BRPI0618450A2 - método, bem como uso de pelo menos um polimorfismo, para a determinação e avaliação do risco de um sujeito desenvolver sìdrome coronariana aguda, sondas e/ou iniciadores nucleotìdicos, microarranjo de ácidos nucléicos e de anticorpos, método para a triagem de compostos, bem como para avaliação de possìvel sensibilidade de um sujeito, kit e uso de um agente capaz de modular a atividade de mmp12 - Google Patents

método, bem como uso de pelo menos um polimorfismo, para a determinação e avaliação do risco de um sujeito desenvolver sìdrome coronariana aguda, sondas e/ou iniciadores nucleotìdicos, microarranjo de ácidos nucléicos e de anticorpos, método para a triagem de compostos, bem como para avaliação de possìvel sensibilidade de um sujeito, kit e uso de um agente capaz de modular a atividade de mmp12 Download PDF

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Publication number
BRPI0618450A2
BRPI0618450A2 BRPI0618450-2A BRPI0618450A BRPI0618450A2 BR PI0618450 A2 BRPI0618450 A2 BR PI0618450A2 BR PI0618450 A BRPI0618450 A BR PI0618450A BR PI0618450 A2 BRPI0618450 A2 BR PI0618450A2
Authority
BR
Brazil
Prior art keywords
subject
risk
acute coronary
coronary syndrome
polymorphism
Prior art date
Application number
BRPI0618450-2A
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English (en)
Inventor
Robert Peter Young
Original Assignee
Synergenz Bioscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synergenz Bioscience Ltd filed Critical Synergenz Bioscience Ltd
Publication of BRPI0618450A2 publication Critical patent/BRPI0618450A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

MéTODO, BEM COMO USO DE PELO MENOS UM POLIMORFISMO, PARA A DETERMINAçãO E AVALIAçãO DO RISCO DE UM SUJEITO DESENVOLVER SìNDROME CORONARIANA AGUDA, SONDAS E/OU INICIADORES NUCLEOTìDICOS, MICROARRANJO DE áCIDOS NUCLéICOS E DE ANTICORPOS, MéTODO PARA A TRIAGEM DE COMPOSTOS, BEM COMO PARA AVALIAçãO DE POSSìVEL SENSIBILIDADE DE UM SUJEITO, KIT E USO DE UM AGENTE CAPAZ DE MODULAR A ATIVIDADE DE MMP1 2. A presente invenção refere-se a métodos para a avaliação do risco de desenvolver síndrome coronariana aguda (ACS) em fumantes e não fumantes, usando a análise de polimorfismos genéticos. A presente invenção também refere-se ao uso de polimorfismos genéticos na avaliação do risco de um sujeito desenvolver ACS. Sondas e iniciadores nucleotídicos, kits e microarranjos adequados para essa avaliação também são apresentados.
BRPI0618450-2A 2005-11-10 2006-11-10 método, bem como uso de pelo menos um polimorfismo, para a determinação e avaliação do risco de um sujeito desenvolver sìdrome coronariana aguda, sondas e/ou iniciadores nucleotìdicos, microarranjo de ácidos nucléicos e de anticorpos, método para a triagem de compostos, bem como para avaliação de possìvel sensibilidade de um sujeito, kit e uso de um agente capaz de modular a atividade de mmp12 BRPI0618450A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NZ54352005 2005-11-10
NZ54398505 2005-12-06
NZ54995106 2006-09-15
PCT/NZ2006/000292 WO2007055602A1 (en) 2005-11-10 2006-11-10 Methods and compositions for the assessment of cardiovascular function and disorders

Publications (1)

Publication Number Publication Date
BRPI0618450A2 true BRPI0618450A2 (pt) 2011-08-30

Family

ID=38023503

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0618450-2A BRPI0618450A2 (pt) 2005-11-10 2006-11-10 método, bem como uso de pelo menos um polimorfismo, para a determinação e avaliação do risco de um sujeito desenvolver sìdrome coronariana aguda, sondas e/ou iniciadores nucleotìdicos, microarranjo de ácidos nucléicos e de anticorpos, método para a triagem de compostos, bem como para avaliação de possìvel sensibilidade de um sujeito, kit e uso de um agente capaz de modular a atividade de mmp12

Country Status (8)

Country Link
US (1) US20100267025A1 (pt)
EP (1) EP1951902A4 (pt)
JP (1) JP2010525788A (pt)
KR (1) KR20080084806A (pt)
AU (1) AU2006312411A1 (pt)
BR (1) BRPI0618450A2 (pt)
CA (1) CA2629388A1 (pt)
WO (1) WO2007055602A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8335652B2 (en) 2004-06-23 2012-12-18 Yougene Corp. Self-improving identification method
US8027791B2 (en) 2004-06-23 2011-09-27 Medtronic, Inc. Self-improving classification system
CA2654761A1 (en) * 2006-06-09 2007-12-13 The University Of British Columbia Interferon gamma polymorphisms as indicators of subject outcome in critically ill subjects
JP5656209B2 (ja) * 2008-09-26 2015-01-21 独立行政法人産業技術総合研究所 ウシタイレリア症の病態評価を可能とする方法
WO2016048388A1 (en) 2014-09-26 2016-03-31 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof
WO2016123163A2 (en) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarkers of vascular disease
WO2019122340A1 (en) * 2017-12-22 2019-06-27 Université D'aix-Marseille In vitro method for predicting a predisposition to acute coronary syndrome
CN111690733B (zh) * 2020-06-22 2022-08-26 复旦大学附属中山医院 一种激素性股骨头坏死易感基因panel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005113786A2 (en) * 2004-05-21 2005-12-01 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with chymase (cma1)
KR20080011289A (ko) * 2005-05-10 2008-02-01 시너젠즈 바이오사이언스 리미티드 폐기능 및 폐질환을 평가하기 위한 성분 및 평가 방법

Also Published As

Publication number Publication date
CA2629388A1 (en) 2007-05-18
US20100267025A1 (en) 2010-10-21
KR20080084806A (ko) 2008-09-19
WO2007055602A1 (en) 2007-05-18
EP1951902A1 (en) 2008-08-06
EP1951902A4 (en) 2009-12-02
AU2006312411A1 (en) 2007-05-18
JP2010525788A (ja) 2010-07-29

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