12 | 2004-06-15 | Tno | Cholesterol verlagend preparaat, voedingssupplement en voedingsmiddel en werkwijzen voor de bereiding daarvan. |
| ATE418976T1 (de) | 2005-08-04 | 2009-01-15 | Extarma Ag | Flüssige zusammensetzung enthaltend arginine und alpha-liponsäure zur verbesserung der sexuellen funktion |
-
2005
- 2005-08-04 AT AT05107206T patent/ATE418976T1/de active
- 2005-08-04 SI SI200530637T patent/SI1754478T1/sl unknown
- 2005-08-04 ES ES05107206T patent/ES2320560T3/es not_active Expired - Lifetime
- 2005-08-04 PL PL05107206T patent/PL1754478T3/pl unknown
- 2005-08-04 PT PT05107206T patent/PT1754478E/pt unknown
- 2005-08-04 DK DK05107206T patent/DK1754478T3/da active
- 2005-08-04 EP EP05107206A patent/EP1754478B1/en not_active Expired - Lifetime
- 2005-08-04 DE DE602005012089T patent/DE602005012089D1/de not_active Expired - Lifetime
-
2006
- 2006-08-04 CN CN2006800289570A patent/CN101237862B/zh active Active
- 2006-08-04 BR BRPI0614434A patent/BRPI0614434B8/pt active IP Right Grant
- 2006-08-04 CN CN201210033057.2A patent/CN102670591B/zh active Active
- 2006-08-04 WO PCT/EP2006/007733 patent/WO2007017191A2/en not_active Ceased
- 2006-08-04 ES ES06776605T patent/ES2388074T3/es active Active
- 2006-08-04 DK DK06776605.5T patent/DK1909782T3/da active
- 2006-08-04 MX MX2008001554A patent/MX2008001554A/es active IP Right Grant
- 2006-08-04 PT PT06776605T patent/PT1909782E/pt unknown
- 2006-08-04 EP EP06776605A patent/EP1909782B1/en active Active
- 2006-08-04 SI SI200631381T patent/SI1909782T1/sl unknown
- 2006-08-04 RU RU2008107877/15A patent/RU2423120C2/ru active
- 2006-08-04 PL PL06776605T patent/PL1909782T3/pl unknown
- 2006-08-04 US US11/568,283 patent/US9107889B2/en active Active
- 2006-08-04 JP JP2008524446A patent/JP5295766B2/ja not_active Expired - Fee Related
- 2006-08-04 UA UAA200802671A patent/UA95917C2/ru unknown
-
2009
- 2009-03-18 CY CY20091100302T patent/CY1109430T1/el unknown
-
2012
- 2012-08-13 CY CY20121100723T patent/CY1113235T1/el unknown
-
2013
- 2013-02-28 JP JP2013038965A patent/JP5925714B2/ja active Active
-
2015
- 2015-11-30 JP JP2015233644A patent/JP2016104738A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: ENCRYPTA GMBH (DE) Free format text: TRANSFERIDO DE: EXTARMA AG |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 28/04/2020, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/08/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |