BRPI0718999A2 - Pirazois substituídos, composições que os contêm, processo de produção e utilização - Google Patents

Pirazois substituídos, composições que os contêm, processo de produção e utilização

Info

Publication number
BRPI0718999A2
BRPI0718999A2 BRPI0718999-0A2A BRPI0718999A BRPI0718999A2 BR PI0718999 A2 BRPI0718999 A2 BR PI0718999A2 BR PI0718999 A BRPI0718999 A BR PI0718999A BR PI0718999 A2 BRPI0718999 A2 BR PI0718999A2
Authority
BR
Brazil
Prior art keywords
pirazois
replaced
production
compositions containing
use process
Prior art date
Application number
BRPI0718999-0A2A
Other languages
English (en)
Inventor
Kirsten Bjergarde
Mark Dodson
Jacques Mauger
Anil Nair
Marcel Patek
Michel Tabart
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0718999A2 publication Critical patent/BRPI0718999A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0718999-0A2A 2006-11-10 2007-11-09 Pirazois substituídos, composições que os contêm, processo de produção e utilização BRPI0718999A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0609812A FR2908409B1 (fr) 2006-11-10 2006-11-10 Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation
PCT/FR2007/001851 WO2008065282A2 (fr) 2006-11-10 2007-11-09 Pyrazoles substituees, compositions les contenant, procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
BRPI0718999A2 true BRPI0718999A2 (pt) 2014-02-25

Family

ID=38169388

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0718999-0A2A BRPI0718999A2 (pt) 2006-11-10 2007-11-09 Pirazois substituídos, composições que os contêm, processo de produção e utilização

Country Status (39)

Country Link
US (3) US7989439B2 (pt)
EP (1) EP2091920B1 (pt)
JP (1) JP5538893B2 (pt)
KR (1) KR20090083456A (pt)
CN (1) CN101553473B (pt)
AR (1) AR063638A1 (pt)
AU (1) AU2007327423B2 (pt)
BR (1) BRPI0718999A2 (pt)
CA (1) CA2667846A1 (pt)
CL (1) CL2007003251A1 (pt)
CO (1) CO6190516A2 (pt)
CR (1) CR10749A (pt)
CY (1) CY1116000T1 (pt)
DK (1) DK2091920T3 (pt)
DO (1) DOP2009000088A (pt)
EA (1) EA019454B1 (pt)
EC (1) ECSP099312A (pt)
ES (1) ES2528385T3 (pt)
FR (1) FR2908409B1 (pt)
HN (1) HN2009000856A (pt)
HR (1) HRP20150070T1 (pt)
IL (1) IL198328A0 (pt)
MA (1) MA30972B1 (pt)
MX (1) MX2009004983A (pt)
MY (1) MY147502A (pt)
NI (1) NI200900078A (pt)
NO (1) NO20091990L (pt)
NZ (1) NZ576709A (pt)
PE (2) PE20081162A1 (pt)
PL (1) PL2091920T3 (pt)
PT (1) PT2091920E (pt)
SI (1) SI2091920T1 (pt)
SV (1) SV2009003253A (pt)
TN (1) TN2009000155A1 (pt)
TW (1) TW200829556A (pt)
UA (1) UA97965C2 (pt)
UY (1) UY30707A1 (pt)
WO (1) WO2008065282A2 (pt)
ZA (1) ZA200903560B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858323B2 (en) * 2004-06-09 2010-12-28 The Regents Of The University Of Michigan Phage microarray profiling of the humoral response to disease
FR2947546B1 (fr) * 2009-07-03 2011-07-01 Sanofi Aventis Derives de pyrazoles, leur preparation et leur application en therapeutique
UY33200A (es) * 2010-01-26 2011-08-31 Sanofi Aventis Derivados de ácido 3-heteroaroilamino-propiónico sustituidos con oxígeno y su uso como productos farmacéuticos
TWI523844B (zh) * 2011-01-26 2016-03-01 賽諾菲公司 經胺基取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途
CN102432639B (zh) * 2011-09-30 2013-11-06 山东大学 1-(2-羟基-3-(苯氨基)丙基)-3-二茂铁基-1h-吡唑-5-甲酸乙酯化合物及其应用
US20150291554A1 (en) 2012-11-02 2015-10-15 Pfizer Inc. Bruton's Tyrosine Kinase Inhibitors
EP3274344B1 (en) * 2015-03-25 2019-04-24 Novartis Ag Formylated n-heterocyclic derivatives as fgfr4 inhibitors
CN107619388A (zh) * 2016-07-13 2018-01-23 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
CN107840842A (zh) 2016-09-19 2018-03-27 北京天诚医药科技有限公司 炔代杂环化合物、其制备方法及其在医药学上的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
JP2004538266A (ja) * 2001-04-27 2004-12-24 バーテックス　ファーマシューティカルズ　インコーポレイテッド ピラゾール由来のキナーゼインヒビター
RU2005135337A (ru) * 2003-04-16 2006-06-10 Астразенека Аб (Se) Производные хиназолина для лечения злокачественного новообразования
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
EP2256106B1 (en) * 2003-07-22 2015-05-06 Astex Therapeutics Limited 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators
JP2008505167A (ja) * 2004-07-05 2008-02-21 アステックス、セラピューティックス、リミテッド 医薬組成物
US20080261952A1 (en) * 2004-08-16 2008-10-23 Jason Bloxham Aryl Urea Derivatives for Treating Obesity
EP1836188A1 (en) * 2004-12-30 2007-09-26 Astex Therapeutics Limited Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
AR052559A1 (es) * 2005-01-21 2007-03-21 Astex Therapeutics Ltd Derivados de pirazol para inhibir cdk's y gsk's
WO2006077425A1 (en) * 2005-01-21 2006-07-27 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors and further antitumor agents
EP1683796A1 (en) * 2005-01-24 2006-07-26 Schering Aktiengesellschaft Pyrazolopyridines, their preparation and their medical use
FR2947546B1 (fr) * 2009-07-03 2011-07-01 Sanofi Aventis Derives de pyrazoles, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
CN101553473B (zh) 2013-06-05
US8410286B2 (en) 2013-04-02
MX2009004983A (es) 2009-05-22
JP5538893B2 (ja) 2014-07-02
NO20091990L (no) 2009-06-02
UA97965C2 (ru) 2012-04-10
TN2009000155A1 (fr) 2010-10-18
FR2908409B1 (fr) 2009-01-09
ES2528385T3 (es) 2015-02-09
WO2008065282A2 (fr) 2008-06-05
US7989439B2 (en) 2011-08-02
EA019454B1 (ru) 2014-03-31
HRP20150070T1 (hr) 2015-02-27
AR063638A1 (es) 2009-02-04
TW200829556A (en) 2008-07-16
SI2091920T1 (sl) 2015-02-27
CR10749A (es) 2009-07-23
NI200900078A (es) 2010-01-27
US8420824B2 (en) 2013-04-16
KR20090083456A (ko) 2009-08-03
AU2007327423B2 (en) 2012-09-06
PE20081162A1 (es) 2008-10-02
WO2008065282A3 (fr) 2008-07-31
US20090291984A1 (en) 2009-11-26
CN101553473A (zh) 2009-10-07
PT2091920E (pt) 2015-02-05
IL198328A0 (en) 2010-02-17
ECSP099312A (es) 2009-06-30
EA200970472A1 (ru) 2009-10-30
AU2007327423A1 (en) 2008-06-05
CL2007003251A1 (es) 2009-08-07
MA30972B1 (fr) 2009-12-01
CO6190516A2 (es) 2010-08-19
DK2091920T3 (en) 2015-01-26
ZA200903560B (en) 2010-08-25
EP2091920B1 (fr) 2014-10-22
HN2009000856A (es) 2011-10-19
US20110237801A1 (en) 2011-09-29
HK1137988A1 (en) 2010-08-13
SV2009003253A (es) 2009-10-27
MY147502A (en) 2012-12-14
JP2010509297A (ja) 2010-03-25
FR2908409A1 (fr) 2008-05-16
NZ576709A (en) 2011-08-26
UY30707A1 (es) 2008-07-03
CA2667846A1 (fr) 2008-06-05
PL2091920T3 (pl) 2015-04-30
CY1116000T1 (el) 2017-01-25
EP2091920A2 (fr) 2009-08-26
US20110237641A1 (en) 2011-09-29
PE20121152A1 (es) 2012-09-07
DOP2009000088A (es) 2013-06-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.