BRPI0705596A2 - process for preparing semicarbazone and / or thiosemicarbazone formulations with cyclodextrins and their derivatives and products obtained therefrom - Google Patents

process for preparing semicarbazone and / or thiosemicarbazone formulations with cyclodextrins and their derivatives and products obtained therefrom

Info

Publication number
BRPI0705596A2
BRPI0705596A2 BRPI0705596A BRPI0705596A2 BR PI0705596 A2 BRPI0705596 A2 BR PI0705596A2 BR PI0705596 A BRPI0705596 A BR PI0705596A BR PI0705596 A2 BRPI0705596 A2 BR PI0705596A2
Authority
BR
Brazil
Prior art keywords
cyclodextrins
derivatives
semicarbazones
formulations
products obtained
Prior art date
Application number
Other languages
Portuguese (pt)
Inventor
Oliveira Beraldo Heloisa De
Matos Coelho Marcio De
Ruben Dario Sinisterra
Maria Carolina Doretto
Vieira Rafael Pinto Pinto
Souza Teixeira Leticia Regina De
Silvia Passos Andrade
Original Assignee
Univ Minas Gerais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minas Gerais filed Critical Univ Minas Gerais
Priority to BRPI0705596 priority Critical patent/BRPI0705596A2/en
Publication of BRPI0705596A2 publication Critical patent/BRPI0705596A2/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCESSO DE PREPARAÇçO DE FORMULAÇÕES DE SEMICARBAZONAS E/OU TIOSSEMICARBAZONAS COM CICLODEXTRINAS E SEUS DERIVADOS E PRODUTOS OBTIDOS DESSE PROCESSO. A presente invenção caracteriza-se pela preparação de formulações de semicarbazonas e/ou tiossemicarbazonas com ciclodextrinas e seus derivados e produtos obtidos desse processo. A presente invenção caracteriza-se pela obtenção de compostos de inclusão de semicarbazonas e/ou tiossemicarbazonas em ciclodextrinas e seus derivados que, testados em modelos experimentais de epilepsia, permitiram a redução da dose anticonvulsivante de lOOmg/kg para 35mg/kg, o que pode significar aumento da biodisponibilidade dos compostos nos sistemas biológicos. Esses resultados obtidos em modelos animais, colocam as semicarbazonas e/ou tiossemicarbazonas incluídas em ciclodextrinas e seus derivados como candidatos a novos agentes anticonvulsivantes. A presente invenção caracteriza-se ainda pelo aumento da eficácia das semicarbazonas e/ou tiossemicarbazonas incluídas em ciclodextrinas e seus derivados, quando comparadas aos componentes livres.PROCESS FOR PREPARATION OF FORMULATIONS OF SEMICARBAZONES AND / OR TIOSEMICARBAZONES WITH CYCLODEXTRINS AND THEIR DERIVATIVES AND PRODUCTS OBTAINED FROM THIS PROCESS. The present invention is characterized by the preparation of formulations of semicarbazones and / or thiosemicarbazones with cyclodextrins and their derivatives and products obtained therefrom. The present invention is characterized by the inclusion of semicarbazones and / or thiosemicarbazones inclusion compounds in cyclodextrins and their derivatives which, tested in experimental epilepsy models, allowed the reduction of anticonvulsant dose from 100mg / kg to 35mg / kg, which may means increased bioavailability of compounds in biological systems. These results obtained in animal models place the semicarbazones and / or thiosemicarbazones included in cyclodextrins and their derivatives as candidates for new anticonvulsant agents. The present invention is further characterized by the increased efficacy of semicarbazones and / or thiosemicarbazones included in cyclodextrins and their derivatives as compared to free components.

BRPI0705596 2007-07-09 2007-07-09 process for preparing semicarbazone and / or thiosemicarbazone formulations with cyclodextrins and their derivatives and products obtained therefrom BRPI0705596A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BRPI0705596 BRPI0705596A2 (en) 2007-07-09 2007-07-09 process for preparing semicarbazone and / or thiosemicarbazone formulations with cyclodextrins and their derivatives and products obtained therefrom

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0705596 BRPI0705596A2 (en) 2007-07-09 2007-07-09 process for preparing semicarbazone and / or thiosemicarbazone formulations with cyclodextrins and their derivatives and products obtained therefrom

Publications (1)

Publication Number Publication Date
BRPI0705596A2 true BRPI0705596A2 (en) 2009-03-03

Family

ID=40601292

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0705596 BRPI0705596A2 (en) 2007-07-09 2007-07-09 process for preparing semicarbazone and / or thiosemicarbazone formulations with cyclodextrins and their derivatives and products obtained therefrom

Country Status (1)

Country Link
BR (1) BRPI0705596A2 (en)

Similar Documents

Publication Publication Date Title
WO2006078992A3 (en) Heteroaryl substituted piperazinyl-pyridine analogues
CL2009000555A1 (en) Compounds derived from tetramates substituted spirocyclically with 4'4'-dioxaspiro; preparation procedure; agent to combat pests and / or unwanted vegetation that comprises said compounds; its preparation and use procedure; compositions and their use
CO6450634A2 (en) PESTICIDED COMPOSITIONS
BR112014026526A2 (en) pesticide compositions and processes related thereto
CR10310A (en) NEW COMPOUNDS
WO2008066789A3 (en) Heteroaryl amide derivatives
BRPI0606397A (en) 1-thio-d-glucitol derivatives
BR112014033104A2 (en) pesticide compositions and processes related thereto
ECSP10010223A (en) AMINOBENZAMIDE DERIVATIVES AS USEFUL AGENTS FOR THE CONTROL OF PARASITES OF ANIMALS
WO2008016811A3 (en) Aminopiperidines and realted compounds
UA99610C2 (en) Heteroaryl amide analogues as p2x7 antagonists
BR112014012822A8 (en) FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANTS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2
WO2007140383A3 (en) Spirocyclic sulfonamides and related compounds
BRPI0908432A2 (en) topical antimicrobial compositions
BRPI0507801A (en) substituted azetidine compounds, process for preparing substituted azetidine compounds, medicament and use of at least one substituted azetidine compound
BR112013007457A8 (en) PHARMACEUTICAL FORMULATIONS CONTAINING RIFAXIMIN, PROCESSES FOR OBTAINING THEM AND METHOD OF TREATMENT OF INTESTINAL DISEASE
BR112012032255A2 (en) anthranilic diamide derivatives
BR112013005136A2 (en) compositions and methods for controlling nematode pests
BRPI0519135A2 (en) macrolides
WO2008024433A3 (en) Haloalkyl-substituted pyrimidinone derivatives
WO2008024438A3 (en) 2-phenoxy pyrimidinone analogues
BR112012018343A2 (en) "immunogenic compositions"
WO2006026135A3 (en) Substituted biaryl piperazinyl-pyridine analogues
WO2008066664A3 (en) Cis-cyclohexyl substituted pyrimidinone derivatives
WO2006076646A3 (en) Heteroaryl substituted quinolin-4-ylamine analogues

Legal Events

Date Code Title Description
B03A Publication of an application: publication of a patent application or of a certificate of addition of invention
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B04C Request for examination: reinstatement - article 33, solely paragraph, of industrial property law
B15K Others concerning applications: alteration of classification

Ipc: A61K 31/175 (2006.01)

B07D Technical examination (opinion) related to article 229 of industrial property law
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B07E Notice of approval relating to section 229 industrial property law
B06V Preliminary requirement: requests without searches performed by other patent offices: suspension of the patent application procedure
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements