BRPI0810480A2 - Variantes da enzima asparaginase e usos das mesmas - Google Patents

Variantes da enzima asparaginase e usos das mesmas

Info

Publication number
BRPI0810480A2
BRPI0810480A2 BRPI0810480-8A2A BRPI0810480A BRPI0810480A2 BR PI0810480 A2 BRPI0810480 A2 BR PI0810480A2 BR PI0810480 A BRPI0810480 A BR PI0810480A BR PI0810480 A2 BRPI0810480 A2 BR PI0810480A2
Authority
BR
Brazil
Prior art keywords
same
enzyme variants
asparaginase enzyme
asparaginase
variants
Prior art date
Application number
BRPI0810480-8A2A
Other languages
English (en)
Inventor
Jan Metske Van Der Laan
Mark Cristiaan Stor
Ilse De Lange
Lisette Mohrmann
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BRPI0810480A2 publication Critical patent/BRPI0810480A2/pt
Publication of BRPI0810480B1 publication Critical patent/BRPI0810480B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/06—Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
    • A23L5/25—Removal of unwanted matter, e.g. deodorisation or detoxification using enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01001—Asparaginase (3.5.1.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • General Preparation And Processing Of Foods (AREA)
BRPI0810480-8A 2007-04-20 2008-04-17 Variantes da enzima asparaginase, sequência de ácido nucleico, constructo de ácido nucleico, vetor de expressão, célula hospedeira recombinante, método de produção de asparaginase e método de produção de variante BRPI0810480B1 (pt)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
EP07106662.5 2007-04-20
EP07106612 2007-04-20
EP07106660 2007-04-20
EP07106612.0 2007-04-20
EP07106664 2007-04-20
EP07106664.1 2007-04-20
EP07106620.3 2007-04-20
EP07106620 2007-04-20
EP07106660.9 2007-04-20
EP07106662 2007-04-20
PCT/EP2008/054692 WO2008128974A1 (en) 2007-04-20 2008-04-17 Asparaginase enzyme variants and uses thereof

Publications (2)

Publication Number Publication Date
BRPI0810480A2 true BRPI0810480A2 (pt) 2014-10-07
BRPI0810480B1 BRPI0810480B1 (pt) 2022-05-17

Family

ID=39711125

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0810480-8A BRPI0810480B1 (pt) 2007-04-20 2008-04-17 Variantes da enzima asparaginase, sequência de ácido nucleico, constructo de ácido nucleico, vetor de expressão, célula hospedeira recombinante, método de produção de asparaginase e método de produção de variante

Country Status (14)

Country Link
US (2) US8617868B2 (pt)
EP (3) EP2662444A1 (pt)
JP (1) JP2010524447A (pt)
CN (1) CN103397012A (pt)
AR (1) AR069362A1 (pt)
AU (1) AU2008240796A1 (pt)
BR (1) BRPI0810480B1 (pt)
CA (1) CA2683078C (pt)
DK (1) DK2139997T3 (pt)
EA (1) EA018424B1 (pt)
ES (1) ES2524343T3 (pt)
IL (1) IL201019A0 (pt)
MX (1) MX2009011179A (pt)
WO (1) WO2008128974A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008240796A1 (en) 2007-04-20 2008-10-30 Dsm Ip Assets B.V. Asparaginase enzyme variants and uses thereof
EP2378897B1 (en) * 2008-12-16 2017-07-19 Novozymes A/S Stabilization of asparaginase
US20110129569A1 (en) 2009-11-26 2011-06-02 Dsm Ip Assets B.V. Method to produce fried vegetable products
EP2563917A1 (en) 2010-04-27 2013-03-06 DSM IP Assets B.V. Novel asparaginase enzyme
CN103003297B (zh) * 2010-07-14 2016-06-01 雀巢产品技术援助有限公司 担子菌的天冬酰胺酶
CA2817224A1 (en) 2010-11-19 2012-05-24 Novozymes North America, Inc. Processes of producing a fermentation product
US9828595B2 (en) 2012-08-17 2017-11-28 Novozymes A/S Thermostable asparaginase variants and polynucleotides encoding same
US9068171B2 (en) 2012-09-06 2015-06-30 Mycotechnology, Inc. Method for myceliating coffee
US9427008B2 (en) 2012-09-06 2016-08-30 Mycotechnology, Inc. Method of myceliation of agricultural substates for producing functional foods and nutraceuticals
CA2893962C (en) 2012-12-06 2021-04-06 Enlivex Therapeutics Ltd Therapeutic apoptotic cell preparations, method for producing same and uses thereof
WO2015033344A1 (en) 2013-09-05 2015-03-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and kits for inhibiting pathogenicity of group a streptococcus (gas) or group g streptococcus (ggs)
US10231469B2 (en) 2014-03-15 2019-03-19 Mycotechnology, Inc. Myceliated products and methods for making myceliated products from cacao and other agricultural substrates
RU2545722C1 (ru) * 2014-03-27 2015-04-10 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") МУТАНТНАЯ РЕКОМБИНАНТНАЯ L-АСПАРАГИНАЗА Wolinella succinogenes (ВАРИАНТЫ)
CN113519814B (zh) 2014-08-26 2024-04-02 麦可科技有限公司 含菌丝液体组织培养物上清与食品的组合物及其用途
US10709157B2 (en) 2014-08-26 2020-07-14 Mycotechnology, Inc. Methods for the production and use of mycelial liquid tissue culture
US9572364B2 (en) 2014-08-26 2017-02-21 Mycotechnology, Inc. Methods for the production and use of mycelial liquid tissue culture
WO2016138476A1 (en) 2015-02-26 2016-09-01 Mycotechnology, Inc. Methods for lowering gluten content using fungal cultures
US11166477B2 (en) 2016-04-14 2021-11-09 Mycotechnology, Inc. Myceliated vegetable protein and food compositions comprising same
KR20210111870A (ko) 2016-04-14 2021-09-13 마이코테크놀로지, 인코포레이티드 균사체화된 고단백 식품 조성물의 제조 방법 및 용도
US10806101B2 (en) 2016-04-14 2020-10-20 Mycotechnology, Inc. Methods for the production and use of myceliated high protein food compositions
DK3463308T4 (da) 2016-06-01 2026-02-09 Servier Ip Uk Ltd Formuleringer af polyalkylenoxid-asparaginase og fremgangsmåder til fremstilling og anvendelse deraf
US20210299233A1 (en) 2018-07-12 2021-09-30 The Children's Medical Center Corporation Method for treating cancer
EP3852543A1 (en) 2018-09-20 2021-07-28 The Better Meat Company Enhanced aerobic fermentation methods for producing edible fungal mycelium blended meats and meat analogue compositions
US12274283B2 (en) 2018-09-20 2025-04-15 The Better Meat Co. Enhanced aerobic fermentation methods for producing edible fungal mycelium blended meats and meat analogue compositions
CN109266635B (zh) * 2018-11-20 2020-12-01 江南大学 一种酶活提高的l-天冬酰胺酶突变体及其构建方法
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3819540B2 (ja) * 1996-06-07 2006-09-13 株式会社林原生物化学研究所 Ｌ−アスパラギナーゼ活性を有する哺乳類由来のポリペプチド
US20030186380A1 (en) 2002-04-01 2003-10-02 Novozymes Biotech, Inc. Methods for producing secreted polypeptides having L-asparaginase activity
WO2004074468A1 (en) 2002-05-30 2004-09-02 Dsm Ip Assets B.V. Novel pectinases and uses thereof
US7524519B2 (en) * 2002-09-20 2009-04-28 The Procter & Gamble Company Method for reducing acrylamide in foods, foods having reduced levels of acrylamide, and article of commerce
US7555108B2 (en) 2002-10-01 2009-06-30 Nortel Networks Limited Presence information for telephony users
CA2501741C (en) 2002-10-11 2012-04-17 Novozymes A/S Method of preparing a heat-treated product
US20040101607A1 (en) 2002-11-22 2004-05-27 The Procter & Gamble Company Method for reducing acrylamide in foods, foods having reduced levels of acrylamide, and article of commerce
BRPI0317298B1 (pt) * 2002-12-19 2017-06-13 Dsm Ip Assets B.V. Methods for the preparation of polynucleotyde, vector and asparaginase, processed host cells, use of asparaginase and foodstuff process for production of food product, vetor heterólogo, methods for preparation of polynucleotyde, vector and asparaginase, processed host cells, use of asparaginase and food product
US20090098248A1 (en) * 2005-05-31 2009-04-16 Lex De Boer Novel Process for Enzymatic Acrylamide Reduction in Food Products
EP2851424B1 (en) * 2007-03-09 2016-09-21 Novozymes A/S Thermostable asparaginases
US20080228595A1 (en) 2007-03-13 2008-09-18 Swapedo.Com, Inc. System for supporting electronic commerce in social networks
BRPI0810481B1 (pt) 2007-04-20 2022-05-17 Dsm Ip Assets B.V. Asparaginases, sequência de ácido nucléico, constructo de ácido nucléico, vetor de expressão recombinante, célula hospedeira recombinante, método para a produção de uma asparaginase e composição
AU2008240796A1 (en) 2007-04-20 2008-10-30 Dsm Ip Assets B.V. Asparaginase enzyme variants and uses thereof
EP2563917A1 (en) 2010-04-27 2013-03-06 DSM IP Assets B.V. Novel asparaginase enzyme

Also Published As

Publication number Publication date
CA2683078C (en) 2016-03-29
US9127266B2 (en) 2015-09-08
EP2662444A1 (en) 2013-11-13
AU2008240796A1 (en) 2008-10-30
CN103397012A (zh) 2013-11-20
ES2524343T3 (es) 2014-12-05
EP2139997B1 (en) 2014-09-24
MX2009011179A (es) 2010-01-20
JP2010524447A (ja) 2010-07-22
CA2683078A1 (en) 2008-10-30
EA018424B1 (ru) 2013-07-30
EP2139997A1 (en) 2010-01-06
US8617868B2 (en) 2013-12-31
WO2008128974A1 (en) 2008-10-30
BRPI0810480B1 (pt) 2022-05-17
US20100183765A1 (en) 2010-07-22
US20140099401A1 (en) 2014-04-10
EA200901430A1 (ru) 2010-04-30
DK2139997T3 (en) 2014-12-08
AR069362A1 (es) 2010-01-20
IL201019A0 (en) 2011-08-01
EP2662443A1 (en) 2013-11-13

Similar Documents

Publication Publication Date Title
NO2022027I1 (no) Combination of daunorubicin and cytarabine
IL201019A0 (en) Asparaginase enzyme variants and uses thereof
BRPI0911656A2 (pt) formulações de nanopartículas e usos das mesmas
BRPI0819714A2 (pt) Formulações de proteína e métodos de produção das mesmas.
BRPI1011404A2 (pt) mutantes e usos dos mesmos
BRPI1008709A2 (pt) composições e usos das mesmas.
BRPI0821658A2 (pt) Anticorpos contra nkg2d humano e usos dos mesmos
BR112012016203A2 (pt) "métodos para melhoria da proliferaçõ e atividade das células exterminadoras naturais"
BRPI0912225A2 (pt) peptídeos de direcionamento lisossomais e usos dos mesmos
EP2160401A4 (en) FUSION MOLECULES AND IL-15 VARIANTS
EP2173377A4 (en) ANTIBODY ENDOSTATIN FUSION PROTEIN AND ITS VARIATIONS
BRPI0908864A2 (pt) formas da rifaximina e usos das mesmas
BRPI0718182A2 (pt) Oligorribonucleotídeos e seus usos.
BRPI0810481A2 (pt) Novas asparaginases e usos destas
BRPI0906682A2 (pt) enzimas de álcool desidrogenase isolada e usos das mesmas
BRPI0819909A2 (pt) anticorpos antimesotelina e usos dos mesmos
DK3560915T3 (da) Polypeptider med oxidoreduktaseaktivitet og anvendelser deraf
DK3219795T3 (da) Fremstilling af aktive kraftigt phosphorylerede humane lysosomale sulfatase-enzymer og anvendelser deraf
BRPI0908021A2 (pt) Composto, composição farmacêutica, e, usos do composto ou da composição farmacêutica
BRPI0817298A2 (pt) Combinações de substâncias ativas com propriedades inseticidas e acaricidas
BRPI0920927A2 (pt) derivados de azaquinolinona e usos dos mesmos
BRPI0907750A2 (pt) Variantes de alfa-amilase de bacillus stearothermophilus e usos dos mesmos
EP2209114A4 (en) ENCODER AND DECODER
DK2137307T3 (da) Termostabile asparaginaser
BRPI0819488A2 (pt) Dispositivos de terapia e gel térmico

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B15K Others concerning applications: alteration of classification

Ipc: C12N 9/82 (2006.01), A23L 5/20 (2016.01), A23L 29/

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/04/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 18A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2876 DE 18-02-2026 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.