BRPI0721796A2 - Ácido nucléico isolado, vetor de dna recombinante, célula hospedeira, método para aumentar a produção de 107891 ou de seus homólogos, microrganismo transformado, processo para produzir 107891, processo para produzir um precursor de 107891, método para produzir um lantibiótico diferente do 17891 e polipeptídeo isolado - Google Patents

Ácido nucléico isolado, vetor de dna recombinante, célula hospedeira, método para aumentar a produção de 107891 ou de seus homólogos, microrganismo transformado, processo para produzir 107891, processo para produzir um precursor de 107891, método para produzir um lantibiótico diferente do 17891 e polipeptídeo isolado Download PDF

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Publication number
BRPI0721796A2
BRPI0721796A2 BRPI0721796-0A BRPI0721796A BRPI0721796A2 BR PI0721796 A2 BRPI0721796 A2 BR PI0721796A2 BR PI0721796 A BRPI0721796 A BR PI0721796A BR PI0721796 A2 BRPI0721796 A2 BR PI0721796A2
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Brazil
Prior art keywords
produce
protector
isolated
nucleic acid
recombinant dna
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BRPI0721796-0A
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English (en)
Inventor
Donadio Stefano
Sosio Margherita
Serina Stefania
Mercorillo Davide
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Sentinella Pharmaceuticals, Inc.
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Publication of BRPI0721796A2 publication Critical patent/BRPI0721796A2/pt

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Genetics & Genomics (AREA)
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  • Wood Science & Technology (AREA)
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  • Mycology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ACIDO NUCLéICO ISOLADO, VETOR DE DNA RECOMBINANTE, CéLULA HOSPEDEIRA, MéTODO PARA AUMENTAR A PRODUçãO DE 107891 OU DE SEUS HOMóLOGOS, MICROORGANISMO TRANSFORMADO, PROCESSO PARA PRODUZIR 107891, PROCESSO PARA PRODUZIR UM PRECURSOR DE 107891, MéTODO PARA PRODUZIR UM LANTIBIóTICO DIFERENTE DO 107891 E POLIPEPTìDEO ISOLADO. A invenção refere-se ao campo dos lantibiáticos, e mais especificamente ao isolamento de moléculas de ácido nucléico que codificam enzimas necessárias para a via biosintética do lantibiótico 107891 e dos seus homólogos.
BRPI0721796-0A 2007-08-03 2007-08-03 Ácido nucléico isolado, vetor de dna recombinante, célula hospedeira, método para aumentar a produção de 107891 ou de seus homólogos, microrganismo transformado, processo para produzir 107891, processo para produzir um precursor de 107891, método para produzir um lantibiótico diferente do 17891 e polipeptídeo isolado BRPI0721796A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2007/002270 WO2009019524A1 (en) 2007-08-03 2007-08-03 Genes and proteins for the biosynthesis of the lantibiotic 107891

Publications (1)

Publication Number Publication Date
BRPI0721796A2 true BRPI0721796A2 (pt) 2012-03-13

Family

ID=38983900

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0721796-0A BRPI0721796A2 (pt) 2007-08-03 2007-08-03 Ácido nucléico isolado, vetor de dna recombinante, célula hospedeira, método para aumentar a produção de 107891 ou de seus homólogos, microrganismo transformado, processo para produzir 107891, processo para produzir um precursor de 107891, método para produzir um lantibiótico diferente do 17891 e polipeptídeo isolado

Country Status (8)

Country Link
US (2) US8609367B2 (pt)
EP (1) EP2190859A1 (pt)
JP (1) JP2010535492A (pt)
CN (1) CN101939328A (pt)
AU (1) AU2007357462B2 (pt)
BR (1) BRPI0721796A2 (pt)
CA (1) CA2695487A1 (pt)
WO (1) WO2009019524A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9422566B2 (en) * 2011-10-12 2016-08-23 Sanofi Gene cluster for biosynthesis of griselimycin and methylgriselimycin
DK3122764T3 (en) * 2014-03-25 2019-04-15 Lanthiopep Bv CYCLIC APELINE ANALOGS
CN106366168B (zh) * 2016-08-26 2020-09-15 上海交通大学 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法
CN106188253B (zh) * 2016-08-26 2020-08-18 上海交通大学 抗菌肽Lexapeptide及其制备方法和用途
CN110669113B (zh) * 2019-10-21 2022-05-17 河北省科学院生物研究所 一种羊毛硫肽前体肽amyA2及其制备方法和应用
CN110684087B (zh) * 2019-10-21 2022-03-29 河北省科学院生物研究所 一种羊毛硫肽前体肽amyA16及其制备方法和应用
CN113354718B (zh) * 2021-06-21 2023-06-02 重庆市畜牧科学院 一种哌尼生素前体、表达盒及其制备方法
CA3226284A1 (en) * 2021-07-08 2023-01-12 Temple University - Of The Commonwealth System Of Higher Education Oligonucleotides and viral untranslated region (utr) for increasing expression of target genes and proteins
CN121344122A (zh) * 2025-12-18 2026-01-16 山东大学 多肽化合物合成酶体系在人工多肽化合物合成中的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0110432D0 (en) * 2001-04-27 2001-06-20 Plant Bioscience Ltd Lantibiotic production
MXPA04000192A (es) * 2001-07-13 2004-03-18 Rhodia Composicion que tiene actividad bacteriostatica y bactericida contra esporas bacterianas y celulas vegetativas y proceso para tratar alimentos con la misma.
US7074559B2 (en) * 2002-03-06 2006-07-11 Refents of the University of Minnesota Mycobacterial diagnostics
ES2281808T3 (es) 2003-07-18 2007-10-01 Vicuron Pharmaceuticals, Inc. Antibiotico 107891, sus factores a1 y a2, composiciones y sales farmaceuticamente aceptables y uso del mismo.

Also Published As

Publication number Publication date
WO2009019524A1 (en) 2009-02-12
EP2190859A1 (en) 2010-06-02
AU2007357462B2 (en) 2013-02-21
US8609367B2 (en) 2013-12-17
JP2010535492A (ja) 2010-11-25
CA2695487A1 (en) 2009-02-12
US20140038297A1 (en) 2014-02-06
AU2007357462A1 (en) 2009-02-12
CN101939328A (zh) 2011-01-05
US20120015418A1 (en) 2012-01-19

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