BRPI0710331A2 - MONOCYCLIC HETEROARYL COMPOUNDS FOR CANCER TREATMENT AND COMPOSITION - Google Patents

MONOCYCLIC HETEROARYL COMPOUNDS FOR CANCER TREATMENT AND COMPOSITION Download PDF

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Publication number
BRPI0710331A2
BRPI0710331A2 BRPI0710331-0A BRPI0710331A BRPI0710331A2 BR PI0710331 A2 BRPI0710331 A2 BR PI0710331A2 BR PI0710331 A BRPI0710331 A BR PI0710331A BR PI0710331 A2 BRPI0710331 A2 BR PI0710331A2
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BR
Brazil
Prior art keywords
composition
cancer treatment
monocyclic heteroaryl
heteroaryl compounds
compounds
Prior art date
Application number
BRPI0710331-0A
Other languages
Portuguese (pt)
Inventor
C. Shakespeare William
Zou Dong
A. Metcalf Chester Iii
K. Sawyer Tomi
Antoinette C. Romero Jan
C. Dalgarno David
Huang Wei-Sheng
Zhu Xiaotian
Wang Yihan
Qi Jiwei
Sundaramoorthi Rajeswari
Mathew Thomas R.
Original Assignee
Ariad Pharmaceuticals, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38694440&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0710331(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ariad Pharmaceuticals, Inc filed Critical Ariad Pharmaceuticals, Inc
Publication of BRPI0710331A2 publication Critical patent/BRPI0710331A2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSTOS HETEROARILA MONOCìCLICOS PARA TRATAMENTO DE CáNCER E COMPOSIçãO. Esta invenção relata compostos da fórmula geral (I) na qual variáveis grupos são como aqui definidos, e para as suas preparações e uso.Monocyclic Heteroaryl Compounds for CANCER TREATMENT AND COMPOSITION. This invention relates to compounds of general formula (I) in which variable groups are as defined herein, and for their preparations and use.

BRPI0710331-0A 2006-05-08 2007-05-08 MONOCYCLIC HETEROARYL COMPOUNDS FOR CANCER TREATMENT AND COMPOSITION BRPI0710331A2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US79847206P 2006-05-08 2006-05-08
US60/798.472 2006-05-08
US83319106P 2006-07-25 2006-07-25
US60/833.191 2006-07-25
US92068707P 2007-03-29 2007-03-29
US60/920.687 2007-03-29
PCT/US2007/011136 WO2007133562A2 (en) 2006-05-08 2007-05-08 Monocyclic heteroaryl compounds

Publications (1)

Publication Number Publication Date
BRPI0710331A2 true BRPI0710331A2 (en) 2012-03-20

Family

ID=38694440

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0710331-0A BRPI0710331A2 (en) 2006-05-08 2007-05-08 MONOCYCLIC HETEROARYL COMPOUNDS FOR CANCER TREATMENT AND COMPOSITION

Country Status (13)

Country Link
US (3) US8278307B2 (en)
EP (1) EP2024366B1 (en)
JP (1) JP5273038B2 (en)
KR (1) KR101441365B1 (en)
CN (1) CN103467385B (en)
AU (1) AU2007249926B8 (en)
BR (1) BRPI0710331A2 (en)
CA (1) CA2650273C (en)
EA (1) EA200870515A1 (en)
ES (1) ES2555515T3 (en)
IL (1) IL194678A (en)
MX (1) MX2008014290A (en)
WO (1) WO2007133562A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1940843A4 (en) 2005-08-11 2010-09-15 Ariad Pharma Inc Unsaturated heterocyclic derivatives
DK2495016T3 (en) * 2005-12-23 2019-12-16 Ariad Pharma Inc Bicyclic heteroaryl compounds
BRPI0710328A2 (en) 2006-05-08 2011-08-09 Ariad Pharma Inc compound of formula I, a tautomer thereof, or a pharmaceutically acceptable salt, hydrate or other solvate thereof and method for treating cancer in a mammal in need thereof and composition
WO2009100536A1 (en) * 2008-02-15 2009-08-20 Methylgene Inc. Inhibitors of kinase activity with 1,2-di-cyclyl substituted alkyne structures
JP5590040B2 (en) 2008-11-12 2014-09-17 アリアド・ファーマシューティカルズ・インコーポレイテッド Pyrazinopyrazine and derivatives as kinase inhibitors
WO2012127030A1 (en) * 2011-03-23 2012-09-27 Proteosys Ag Arylpiperazines as neuroprotective agents
CN103421005A (en) * 2012-05-16 2013-12-04 上海医药集团股份有限公司 Acetylene derivative capable of resisting activity of tumor
CN103848829B (en) 2012-11-28 2017-04-12 南京圣和药业股份有限公司 Heteroaryl alkyne compounds and application thereof
CA2815506C (en) 2012-12-12 2018-12-11 Ariad Pharmaceuticals, Inc. Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
US20140343282A1 (en) 2013-05-16 2014-11-20 Apicore, Llc Processes for making ponatinib and intermediates thereof
GB2522226A (en) * 2014-01-17 2015-07-22 Agency Science Tech & Res Heteroaryl alkyne derivatives and uses thereof
DK3169671T3 (en) 2014-07-17 2019-09-23 Sunshine Lake Pharma Co Ltd 1- (5- (TERT.-BUTYL) ISOXAZOL-3-YL) -3- (4 - ((PHENYL) ETHYNYL) PHENYL) URE ADDITIVES AND RELATED COMPOUNDS AS FLT3 INHIBITORS FOR TREATMENT OF CANCER
CN105646361B (en) * 2016-02-17 2017-12-01 吉首大学 A kind of 2,4,5 triarylimidazoles type compounds and its preparation method and purposes
WO2018112136A1 (en) 2016-12-15 2018-06-21 Ariad Pharmaceuticals, Inc. Aminothiazole compounds as c-kit inhibitors

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9823871D0 (en) 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
HN2001000008A (en) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals AMIDA COMPOSITE AND PHARMACEUTICAL COMPOSITIONS TO INHIBIT PROTEINKINASES, AND THE INSTRUCTIONS FOR USE
DE10021246A1 (en) 2000-04-25 2001-10-31 Schering Ag New N-substituted benzamide derivatives are tyrosine kinase KDR and FLT inhibitors useful e.g. for treating tumors, psoriasis, rheumatoid arthritis, diabetic retinopathy or liver sclerosis
NZ525591A (en) 2000-10-05 2004-04-30 Fujisawa Pharmaceutical Co Benzamide compounds as Apo B secretion inhibitors
SE0100903D0 (en) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
IL159811A0 (en) 2001-07-13 2004-06-20 Neurogen Corp Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands
US20040110802A1 (en) * 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
GB0230089D0 (en) 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
DE10306250A1 (en) 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituted N-aryl heterocycles, processes for their preparation and their use as pharmaceuticals
US20050014753A1 (en) * 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
AU2004276337B2 (en) 2003-09-24 2009-11-12 Methylgene Inc. Inhibitors of histone deacetylase
US20080027076A1 (en) 2003-12-24 2008-01-31 Astrazeneca Ab Pyrimidines With Tie2 (Tek) Activity
ES2317079T3 (en) 2003-12-24 2009-04-16 Astrazeneca Ab PYRIMIDINS WITH ACTIVITY TIE2 (TEK).
AU2005231980B2 (en) 2004-04-07 2011-09-08 Merck Serono Sa 1,1'-(1,2-ethynediyl)bis-benzene derivatives as PTP 1-B inhibitors
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
GB0502418D0 (en) * 2005-02-05 2005-03-16 Astrazeneca Ab Compounds
EP1893605A2 (en) * 2005-03-31 2008-03-05 AstraZeneca AB Saminopyrimidine derivates with tie2 inhibiting activity
US20100216798A1 (en) 2005-07-29 2010-08-26 Astellas Pharma Inc Fused heterocycles as lck inhibitors
EP1940843A4 (en) * 2005-08-11 2010-09-15 Ariad Pharma Inc Unsaturated heterocyclic derivatives
DK2495016T3 (en) 2005-12-23 2019-12-16 Ariad Pharma Inc Bicyclic heteroaryl compounds
CN101490053B (en) * 2006-05-08 2013-09-11 阿里亚德医药股份有限公司 Monocyclic Heteroaryl Compounds
BRPI0710328A2 (en) 2006-05-08 2011-08-09 Ariad Pharma Inc compound of formula I, a tautomer thereof, or a pharmaceutically acceptable salt, hydrate or other solvate thereof and method for treating cancer in a mammal in need thereof and composition

Also Published As

Publication number Publication date
CA2650273A1 (en) 2007-11-22
KR20090018942A (en) 2009-02-24
EP2024366A2 (en) 2009-02-18
ES2555515T3 (en) 2016-01-04
AU2007249926A8 (en) 2013-11-07
AU2007249926A1 (en) 2007-11-22
US20090149471A1 (en) 2009-06-11
MX2008014290A (en) 2008-11-26
AU2007249926B2 (en) 2013-07-04
JP2009536652A (en) 2009-10-15
CA2650273C (en) 2016-06-07
WO2007133562A2 (en) 2007-11-22
US20170369446A1 (en) 2017-12-28
CN103467385A (en) 2013-12-25
WO2007133562A3 (en) 2008-10-02
IL194678A (en) 2017-03-30
CN103467385B (en) 2016-03-09
US8278307B2 (en) 2012-10-02
EP2024366A4 (en) 2011-06-29
EA200870515A1 (en) 2009-06-30
KR101441365B1 (en) 2014-09-18
AU2007249926B8 (en) 2013-11-07
US20130005738A1 (en) 2013-01-03
JP5273038B2 (en) 2013-08-28
EP2024366B1 (en) 2015-09-16

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Ipc: C07D 487/00 (2006.01), A61P 35/00 (2006.01), A61P

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