BRPI0718633A2 - Mutante de trombina, polinucleotídeo, vetor recombinante, transformante, método para produzir um mutante de trombina, e, composição farmacêutica. - Google Patents

Mutante de trombina, polinucleotídeo, vetor recombinante, transformante, método para produzir um mutante de trombina, e, composição farmacêutica.

Info

Publication number
BRPI0718633A2
BRPI0718633A2 BRPI0718633-9A2A BRPI0718633A BRPI0718633A2 BR PI0718633 A2 BRPI0718633 A2 BR PI0718633A2 BR PI0718633 A BRPI0718633 A BR PI0718633A BR PI0718633 A2 BRPI0718633 A2 BR PI0718633A2
Authority
BR
Brazil
Prior art keywords
thrombin mutant
polynucleotide
transformer
producing
pharmaceutical composition
Prior art date
Application number
BRPI0718633-9A2A
Other languages
English (en)
Inventor
Kazuya Hosokawa
Tomoko Wada
Original Assignee
Chisso Corp
Fujimori Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chisso Corp, Fujimori Kogyo Co Ltd filed Critical Chisso Corp
Publication of BRPI0718633A2 publication Critical patent/BRPI0718633A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
BRPI0718633-9A2A 2006-11-15 2007-11-15 Mutante de trombina, polinucleotídeo, vetor recombinante, transformante, método para produzir um mutante de trombina, e, composição farmacêutica. BRPI0718633A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006309007 2006-11-15
PCT/JP2007/072169 WO2008059917A1 (en) 2006-11-15 2007-11-15 Thrombin mutant

Publications (1)

Publication Number Publication Date
BRPI0718633A2 true BRPI0718633A2 (pt) 2013-11-19

Family

ID=39401721

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0718633-9A2A BRPI0718633A2 (pt) 2006-11-15 2007-11-15 Mutante de trombina, polinucleotídeo, vetor recombinante, transformante, método para produzir um mutante de trombina, e, composição farmacêutica.

Country Status (10)

Country Link
US (1) US8088372B2 (pt)
EP (2) EP2093290A4 (pt)
JP (1) JPWO2008059917A1 (pt)
KR (1) KR20090081388A (pt)
CN (1) CN101535479A (pt)
AU (1) AU2007320353A1 (pt)
BR (1) BRPI0718633A2 (pt)
CA (1) CA2669641A1 (pt)
RU (1) RU2009122486A (pt)
WO (1) WO2008059917A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009086552A1 (en) * 2008-01-02 2009-07-09 The Trustees Of The University Of Pennsylvania Targeting recombinant therapeutics to circulating red blood cells
AU2024217941B2 (en) * 2023-02-07 2026-02-05 Hunan Jiudian Pharmaceutical Co., Ltd Polypeptide and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688768A (en) 1991-02-19 1997-11-18 Cor Therapeutics, Inc. Recombinant thrombin receptor and related pharmaceuticals
US5256766A (en) 1991-02-19 1993-10-26 The Regents Of The University Of California Recombinant thrombin receptor and related pharmaceuticals
AU1096595A (en) 1993-11-12 1995-05-29 Gilead Sciences, Inc. Thrombin mutants
AT404357B (de) 1995-06-13 1998-11-25 Immuno Ag Prothrombin-derivate
CA2560247A1 (en) * 2004-03-19 2005-09-29 Chisso Corporation Thrombin derivative and pharmaceutical composition containing the same

Also Published As

Publication number Publication date
KR20090081388A (ko) 2009-07-28
EP2399994A1 (en) 2011-12-28
EP2093290A4 (en) 2010-03-24
RU2009122486A (ru) 2010-12-20
WO2008059917A1 (en) 2008-05-22
AU2007320353A1 (en) 2008-05-22
CN101535479A (zh) 2009-09-16
US20100040597A1 (en) 2010-02-18
US8088372B2 (en) 2012-01-03
JPWO2008059917A1 (ja) 2010-03-04
CA2669641A1 (en) 2008-05-22
EP2093290A1 (en) 2009-08-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2277 DE 26/08/2014.

B25B Requested transfer of rights rejected

Owner name: CHISSO CORPORATION (JP) , FUJIMORI KOGYO CO., LTD.