BRPI0718429A2 - Suspensões aquosas farmacêuticas contendo o rebamipide e processo para a fabricação das mesmas - Google Patents

Suspensões aquosas farmacêuticas contendo o rebamipide e processo para a fabricação das mesmas

Info

Publication number
BRPI0718429A2
BRPI0718429A2 BRPI0718429-8A2A BRPI0718429A BRPI0718429A2 BR PI0718429 A2 BRPI0718429 A2 BR PI0718429A2 BR PI0718429 A BRPI0718429 A BR PI0718429A BR PI0718429 A2 BRPI0718429 A2 BR PI0718429A2
Authority
BR
Brazil
Prior art keywords
manufacturing
same
suspensions containing
water suspensions
pharmaceutical water
Prior art date
Application number
BRPI0718429-8A2A
Other languages
English (en)
Inventor
Yoshito Masuda
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BRPI0718429A2 publication Critical patent/BRPI0718429A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0718429-8A2A 2006-10-26 2007-10-24 Suspensões aquosas farmacêuticas contendo o rebamipide e processo para a fabricação das mesmas BRPI0718429A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006291535 2006-10-26
PCT/JP2007/071167 WO2008050896A1 (en) 2006-10-26 2007-10-24 Aqueous pharmaceutical suspensions containing rebamipide and manufacturing process thereof

Publications (1)

Publication Number Publication Date
BRPI0718429A2 true BRPI0718429A2 (pt) 2013-11-12

Family

ID=39324676

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0718429-8A2A BRPI0718429A2 (pt) 2006-10-26 2007-10-24 Suspensões aquosas farmacêuticas contendo o rebamipide e processo para a fabricação das mesmas

Country Status (19)

Country Link
US (1) US8772317B2 (pt)
EP (1) EP2077840A4 (pt)
JP (1) JP5250551B2 (pt)
KR (2) KR101491965B1 (pt)
CN (1) CN101528229B (pt)
AR (1) AR063366A1 (pt)
AU (1) AU2007309968B2 (pt)
BR (1) BRPI0718429A2 (pt)
CA (1) CA2665024C (pt)
IL (1) IL197950A0 (pt)
MX (1) MX2009004433A (pt)
MY (1) MY148303A (pt)
NZ (1) NZ576224A (pt)
RU (1) RU2467751C2 (pt)
SG (1) SG175628A1 (pt)
TW (1) TWI415629B (pt)
UA (1) UA95989C2 (pt)
WO (1) WO2008050896A1 (pt)
ZA (1) ZA200902778B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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TW200808375A (en) 2006-05-12 2008-02-16 Otsuka Pharma Co Ltd Hydrogel suspension and manufacturing process thereof
AU2009261101B2 (en) * 2008-06-19 2013-11-07 Otsuka Pharmaceutical Co., Ltd. A pharmaceutical composition comprising rebamipide
US20140010882A1 (en) * 2011-03-24 2014-01-09 Takakuni Matsuda Pharmaceutical composition for treating a disease in the oral cavity comprising rebamipide
CN102240260B (zh) * 2011-05-17 2012-05-23 山东省医疗器械研究所 一种治疗阴道干涩症的药物及其制备方法
TW201322982A (zh) 2011-11-01 2013-06-16 Otsuka Pharma Co Ltd 用於治療前眼疾病之藥劑，該藥劑包含瑞巴派特及眼淚保持劑
JP6170077B2 (ja) * 2012-02-16 2017-07-26 エータイアー ファーマ， インコーポレイテッド 自己免疫および炎症疾患を処置するためのヒスチジルｔＲＮＡ合成酵素
AR090775A1 (es) * 2012-04-23 2014-12-03 Otsuka Pharma Co Ltd Preparado inyectable
TW201536287A (zh) * 2013-09-05 2015-10-01 Otsuka Pharma Co Ltd 瑞巴派特的局部止血用途
CN104586762A (zh) * 2014-04-11 2015-05-06 广州仁恒医药科技有限公司 含有瑞巴派特的药物组合物及其制备方法
CN103976946A (zh) * 2014-05-20 2014-08-13 广州艾格生物科技有限公司 一种含有水溶性高分子聚合物的瑞巴派特混悬滴眼液及其制备方法
JP6854587B2 (ja) * 2015-04-17 2021-04-07 ロート製薬株式会社 医薬製剤
JP7324566B2 (ja) * 2015-05-28 2023-08-10 ロート製薬株式会社 水性眼科組成物
CN105147606A (zh) * 2015-08-18 2015-12-16 广州仁恒医药科技有限公司 一种瑞巴派特水悬浮液的制备方法
KR101718733B1 (ko) 2015-08-21 2017-03-22 국제약품 주식회사 레바미피드의 가용화 방법 및 이에 의해 제조된 안구건조증 치료용 액제
KR20170039347A (ko) 2015-10-01 2017-04-11 삼진제약주식회사 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법
KR102307958B1 (ko) 2015-10-01 2021-10-05 삼진제약주식회사 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법
JP2017109996A (ja) * 2015-12-11 2017-06-22 日本合成化学工業株式会社 結晶成長抑制剤
CN107349181B (zh) * 2016-05-09 2021-02-19 四川科伦药物研究院有限公司 含有瑞巴派特和聚维酮的眼科水悬浮液及其制备方法
KR101923519B1 (ko) * 2018-06-26 2019-02-27 대우제약 주식회사 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법
KR20200019451A (ko) 2018-08-14 2020-02-24 대우제약 주식회사 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법
WO2021199813A1 (ja) * 2020-03-31 2021-10-07 参天製薬株式会社 レバミピドまたはその塩および高分子を含有する水性懸濁液
KR102659338B1 (ko) 2023-05-18 2024-04-19 국제약품 주식회사 안구건조증 치료용 약제학적 조성물
KR102857592B1 (ko) * 2024-12-06 2025-09-09 피투케이바이오 주식회사 사이클로스포린 및 레바미피드를 포함하는 점안액 조성물 및 이의 제조 방법

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DE3856173D1 (de) * 1987-10-21 1998-06-10 Siemens Ag Verfahren zum Herstellen eines Bipolartransistors mit isolierter Gateelektrode
US5188826A (en) * 1988-02-08 1993-02-23 Insite Vision Incorporated Topical ophthalmic suspensions
ATE145328T1 (de) * 1991-03-27 1996-12-15 Senju Pharma Co Verfahren zur herstellung einer wässrigen suspension
US5540930A (en) * 1993-10-25 1996-07-30 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment
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US5576311A (en) * 1994-11-30 1996-11-19 Pharmos Corporation Cyclodextrins as suspending agents for pharmaceutical suspensions
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AR004214A1 (es) * 1995-10-12 1998-11-04 Otsuka Pharma Co Ltd Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
JP3402195B2 (ja) 1997-05-14 2003-04-28 千寿製薬株式会社 再分散性の良い水性懸濁液剤
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TW200613006A (en) 2004-09-10 2006-05-01 Otsuka Pharma Co Ltd Rebamipide preparation for rectal administration to be prepared before using
TWI363626B (en) * 2004-11-15 2012-05-11 Otsuka Pharma Co Ltd Aqueous ophthalmic suspension of crystalline rebamipide
TW200808375A (en) * 2006-05-12 2008-02-16 Otsuka Pharma Co Ltd Hydrogel suspension and manufacturing process thereof

Also Published As

Publication number Publication date
MY148303A (en) 2013-03-29
RU2009119717A (ru) 2010-12-10
US20100029714A1 (en) 2010-02-04
UA95989C2 (uk) 2011-09-26
WO2008050896A1 (en) 2008-05-02
EP2077840A1 (en) 2009-07-15
KR101491965B1 (ko) 2015-02-10
JP5250551B2 (ja) 2013-07-31
MX2009004433A (es) 2009-05-08
HK1133188A1 (en) 2010-03-19
TW200822936A (en) 2008-06-01
CA2665024C (en) 2015-04-07
RU2467751C2 (ru) 2012-11-27
CA2665024A1 (en) 2008-05-02
CN101528229A (zh) 2009-09-09
CN101528229B (zh) 2012-07-04
EP2077840A4 (en) 2010-08-11
KR20140088228A (ko) 2014-07-09
IL197950A0 (en) 2009-12-24
KR20090073248A (ko) 2009-07-02
AU2007309968B2 (en) 2012-09-06
JP2010507566A (ja) 2010-03-11
AU2007309968A1 (en) 2008-05-02
SG175628A1 (en) 2011-11-28
AR063366A1 (es) 2009-01-21
TWI415629B (zh) 2013-11-21
US8772317B2 (en) 2014-07-08
NZ576224A (en) 2010-12-24
ZA200902778B (en) 2010-02-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]