BRPI0713330A2 - adjuvantes e métodos de uso - Google Patents

adjuvantes e métodos de uso Download PDF

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Publication number
BRPI0713330A2
BRPI0713330A2 BRPI0713330-8A BRPI0713330A BRPI0713330A2 BR PI0713330 A2 BRPI0713330 A2 BR PI0713330A2 BR PI0713330 A BRPI0713330 A BR PI0713330A BR PI0713330 A2 BRPI0713330 A2 BR PI0713330A2
Authority
BR
Brazil
Prior art keywords
methods
adjuvants
nkt cell
agonist compounds
cell agonist
Prior art date
Application number
BRPI0713330-8A
Other languages
English (en)
Inventor
Teyton Luc
Bendelac Albert
B. Savage Paul
Original Assignee
The Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Scripps Research Institute filed Critical The Scripps Research Institute
Publication of BRPI0713330A2 publication Critical patent/BRPI0713330A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ADJUVANTES E MéTODOS DE USO. Esta invenção fornece composições que compreendem compostos agonistas de células NKT e um veículo fisiologicamente aceitável. Métodos para estimular uma célula NKT e intensificar uma resposta imune também são descritos. São fornecidas ainda preparações de vacinas que compreendem compostos agonistas de células NKT.
BRPI0713330-8A 2006-06-30 2007-06-29 adjuvantes e métodos de uso BRPI0713330A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80633006P 2006-06-30 2006-06-30
US60/806.330 2006-06-30
PCT/US2007/072451 WO2008005824A1 (en) 2006-06-30 2007-06-29 Adjuvants and methods of use

Publications (1)

Publication Number Publication Date
BRPI0713330A2 true BRPI0713330A2 (pt) 2012-04-17

Family

ID=38894900

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0713330-8A BRPI0713330A2 (pt) 2006-06-30 2007-06-29 adjuvantes e métodos de uso

Country Status (8)

Country Link
US (2) US7794722B2 (pt)
EP (1) EP2040541B1 (pt)
JP (1) JP5564672B2 (pt)
AU (1) AU2007269299B2 (pt)
BR (1) BRPI0713330A2 (pt)
CA (1) CA2655947C (pt)
WO (1) WO2008005824A1 (pt)
ZA (1) ZA200900203B (pt)

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US7645873B2 (en) 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
PT1848813E (pt) 2005-01-28 2013-07-15 Scripps Research Inst Activação de glicolípidos bacterianos de células nkt restritas ao cd1d
DK2056842T3 (da) 2006-04-07 2013-01-14 Univ Chicago Modificeret galactosylceramid til behandling af cancerøse sygdomme
IL178821A0 (en) * 2006-05-25 2007-07-04 Ilan Yaron Direct and indirect modulation of composition and structure of cell membrane by ??-glycolipids
EP2040541B1 (en) 2006-06-30 2016-03-23 The Scripps Research Institute Adjuvants and methods of use
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
EP2058011A1 (en) 2007-11-07 2009-05-13 Wittycell Nkt cell activating gycolipids covalently bound antigens and/or drug
RU2537188C2 (ru) * 2007-12-05 2014-12-27 Виттисель Композиции и способы для усиления имунного ответа на антигены
AU2009268937A1 (en) 2008-06-16 2010-01-14 Aj Park Compositions for inducing immune responses specific to Globo H and SSEA3 and uses thereof in cancer treatment
JP5809560B2 (ja) 2008-10-08 2015-11-11 アビヴァックス インフルエンザに対して使用するためのワクチン組成物
KR102458982B1 (ko) 2014-07-24 2022-10-26 라이트벡스 비.브이. 아주반트
TWI745275B (zh) * 2014-09-08 2021-11-11 中央研究院 使用醣脂激活人類ｉＮＫＴ細胞
WO2019190986A1 (en) * 2018-03-26 2019-10-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 3-o-sulfo-galactosylceramide analogs as activators of type ii nkt cells and uses thereof
EP3925963A1 (en) * 2020-06-18 2021-12-22 Helmholtz-Zentrum für Infektionsforschung GmbH Phytosphingosine derivatives as adjuvants in immune stimulation

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ATE115859T1 (de) * 1987-06-26 1995-01-15 Solco Basel Ag Neue pharmazeutische präparate sowie neue lactosylverbindungen und ihre herstellung.
US5242800A (en) * 1990-01-30 1993-09-07 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Receptor for pathogenic fungi
DK84691D0 (da) * 1991-05-07 1991-05-07 Karsten Buschard Visse glycolipider og specifikke catchere for disse til anvendelse ved profylaxe eller terapi af diabetes, og/eller dermed forbundne komplikationer samt anvendelse af saadanne glycolipider til detektion af oe-celle-antistoffer (ica) i et individ og anvendelse af saadanne catchere til detektion af langerhans-oe-celler i pancreas-praeparater
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
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PT1848813E (pt) * 2005-01-28 2013-07-15 Scripps Research Inst Activação de glicolípidos bacterianos de células nkt restritas ao cd1d
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DK2056842T3 (da) 2006-04-07 2013-01-14 Univ Chicago Modificeret galactosylceramid til behandling af cancerøse sygdomme
EP2040541B1 (en) 2006-06-30 2016-03-23 The Scripps Research Institute Adjuvants and methods of use

Also Published As

Publication number Publication date
US20110027323A1 (en) 2011-02-03
EP2040541A4 (en) 2012-08-29
EP2040541B1 (en) 2016-03-23
US20080095787A1 (en) 2008-04-24
CA2655947A1 (en) 2008-01-10
US7794722B2 (en) 2010-09-14
AU2007269299A2 (en) 2009-01-29
WO2008005824A1 (en) 2008-01-10
ZA200900203B (en) 2013-06-26
US8932594B2 (en) 2015-01-13
CA2655947C (en) 2016-08-02
EP2040541A1 (en) 2009-04-01
AU2007269299B2 (en) 2013-01-17
JP2009542712A (ja) 2009-12-03
JP5564672B2 (ja) 2014-07-30
AU2007269299A1 (en) 2008-01-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]