BRPI0718145B8 - método de micronização - Google Patents
método de micronizaçãoInfo
- Publication number
- BRPI0718145B8 BRPI0718145B8 BRPI0718145A BRPI0718145A BRPI0718145B8 BR PI0718145 B8 BRPI0718145 B8 BR PI0718145B8 BR PI0718145 A BRPI0718145 A BR PI0718145A BR PI0718145 A BRPI0718145 A BR PI0718145A BR PI0718145 B8 BRPI0718145 B8 BR PI0718145B8
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- dispersion
- bars
- hour
- biological activity
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 239000006185 dispersion Substances 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- 230000004071 biological effect Effects 0.000 abstract 2
- 238000003801 milling Methods 0.000 abstract 2
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000000227 grinding Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000005549 size reduction Methods 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/06—Jet mills
- B02C19/061—Jet mills of the cylindrical type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/06—Jet mills
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Disintegrating Or Milling (AREA)
- Medicinal Preparation (AREA)
Abstract
método de micronização a invenção refere-se a um método para a micronização de uma dispersão de partículas compreendendo uma proteína apresentando um nível preddeterminado de atividade biológica. o método compreende a introdução da dispersão em um aparelho de moagem com câmara de vórtice sob condições de moagem o que resulta em um pó de proteína apresentando uma distribuição de tamanho de partícula de 5 a 100 mim e/ou exibindo uma redução de tamanho de 30 a 400 vezes da dispersão de partícula de proteína a partir de seu tamanho original, e mantendo pelo menos 80% do nível predeterminado da atividade biológica da proteína . as condições de moagem inciuem um ou mais parâmetros selecionados dos seguintes: pressão de entrada entre 1 e 7 bars; pressão no injetor entre 0,2 e 5 bars; taxa de carga entre 0,1 e 5 kg/hora; e fluxo de gás entre 30 e 100 m3/hora.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85604206P | 2006-11-02 | 2006-11-02 | |
| PCT/IL2007/001318 WO2008053475A1 (en) | 2006-11-02 | 2007-10-30 | Method of micronization |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0718145A2 BRPI0718145A2 (pt) | 2013-11-05 |
| BRPI0718145B1 BRPI0718145B1 (pt) | 2020-12-08 |
| BRPI0718145B8 true BRPI0718145B8 (pt) | 2021-05-25 |
Family
ID=38988026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0718145A BRPI0718145B8 (pt) | 2006-11-02 | 2007-10-30 | método de micronização |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8322637B2 (pt) |
| EP (1) | EP2106296B1 (pt) |
| JP (1) | JP5373618B2 (pt) |
| KR (1) | KR101411933B1 (pt) |
| CN (1) | CN101534952B (pt) |
| AU (1) | AU2007315724B2 (pt) |
| BR (1) | BRPI0718145B8 (pt) |
| CA (1) | CA2667969C (pt) |
| ES (1) | ES2649755T3 (pt) |
| RU (1) | RU2443413C2 (pt) |
| TW (1) | TWI411450B (pt) |
| WO (1) | WO2008053475A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2322279B1 (en) | 2009-11-17 | 2016-05-11 | Biohyst Overseas Sagl | Biomass crushing and separating device |
| WO2011092694A2 (en) | 2010-01-28 | 2011-08-04 | Omrix Biopharmaceuticals Ltd. | Method for improved fibrin sealing |
| US8846849B2 (en) | 2011-05-13 | 2014-09-30 | Ethicon, Inc. | Tissue sealants from plasma derived proteins |
| US9056092B2 (en) * | 2011-12-02 | 2015-06-16 | Ethicon, Inc. | Hemostatic bioabsorbable device with polyethylene glycol binder |
| CA3078563A1 (en) | 2011-12-29 | 2013-07-04 | Omrix Biopharmaceuticals Ltd. | Method and device for fast dissolution of solid protein composition |
| JP2014200721A (ja) * | 2013-04-02 | 2014-10-27 | 茂明 丸尾 | ジェットミル装置 |
| US10532093B2 (en) * | 2014-07-18 | 2020-01-14 | Mds Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Thermostable freeze dried rotavirus vaccine formulation and process to prepare thereof |
| CN107413489B (zh) * | 2017-04-26 | 2019-11-12 | 阜阳市鑫源建材有限公司 | 一种利用超临界二氧化碳制备超细矿渣粉的方法 |
| US20250073313A1 (en) | 2021-12-21 | 2025-03-06 | Omrix Biopharmaceuticals Ltd. | Highly soluble fibrinogen compositions |
| CN116942532B (zh) * | 2023-09-20 | 2023-12-12 | 北京爱力佳医药科技有限公司 | 一种粉状药物制备装置 |
| CN117244668B (zh) * | 2023-11-17 | 2024-03-22 | 哈尔滨瀚邦医疗科技有限公司 | 一种生物止血材料粉碎筛选系统 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4502641A (en) * | 1981-04-29 | 1985-03-05 | E. I. Du Pont De Nemours And Company | Fluid energy mill with differential pressure means |
| CN1013648B (zh) * | 1986-06-27 | 1991-08-28 | 匈牙利铝工业托拉斯 | 一种气流粉碎机 |
| US5021554A (en) * | 1989-02-24 | 1991-06-04 | Eli Lilly And Company | Process for protein particle size reduction using a fluid-energy mill |
| CN1031450C (zh) * | 1989-05-15 | 1996-04-03 | 佳能株式会社 | 气流分级器，制备色料的方法和装置 |
| EP0534178B1 (en) | 1991-09-27 | 2001-04-18 | Omrix Biopharmaceuticals S.A. | Improved tissue glue prepared by using cryoprecipitate |
| ATE146359T1 (de) * | 1992-01-21 | 1997-01-15 | Stanford Res Inst Int | Verbessertes verfahren zur herstellung von mikronisierter polypeptidarzneimitteln |
| RU2029621C1 (ru) | 1992-10-12 | 1995-02-27 | Владимир Николаевич Сорокин | Способ вихревого измельчения материала |
| US5855326A (en) * | 1997-05-23 | 1999-01-05 | Super Fine Ltd. | Process and device for controlled cominution of materials in a whirl chamber |
| AU2002314081B2 (en) | 2001-05-21 | 2007-04-05 | Omrix Biopharmaceuticals S.A. | Removal pf plasmin(Ogen) from protein solutions |
| US6789756B2 (en) * | 2002-02-20 | 2004-09-14 | Super Fine Ltd. | Vortex mill for controlled milling of particulate solids |
| GB0219815D0 (en) * | 2002-08-24 | 2002-10-02 | Accentus Plc | Preparation of small crystals |
| US20040121003A1 (en) * | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
| CN1295021C (zh) * | 2004-04-15 | 2007-01-17 | 杨富茂 | 机械湍流磨 |
-
2007
- 2007-10-30 CN CN2007800410729A patent/CN101534952B/zh active Active
- 2007-10-30 KR KR1020097008701A patent/KR101411933B1/ko active Active
- 2007-10-30 CA CA2667969A patent/CA2667969C/en active Active
- 2007-10-30 TW TW096141122A patent/TWI411450B/zh not_active IP Right Cessation
- 2007-10-30 WO PCT/IL2007/001318 patent/WO2008053475A1/en not_active Ceased
- 2007-10-30 JP JP2009535879A patent/JP5373618B2/ja active Active
- 2007-10-30 BR BRPI0718145A patent/BRPI0718145B8/pt not_active IP Right Cessation
- 2007-10-30 EP EP07827292.9A patent/EP2106296B1/en active Active
- 2007-10-30 AU AU2007315724A patent/AU2007315724B2/en active Active
- 2007-10-30 US US12/312,221 patent/US8322637B2/en active Active
- 2007-10-30 RU RU2009119390/15A patent/RU2443413C2/ru active
- 2007-10-30 ES ES07827292.9T patent/ES2649755T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2667969C (en) | 2014-10-14 |
| CN101534952A (zh) | 2009-09-16 |
| RU2443413C2 (ru) | 2012-02-27 |
| JP5373618B2 (ja) | 2013-12-18 |
| EP2106296A1 (en) | 2009-10-07 |
| US8322637B2 (en) | 2012-12-04 |
| WO2008053475A1 (en) | 2008-05-08 |
| TWI411450B (zh) | 2013-10-11 |
| US20100068196A1 (en) | 2010-03-18 |
| AU2007315724B2 (en) | 2012-04-12 |
| BRPI0718145A2 (pt) | 2013-11-05 |
| AU2007315724A1 (en) | 2008-05-08 |
| ES2649755T3 (es) | 2018-01-15 |
| TW200826973A (en) | 2008-07-01 |
| EP2106296B1 (en) | 2017-09-06 |
| JP2010509047A (ja) | 2010-03-25 |
| KR101411933B1 (ko) | 2014-06-27 |
| BRPI0718145B1 (pt) | 2020-12-08 |
| KR20090076945A (ko) | 2009-07-13 |
| RU2009119390A (ru) | 2010-12-10 |
| CN101534952B (zh) | 2012-10-31 |
| CA2667969A1 (en) | 2008-05-08 |
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Legal Events
| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/12/2020, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/10/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 17A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2798 DE 20-08-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |