BRPI0810641A2 - "compostos farmacêuticos". - Google Patents

"compostos farmacêuticos".

Info

Publication number: BRPI0810641A2
Authority: BR; Brazil
Prior art keywords: disorders; pharmaceutical compounds; function; compounds; pi3k
Prior art date: 2007-04-12

Application number

BRPI0810641A

Other languages

English (en)

Inventor

Mcdonald Edward

Amandine Dechaux Elsa

Martin Large Jonathan

Anthony Pegg Neil

John Goldsmith Paul

Joseph Shuttleworth Stephen

Price Stephen

Colin Hancox Timothy

Original Assignee

Hoffmann La Roche

The Institute Of Cancer Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-04-12

Filing date

2008-04-14

Publication date

2019-09-24

2007-04-12 Priority claimed from GB0707088A external-priority patent/GB0707088D0/en

2007-04-19 Priority claimed from GB0707611A external-priority patent/GB0707611D0/en

2008-04-14 Application filed by Hoffmann La Roche, The Institute Of Cancer Res filed Critical Hoffmann La Roche

2019-09-24 Publication of BRPI0810641A2 publication Critical patent/BRPI0810641A2/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Dental Preparations (AREA)

BRPI0810641A 2007-04-12 2008-04-14 "compostos farmacêuticos". BRPI0810641A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0707088A GB0707088D0 (en)	2007-04-12	2007-04-12	Pharmaceutical compounds
GB0707611A GB0707611D0 (en)	2007-04-19	2007-04-19	Pharmaceutical compounds
PCT/GB2008/001301 WO2008125839A2 (en)	2007-04-12	2008-04-14	Pyrimidine derivatives as inhibitors of phosphatidylinositol-3-kinase

Publications (1)

Publication Number	Publication Date
BRPI0810641A2 true BRPI0810641A2 (pt)	2019-09-24

Family

ID=39832798

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0810641A BRPI0810641A2 (pt)	2007-04-12	2008-04-14	"compostos farmacêuticos".

Country Status (13)

Country	Link
US (1)	US20100130496A1 (pt)
EP (1)	EP2150546B1 (pt)
JP (1)	JP2010523639A (pt)
KR (1)	KR20100016433A (pt)
CN (1)	CN101765597A (pt)
AT (1)	ATE496045T1 (pt)
AU (1)	AU2008237721A1 (pt)
BR (1)	BRPI0810641A2 (pt)
CA (1)	CA2683624A1 (pt)
DE (1)	DE602008004650D1 (pt)
IL (1)	IL201365A0 (pt)
MX (1)	MX2009010886A (pt)
WO (1)	WO2008125839A2 (pt)

Families Citing this family (35)

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EP2146981A1 (en) *	2007-04-12	2010-01-27	F. Hoffmann-Roche AG	Pharmaceutical compounds
CA2729045A1 (en)	2008-07-31	2010-02-04	Philippe Bergeron	Pyrimidine compounds, compositions and methods of use
JP5555236B2 (ja)	2008-08-25	2014-07-23	アイアールエム・リミテッド・ライアビリティ・カンパニー	ヘッジホッグ経路モジュレーター
TWI378933B (en)	2008-10-14	2012-12-11	Daiichi Sankyo Co Ltd	Morpholinopurine derivatives
JPWO2010092962A1 (ja)	2009-02-12	2012-08-16	アステラス製薬株式会社	へテロ環誘導体
EP2499143B1 (en)	2009-11-12	2016-03-16	F.Hoffmann-La Roche Ag	N7-substituted purine and pyrazolopyrimidine compounds, compositions and methods of use
JP5579864B2 (ja)	2009-11-12	2014-08-27	エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト	Ｎ−９−置換プリン化合物、組成物及び使用の方法
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
EP2604601B1 (en)	2010-08-10	2016-02-24	Astellas Pharma Inc.	Hetero ring compound
CN103189356B (zh)	2010-09-29	2015-11-25	英特维特国际股份有限公司	N-杂芳基化合物
TW201500358A (zh)	2010-12-16	2015-01-01	赫夫門羅氏藥廠股份有限公司	三環ｐｉ３ｋ抑制劑化合物及其使用方法
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2790705B1 (en)	2011-12-15	2017-12-06	Novartis AG	Use of inhibitors of the activity or function of pi3k
AU2013241853B2 (en)	2012-03-28	2017-11-09	Intervet International B.V.	Heteroaryl compounds with A-cyclic bridging unit
KR20160027219A (ko)	2012-05-23	2016-03-09	에프. 호프만-라 로슈 아게	내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법
US20150258127A1 (en)	2012-10-31	2015-09-17	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for preventing antiphospholipid syndrome (aps)
WO2015071230A1 (en) *	2013-11-15	2015-05-21	Bayer Cropscience Ag	Catalytic hydrogenation of nitriles
RU2713179C2 (ru)	2014-02-21	2020-02-04	Фрост Биолоджик, Инк.	Антимитотические амиды для лечения рака и пролиферативных заболеваний
WO2016059220A1 (en)	2014-10-16	2016-04-21	INSERM (Institut National de la Santé et de la Recherche Médicale)	Tcr-activating agents for use in the treatment of t-all
GB201602527D0 (en) *	2016-02-12	2016-03-30	Glaxosmithkline Ip Dev Ltd	Chemical compounds
EP3558944B1 (en)	2016-12-21	2022-03-09	Bayer CropScience Aktiengesellschaft	Hydrogenation of a substituted 2-methyl cyanopyridyl derivative in the presence of a raney cobalt catalyst
CN110914265B (zh) *	2017-05-15	2022-12-23	密歇根大学董事会	作为lsd-1抑制剂的吡咯并[2,3-c]吡啶和相关类似物
EP3676264A1 (en) *	2017-08-28	2020-07-08	Acurastem Inc.	Pikfyve kinase inhibitors
GB201810669D0 (en) *	2018-06-28	2018-08-15	Stiftelsen Alzecure	New compounds
CN118619944A (zh) *	2019-06-06	2024-09-10	北京泰德制药股份有限公司	作为atr激酶抑制剂的2,4,6-三取代的嘧啶化合物
JP7727627B2 (ja)	2019-12-04	2025-08-21	シーエイチディーアイファウンデーション，インコーポレーテッド	Ａｔｍキナーゼ阻害剤及び組成物並びにそれらの使用の方法
KR20220153582A (ko)	2020-02-14	2022-11-18	솔크 인스티튜트 포 바이올로지칼 스터디즈	마크로시클릭 ulk1/2 억제제
KR20220153581A (ko) *	2020-02-14	2022-11-18	솔크 인스티튜트 포 바이올로지칼 스터디즈	Ulk1/2 의 억제제 및 이의 사용 방법
CN119841806A (zh) *	2023-10-16	2025-04-18	中国医学科学院药物研究所	多取代的喹唑啉类化合物及其制备方法、用途和药物组合物

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KR100774855B1 (ko) *	2000-04-27	2007-11-08	아스텔라스세이야쿠 가부시키가이샤	축합 헤테로아릴 유도체
EA013811B1 (ru) *	2002-11-21	2010-08-30	Новартис Вэксинес Энд Дайэгностикс, Инк.	2,4,6-тризамещённые пиримидины, являющиеся ингибиторами фосфотидилинозитол(pi)-3-киназы, и их применение при лечении рака
WO2005000404A2 (en) *	2003-05-29	2005-01-06	Synta Pharmaceuticals, Corp.	Heterocyclic compounds for preventing and treating disorders associated with excessive bone loss
JP4906715B2 (ja) *	2004-05-08	2012-03-28	ニューロジェン・コーポレーション	４，５−ジ置換−２−アリールピリミジン類
US7851466B2 (en) *	2004-11-19	2010-12-14	Synta Pharmaceuticals Corp.	Pyrimidine compounds and uses thereof
GB0520657D0 (en) *	2005-10-11	2005-11-16	Ludwig Inst Cancer Res	Pharmaceutical compounds

2008
- 2008-04-14 JP JP2010502577A patent/JP2010523639A/ja active Pending
- 2008-04-14 DE DE602008004650T patent/DE602008004650D1/de active Active
- 2008-04-14 AU AU2008237721A patent/AU2008237721A1/en not_active Abandoned
- 2008-04-14 CN CN200880019513A patent/CN101765597A/zh active Pending
- 2008-04-14 EP EP08736964A patent/EP2150546B1/en not_active Not-in-force
- 2008-04-14 KR KR1020097023504A patent/KR20100016433A/ko not_active Withdrawn
- 2008-04-14 MX MX2009010886A patent/MX2009010886A/es not_active Application Discontinuation
- 2008-04-14 AT AT08736964T patent/ATE496045T1/de not_active IP Right Cessation
- 2008-04-14 BR BRPI0810641A patent/BRPI0810641A2/pt not_active IP Right Cessation
- 2008-04-14 WO PCT/GB2008/001301 patent/WO2008125839A2/en not_active Ceased
- 2008-04-14 CA CA002683624A patent/CA2683624A1/en not_active Abandoned
- 2008-04-14 US US12/594,529 patent/US20100130496A1/en not_active Abandoned
2009
- 2009-10-11 IL IL201365A patent/IL201365A0/en unknown

Also Published As

Publication number	Publication date
JP2010523639A (ja)	2010-07-15
EP2150546A2 (en)	2010-02-10
US20100130496A1 (en)	2010-05-27
EP2150546B1 (en)	2011-01-19
DE602008004650D1 (de)	2011-03-03
CN101765597A (zh)	2010-06-30
AU2008237721A1 (en)	2008-10-23
CA2683624A1 (en)	2008-10-23
KR20100016433A (ko)	2010-02-12
IL201365A0 (en)	2010-05-31
WO2008125839A3 (en)	2008-12-24
MX2009010886A (es)	2009-12-14
ATE496045T1 (de)	2011-02-15
WO2008125839A2 (en)	2008-10-23

Legal Events

Date	Code	Title	Description
2019-10-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2020-01-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0810641A2 (pt)	2019-09-24	"compostos farmacêuticos".
MX2009010881A (es)	2009-12-14	Compuestos farmaceuticos.
GB0423653D0 (en)	2004-11-24	Pharmaceutical compounds
MX2008013578A (es)	2009-03-23	Derivados de tieno [3,2-d]pirimidina utiles como inhibidores de fosfatidilinositol 3-cinasa(p13k).
MX2009010884A (es)	2009-12-14	2-morfolin-4-il-pirimidinas como inhibidores de fosfatidilinositol-3-cinasa (pi3k).
ATE510841T1 (de)	2011-06-15	Thiazoliopyrimidine und ihre verwendung als hemmer der phosphatidylinositol-3 kinase
WO2009053715A8 (en)	2010-06-03	Thienopyrimidiene derivatives as pi3k inhibitors
TN2012000062A1 (en)	2013-09-19	Jak 2 inhibitors and their use for the treatment of myeloproliferative deseases and cancer
PH12013501594A1 (en)	2014-05-12	Substituted indazole derivatives active as kinase inhibitors
WO2006067445A3 (en)	2006-09-14	Csf-1r kinase inhibitors
EA201000090A1 (ru)	2010-06-30	Тризамещенные производные пиримидина для лечения пролиферативных заболеваний
IL198116A (en)	2016-06-30	Carboxamides of pyrimidine that are annealed to rings of 5 and 6 atoms including nitrogen atom and their pharmacy preparations
SG170101A1 (en)	2011-04-29	2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial.
EA201000092A1 (ru)	2010-06-30	Тризамещенные пиримидиновые производные для лечения пролиферативных заболеваний
WO2009155121A3 (en)	2010-02-18	Inhibitors of pi3 kinase
WO2007084391A3 (en)	2008-03-20	Thiazole compounds as protein kinase b ( pkb) inhibitors
UA115320C2 (uk)	2017-10-25	Інгібітори кінази
MX2008013212A (es)	2008-10-22	4-anilinquinolina-3-carboxamidas como inhibidores de la cinsa csf-1r.
WO2009039397A3 (en)	2009-05-22	Substituted amides, methods of making, use thereof for the treatment of diseases such as cancer
TN2009000444A1 (en)	2011-03-31	Combination therapy with a compound acting as a plateletadp receptor inhibitor
WO2007113558A8 (en)	2008-03-13	Quinazolinone derivatives having b-raf inhibitory activity
WO2008036308A3 (en)	2008-05-08	Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith
MX2009011059A (es)	2009-11-26	Aminopirimidinas utiles como inhibidores de cinasas.
WO2014106800A3 (en)	2014-12-18	Substituted 2-amino pyrimidine derivatives as kinase inhibitors
MX2007013624A (es)	2008-02-12	Inhibidores de proteina cinasa.