BRPI0617480A2 - ANTICORPO ISOLADO, OU FRAGMENTO DO MESMO, COMPOSIÇÃO FARMACÊUTICA, MÉTODOS PARA PREVENIR A LIGAÇÃO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab EM UM NEURÔNIO, PARA INIBIR O CONJUNTO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, PARA BLOQUEAR A FOSFORILAÇÃO DE UMA PROTEÍNA TAU EM SER202/THR205, PARA IDENTIFICAR UM AGENTE TERAPÊUTICO QUE PREVINE A LIGAÇÃO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab EM UM NEURÔNIO, PARA DETECTAR LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, E PARA DIAGNOSTICAR UMA DOENÇA ASSOCIADA COM LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, USO DE UMA COMPOSIÇÃO FARMACÊUTICA, E, KIT PARA DETERCTAR LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab - Google Patents

ANTICORPO ISOLADO, OU FRAGMENTO DO MESMO, COMPOSIÇÃO FARMACÊUTICA, MÉTODOS PARA PREVENIR A LIGAÇÃO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab EM UM NEURÔNIO, PARA INIBIR O CONJUNTO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, PARA BLOQUEAR A FOSFORILAÇÃO DE UMA PROTEÍNA TAU EM SER202/THR205, PARA IDENTIFICAR UM AGENTE TERAPÊUTICO QUE PREVINE A LIGAÇÃO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab EM UM NEURÔNIO, PARA DETECTAR LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, E PARA DIAGNOSTICAR UMA DOENÇA ASSOCIADA COM LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, USO DE UMA COMPOSIÇÃO FARMACÊUTICA, E, KIT PARA DETERCTAR LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab

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Publication number
BRPI0617480A2
BRPI0617480A2 BRPI0617480A BRPI0617480A BRPI0617480A2 BR PI0617480 A2 BRPI0617480 A2 BR PI0617480A2 BR PI0617480 A BRPI0617480 A BR PI0617480A BR PI0617480 A BRPI0617480 A BR PI0617480A BR PI0617480 A2 BRPI0617480 A2 BR PI0617480A2
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BR
Brazil
Prior art keywords
diffusible
ligands
derivative
derivative ligands
difusible
Prior art date
Application number
BRPI0617480A
Other languages
English (en)
Inventor
Kinney Gene
R Strohl William
An Zhiqiang
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Priority claimed from PCT/US2006/040508 external-priority patent/WO2007050359A2/en
Publication of BRPI0617480A2 publication Critical patent/BRPI0617480A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Biomedical Technology (AREA)
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  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
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  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
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Abstract

ANTICORPO ISOLADO, OU FRAGMENTO DO MESMO, COMPOSIÇÃO FARMACÊUTICA, MÉTODOS PARA PREVENIR A LIGAÇÃO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE A(beta)B EM UM NEURÔNIO, PARA INIBIR O CONJUNTO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE A(beta)B, PARA BLOQUEAR A FOSFORILAÇÃO DE PROTEÍNA TAU EM SER202/THR205, PARA IDENTIFICAR UM AGENTE TERAPÊUTICO QUE PREVINE A LIGAÇÃO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE A(beta)B EM UM NEURÔNIO, PARA DETECTAR LIGANDOS DIFUSÍVEIS DERIVADOS DE A(beta)B, E PARA DIAGNOSTICAR UMA DOENÇA ASSOCIADA COM LIGANDOS DIFUSÍVEIS DERIVADOS DE A(beta)B, USO DE UMA COMPOSIÇÃO FARMACÊUTICA, E, KIT PARA DETECTAR LIGANDOS DIFUSÍVEIS DERIVADOS DE A(beta)B. A presente invenção refere-se aos anticorpos que diferentemente reconhecem conformações multidimensionais de ligandos difusíveis derivados de A(beta)B, também conhecidos como ADDLs. Os anticorpos da invenção podem distinguir entre extratos de cérebro de humano de controle e de mal de Alzheimer e são úteis em métodos de detectar ADDLs e de diagnosticar mal de Alzheimer. Os presentes anticorpos também bloqueiam a ligação de ADDLs em neurônios, o conjunto de ADDLs, e fosforilação tau e são úteis em métodos para a prevenção e o tratamento de doenças associadas com oligômeros solúveis de amilóide (beta)B 1-42.
BRPI0617480A 2004-10-25 2006-10-17 ANTICORPO ISOLADO, OU FRAGMENTO DO MESMO, COMPOSIÇÃO FARMACÊUTICA, MÉTODOS PARA PREVENIR A LIGAÇÃO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab EM UM NEURÔNIO, PARA INIBIR O CONJUNTO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, PARA BLOQUEAR A FOSFORILAÇÃO DE UMA PROTEÍNA TAU EM SER202/THR205, PARA IDENTIFICAR UM AGENTE TERAPÊUTICO QUE PREVINE A LIGAÇÃO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab EM UM NEURÔNIO, PARA DETECTAR LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, E PARA DIAGNOSTICAR UMA DOENÇA ASSOCIADA COM LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, USO DE UMA COMPOSIÇÃO FARMACÊUTICA, E, KIT PARA DETERCTAR LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab BRPI0617480A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62177604P 2004-10-25 2004-10-25
US65253805P 2005-02-14 2005-02-14
PCT/US2005/038125 WO2006055178A2 (en) 2004-10-25 2005-10-21 Anti-addl antibodies and uses thereof
PCT/US2006/040508 WO2007050359A2 (en) 2005-10-21 2006-10-17 Anti-addl monoclonal antibody and use thereof

Publications (1)

Publication Number Publication Date
BRPI0617480A2 true BRPI0617480A2 (pt) 2017-07-11

Family

ID=36407593

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0516962-3A BRPI0516962A (pt) 2004-10-25 2005-10-21 anticorpo isolado, ou fragmento do mesmo, composição farmacêutica, métodos para prevenir a ligação de ligantes difundìveis derivados de abeta a um neurÈnio, para inibir a constituição de ligantes difundìveis, para bloquear a fosforilação de proteìna, para tratar profilaticamente ou terapeuticamente uma doença, para identificar um agente terapêutico, para detectar ligantes difundìveis, e para diagnosticar uma doença, e, kit para detectar ligantes difundìveis
BRPI0617480A BRPI0617480A2 (pt) 2004-10-25 2006-10-17 ANTICORPO ISOLADO, OU FRAGMENTO DO MESMO, COMPOSIÇÃO FARMACÊUTICA, MÉTODOS PARA PREVENIR A LIGAÇÃO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab EM UM NEURÔNIO, PARA INIBIR O CONJUNTO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, PARA BLOQUEAR A FOSFORILAÇÃO DE UMA PROTEÍNA TAU EM SER202/THR205, PARA IDENTIFICAR UM AGENTE TERAPÊUTICO QUE PREVINE A LIGAÇÃO DE LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab EM UM NEURÔNIO, PARA DETECTAR LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, E PARA DIAGNOSTICAR UMA DOENÇA ASSOCIADA COM LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab, USO DE UMA COMPOSIÇÃO FARMACÊUTICA, E, KIT PARA DETERCTAR LIGANDOS DIFUSÍVEIS DERIVADOS DE Ab

Family Applications Before (1)

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BRPI0516962-3A BRPI0516962A (pt) 2004-10-25 2005-10-21 anticorpo isolado, ou fragmento do mesmo, composição farmacêutica, métodos para prevenir a ligação de ligantes difundìveis derivados de abeta a um neurÈnio, para inibir a constituição de ligantes difundìveis, para bloquear a fosforilação de proteìna, para tratar profilaticamente ou terapeuticamente uma doença, para identificar um agente terapêutico, para detectar ligantes difundìveis, e para diagnosticar uma doença, e, kit para detectar ligantes difundìveis

Country Status (12)

Country Link
US (5) US7811563B2 (pt)
EP (2) EP1812062B1 (pt)
JP (4) JP5173426B2 (pt)
KR (1) KR20070094890A (pt)
AU (1) AU2005306997B2 (pt)
BR (2) BRPI0516962A (pt)
CA (1) CA2584859C (pt)
IL (2) IL182554A0 (pt)
NO (1) NO20072700L (pt)
NZ (1) NZ554725A (pt)
RU (1) RU2007119382A (pt)
WO (1) WO2006055178A2 (pt)

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