BRPI0712899A2 - derivados de leptomicina - Google Patents

derivados de leptomicina Download PDF

Info

Publication number: BRPI0712899A2
Authority: BR; Brazil
Prior art keywords: oxo; derivative; ieptomycin; methyl; formula
Prior art date: 2006-06-09

Application number

BRPI0712899-1A

Other languages

English (en)

Portuguese (pt)

Inventor

Herve Bouchard

Alain Commercon

Ravi V J Chari

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-09

Filing date

2007-05-23

Publication date

2013-01-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37311892&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0712899(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-05-23 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2013-01-08 Publication of BRPI0712899A2 publication Critical patent/BRPI0712899A2/pt

Links

YACHGFWEQXFSBS-RJXCBBHPSA-N leptomycin Chemical class OC(=O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(\C)/C=C/C[C@@H](C)\C=C(/CC)\C=C\[C@@H]1OC(=O)C=C[C@@H]1C YACHGFWEQXFSBS-RJXCBBHPSA-N 0.000 title claims abstract 6
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims abstract description 14
239000003153 chemical reaction reagent Substances 0.000 claims abstract description 12
239000011230 binding agent Substances 0.000 claims description 72
150000001875 compounds Chemical class 0.000 claims description 44
238000000034 method Methods 0.000 claims description 29
239000002253 acid Substances 0.000 claims description 26
239000003814 drug Substances 0.000 claims description 24
-1 2-mercaptoethyl Chemical group 0.000 claims description 23
206010028980 Neoplasm Diseases 0.000 claims description 22
150000003839 salts Chemical class 0.000 claims description 20
201000011510 cancer Diseases 0.000 claims description 19
125000000217 alkyl group Chemical group 0.000 claims description 16
239000003446 ligand Substances 0.000 claims description 14
150000003573 thiols Chemical group 0.000 claims description 13
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 9
229930190887 Leptomycin Natural products 0.000 claims description 8
238000002360 preparation method Methods 0.000 claims description 7
230000008569 process Effects 0.000 claims description 7
238000004519 manufacturing process Methods 0.000 claims description 5
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 4
239000013078 crystal Substances 0.000 claims description 4
UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 claims description 4
150000004677 hydrates Chemical class 0.000 claims description 4
CYWGSFFHHMQKET-UHFFFAOYSA-N 2-methylsulfanylethanamine Chemical compound CSCCN CYWGSFFHHMQKET-UHFFFAOYSA-N 0.000 claims description 3
230000003287 optical effect Effects 0.000 claims description 3
125000005010 perfluoroalkyl group Chemical group 0.000 claims description 3
239000008194 pharmaceutical composition Substances 0.000 claims description 3
239000003638 chemical reducing agent Substances 0.000 claims description 2
229910052739 hydrogen Inorganic materials 0.000 claims description 2
QECBVZBMGUAZDL-JSADDXMJSA-N leptomycin A Chemical compound OC(=O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(\C)/C=C/C[C@@H](C)\C=C(/C)\C=C\[C@@H]1OC(=O)C=C[C@@H]1C QECBVZBMGUAZDL-JSADDXMJSA-N 0.000 claims description 2
BQWBEDSJTMWJAE-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-[(2-iodoacetyl)amino]benzoate Chemical compound C1=CC(NC(=O)CI)=CC=C1C(=O)ON1C(=O)CCC1=O BQWBEDSJTMWJAE-UHFFFAOYSA-N 0.000 claims 1
IHVODYOQUSEYJJ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 6-[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]hexanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCNC(=O)C(CC1)CCC1CN1C(=O)C=CC1=O IHVODYOQUSEYJJ-UHFFFAOYSA-N 0.000 claims 1
LCVDHXURABCEDA-UHFFFAOYSA-N 2-(methyldisulfanyl)ethanamine Chemical compound CSSCCN LCVDHXURABCEDA-UHFFFAOYSA-N 0.000 claims 1
101100476722 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SBA1 gene Proteins 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
208000021070 secondary pulmonary alveolar proteinosis Diseases 0.000 claims 1
230000001472 cytotoxic effect Effects 0.000 abstract description 14
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UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract description 8
230000001225 therapeutic effect Effects 0.000 abstract description 5
210000004027 cell Anatomy 0.000 description 106
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 60
239000000562 conjugate Substances 0.000 description 45
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 33
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 28
238000006243 chemical reaction Methods 0.000 description 24
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YACHGFWEQXFSBS-XYERBDPFSA-N leptomycin B Chemical class OC(=O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(\C)/C=C/C[C@@H](C)/C=C(/CC)\C=C\[C@@H]1OC(=O)C=C[C@@H]1C YACHGFWEQXFSBS-XYERBDPFSA-N 0.000 description 18
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ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
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YEDUAINPPJYDJZ-UHFFFAOYSA-N 2-hydroxybenzothiazole Chemical compound C1=CC=C2SC(O)=NC2=C1 YEDUAINPPJYDJZ-UHFFFAOYSA-N 0.000 description 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
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NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 5
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ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 description 4
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MBPAUMHSIFBANF-UHFFFAOYSA-N 1-amino-2-methylpropane-2-thiol Chemical compound CC(C)(S)CN MBPAUMHSIFBANF-UHFFFAOYSA-N 0.000 description 3
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6863—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from stomach or intestines cancer cell
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Cell Biology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Pyrane Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

BRPI0712899-1A 2006-06-09 2007-05-23 derivados de leptomicina BRPI0712899A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP06290948.6		2006-06-09
EP06290948A EP1864682A1 (en)	2006-06-09	2006-06-09	Leptomycin derivatives
PCT/IB2007/001328 WO2007144709A2 (en)	2006-06-09	2007-05-23	Leptomycin derivatives

Publications (1)

Publication Number	Publication Date
BRPI0712899A2 true BRPI0712899A2 (pt)	2013-01-08

Family

ID=37311892

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0712899-1A BRPI0712899A2 (pt)	2006-06-09	2007-05-23	derivados de leptomicina

Country Status (28)

Country	Link
US (2)	US7816543B2 (es)
EP (3)	EP1864682A1 (es)
JP (1)	JP5162581B2 (es)
KR (1)	KR20090018103A (es)
CN (2)	CN101466409B (es)
AR (1)	AR063668A1 (es)
AU (1)	AU2007258896B2 (es)
BR (1)	BRPI0712899A2 (es)
CA (1)	CA2654322A1 (es)
CL (1)	CL2007001648A1 (es)
CR (1)	CR10459A (es)
EA (1)	EA017345B1 (es)
EC (1)	ECSP088936A (es)
GT (1)	GT200800277A (es)
HN (1)	HN2008001788A (es)
IL (1)	IL195419A0 (es)
MA (1)	MA30689B1 (es)
ME (1)	MEP88208A (es)
MX (1)	MX2008015728A (es)
MY (1)	MY148231A (es)
NO (1)	NO20085127L (es)
NZ (1)	NZ572947A (es)
SG (2)	SG174066A1 (es)
TN (1)	TNSN08463A1 (es)
TW (1)	TWI411609B (es)
UA (1)	UA95959C2 (es)
WO (1)	WO2007144709A2 (es)
ZA (1)	ZA200810015B (es)

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CN101732308B (zh) *	2008-11-17	2011-11-30	中国人民解放军军事医学科学院毒物药物研究所	来普霉素b的新用途及含有它的药物组合物和产品
CA3014224C (en)	2009-02-05	2022-05-24	Immunogen, Inc.	Condensed benzodiazepine-indoline derivatives and processes to prepare said derivatives
FR2947269B1 (fr)	2009-06-29	2013-01-18	Sanofi Aventis	Nouveaux composes anticancereux
FR2949469A1 (fr)	2009-08-25	2011-03-04	Sanofi Aventis	Derives anticancereux, leur preparation et leur application en therapeutique
UY32913A (es)	2009-10-02	2011-04-29	Sanofi Aventis	Nuevos maitansinoides y el uso de dichos maitansinoides para preparar conjugados con un anticuero
AR080154A1 (es)	2010-02-10	2012-03-14	Immunogen Inc	Anticuerpos cd20 y su utilizacion
FR2963007B1 (fr)	2010-07-26	2013-04-05	Sanofi Aventis	Derives anticancereux, leur preparation et leur application therapeutique
SI2675480T1 (sl)	2011-02-15	2019-05-31	Immunogen, Inc.	Metode priprave konjugatov
PL2872157T3 (pl)	2012-07-12	2020-07-13	Hangzhou Dac Biotech Co., Ltd	Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi
GB201309807D0 (en) *	2013-05-31	2013-07-17	Pharma Mar Sau	Antibody drug conjugates
US20150148411A1 (en) *	2013-11-25	2015-05-28	The Rockefeller University	Compositions and methods for diagnosis and therapy of disorders related to alterations of myh9
CN110478495A (zh)	2014-06-30	2019-11-22	塔弗达治疗有限公司	靶向缀合物及其颗粒和制剂
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US11236059B2 (en)	2017-08-09	2022-02-01	Helmholtz-Zentrum Fuer Infektionsforschung Gmbh	Targeted cytotoxic ratjadone derivatives and conjugates thereof
TWI824043B (zh)	2018-10-25	2023-12-01	西班牙商瑪製藥股份有限公司	藥物抗體共軛物
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2006
- 2006-06-09 EP EP06290948A patent/EP1864682A1/en not_active Withdrawn
2007
- 2007-05-23 CN CN2007800215355A patent/CN101466409B/zh not_active Expired - Fee Related
- 2007-05-23 EA EA200870615A patent/EA017345B1/ru not_active IP Right Cessation
- 2007-05-23 BR BRPI0712899-1A patent/BRPI0712899A2/pt not_active IP Right Cessation
- 2007-05-23 EP EP07734635A patent/EP2032172B1/en active Active
- 2007-05-23 MX MX2008015728A patent/MX2008015728A/es active IP Right Grant
- 2007-05-23 MY MYPI20084971A patent/MY148231A/en unknown
- 2007-05-23 WO PCT/IB2007/001328 patent/WO2007144709A2/en not_active Ceased
- 2007-05-23 NZ NZ572947A patent/NZ572947A/en not_active IP Right Cessation
- 2007-05-23 CA CA002654322A patent/CA2654322A1/en not_active Abandoned
- 2007-05-23 SG SG2011057809A patent/SG174066A1/en unknown
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- 2007-05-23 JP JP2009513781A patent/JP5162581B2/ja not_active Expired - Fee Related
- 2007-05-23 AU AU2007258896A patent/AU2007258896B2/en not_active Ceased
- 2007-05-23 CN CN2012102164755A patent/CN102731611A/zh active Pending
- 2007-05-23 UA UAA200900137A patent/UA95959C2/ru unknown
- 2007-05-23 ME MEP-882/08A patent/MEP88208A/xx unknown
- 2007-05-23 KR KR1020087029913A patent/KR20090018103A/ko not_active Abandoned
- 2007-05-23 EP EP11188684A patent/EP2540320A1/en not_active Withdrawn
- 2007-05-24 TW TW096118553A patent/TWI411609B/zh not_active IP Right Cessation
- 2007-06-07 CL CL2007001648A patent/CL2007001648A1/es unknown
- 2007-06-08 AR ARP070102511A patent/AR063668A1/es not_active Application Discontinuation
2008
- 2008-11-17 TN TNP2008000463A patent/TNSN08463A1/en unknown
- 2008-11-20 IL IL195419A patent/IL195419A0/en unknown
- 2008-11-24 US US12/276,568 patent/US7816543B2/en not_active Expired - Fee Related
- 2008-11-25 CR CR10459A patent/CR10459A/es not_active Application Discontinuation
- 2008-11-25 ZA ZA2008/10015A patent/ZA200810015B/en unknown
- 2008-12-03 EC EC2008008936A patent/ECSP088936A/es unknown
- 2008-12-08 GT GT200800277A patent/GT200800277A/es unknown
- 2008-12-09 HN HN2008001788A patent/HN2008001788A/es unknown
- 2008-12-09 NO NO20085127A patent/NO20085127L/no not_active Application Discontinuation
- 2008-12-26 MA MA31515A patent/MA30689B1/fr unknown
2010
- 2010-09-14 US US12/881,792 patent/US20110002947A1/en not_active Abandoned

Also Published As

Publication number	Publication date
IL195419A0 (en)	2009-08-03
TW200812996A (en)	2008-03-16
UA95959C2 (en)	2011-09-26
GT200800277A (es)	2009-06-16
MA30689B1 (fr)	2009-09-01
MX2008015728A (es)	2009-01-09
CL2007001648A1 (es)	2008-01-18
US20110002947A1 (en)	2011-01-06
CN101466409A (zh)	2009-06-24
JP2009539820A (ja)	2009-11-19
AU2007258896A1 (en)	2007-12-21
CN102731611A (zh)	2012-10-17
HK1134240A1 (en)	2010-04-23
EP1864682A1 (en)	2007-12-12
NZ572947A (en)	2011-12-22
EP2540320A1 (en)	2013-01-02
AU2007258896B2 (en)	2013-01-24
KR20090018103A (ko)	2009-02-19
CR10459A (es)	2009-01-09
MY148231A (en)	2013-03-29
WO2007144709A3 (en)	2008-06-12
CA2654322A1 (en)	2007-12-21
US7816543B2 (en)	2010-10-19
ECSP088936A (es)	2009-01-30
EA200870615A1 (ru)	2009-04-28
US20090182038A1 (en)	2009-07-16
TNSN08463A1 (en)	2010-04-14
NO20085127L (no)	2009-01-08
TWI411609B (zh)	2013-10-11
MEP88208A (en)	2011-12-20
HN2008001788A (es)	2012-08-27
SG174066A1 (en)	2011-09-29
EA017345B1 (ru)	2012-11-30
SG174067A1 (en)	2011-09-29
EP2032172B1 (en)	2012-06-06
ZA200810015B (en)	2010-02-24
CN101466409B (zh)	2012-11-21
WO2007144709A2 (en)	2007-12-21
AR063668A1 (es)	2009-02-11
JP5162581B2 (ja)	2013-03-13
EP2032172A2 (en)	2009-03-11

Legal Events

Date	Code	Title	Description
2016-09-20	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 9A ANUIDADE.
2017-01-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.
2018-03-27	B15K	Others concerning applications: alteration of classification	Ipc: A61K 47/68 (2017.01), A61P 35/00 (2006.01)

Publication	Publication Date	Title
EP2032172B1 (en)	2012-06-06	Leptomycin derivatives
EP1651162B1 (en)	2015-10-21	Improved cytotoxic agents comprising new maytansinoids
US8435528B2 (en)	2013-05-07	Cytotoxic agents comprising new maytansinoids
EP1832577A1 (en)	2007-09-12	Improved prodrugs of CC-1065 analogs
KR20230127918A (ko)	2023-09-01	신규 항체 약물 접합체
HK1175787A (en)	2013-07-12	Leptomycin derivatives
HK1134240B (en)	2013-06-28	Leptomycin derivatives
HK40012682A (en)	2020-07-31	Improved cytotoxic agents comprising new maytansinoids
HK40012682B (en)	2021-09-03	Improved cytotoxic agents comprising new maytansinoids
HK1225022A1 (en)	2017-09-01	Improved cytotoxic agents comprising new maytansinoids