BRPI0721796A2 - Ácido nucléico isolado, vetor de dna recombinante, célula hospedeira, método para aumentar a produção de 107891 ou de seus homólogos, microrganismo transformado, processo para produzir 107891, processo para produzir um precursor de 107891, método para produzir um lantibiótico diferente do 17891 e polipeptídeo isolado - Google Patents

Ácido nucléico isolado, vetor de dna recombinante, célula hospedeira, método para aumentar a produção de 107891 ou de seus homólogos, microrganismo transformado, processo para produzir 107891, processo para produzir um precursor de 107891, método para produzir um lantibiótico diferente do 17891 e polipeptídeo isolado Download PDF

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Publication number
BRPI0721796A2
BRPI0721796A2 BRPI0721796-0A BRPI0721796A BRPI0721796A2 BR PI0721796 A2 BRPI0721796 A2 BR PI0721796A2 BR PI0721796 A BRPI0721796 A BR PI0721796A BR PI0721796 A2 BRPI0721796 A2 BR PI0721796A2
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BR
Brazil
Prior art keywords
produce
protector
isolated
nucleic acid
recombinant dna
Prior art date
Application number
BRPI0721796-0A
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English (en)
Inventor
Donadio Stefano
Sosio Margherita
Serina Stefania
Mercorillo Davide
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Sentinella Pharmaceuticals, Inc.
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Application filed by Sentinella Pharmaceuticals, Inc. filed Critical Sentinella Pharmaceuticals, Inc.
Publication of BRPI0721796A2 publication Critical patent/BRPI0721796A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
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    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
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  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

ACIDO NUCLéICO ISOLADO, VETOR DE DNA RECOMBINANTE, CéLULA HOSPEDEIRA, MéTODO PARA AUMENTAR A PRODUçãO DE 107891 OU DE SEUS HOMóLOGOS, MICROORGANISMO TRANSFORMADO, PROCESSO PARA PRODUZIR 107891, PROCESSO PARA PRODUZIR UM PRECURSOR DE 107891, MéTODO PARA PRODUZIR UM LANTIBIóTICO DIFERENTE DO 107891 E POLIPEPTìDEO ISOLADO. A invenção refere-se ao campo dos lantibiáticos, e mais especificamente ao isolamento de moléculas de ácido nucléico que codificam enzimas necessárias para a via biosintética do lantibiótico 107891 e dos seus homólogos.
BRPI0721796-0A 2007-08-03 2007-08-03 Ácido nucléico isolado, vetor de dna recombinante, célula hospedeira, método para aumentar a produção de 107891 ou de seus homólogos, microrganismo transformado, processo para produzir 107891, processo para produzir um precursor de 107891, método para produzir um lantibiótico diferente do 17891 e polipeptídeo isolado BRPI0721796A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2007/002270 WO2009019524A1 (en) 2007-08-03 2007-08-03 Genes and proteins for the biosynthesis of the lantibiotic 107891

Publications (1)

Publication Number Publication Date
BRPI0721796A2 true BRPI0721796A2 (pt) 2012-03-13

Family

ID=38983900

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0721796-0A BRPI0721796A2 (pt) 2007-08-03 2007-08-03 Ácido nucléico isolado, vetor de dna recombinante, célula hospedeira, método para aumentar a produção de 107891 ou de seus homólogos, microrganismo transformado, processo para produzir 107891, processo para produzir um precursor de 107891, método para produzir um lantibiótico diferente do 17891 e polipeptídeo isolado

Country Status (8)

Country Link
US (2) US8609367B2 (pt)
EP (1) EP2190859A1 (pt)
JP (1) JP2010535492A (pt)
CN (1) CN101939328A (pt)
AU (1) AU2007357462B2 (pt)
BR (1) BRPI0721796A2 (pt)
CA (1) CA2695487A1 (pt)
WO (1) WO2009019524A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104024272B (zh) * 2011-10-12 2018-04-20 赛诺菲 用于浅灰霉素和甲基浅灰霉素的生物合成的基因簇
WO2015147641A1 (en) * 2014-03-25 2015-10-01 Lanthiopep B.V. Cyclic apelin analogs
CN106188253B (zh) * 2016-08-26 2020-08-18 上海交通大学 抗菌肽Lexapeptide及其制备方法和用途
CN106366168B (zh) * 2016-08-26 2020-09-15 上海交通大学 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法
CN110684087B (zh) * 2019-10-21 2022-03-29 河北省科学院生物研究所 一种羊毛硫肽前体肽amyA16及其制备方法和应用
CN110669113B (zh) * 2019-10-21 2022-05-17 河北省科学院生物研究所 一种羊毛硫肽前体肽amyA2及其制备方法和应用
CN113354718B (zh) * 2021-06-21 2023-06-02 重庆市畜牧科学院 一种哌尼生素前体、表达盒及其制备方法
CN117979994A (zh) * 2021-07-08 2024-05-03 天普大学-联邦高等教育系统 用于增加靶基因和蛋白质的表达的寡核苷酸和病毒未转译区(utr)
CN121344122A (zh) * 2025-12-18 2026-01-16 山东大学 多肽化合物合成酶体系在人工多肽化合物合成中的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0110432D0 (en) * 2001-04-27 2001-06-20 Plant Bioscience Ltd Lantibiotic production
ATE347277T1 (de) * 2001-07-13 2006-12-15 Danisco Zusammensetzung mit bakteriostatischen und bakteriziden eigenschaften gegen bakterielle sporen und zellen und verfahren zu deren verwendung zur behandlung von lebensmitteln
US7074559B2 (en) * 2002-03-06 2006-07-11 Refents of the University of Minnesota Mycobacterial diagnostics
BRPI0412591A (pt) * 2003-07-18 2006-09-19 Vicuron Pharm Inc antibiótico 107891, seus fatores a1 e a2, sais e composições farmaceuticamente aceitáveis e uso destes

Also Published As

Publication number Publication date
AU2007357462A1 (en) 2009-02-12
CN101939328A (zh) 2011-01-05
WO2009019524A1 (en) 2009-02-12
EP2190859A1 (en) 2010-06-02
US20120015418A1 (en) 2012-01-19
US8609367B2 (en) 2013-12-17
JP2010535492A (ja) 2010-11-25
AU2007357462B2 (en) 2013-02-21
US20140038297A1 (en) 2014-02-06
CA2695487A1 (en) 2009-02-12

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