BRPI0614966A2 - vetor de expressão, bactéria de ácido lático, apolipoproteína isenta de endotoxina, e, método de produção de uma apolipoproteína isenta de endotoxina - Google Patents

vetor de expressão, bactéria de ácido lático, apolipoproteína isenta de endotoxina, e, método de produção de uma apolipoproteína isenta de endotoxina

Info

Publication number: BRPI0614966A2
Authority: BR; Brazil
Prior art keywords: endotoxin; free apolipoprotein; producing; lactic acid; expression vector
Prior art date: 2005-08-26

Application number

BRPI0614966A

Other languages

English (en)

Inventor

Jean-Louis Dasseux

Original Assignee

Cerenis Therapeutics Holding S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-26

Filing date

2006-08-25

Publication date

2016-09-13

2006-08-25 Application filed by Cerenis Therapeutics Holding S A filed Critical Cerenis Therapeutics Holding S A

2016-09-13 Publication of BRPI0614966A2 publication Critical patent/BRPI0614966A2/pt

Links

102000007592 Apolipoproteins Human genes 0.000 title 2
108010071619 Apolipoproteins Proteins 0.000 title 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title 2
241000894006 Bacteria Species 0.000 title 1
239000013604 expression vector Substances 0.000 title 1
235000014655 lactic acid Nutrition 0.000 title 1
239000004310 lactic acid Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Cardiology (AREA)
Toxicology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cell Biology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

BRPI0614966A 2005-08-26 2006-08-25 vetor de expressão, bactéria de ácido lático, apolipoproteína isenta de endotoxina, e, método de produção de uma apolipoproteína isenta de endotoxina BRPI0614966A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71229505P	2005-08-26	2005-08-26
PCT/IB2006/052968 WO2007023476A2 (en)	2005-08-26	2006-08-25	Compositions and methods for producing apolipoprotein gene products in lactic acid bacteria

Publications (1)

Publication Number	Publication Date
BRPI0614966A2 true BRPI0614966A2 (pt)	2016-09-13

Family

ID=37772013

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0614966A BRPI0614966A2 (pt)	2005-08-26	2006-08-25	vetor de expressão, bactéria de ácido lático, apolipoproteína isenta de endotoxina, e, método de produção de uma apolipoproteína isenta de endotoxina

Country Status (10)

Country	Link
US (1)	US20070048823A1 (pt)
EP (1)	EP1917278A2 (pt)
JP (1)	JP2009505652A (pt)
KR (1)	KR20080049066A (pt)
CN (1)	CN101253195A (pt)
AU (1)	AU2006282722A1 (pt)
BR (1)	BRPI0614966A2 (pt)
CA (1)	CA2619943A1 (pt)
IL (1)	IL189610A0 (pt)
WO (1)	WO2007023476A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008104890A2 (en) *	2007-02-28	2008-09-04	Cerenis Therapeutics Holding Sa	Compositions and methods for producing apolipoprotein
EP2305309A2 (en)	2008-06-13	2011-04-06	Proyecto de Biomedicina Cima, S.L.	Conjugates for the administration of biologically active compounds
LT2673296T (lt)	2011-02-07	2019-02-25	Cerenis Therapeutics Holding Sa	Lipoproteino kompleksai ir jų gamyba ir jų panaudojimai
CN104010646A (zh) *	2011-12-21	2014-08-27	Csl有限公司	用于载脂蛋白制剂的剂量方案
US20190046608A1 (en)	2017-08-10	2019-02-14	Cerenis Therapeutics Holding Sa	Apomers
TW201919712A (zh)	2017-08-10	2019-06-01	法商塞勒尼斯醫療控股公司	運送子(cargomers)
KR20230004605A (ko)	2020-04-16	2023-01-06	아비오닉스 파마 에스에이	지질 결합 단백질-기반 복합체를 사용하여 급성 상태를 치료하는 방법
CA3197168A1 (en)	2020-10-01	2022-04-07	Abionyx Pharma Sa	Methods for treating eye diseases using lipid binding protein-based complexes
CA3216226A1 (en)	2021-04-15	2022-10-20	Abionyx Pharma Sa	Use of lipid binding protein-based complexes in organ preservation solutions
CN119317440A (zh)	2022-04-06	2025-01-14	阿比奥尼克斯制药公司	使用基于脂质结合蛋白的复合物治疗白细胞增多、内皮功能障碍和心脏炎的方法
US20250230208A1 (en)	2022-04-06	2025-07-17	Abionyx Pharma Sa	Methods for treating eye diseases using lipid binding protein-based complexes
CA3258787A1 (en)	2022-06-10	2023-12-14	Abionyx Pharma Sa	METHODS OF TREATMENT OF HYPERINFLAMMATORY DISEASES USING LIPID-BINDING PROTEIN COMPLEXES
WO2023237935A2 (en)	2022-06-10	2023-12-14	Abionyx Pharma Sa	Methods for treating acute conditions using lipid binding protein-based complexes
KR20260010675A (ko)	2023-01-13	2026-01-21	아비오닉스 파마 에스에이	지질 결합 단백질 분자 치료
IL327995A (en)	2023-10-31	2026-06-01	Abionyx Pharma Sa	Lipid binding protein molecule therapy

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5128318A (en) *	1987-05-20	1992-07-07	The Rogosin Institute	Reconstituted HDL particles and uses thereof
GB8712540D0 (en) *	1987-05-28	1987-07-01	Ucb Sa	Expression of human proapolipoprotein a-i
SE9203753D0 (sv) *	1992-12-11	1992-12-11	Kabi Pharmacia Ab	Expression system for producing apolipoprotein ai-m
US5932536A (en) *	1994-06-14	1999-08-03	The Rockefeller University	Compositions for neutralization of lipopolysaccharides
EP1162271A3 (en) *	1994-11-18	2003-01-15	Stichting Nederlands Instituut Voor Zuivelonderzoek	Method for controlling the gene expression in lactic acid bacteria
EP0925364B1 (en) *	1996-09-06	2002-10-23	Bioteknologisk Institut	A lactic acid bacterial regulatable expression system
US20030199035A1 (en) *	1997-12-17	2003-10-23	Jose Arnau	Metabolically engineered lactic acid bacteria and means for providing same
ES2276691T3 (es) *	1999-08-06	2007-07-01	Bioneer A/S	Peptidos señales aislados de lactococcus lactis.
US6544792B1 (en) *	1999-12-21	2003-04-08	Genencor International, Inc.	Production of secreted polypeptides
DK1356073T3 (da) *	2000-10-20	2010-04-06	Bioneer As	Fermenteringsfremgangsmåde til fremstilling af heterologe genprodukter i mælkesyrebakterier
WO2002038609A2 (en) *	2000-11-10	2002-05-16	Proteopharma Aps	Apolipoprotein conjugates
KR100457879B1 (ko) *	2001-02-24	2004-11-18	주식회사 비피도	비피도박테리움 유래 신규 플라스미드, 이를 이용한 재조합 발현 벡터 및 형질전환 방법
MXPA04011312A (es) *	2002-05-17	2005-02-14	Esperion Therapeutics Inc	Metodo para el tratamiento de desordenes dislipidemicos.
US6953840B2 (en) *	2002-07-30	2005-10-11	Esperion Therapeutics, Inc.	Methods of using non-human animal Apolipoprotein A-I protein

2006
- 2006-08-25 BR BRPI0614966A patent/BRPI0614966A2/pt not_active IP Right Cessation
- 2006-08-25 US US11/467,500 patent/US20070048823A1/en not_active Abandoned
- 2006-08-25 CN CNA2006800312882A patent/CN101253195A/zh active Pending
- 2006-08-25 JP JP2008527580A patent/JP2009505652A/ja not_active Withdrawn
- 2006-08-25 EP EP06795789A patent/EP1917278A2/en not_active Withdrawn
- 2006-08-25 KR KR1020087007231A patent/KR20080049066A/ko not_active Withdrawn
- 2006-08-25 AU AU2006282722A patent/AU2006282722A1/en not_active Abandoned
- 2006-08-25 CA CA002619943A patent/CA2619943A1/en not_active Abandoned
- 2006-08-25 WO PCT/IB2006/052968 patent/WO2007023476A2/en not_active Ceased
2008
- 2008-02-19 IL IL189610A patent/IL189610A0/en unknown

Also Published As

Publication number	Publication date
CA2619943A1 (en)	2007-03-01
EP1917278A2 (en)	2008-05-07
CN101253195A (zh)	2008-08-27
AU2006282722A1 (en)	2007-03-01
WO2007023476A3 (en)	2007-07-05
US20070048823A1 (en)	2007-03-01
KR20080049066A (ko)	2008-06-03
WO2007023476A2 (en)	2007-03-01
IL189610A0 (en)	2008-08-07
JP2009505652A (ja)	2009-02-12

Legal Events

Date	Code	Title	Description
2012-01-24	B06G	Technical and formal requirements: other requirements [chapter 6.7 patent gazette]	Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 PAR 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO NO ORIGINAL, TRASLADO OU FOTOCOPIA AUTENTICADA.
2012-12-25	B11Z	Dismissal: petition dismissal - article 216, par 2 of industrial property law	Free format text: REFERENTE A PETICAO NO 20080028589/RJ DE 27/02/2008.
2016-08-30	B11M	Decision cancelled [chapter 11.13 patent gazette]	Free format text: O DESPACHO 11.6.1 ESTA SENDO ANULADO TENDO POR BASE A DETERMINACAO DO DIRETOR DE PATENTES, A QUAL E CALCADA NO PARECER NO 0003-2014 AGU/PGF/PFE/INPI/COOPHI-LBC-1.0.
2016-09-06	B06H	Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]	Free format text: O DESPACHO 6.7 ESTA SENDO ANULADO TENDO POR BASE A DETERMINACAO DO DIRETOR DE PATENTES, A QUAL E CALCADA NO PARECER NO 0003-2014 AGU/PGF/PFE/INPI/COOPHI-LBC-1.0.
2016-09-27	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 6A, 7A, 8A, 9A E 10A ANUIDADES.
2017-01-17	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2386 DE 27-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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