BRPI0620291B8 - método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune - Google Patents

método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune

Info

Publication number
BRPI0620291B8
BRPI0620291B8 BRPI0620291A BRPI0620291A BRPI0620291B8 BR PI0620291 B8 BRPI0620291 B8 BR PI0620291B8 BR PI0620291 A BRPI0620291 A BR PI0620291A BR PI0620291 A BRPI0620291 A BR PI0620291A BR PI0620291 B8 BRPI0620291 B8 BR PI0620291B8
Authority
BR
Brazil
Prior art keywords
immune modulator
bacterial strains
modulator composition
diaminodiphenyl sulfone
roughened
Prior art date
Application number
BRPI0620291A
Other languages
English (en)
Inventor
Ann Stanford Cynthia
Mcintyre Graham
Lawson Stanford John
Adelmo Bottasso Oscar
Original Assignee
Bioeos Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioeos Ltd filed Critical Bioeos Ltd
Publication of BRPI0620291A2 publication Critical patent/BRPI0620291A2/pt
Publication of BRPI0620291B1 publication Critical patent/BRPI0620291B1/pt
Publication of BRPI0620291B8 publication Critical patent/BRPI0620291B8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
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    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
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    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/32—Mycobacterium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biotechnology (AREA)
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  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
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Abstract

método de produzir cepas rugosas de bactérias e usos das mesmas a presente invenção refere-se a um método de produzir cepas rugosas de uma bactéria, como mycobacterium obuense, sendo que referido método compreende expor referida bactéria a uma sulfona e/ou sulfonamida (como 4,4'- diaminodifenil sulfona ou um análogo da mesma). uma cepa rugosa de mycobacterium obuense produzível por meio de referido método, e usos da mesma. em particular, usos de uma cepa rugosa de mycobacterium obuense depositada sob o tratado de budapeste na nctc com o número de acesso nctc 13365.
BRPI0620291A 2005-12-21 2006-12-19 método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune BRPI0620291B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0526033.6 2005-12-21
GBGB0526033.6A GB0526033D0 (en) 2005-12-21 2005-12-21 Method
PCT/GB2006/004780 WO2007071978A1 (en) 2005-12-21 2006-12-19 Method of producing rough strains of bacteria and uses thereof

Publications (3)

Publication Number Publication Date
BRPI0620291A2 BRPI0620291A2 (pt) 2011-11-08
BRPI0620291B1 BRPI0620291B1 (pt) 2020-12-15
BRPI0620291B8 true BRPI0620291B8 (pt) 2021-05-25

Family

ID=35840894

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0620291A BRPI0620291B8 (pt) 2005-12-21 2006-12-19 método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune

Country Status (15)

Country Link
US (2) US8071354B2 (pt)
EP (2) EP1963484B1 (pt)
JP (1) JP5202330B2 (pt)
CN (1) CN101384699B (pt)
AT (1) ATE519838T1 (pt)
AU (1) AU2006328209B2 (pt)
BR (1) BRPI0620291B8 (pt)
CA (1) CA2633127C (pt)
DK (1) DK1963484T3 (pt)
ES (1) ES2369569T3 (pt)
GB (1) GB0526033D0 (pt)
NZ (1) NZ568810A (pt)
PL (1) PL1963484T3 (pt)
SI (1) SI1963484T1 (pt)
WO (1) WO2007071978A1 (pt)

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GB0716778D0 (en) * 2007-08-29 2007-10-10 Bioeos Ltd Use
GB201120779D0 (en) * 2011-12-02 2012-01-11 Immodulon Therapeutics Ltd Cancer therapy
GB201216800D0 (en) * 2012-09-20 2012-11-07 Immodulon Therapeutics Ltd Novel use
GB201322725D0 (en) 2013-12-20 2014-02-05 Immodulon Therapeutics Ltd Cancer therapy
WO2016207646A1 (en) 2015-06-24 2016-12-29 Immodulon Therapeutics Limited A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy
AU2017222692A1 (en) * 2016-02-25 2018-09-27 Thomas Julius Borody Compositions and methods of treatment of chronic infectious diseases
MX2018015537A (es) * 2016-06-24 2019-09-16 Aptimmune Biologics Inc Metodos para acondicionar un sistema inmunitario porcino.
CN115813955A (zh) 2017-06-14 2023-03-21 4D制药研究有限公司 包含细菌菌株的组合物
US11077179B2 (en) 2017-08-10 2021-08-03 Epicgenetics, Inc. Method for treating fibromyalgia and chronic fatigue syndrome
WO2020089488A1 (en) * 2018-11-02 2020-05-07 4D Pharma Research Limited Compositions comprising bacterial strains
WO2020115161A1 (en) 2018-12-04 2020-06-11 Sabiotec Spin-Off Sl Immunostimulant for use against pathogens
MA54161A (fr) 2018-12-12 2022-03-23 4D Pharma Res Ltd Compositions comprenant des souches bactériennes parabacteroides pour le traitement du cancer
JP7712684B2 (ja) * 2020-01-21 2025-07-24 ▲遼▼▲寧▼格瑞仕特生物制▲藥▼有限公司 ロドコッカス・ルーバーの細胞壁骨格の再生医学における用途
GB202004007D0 (en) * 2020-03-19 2020-05-06 Immodulon Therapeutics Ltd Coronavirus

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Also Published As

Publication number Publication date
EP1963484A1 (en) 2008-09-03
ATE519838T1 (de) 2011-08-15
EP2298860A2 (en) 2011-03-23
US20090304749A1 (en) 2009-12-10
SI1963484T1 (sl) 2012-06-29
ES2369569T8 (es) 2012-06-26
EP1963484B1 (en) 2011-08-10
US20120082699A1 (en) 2012-04-05
JP5202330B2 (ja) 2013-06-05
GB0526033D0 (en) 2006-02-01
NZ568810A (en) 2011-09-30
ES2369569T3 (es) 2011-12-02
CN101384699A (zh) 2009-03-11
BRPI0620291A2 (pt) 2011-11-08
WO2007071978A1 (en) 2007-06-28
PL1963484T3 (pl) 2012-08-31
CN101384699B (zh) 2012-10-10
CA2633127C (en) 2015-08-04
US8512694B2 (en) 2013-08-20
AU2006328209A1 (en) 2007-06-28
DK1963484T3 (da) 2011-09-19
BRPI0620291B1 (pt) 2020-12-15
EP2298860A3 (en) 2012-04-25
JP2009520489A (ja) 2009-05-28
CA2633127A1 (en) 2007-06-28
AU2006328209B2 (en) 2012-10-11
US8071354B2 (en) 2011-12-06

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