BRPI0720035A2 - métodos para tratar um paciente tendo uma doença ou distúrbio, para tratar um paciente com doença autoimune, para neutralizar um perfil de expressão do marcador pd indutível por ifn do tipo 1 ou ifnalfa em um paciente, para monitorar ou prognosticar progressão de doença autoimune de um paciente, para monitorar a progressão da doença de um paciente que recebe o tratamento com um agente terapêutico que liga-se a e modula a atividade de ifnalfa, para identificar um paciente como um candidato para um agente terapêutico que liga-se a e modula a atividade de ifnalfa, para diagnosticar um paciente como tendo um distùrbio associado com níveis aumentados de ifnalfa, para identificar um terapêutico candidato para o tratamento de distùrbios mediados por ifnalfa e para detectar atividade de ifn em uma amostra, conjunto de sondas, e, kit - Google Patents

métodos para tratar um paciente tendo uma doença ou distúrbio, para tratar um paciente com doença autoimune, para neutralizar um perfil de expressão do marcador pd indutível por ifn do tipo 1 ou ifnalfa em um paciente, para monitorar ou prognosticar progressão de doença autoimune de um paciente, para monitorar a progressão da doença de um paciente que recebe o tratamento com um agente terapêutico que liga-se a e modula a atividade de ifnalfa, para identificar um paciente como um candidato para um agente terapêutico que liga-se a e modula a atividade de ifnalfa, para diagnosticar um paciente como tendo um distùrbio associado com níveis aumentados de ifnalfa, para identificar um terapêutico candidato para o tratamento de distùrbios mediados por ifnalfa e para detectar atividade de ifn em uma amostra, conjunto de sondas, e, kit

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Publication number
BRPI0720035A2
BRPI0720035A2 BRPI0720035-8A BRPI0720035A BRPI0720035A2 BR PI0720035 A2 BRPI0720035 A2 BR PI0720035A2 BR PI0720035 A BRPI0720035 A BR PI0720035A BR PI0720035 A2 BRPI0720035 A2 BR PI0720035A2
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BR
Brazil
Prior art keywords
patient
ifnalfa
activity
binds
modulates
Prior art date
Application number
BRPI0720035-8A
Other languages
English (en)
Inventor
Yao Yihong
Jallal Bahija
Cibotti Ricardo
Coyle Anthony
Keiner Peter
Original Assignee
Medimmune, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune, Llc filed Critical Medimmune, Llc
Publication of BRPI0720035A2 publication Critical patent/BRPI0720035A2/pt

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

método para identificar um paciente como um candidato para um agente terapêutico que liga-se a e modula a atividade de ifnalfa a presente invenção abrange perfis de expressão do marcador pd induzido por ifn tipo 1 e ifnalfa, kits e métodos para a identificação de tais perfis de expressão do marcador pd induzido por ifnalfa. os perfis de expressão do marcador pd induzido por ifn tipo 1 e ifna também podem ser usados, por exemplo, em métodos de tratar pacientes tendo um distúrbio mediado por ifn do tipo 1 ou ifnalfa, métodos de monitorar a progressão da doença de pacientes que recebem o tratamento com um agente terapêutico que liga-se a e modula a atividade de ifna, identificação de pacientes como candidatos a receber um terapêutico que liga-se a e neutraliza atividade de ifna e em diagnosticar ou fornecer um prognóstico a pacientes tendo distúrbios induzidos por ifnalfa.
BRPI0720035-8A 2006-12-06 2007-12-06 métodos para tratar um paciente tendo uma doença ou distúrbio, para tratar um paciente com doença autoimune, para neutralizar um perfil de expressão do marcador pd indutível por ifn do tipo 1 ou ifnalfa em um paciente, para monitorar ou prognosticar progressão de doença autoimune de um paciente, para monitorar a progressão da doença de um paciente que recebe o tratamento com um agente terapêutico que liga-se a e modula a atividade de ifnalfa, para identificar um paciente como um candidato para um agente terapêutico que liga-se a e modula a atividade de ifnalfa, para diagnosticar um paciente como tendo um distùrbio associado com níveis aumentados de ifnalfa, para identificar um terapêutico candidato para o tratamento de distùrbios mediados por ifnalfa e para detectar atividade de ifn em uma amostra, conjunto de sondas, e, kit BRPI0720035A2 (pt)

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
US87300806P 2006-12-06 2006-12-06
US60/873008 2006-12-06
US90776207P 2007-04-16 2007-04-16
US90776707P 2007-04-16 2007-04-16
US60/907767 2007-04-16
US60/907762 2007-04-16
US92421907P 2007-05-03 2007-05-03
US92422007P 2007-05-03 2007-05-03
US60/924219 2007-05-03
US60/924220 2007-05-03
US92458407P 2007-05-21 2007-05-21
US60/924584 2007-05-21
US96018707P 2007-09-19 2007-09-19
US60/960187 2007-09-19
US99617607P 2007-11-05 2007-11-05
US99617407P 2007-11-05 2007-11-05
US60/996174 2007-11-05
US60/996176 2007-11-05
US99621907P 2007-11-06 2007-11-06
US60/996219 2007-11-06
US99682007P 2007-12-06 2007-12-06
PCT/US2007/024947 WO2008070137A2 (en) 2006-12-06 2007-12-06 Interferon alpha-induced pharmacodynamic markers
PCT/US2007/024941 WO2008070135A2 (en) 2006-12-06 2007-12-06 Methods of treating systemic lupus erythematosus
US60/996820 2007-12-06
USPCT/US2007/024941 2007-12-06

Publications (1)

Publication Number Publication Date
BRPI0720035A2 true BRPI0720035A2 (pt) 2019-05-07

Family

ID=39492862

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0719912-0A2A BRPI0719912A2 (pt) 2006-12-06 2007-12-06 Método para tratar lupus eritematoso sistêmico, e, método para reduzir elevações passageiras de índice de atividade da doença lupus eritematoso sistêmico
BRPI0720035-8A BRPI0720035A2 (pt) 2006-12-06 2007-12-06 métodos para tratar um paciente tendo uma doença ou distúrbio, para tratar um paciente com doença autoimune, para neutralizar um perfil de expressão do marcador pd indutível por ifn do tipo 1 ou ifnalfa em um paciente, para monitorar ou prognosticar progressão de doença autoimune de um paciente, para monitorar a progressão da doença de um paciente que recebe o tratamento com um agente terapêutico que liga-se a e modula a atividade de ifnalfa, para identificar um paciente como um candidato para um agente terapêutico que liga-se a e modula a atividade de ifnalfa, para diagnosticar um paciente como tendo um distùrbio associado com níveis aumentados de ifnalfa, para identificar um terapêutico candidato para o tratamento de distùrbios mediados por ifnalfa e para detectar atividade de ifn em uma amostra, conjunto de sondas, e, kit

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0719912-0A2A BRPI0719912A2 (pt) 2006-12-06 2007-12-06 Método para tratar lupus eritematoso sistêmico, e, método para reduzir elevações passageiras de índice de atividade da doença lupus eritematoso sistêmico

Country Status (10)

Country Link
US (5) US20100143373A1 (pt)
EP (3) EP2073844A4 (pt)
JP (4) JP2010512313A (pt)
KR (2) KR101532797B1 (pt)
AU (2) AU2007327993B2 (pt)
BR (2) BRPI0719912A2 (pt)
CA (2) CA2670594A1 (pt)
MX (1) MX2009005787A (pt)
RU (2) RU2527068C2 (pt)
WO (2) WO2008070137A2 (pt)

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