BRPI0711119A2 - administração microbiana de peptìdeos intestinais associados à obesidade - Google Patents

administração microbiana de peptìdeos intestinais associados à obesidade Download PDF

Info

Publication number
BRPI0711119A2
BRPI0711119A2 BRPI0711119-3A BRPI0711119A BRPI0711119A2 BR PI0711119 A2 BRPI0711119 A2 BR PI0711119A2 BR PI0711119 A BRPI0711119 A BR PI0711119A BR PI0711119 A2 BRPI0711119 A2 BR PI0711119A2
Authority
BR
Brazil
Prior art keywords
obesity
administration
intestinal peptides
microbial administration
associated intestinal
Prior art date
Application number
BRPI0711119-3A
Other languages
English (en)
Inventor
Pieter Rottiers
Original Assignee
Actogenix Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actogenix Nv filed Critical Actogenix Nv
Publication of BRPI0711119A2 publication Critical patent/BRPI0711119A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dairy Products (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

ADMINISTRAçãO MICROBIANA DE PEPTìDEOS INTESTINAIS ASSOCIADOS A OBESIDADE. A presente invenção se refere à administração microbiana de peptídeos associados à obesidade. Mais especificamente a invenção relata o uso de leveduras e/ou bactérias do ácido láctico geneticamente modificadas para a administração de neuropeptideos e/ou hormónios peptídicos que atuam na estimulação ou inibição da ingestão alimentar e/ou da homeostase energética.
BRPI0711119-3A 2006-05-02 2007-05-02 administração microbiana de peptìdeos intestinais associados à obesidade BRPI0711119A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06113388 2006-05-02
PCT/EP2007/054266 WO2007128757A2 (en) 2006-05-02 2007-05-02 Microbial intestinal delivery of obesity related peptides

Publications (1)

Publication Number Publication Date
BRPI0711119A2 true BRPI0711119A2 (pt) 2011-08-30

Family

ID=36660825

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0711119-3A BRPI0711119A2 (pt) 2006-05-02 2007-05-02 administração microbiana de peptìdeos intestinais associados à obesidade

Country Status (9)

Country Link
US (1) US20090074734A1 (pt)
EP (2) EP3255149A3 (pt)
JP (1) JP2009535380A (pt)
CN (1) CN101437945A (pt)
AU (1) AU2007247137A1 (pt)
BR (1) BRPI0711119A2 (pt)
CA (1) CA2649932A1 (pt)
RU (1) RU2008147398A (pt)
WO (1) WO2007128757A2 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
KR101106510B1 (ko) 2006-05-30 2012-01-20 인타르시아 세라퓨틱스 인코포레이티드 투피스, 내부채널 삼투압 전달 시스템 유동 조절기
CA2670821C (en) 2006-08-09 2012-05-15 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
AU2006350707A1 (en) * 2006-11-08 2008-05-15 Chongxi Yu Transdermal delivery systems of peptides and related compounds
WO2008071751A1 (en) * 2006-12-14 2008-06-19 Actogenix N.V. Delivery of binding molecules to induce immunomodulation
CA2683610C (en) 2007-04-23 2013-01-08 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
WO2009102467A2 (en) 2008-02-13 2009-08-20 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
CN105754918A (zh) 2008-04-09 2016-07-13 康奈尔大学 在哺乳动物宿主内作为信号介质的共生菌
PL2427475T3 (pl) * 2009-05-08 2021-07-19 Techfields Biochem Co., Ltd. Kompozycje proleku o wysokim przenikaniu peptydów i związków powiązanych z peptydami
MX378797B (es) 2009-09-28 2025-03-10 Intarcia Therapeutics Inc Establecimiento y/o terminacion rapidos de suministro de estado estable sustancial de farmaco.
JP6033780B2 (ja) 2010-10-15 2016-11-30 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ 内分泌障害、胃腸障害または自己免疫障害を処置するための組成物および方法
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
DK2758512T3 (en) 2011-09-23 2018-07-23 Intrexon Actobiotics Nv MODIFIED GRAM POSITIVE BACTERIES AND APPLICATIONS THEREOF
CA2848471C (en) 2011-09-23 2021-11-16 Actogenix Nv Modified gram positive bacteria and uses thereof
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP3237622B1 (en) 2014-12-23 2021-02-24 Ilya Pharma AB Methods for wound healing
CN113598842A (zh) 2015-06-03 2021-11-05 因塔西亚制药公司 植入物放置和移除系统
US10111932B2 (en) * 2015-08-26 2018-10-30 Syracuse University Coagonists of glucagon-like peptide 1 receptor and neuropeptide Y2 receptor
KR102574993B1 (ko) 2016-05-16 2023-09-06 인타르시아 세라퓨틱스 인코포레이티드 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
WO2018129058A1 (en) 2017-01-03 2018-07-12 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug
CN112370525A (zh) * 2020-11-12 2021-02-19 西北农林科技大学 一种用于瘦素免疫调节的口服重组酵母菌株

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
ATE164852T1 (de) * 1990-01-24 1998-04-15 Douglas I Buckley Glp-1-analoga verwendbar in der diabetesbehandlung
US5637481A (en) 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
PT1621554E (pt) 1992-08-21 2009-07-13 Univ Bruxelles Imunoglobtainas desprovidas de cadeias leves
IT1270123B (it) * 1994-10-05 1997-04-28 Dompe Spa Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia
EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
GB9521568D0 (en) 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
CA2246431A1 (en) * 1996-01-19 1997-07-24 Board Of Regents, The University Of Texas System Recombinant expression of proteins from secretory cell lines
ATE259829T1 (de) 1998-10-20 2004-03-15 Vlaams Interuniv Inst Biotech Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis
PT1739178E (pt) 1999-07-05 2010-11-17 Actogenix Nv Libertação de péptidos trifólios
AUPQ387599A0 (en) * 1999-11-05 1999-12-02 Metabolic Pharmaceuticals Limited Product and method for control of obesity
WO2002002781A1 (en) 2000-06-30 2002-01-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Heterodimeric fusion proteins
GB2368792A (en) 2000-10-06 2002-05-15 Roger Randal Charles New Absorption enhancers
US7374930B2 (en) * 2002-05-21 2008-05-20 Expression Genetics, Inc. GLP-1 gene delivery for the treatment of type 2 diabetes
WO2004036186A2 (en) * 2002-10-17 2004-04-29 Alkermes Controlled Therapeutics, Inc. Ii Microencapsulation and sustained release of biologically active polypeptides
US7229966B2 (en) * 2002-12-17 2007-06-12 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
US20050032160A1 (en) * 2003-01-21 2005-02-10 Newgard Christopher B. Cell-based therapies for diabetes mellitus and other glucose intolerant states
NZ543274A (en) * 2003-05-14 2007-12-21 Emisphere Tech Inc Compositions for delivering peptide YY and PYY agonists
WO2005023291A2 (en) * 2003-09-11 2005-03-17 Novo Nordisk A/S Use of glp1-agonists in the treatment of patients with type i diabetes
WO2005112633A2 (en) 2004-05-14 2005-12-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
EP1751270A1 (en) * 2004-05-18 2007-02-14 VIB vzw Self-containing lactobacillus strain
AU2006279276A1 (en) * 2005-07-29 2007-02-15 Amprotein Corporation Chimeric therapeutic agents
US9017662B2 (en) 2005-08-30 2015-04-28 Actogenix N.V. Anti-TNF alpha producing lactic acid bacteria for the treatment of chronic enterocolitis
US20090192083A1 (en) * 2006-02-24 2009-07-30 Currie Mark G Methods and compositions for the treatment of gastrointestinal disorders

Also Published As

Publication number Publication date
EP3255149A3 (en) 2018-04-18
JP2009535380A (ja) 2009-10-01
CA2649932A1 (en) 2007-11-15
WO2007128757A8 (en) 2017-05-04
RU2008147398A (ru) 2010-06-10
US20090074734A1 (en) 2009-03-19
WO2007128757A2 (en) 2007-11-15
WO2007128757A3 (en) 2008-02-14
EP2016178A2 (en) 2009-01-21
EP2016178B1 (en) 2017-07-12
CN101437945A (zh) 2009-05-20
AU2007247137A1 (en) 2007-11-15
EP3255149A2 (en) 2017-12-13

Similar Documents

Publication Publication Date Title
WO2007128757A3 (en) Microbial intestinal delivery of obesity related peptides
ES2512141T3 (es) Análogo peptídico de oxintomodulina
ES2486675T3 (es) Análogo de péptido de oxintomodulina
Ning et al. Epigallocatechin gallate protects mice against methionine–choline-deficient-diet-induced nonalcoholic steatohepatitis by improving gut microbiota to attenuate hepatic injury and regulate metabolism
BR132020021160F1 (pt) Composição compreendendo um fermentado de bactéria probiótica lactobacillus paracasei cba l74 e uso do mesmo
ES2621482T3 (es) Uso de micelas de proteínas de suero lácteo, para mejorar el gasto energético y la saciedad
CN108478790B (zh) Bt脂肽作为用于肥胖和相关疾病的治疗剂的用途
Tulipano Role of bioactive peptide sequences in the potential impact of dairy protein intake on metabolic health
EP2772267A3 (en) Immunogenic compositions and methods
BRPI0818079B8 (pt) composição de lipídeo
DK1978821T3 (da) Fremgangsmåde til at modificere tarmflora i dyr
BR112016010803B8 (pt) Suplemento alimentar a base de ácido resínico e uso não terapêutico de um suplemento alimentar a base de ácido resínico
CL2009000905A1 (es) Composicion comestible que comprende bifidobacterium longum atcc baa-999; y su uso para tratar o prevenir la ansiedad y/o desordenes relacionados con ansiedad.
BR112012016982B8 (pt) bactéria de ácido lático recombinante de grau alimentício e composição terapêutica
PL1986669T3 (pl) Zastosowanie Bifidobacterium longum do zapobiegania i leczenia zapalenia
BR112014030434A2 (pt) método não terapêutico; uso de uma proteína; composição nutricional; e uso da composição nutricional
BR112014016810A8 (pt) composições e métodos para tratamento de distúrbios metabólicos
RU2010126327A (ru) Композиция на основе пробиотических бактерий совместно с пребиотиком и ее применение в предупреждении и/или лечении респираторных патологий и/или инфекций и для улучшения функций кишечника
IN2012DN05908A (pt)
WO2009103555A3 (en) Mucosal membrane receptor and uses thereof
MX2013006094A (es) Metodo para inhibir patogenos usando composicion nutricional.
BR112012018970A2 (pt) método para selagem aprimorada com fibrina
Jiang et al. Effects of dietary non-fiber carbohydrates on composition and function of gut microbiome in monogastrics: A review
ECSP077423A (es) Coadministración de tigeciclina y digoxin
WO2009019307A3 (en) Oral calcitonin compositions and applications thereof

Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A E 5A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 4A E 5A ANUIDADES.