BRPI0717775A2 - Preparação de estansoporfina de alta pureza em larga escala - Google Patents

Preparação de estansoporfina de alta pureza em larga escala

Info

Publication number: BRPI0717775A2
Authority: BR; Brazil
Prior art keywords: stansoporfin; preparation; high purity; purity; scale
Prior art date: 2006-10-04

Application number

BRPI0717775-5A2A

Other languages

English (en)

Inventor

George S Drummond

Robert Caroselli

Keith A Cooke

Daniel Levine

David G Roe

Christopher P Boucher

Original Assignee

Infacare Pharmaceutical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-04

Filing date

2007-10-04

Publication date

2014-04-29

2007-10-04 Application filed by Infacare Pharmaceutical Corp filed Critical Infacare Pharmaceutical Corp

2014-04-29 Publication of BRPI0717775A2 publication Critical patent/BRPI0717775A2/pt

2020-10-13 Publication of BRPI0717775B1 publication Critical patent/BRPI0717775B1/pt

2021-05-25 Publication of BRPI0717775B8 publication Critical patent/BRPI0717775B8/pt

Links

239000000203 mixture Substances 0.000 abstract 2
LLDZJTIZVZFNCM-UHFFFAOYSA-J 3-[18-(2-carboxyethyl)-8,13-diethyl-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;dichlorotin(2+) Chemical compound [H+].[H+].[Cl-].[Cl-].[Sn+4].[N-]1C(C=C2C(=C(C)C(=CC=3C(=C(C)C(=C4)N=3)CC)[N-]2)CCC([O-])=O)=C(CCC([O-])=O)C(C)=C1C=C1C(C)=C(CC)C4=N1 LLDZJTIZVZFNCM-UHFFFAOYSA-J 0.000 abstract 1
229950001307 stannsoporfin Drugs 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2284—Compounds with one or more Sn-N linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

BRPI0717775A 2006-10-04 2007-10-04 preparação de estansoporfina de alta pureza em larga escala BRPI0717775B8 (pt)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US84964106P	2006-10-04	2006-10-04
US60/849,641		2006-10-04
US90460107P	2007-02-28	2007-02-28
US60/904,601		2007-02-28
PCT/US2007/021485 WO2008045377A2 (en)	2006-10-04	2007-10-04	High-purity large-scale preparation of stannsoporfin

Publications (3)

Publication Number	Publication Date
BRPI0717775A2 true BRPI0717775A2 (pt)	2014-04-29
BRPI0717775B1 BRPI0717775B1 (pt)	2020-10-13
BRPI0717775B8 BRPI0717775B8 (pt)	2021-05-25

Family

ID=39144566

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0717775A BRPI0717775B8 (pt)	2006-10-04	2007-10-04	preparação de estansoporfina de alta pureza em larga escala

Country Status (22)

Country	Link
US (9)	US7960371B2 (pt)
EP (3)	EP2992886A1 (pt)
JP (2)	JP5524622B2 (pt)
KR (5)	KR101253541B1 (pt)
CN (2)	CN101573122B (pt)
AT (1)	ATE524187T1 (pt)
AU (1)	AU2007307111B2 (pt)
BR (1)	BRPI0717775B8 (pt)
CA (1)	CA2665075C (pt)
CY (1)	CY1114562T1 (pt)
DK (1)	DK2079472T3 (pt)
EA (2)	EA030262B1 (pt)
ES (1)	ES2556359T3 (pt)
HR (1)	HRP20110746T1 (pt)
IL (4)	IL197838A (pt)
MX (2)	MX2009003530A (pt)
NO (1)	NO20091575L (pt)
NZ (4)	NZ576030A (pt)
PL (1)	PL2079472T3 (pt)
PT (1)	PT2079472E (pt)
RS (1)	RS52185B (pt)
WO (1)	WO2008045377A2 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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US7375216B2 (en)	2002-06-04	2008-05-20	Infacare Pharmaceutical Corporation	Preparation of metal mesoporphyrin compounds
US20060222668A1 (en) *	2005-04-01	2006-10-05	Wellspring Pharmaceutical Corporation	Stannsoporfin compositions, drug products and methods of manufacture
EP2992886A1 (en)	2006-10-04	2016-03-09	InfaCare Pharmaceutical Corporation	High-purity large-scale preparation of stannsoporfin
EP2691398B1 (en)	2011-03-30	2016-09-28	InfaCare Pharmaceutical Corporation	Methods for synthesizing metal mesoporphyrins
KR20140107355A (ko) *	2011-12-01	2014-09-04	인파케어 파마슈티칼 코포레이션	스탠소포르핀을 이용한 고빌리루빈혈증의 치료 방법들
CN103214491B (zh) *	2013-03-13	2016-01-20	南京理工大学	[2,7,12,18-四甲基-3,8-二乙基-13,17-二羧基乙基]-卟啉的制备方法
AU2015324103C1 (en)	2014-09-29	2020-08-20	Fred Hutchinson Cancer Center	Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
RS64652B1 (sr)	2019-02-28	2023-10-31	Renibus Therapeutics Inc	Novi sastavi gvožđa i metode pravljenja i upotrebe istih
US20230167124A1 (en) *	2020-10-02	2023-06-01	Adgero Biopharmaceuticals Holdings, Inc.	Methods for the Production of Nickel (II) Etioporphyrin-I
WO2025165353A1 (en) *	2024-01-31	2025-08-07	Renibus Therapeutics, Inc.	Novel stannic protoporfin compositions, methods of making, and uses thereof

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2007
- 2007-10-04 EP EP15185138.3A patent/EP2992886A1/en not_active Withdrawn
- 2007-10-04 EP EP07839341A patent/EP2079472B1/en active Active
- 2007-10-04 KR KR1020097008733A patent/KR101253541B1/ko not_active Expired - Fee Related
- 2007-10-04 EA EA201400124A patent/EA030262B1/ru not_active IP Right Cessation
- 2007-10-04 MX MX2009003530A patent/MX2009003530A/es active IP Right Grant
- 2007-10-04 RS RS20110455A patent/RS52185B/sr unknown
- 2007-10-04 US US11/867,559 patent/US7960371B2/en active Active
- 2007-10-04 NZ NZ576030A patent/NZ576030A/en not_active IP Right Cessation
- 2007-10-04 BR BRPI0717775A patent/BRPI0717775B8/pt not_active IP Right Cessation
- 2007-10-04 EP EP11176115.1A patent/EP2384756B1/en not_active Not-in-force
- 2007-10-04 MX MX2011007519A patent/MX345035B/es unknown
- 2007-10-04 PL PL07839341T patent/PL2079472T3/pl unknown
- 2007-10-04 KR KR1020127032529A patent/KR101400714B1/ko not_active Expired - Fee Related
- 2007-10-04 KR KR1020147023615A patent/KR101573013B1/ko not_active Expired - Fee Related
- 2007-10-04 DK DK07839341.0T patent/DK2079472T3/da active
- 2007-10-04 ES ES11176115.1T patent/ES2556359T3/es active Active
- 2007-10-04 KR KR1020147002613A patent/KR20140023447A/ko not_active Ceased
- 2007-10-04 AT AT07839341T patent/ATE524187T1/de active
- 2007-10-04 NZ NZ703991A patent/NZ703991A/en not_active IP Right Cessation
- 2007-10-04 EA EA200970344A patent/EA019864B1/ru unknown
- 2007-10-04 CA CA2665075A patent/CA2665075C/en active Active
- 2007-10-04 NZ NZ61567307A patent/NZ615673A/en not_active IP Right Cessation
- 2007-10-04 JP JP2009531482A patent/JP5524622B2/ja not_active Expired - Fee Related
- 2007-10-04 AU AU2007307111A patent/AU2007307111B2/en not_active Ceased
- 2007-10-04 KR KR1020157033361A patent/KR20150138415A/ko not_active Ceased
- 2007-10-04 PT PT07839341T patent/PT2079472E/pt unknown
- 2007-10-04 CN CN200780043624.XA patent/CN101573122B/zh not_active Expired - Fee Related
- 2007-10-04 HR HR20110746T patent/HRP20110746T1/hr unknown
- 2007-10-04 CN CN201410188263.XA patent/CN104116745B/zh not_active Expired - Fee Related
- 2007-10-04 NZ NZ599321A patent/NZ599321A/xx not_active IP Right Cessation
- 2007-10-04 WO PCT/US2007/021485 patent/WO2008045377A2/en not_active Ceased
2009
- 2009-03-26 IL IL197838A patent/IL197838A/en active IP Right Grant
- 2009-04-21 NO NO20091575A patent/NO20091575L/no not_active Application Discontinuation
2010
- 2010-12-15 US US12/968,651 patent/US8530458B2/en not_active Expired - Fee Related
2011
- 2011-10-07 CY CY20111100961T patent/CY1114562T1/el unknown
- 2011-10-27 IL IL215978A patent/IL215978A/en active IP Right Grant
2013
- 2013-09-05 US US14/019,513 patent/US8835416B2/en active Active
- 2013-11-08 JP JP2013232129A patent/JP6195367B2/ja not_active Expired - Fee Related
2014
- 2014-08-14 US US14/460,080 patent/US9107927B2/en not_active Expired - Fee Related
2015
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IL197838A0 (en)	2009-12-24
US8835416B2 (en)	2014-09-16
NZ599321A (en)	2013-09-27
NZ576030A (en)	2012-06-29
JP2010505853A (ja)	2010-02-25
NZ703991A (en)	2016-07-29
HK1132191A1 (en)	2010-02-19
IL248539A0 (en)	2016-12-29
EP2384756B1 (en)	2015-09-16
US20110082292A1 (en)	2011-04-07
KR101573013B1 (ko)	2015-12-04
EP2079472A2 (en)	2009-07-22
WO2008045377A2 (en)	2008-04-17
AU2007307111B2 (en)	2012-03-08
US20080125585A1 (en)	2008-05-29
US20200255458A1 (en)	2020-08-13
US10662209B2 (en)	2020-05-26
CA2665075A1 (en)	2008-04-17
CY1114562T1 (el)	2016-10-05
EA030262B1 (ru)	2018-07-31
CN104116745A (zh)	2014-10-29
KR20140023447A (ko)	2014-02-26
CN101573122A (zh)	2009-11-04
EP2384756A3 (en)	2012-02-22
PT2079472E (pt)	2011-11-24
EP2384756A2 (en)	2011-11-09
CN101573122B (zh)	2016-08-03
US20160000802A1 (en)	2016-01-07
JP5524622B2 (ja)	2014-06-18
KR20090079219A (ko)	2009-07-21
CN104116745B (zh)	2018-07-06
US10273255B2 (en)	2019-04-30
EP2992886A1 (en)	2016-03-09
IL215978A0 (en)	2011-12-29
US20140005380A1 (en)	2014-01-02
KR20130010026A (ko)	2013-01-24
EA019864B1 (ru)	2014-06-30
HRP20110746T1 (hr)	2011-11-30
US11078220B2 (en)	2021-08-03
KR20140114894A (ko)	2014-09-29
KR20150138415A (ko)	2015-12-09
JP2014193839A (ja)	2014-10-09
IL265947A (en)	2019-05-30
PL2079472T3 (pl)	2012-01-31
MX345035B (es)	2017-01-16
EA201400124A1 (ru)	2015-01-30
DK2079472T3 (da)	2011-10-31
KR101400714B1 (ko)	2014-05-30
WO2008045377A3 (en)	2008-06-05
US9902745B2 (en)	2018-02-27
US8530458B2 (en)	2013-09-10
US20170073362A1 (en)	2017-03-16
US9517239B2 (en)	2016-12-13
US9107927B2 (en)	2015-08-18
JP6195367B2 (ja)	2017-09-13
IL197838A (en)	2016-11-30
ES2556359T3 (es)	2016-01-15
HK1162939A1 (en)	2012-09-07
EP2079472B1 (en)	2011-09-14
US20150051184A1 (en)	2015-02-19
NZ615673A (en)	2015-03-27
MX2009003530A (es)	2009-06-26
US20190202846A1 (en)	2019-07-04
KR101253541B1 (ko)	2013-04-15
US7960371B2 (en)	2011-06-14
BRPI0717775B1 (pt)	2020-10-13
EA200970344A1 (ru)	2009-10-30
BRPI0717775B8 (pt)	2021-05-25
ATE524187T1 (de)	2011-09-15
CA2665075C (en)	2014-03-18
RS52185B (sr)	2012-10-31
US20180134735A1 (en)	2018-05-17
AU2007307111A1 (en)	2008-04-17
NO20091575L (no)	2009-07-02
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