BRPI0721103A2 - Lipase, método de determinação do desempenho da digestão in vitro de uma lipase em comparação com uma lipase de referência, uso de uma lipase ou de uma mistura de lipases, composição farmacêutica, e, método para o tratamento de doença - Google Patents
Lipase, método de determinação do desempenho da digestão in vitro de uma lipase em comparação com uma lipase de referência, uso de uma lipase ou de uma mistura de lipases, composição farmacêutica, e, método para o tratamento de doença Download PDFInfo
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- BRPI0721103A2 BRPI0721103A2 BRPI0721103-1A BRPI0721103A BRPI0721103A2 BR PI0721103 A2 BRPI0721103 A2 BR PI0721103A2 BR PI0721103 A BRPI0721103 A BR PI0721103A BR PI0721103 A2 BRPI0721103 A2 BR PI0721103A2
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- lipase
- seq
- protease
- amylase
- activity
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Classifications
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
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- A—HUMAN NECESSITIES
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Landscapes
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- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
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- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87119606P | 2006-12-21 | 2006-12-21 | |
| US60/871196 | 2006-12-21 | ||
| PCT/US2007/087168 WO2008079685A2 (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0721103A2 true BRPI0721103A2 (pt) | 2014-03-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0721103-1A BRPI0721103A2 (pt) | 2006-12-21 | 2007-12-12 | Lipase, método de determinação do desempenho da digestão in vitro de uma lipase em comparação com uma lipase de referência, uso de uma lipase ou de uma mistura de lipases, composição farmacêutica, e, método para o tratamento de doença |
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| Country | Link |
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| US (3) | US8273348B2 (de) |
| EP (6) | EP2099907A2 (de) |
| JP (1) | JP5406040B2 (de) |
| KR (1) | KR20090101930A (de) |
| CN (2) | CN101743308B (de) |
| AR (1) | AR064494A1 (de) |
| AU (1) | AU2007337150A1 (de) |
| BR (1) | BRPI0721103A2 (de) |
| CA (3) | CA2670643C (de) |
| IL (1) | IL198893A0 (de) |
| MX (1) | MX2009006597A (de) |
| NO (1) | NO20092729L (de) |
| RU (1) | RU2009128067A (de) |
| TW (1) | TW200829698A (de) |
| WO (1) | WO2008079685A2 (de) |
| ZA (1) | ZA200903598B (de) |
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| CA2560613C (en) | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| PL2278002T3 (pl) | 2005-07-29 | 2017-12-29 | Abbott Laboratories Gmbh | Pankreatyna o zmniejszonej zawartości wirusowej |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| JP5406040B2 (ja) * | 2006-12-21 | 2014-02-05 | ノボザイムス アクティーゼルスカブ | 医薬使用のためのリパーゼ変異体 |
| AR070491A1 (es) * | 2008-02-29 | 2010-04-07 | Novozymes As | Variante de enzima lipolitica con estabilidad aumentada y polinucleotidos que la codifican |
| EP2254996B1 (de) | 2008-02-29 | 2013-07-17 | DSM IP Assets B.V. | Lipasen mit hoher spezifität für kurzkettige fettsäuren und verwendungen davon |
| JP2011513539A (ja) * | 2008-02-29 | 2011-04-28 | ザ プロクター アンド ギャンブル カンパニー | リパーゼを含む洗剤組成物 |
| EP3434764B1 (de) | 2009-12-09 | 2026-04-08 | The Procter & Gamble Company | Stoff- und heimpflegeprodukte |
| CN109022518A (zh) | 2011-07-22 | 2018-12-18 | 诺维信北美公司 | 用于预处理纤维素材料和改进其水解的方法 |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| ES2887576T3 (es) * | 2011-12-29 | 2021-12-23 | Novozymes As | Composiciones detergentes con variantes de lipasa |
| EP4570895A3 (de) | 2012-02-03 | 2026-01-14 | Novozymes A/S | Lipasevarianten und polynukleotide zu deren codierung |
| EP2834353B1 (de) | 2012-04-02 | 2017-07-19 | Novozymes A/S | Lipasevarianten und polynukleotide zu deren codierung |
| CN110093330B (zh) * | 2012-10-12 | 2023-11-28 | 丹尼斯科美国公司 | 包含脂解酶变体的组合物和方法 |
| MX392247B (es) * | 2013-05-14 | 2025-03-24 | Novozymes As | Composiciones detergentes. |
| ES2956266T3 (es) * | 2013-07-19 | 2023-12-18 | Danisco Us Inc | Composiciones y procedimientos que comprenden una variante de enzima lipolítica |
| WO2016079305A1 (en) * | 2014-11-20 | 2016-05-26 | Novozymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| EP3227442B1 (de) * | 2014-12-05 | 2022-02-16 | Novozymes A/S | Lipasevarianten und polynukleotide zur codierung davon |
| CA2965232A1 (en) * | 2014-12-09 | 2016-06-16 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| US20180355404A1 (en) | 2015-04-07 | 2018-12-13 | Novozymes A/S | Methods for selecting enzymes having lipase activity |
| CA2987160C (en) * | 2015-07-01 | 2022-12-13 | Novozymes A/S | Methods of reducing odor |
| WO2017005640A1 (en) * | 2015-07-03 | 2017-01-12 | Novozymes A/S | Detergent compositions with improved stability in the presence of sulfites |
| CN109790525A (zh) | 2016-07-18 | 2019-05-21 | 诺维信公司 | 脂肪酶变体、编码其的多核苷酸及其用途 |
| EP3575398A4 (de) * | 2017-01-30 | 2020-11-11 | Nippon Medical School Foundation | Mutant von capsid-protein des adeno-assoziierten virus (aav) |
| CN118910005A (zh) * | 2017-09-27 | 2024-11-08 | 诺维信公司 | 脂肪酶变体和包含此类脂肪酶变体的微囊组合物 |
| MX2020003779A (es) * | 2017-09-27 | 2020-08-03 | Procter & Gamble | Composiciones detergentes que comprenden lipasas. |
| US20210071155A1 (en) * | 2018-02-08 | 2021-03-11 | Novozymes A/S | Lipase Variants and Compositions Thereof |
| US12269847B2 (en) * | 2018-08-16 | 2025-04-08 | Donaldson Company, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
| JP7741827B2 (ja) * | 2020-06-24 | 2025-09-18 | シリアン アクチェンゲゼルシャフト | 新規リパーゼ酵素 |
| WO2022090361A2 (en) * | 2020-10-29 | 2022-05-05 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
| CN116732002A (zh) * | 2022-03-01 | 2023-09-12 | 中国科学院天津工业生物技术研究所 | 一种耐受表面活性剂的脂肪酶变体及其应用 |
| WO2023247664A2 (en) * | 2022-06-24 | 2023-12-28 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| CN118272341A (zh) * | 2022-12-21 | 2024-07-02 | 丰益(上海)生物技术研发中心有限公司 | 突变的脂肪酶 |
| CN121874156A (zh) * | 2023-12-01 | 2026-04-17 | 青岛蔚蓝生物集团有限公司 | 脂肪酶突变体及其应用 |
| TWI903491B (zh) * | 2024-05-09 | 2025-11-01 | 國立高雄科技大學 | 水體與沉積物通量培養系統 |
Family Cites Families (49)
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| DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
| DK46693D0 (de) * | 1993-04-23 | 1993-04-23 | Novo Nordisk As | |
| ES2121786T3 (es) | 1990-09-13 | 1998-12-16 | Novo Nordisk As | Variantes de lipasa. |
| US5869438A (en) | 1990-09-13 | 1999-02-09 | Novo Nordisk A/S | Lipase variants |
| DK0561907T3 (da) | 1990-12-05 | 1999-05-31 | Novo Nordisk As | Proteiner med ændrede epitoper og fremgangsmåder til fremstilling deraf |
| US5914306A (en) | 1991-05-01 | 1999-06-22 | Novo Nordisk A/S | Stabilized enzymes |
| DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
| US5866526A (en) | 1993-10-04 | 1999-02-02 | Novo Nordisk A/S | Enzyme preparation comprising a modified enzyme |
| CA2183431A1 (en) * | 1994-02-22 | 1995-08-24 | Allan Svendsen | A method of preparing a variant of a lipolytic enzyme |
| AU3924095A (en) | 1994-11-24 | 1996-06-17 | Novo Nordisk A/S | A process for producing polypeptides with reduced allergenicity |
| JPH10510516A (ja) | 1994-12-07 | 1998-10-13 | ノボ ノルディスク アクティーゼルスカブ | アレルゲン性を減らしたポリペプチド |
| ATE210180T1 (de) | 1995-01-26 | 2001-12-15 | Novozymes As | Xylanase beinhaltende futterzusätze für tiere |
| ATE282087T1 (de) | 1995-07-14 | 2004-11-15 | Novozymes As | Modifiziertes enzym mit lipolytischer aktivität |
| WO1997007202A1 (en) | 1995-08-11 | 1997-02-27 | Novo Nordisk A/S | Novel lipolytic enzymes |
| US6495357B1 (en) * | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| JP2002510963A (ja) | 1997-01-10 | 2002-04-09 | ノボザイムス アクティーゼルスカブ | スキンケア用酵素修飾体 |
| AU740207B2 (en) * | 1997-02-06 | 2001-11-01 | Novozymes A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| DE69838551T2 (de) | 1997-06-25 | 2008-07-24 | Novozymes A/S | Modifiziertes polypeptid |
| AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| CN1247776C (zh) * | 1998-02-17 | 2006-03-29 | 诺维信公司 | 脂肪酶变体 |
| JP2002527059A (ja) | 1998-10-13 | 2002-08-27 | ノボザイムス アクティーゼルスカブ | 低められた免疫応答を有する修飾されたポリペプチド |
| ATE263778T1 (de) | 1998-10-30 | 2004-04-15 | Novozymes As | Niedrigallergene proteinvarianten |
| CA2348822A1 (en) | 1998-10-30 | 2000-05-11 | Novozymes A/S | Glycosylated proteins having reduced allergenicity |
| DK1131416T3 (da) | 1998-11-27 | 2009-10-26 | Novozymes As | Lipolytiske enzymvarianter |
| US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
| BR0009012A (pt) | 1999-03-17 | 2001-12-26 | Solvay Pharm Gmbh | Medicamento para o tratamento de diabete |
| EP2278000A1 (de) * | 1999-03-31 | 2011-01-26 | Novozymes A/S | Lipasevariante |
| KR20010108379A (ko) | 1999-03-31 | 2001-12-07 | 피아 스타르 | 리파제 변이체 |
| CA2395343C (en) | 2000-02-08 | 2009-06-30 | F. Hoffmann-La Roche Ag | Use of acid-stable proteases in animal feed |
| US7226770B2 (en) | 2000-04-28 | 2007-06-05 | Novozymes A/S | Lipolytic enzyme variant |
| ATE426668T1 (de) * | 2001-01-10 | 2009-04-15 | Novozymes As | Variante eines lipolytischen enzyms |
| AR032392A1 (es) | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| CN1491278A (zh) | 2001-02-07 | 2004-04-21 | ŵά�Ź�˾ | 脂酶变体 |
| DK2295556T3 (en) | 2002-01-16 | 2015-01-26 | Novozymes As | Lipolytic Enzyme Variants and Method of Preparation thereof. |
| US20060234340A1 (en) | 2003-02-06 | 2006-10-19 | Novozymes A/S | Human heavy chain antibody expression in flamentous fungi |
| DK2270140T3 (en) | 2003-05-09 | 2016-03-14 | Novozymes As | Lipolytic enzyme variants |
| WO2004111216A2 (en) | 2003-06-19 | 2004-12-23 | Novozymes A/S | Phospholipase variants |
| EP1639107B1 (de) | 2003-06-19 | 2013-08-14 | Novozymes A/S | Verbesserte proteasen und methoden zu deren herstellung |
| JP2007535913A (ja) | 2004-01-21 | 2007-12-13 | ノボザイムス アクティーゼルスカブ | ヘテロカリオン菌類又は菌類宿主細胞におけるモノクローナル抗体の生成 |
| CA2560613C (en) | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| DK1809320T3 (da) | 2004-10-14 | 2010-11-15 | Cystic Fibrosis Foundation The | Præparater indeholdende lipase, protease og amylase til behandling af pankreatisk insufficiens |
| US20080138856A1 (en) | 2005-02-10 | 2008-06-12 | Novozymes A/S | Enzymatic Enantioselective Ester or Amide Hydrolysis or Synthesis |
| EP1896057A2 (de) | 2005-06-24 | 2008-03-12 | Novozymes A/S | Amylasen zur pharmazeutischen verwendung |
| CA2612648A1 (en) * | 2005-06-24 | 2006-12-28 | Novozymes A/S | Lipases for pharmaceutical use |
| KR20080017039A (ko) | 2005-06-24 | 2008-02-25 | 노보자임스 에이/에스 | 약학적 용도의 프로테아제 |
| WO2007080197A2 (en) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Immobilised enzymes |
| ES2628940T3 (es) * | 2006-01-23 | 2017-08-04 | Novozymes A/S | Variantes de lipasa |
| JP2009523900A (ja) * | 2006-01-23 | 2009-06-25 | ザ プロクター アンド ギャンブル カンパニー | リパーゼと漂白剤触媒を含む組成物 |
| JP5406040B2 (ja) * | 2006-12-21 | 2014-02-05 | ノボザイムス アクティーゼルスカブ | 医薬使用のためのリパーゼ変異体 |
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2007
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- 2007-12-12 WO PCT/US2007/087168 patent/WO2008079685A2/en not_active Ceased
- 2007-12-12 EP EP07869130A patent/EP2099907A2/de not_active Withdrawn
- 2007-12-12 BR BRPI0721103-1A patent/BRPI0721103A2/pt not_active IP Right Cessation
- 2007-12-12 EP EP10172609.9A patent/EP2261328B1/de active Active
- 2007-12-12 EP EP12155319.2A patent/EP2455462B1/de active Active
- 2007-12-12 EP EP12155294.7A patent/EP2455459B1/de active Active
- 2007-12-12 CA CA2670643A patent/CA2670643C/en active Active
- 2007-12-12 EP EP12155317.6A patent/EP2455461B1/de active Active
- 2007-12-12 CN CN200780051638.6A patent/CN101743308B/zh active Active
- 2007-12-12 EP EP12155315A patent/EP2455460A3/de not_active Withdrawn
- 2007-12-12 CA CA2961041A patent/CA2961041C/en active Active
- 2007-12-12 KR KR1020097014850A patent/KR20090101930A/ko not_active Withdrawn
- 2007-12-12 AU AU2007337150A patent/AU2007337150A1/en not_active Abandoned
- 2007-12-12 CN CN201510504893.8A patent/CN105112386A/zh active Pending
- 2007-12-12 CA CA3081308A patent/CA3081308C/en active Active
- 2007-12-12 MX MX2009006597A patent/MX2009006597A/es not_active Application Discontinuation
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- 2007-12-12 US US12/519,868 patent/US8273348B2/en active Active
- 2007-12-18 TW TW096148377A patent/TW200829698A/zh unknown
- 2007-12-21 AR ARP070105859A patent/AR064494A1/es not_active Application Discontinuation
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