BRPI0720849A2 - Processos para a preparação de (3r,4r)-n-(4-clorofenil)-1-(2,2-difluoretil)-n'-(2-flúor-4- (2-oxo-1-(2h)-piridinil)fenil]-3,4-pirrolidinadicarboxam ida - Google Patents

Processos para a preparação de (3r,4r)-n-(4-clorofenil)-1-(2,2-difluoretil)-n'-(2-flúor-4- (2-oxo-1-(2h)-piridinil)fenil]-3,4-pirrolidinadicarboxam ida

Info

Publication number
BRPI0720849A2
BRPI0720849A2 BRPI0720849-9A2A BRPI0720849A BRPI0720849A2 BR PI0720849 A2 BRPI0720849 A2 BR PI0720849A2 BR PI0720849 A BRPI0720849 A BR PI0720849A BR PI0720849 A2 BRPI0720849 A2 BR PI0720849A2
Authority
BR
Brazil
Prior art keywords
pyrrolydinadicarboxam
difluoretyl
ida
fluor
pyridinyl
Prior art date
Application number
BRPI0720849-9A2A
Other languages
English (en)
Inventor
Jean-Michel Adam
Pascal Dott
Hans Iding
Hans-Juergen Mair
Reinhard Reents
Beat Wirz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0720849A2 publication Critical patent/BRPI0720849A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
BRPI0720849-9A2A 2006-12-22 2007-12-12 Processos para a preparação de (3r,4r)-n-(4-clorofenil)-1-(2,2-difluoretil)-n'-(2-flúor-4- (2-oxo-1-(2h)-piridinil)fenil]-3,4-pirrolidinadicarboxam ida BRPI0720849A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126969 2006-12-22
PCT/EP2007/063833 WO2008077797A1 (en) 2006-12-22 2007-12-12 Processes for the preparation of (3r, 4r) -n- (4 -chlorophenyl) -1- (2, 2-difluoroethyl) -n' - [2-fluoro-4- (2-oxo-1 (2h) -pyridinyl) phenyl] -3, 4-pyrrolidinedicarboxamide

Publications (1)

Publication Number Publication Date
BRPI0720849A2 true BRPI0720849A2 (pt) 2014-03-11

Family

ID=39054096

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0720849-9A2A BRPI0720849A2 (pt) 2006-12-22 2007-12-12 Processos para a preparação de (3r,4r)-n-(4-clorofenil)-1-(2,2-difluoretil)-n'-(2-flúor-4- (2-oxo-1-(2h)-piridinil)fenil]-3,4-pirrolidinadicarboxam ida

Country Status (10)

Country Link
US (1) US7872141B2 (pt)
EP (1) EP2097401A1 (pt)
JP (1) JP2010513381A (pt)
KR (1) KR20090094386A (pt)
CN (1) CN101611026A (pt)
AU (1) AU2007338102A1 (pt)
BR (1) BRPI0720849A2 (pt)
CA (1) CA2672835A1 (pt)
MX (1) MX2009006818A (pt)
WO (1) WO2008077797A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2624569A1 (en) * 2005-10-03 2007-04-12 Biosite Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
CN101679373A (zh) * 2007-05-10 2010-03-24 弗·哈夫曼-拉罗切有限公司 Fxa抑制剂的新固体形式
CN102241618B (zh) * 2010-05-14 2013-08-07 北京大学 1，3，4-三取代或3，4-二取代的吡咯环化合物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003247608A1 (en) * 2002-06-25 2004-01-06 Wyeth Use of cyclothiocarbamate derivatives in treatment of hormone-related conditions
EP1531824A4 (en) * 2002-06-25 2005-09-21 Wyeth Corp CYCLOTHIOCARBAMATE DERIVATIVES AS PR-MODULATORS AND THEIR USE IN THE TREATMENT OF SKIN DISEASES
AU2004265101B2 (en) * 2003-08-14 2009-06-11 F. Hoffmann-La Roche Ag Gabanergic modulators
US7550487B2 (en) * 2004-03-26 2009-06-23 Hoffmann-La Roche Inc. Pyrrolidine-3,4-dicarboxamide derivatives
MX2007013415A (es) * 2005-05-04 2008-01-15 Hoffmann La Roche Compuestos antivirales heterociclicos.

Also Published As

Publication number Publication date
MX2009006818A (es) 2009-07-02
US20080214826A1 (en) 2008-09-04
WO2008077797A1 (en) 2008-07-03
US7872141B2 (en) 2011-01-18
CN101611026A (zh) 2009-12-23
JP2010513381A (ja) 2010-04-30
KR20090094386A (ko) 2009-09-04
AU2007338102A1 (en) 2008-07-03
EP2097401A1 (en) 2009-09-09
CA2672835A1 (en) 2008-07-03

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2277 DE 26/08/2014.