BRPI0811016A2 - Proteína li truncada do papiloma vírus humano tipo 16 - Google Patents
Proteína li truncada do papiloma vírus humano tipo 16Info
- Publication number
- BRPI0811016A2 BRPI0811016A2 BRPI0811016A BRPI0811016A2 BR PI0811016 A2 BRPI0811016 A2 BR PI0811016A2 BR PI0811016 A BRPI0811016 A BR PI0811016A BR PI0811016 A2 BRPI0811016 A2 BR PI0811016A2
- Authority
- BR
- Brazil
- Prior art keywords
- human virus
- protein
- type
- human
- virus
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710097762.8 | 2007-04-29 | ||
| CN200710097762 | 2007-04-29 | ||
| CN200810008761 | 2008-01-23 | ||
| CN200810008761.6 | 2008-01-23 | ||
| PCT/CN2008/000872 WO2008134934A1 (fr) | 2007-04-29 | 2008-04-29 | Protéine l1 tronquée du papillomavirus 16 humain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0811016A2 true BRPI0811016A2 (pt) | 2015-01-27 |
| BRPI0811016B1 BRPI0811016B1 (pt) | 2021-09-21 |
Family
ID=39943110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0811016-6A BRPI0811016B1 (pt) | 2007-04-29 | 2008-04-29 | Proteína li truncada do papiloma vírus humano tipo 16 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9428555B2 (pt) |
| EP (1) | EP2154147B1 (pt) |
| CN (1) | CN101293918B (pt) |
| BR (1) | BRPI0811016B1 (pt) |
| DK (1) | DK2154147T3 (pt) |
| WO (1) | WO2008134934A1 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9364529B2 (en) | 2007-04-29 | 2016-06-14 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | Truncated L1 protein of human papillomavirus type 18 |
| DK2154147T3 (en) | 2007-04-29 | 2015-12-07 | Beijing Wantai Biological Pharmacy Entpr Co Ltd | Truncated L1 protein of human papillomavirus 16 |
| CN101343315B (zh) * | 2007-05-29 | 2012-06-13 | 厦门大学 | 截短的人乳头瘤病毒6型l1蛋白 |
| WO2012000454A1 (zh) * | 2010-07-02 | 2012-01-05 | 厦门大学 | 截短的人乳头瘤病毒52型l1蛋白 |
| CN102229660B (zh) * | 2011-05-25 | 2015-04-22 | 厦门大学 | 截短的人乳头瘤病毒33型l1蛋白 |
| CN102747047B (zh) * | 2012-02-28 | 2016-03-23 | 厦门大学 | 人乳头瘤病毒型别杂合病毒样颗粒及其制备方法 |
| CN105002190B (zh) * | 2013-12-03 | 2022-11-08 | 北京康乐卫士生物技术股份有限公司 | 11型重组人乳头瘤病毒病毒样颗粒及其制备方法 |
| US10413603B2 (en) * | 2014-06-19 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for improved human papilloma virus constructs |
| KR101825996B1 (ko) * | 2014-12-26 | 2018-02-09 | 아이진 주식회사 | 인유두종 바이러스의 바이러스 유사 입자 제조방법 |
| CN107188932B (zh) * | 2016-03-15 | 2020-02-11 | 中国医学科学院基础医学研究所 | 截短型人乳头瘤病毒16型l1蛋白及其应用 |
| CN107188966B (zh) | 2016-03-15 | 2020-03-31 | 中国医学科学院基础医学研究所 | 一种乳头瘤病毒嵌合蛋白及其用途 |
| CN106884017B (zh) * | 2016-12-28 | 2024-03-26 | 中国食品药品检定研究院 | 用于包装柯萨奇病毒b5假病毒的重组表达质粒、假病毒、试剂盒和方法 |
| BR112020000833A2 (pt) * | 2017-07-14 | 2020-07-21 | Xiamen University | mutante de proteína l1 de papiloma vírus humano tipo 16 |
| KR102803235B1 (ko) * | 2018-06-04 | 2025-05-07 | 시아먼 유니버시티 | 타입 39 인유두종 바이러스 l1 단백질의 돌연변이체 |
| WO2021013069A1 (zh) * | 2019-07-19 | 2021-01-28 | 神州细胞工程有限公司 | 嵌合的人乳头瘤病毒11型l1蛋白 |
| CN114716560B (zh) | 2021-01-04 | 2024-02-02 | 中国医学科学院基础医学研究所 | 一种人乳头瘤病毒18型嵌合蛋白及其用途 |
| CN114716561B (zh) | 2021-01-04 | 2024-03-12 | 中国医学科学院基础医学研究所 | 一种人乳头瘤病毒31型嵌合蛋白及其用途 |
| CN114292321B (zh) * | 2021-12-30 | 2023-06-16 | 重庆澳龙生物制品有限公司 | 可溶性表达eg95蛋白及其制备方法和应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1618888T3 (da) | 1993-03-09 | 2011-04-04 | Univ Rochester | Fremstilling af humant papillomvirus-capsidprotein og viruslignende partikler |
| AUPM566794A0 (en) * | 1994-05-17 | 1994-06-09 | University Of Queensland, The | Process and product |
| IL113817A (en) * | 1994-06-30 | 2001-03-19 | Merck & Co Inc | Polynucleotide vaccne for papillomavirus |
| DE122007000093I1 (de) | 1994-10-07 | 2008-03-27 | Univ Loyola Chicago | Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung |
| US5840306A (en) * | 1995-03-22 | 1998-11-24 | Merck & Co., Inc. | DNA encoding human papillomavirus type 18 |
| IL117459A (en) | 1995-03-22 | 2005-11-20 | Merck & Co Inc | Dna encoding human papillomavirus type 18 |
| US5820870A (en) * | 1995-03-22 | 1998-10-13 | Merck & Co., Inc. | Recombinant human papillomavirus type 18 vaccine |
| US6908615B1 (en) * | 1996-03-18 | 2005-06-21 | Merck & Co., Inc. | DNA encoding human papilloma virus type 18 |
| US7351533B2 (en) * | 1997-09-05 | 2008-04-01 | Medimmune, Inc. | In vitro method for disassmbly/reassembly of papillomavirus virus-like particles (VLPs). Homogeneous VLP and cavsomere compositions produced by said methods: use thereof as vehicle for improved purification, and delivery of active agents |
| US6228368B1 (en) * | 1997-10-06 | 2001-05-08 | Loyola University Of Chicago | Papilloma virus capsomere formulations and method of use |
| US7182947B2 (en) * | 1998-02-20 | 2007-02-27 | Medigene Ag | Papillomavirus truncated L1 protein and fusion protein constructs |
| US20020039584A1 (en) * | 1998-02-20 | 2002-04-04 | Medigene Ag | Papilloma virus capsomere vaccine formulations and methods of use |
| US20020193565A1 (en) * | 1998-03-27 | 2002-12-19 | Stanley Margaret Anne | Antigen preparation and use |
| BR9913026A (pt) | 1998-08-14 | 2001-09-25 | Merck & Co Inc | Processo de purificação de partìculas semelhantes a vìrus (vlps) de papilomavìrus recombinante, e, processo de preparação de um produto de vlp de papilomavìrus humano purificado adequado para uso em uma vacina para humano |
| AU3730600A (en) * | 1999-03-18 | 2000-10-04 | Xiaojiang Chen | Compositions preparations and uses of human papillomavirus l1 protein |
| DE10059630A1 (de) | 2000-12-01 | 2002-06-06 | Medigene Ag | Arzneimittel zur Vermeidung oder Behandlung von durch humanen Papillomavirus-Typ 18-hervorgerufenem Tumor |
| AP2004003021A0 (en) | 2001-08-31 | 2004-06-30 | Univ Cape Town | Vectors, constructs and transgenic plants for HPV-11 and HPV-16 L1 capsid protein. |
| GB0206360D0 (en) * | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| GB0206359D0 (en) | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| AU2003228816A1 (en) | 2002-05-02 | 2003-11-17 | Boyce Thompson Institute For Plant Research, Inc. | Production of papillomavirus vaccines in plants |
| CN1293093C (zh) * | 2002-08-30 | 2007-01-03 | 马润林 | 乳头瘤病毒衣壳蛋白的原核制备和应用 |
| ATE503492T1 (de) | 2002-12-20 | 2011-04-15 | Glaxosmithkline Biolog Sa | Verwendung von hpv16 und hpv18 vlps als vakzine gegen eine oder mehrere onkogene hpv des typus 31,33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68 |
| MY139500A (en) | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
| CN1683010A (zh) | 2005-02-06 | 2005-10-19 | 哈尔滨医科大学 | 人乳头瘤病毒型双价病毒样颗粒混合蛋白抗原及构建方法 |
| CN100392084C (zh) | 2006-03-13 | 2008-06-04 | 曾毅 | 含密码子优化型hpv16l1基因的重组腺病毒 |
| CN101153280B (zh) | 2006-09-29 | 2015-08-19 | 厦门大学 | 从原核生物中纯化人乳头瘤病毒晚期蛋白l1的方法 |
| EP2129394B1 (en) * | 2007-03-09 | 2012-06-20 | Merck Sharp & Dohme Corp. | Papillomavirus vaccine compositions |
| US9364529B2 (en) * | 2007-04-29 | 2016-06-14 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | Truncated L1 protein of human papillomavirus type 18 |
| DK2154147T3 (en) | 2007-04-29 | 2015-12-07 | Beijing Wantai Biological Pharmacy Entpr Co Ltd | Truncated L1 protein of human papillomavirus 16 |
| DK2910566T5 (en) * | 2007-05-29 | 2016-11-07 | Univ Xiamen | Truncated L1 protein of human papillomavirus 11 |
-
2008
- 2008-04-29 DK DK08748431.7T patent/DK2154147T3/en active
- 2008-04-29 CN CN2008100938168A patent/CN101293918B/zh active Active
- 2008-04-29 US US12/598,186 patent/US9428555B2/en active Active
- 2008-04-29 WO PCT/CN2008/000872 patent/WO2008134934A1/zh not_active Ceased
- 2008-04-29 EP EP08748431.7A patent/EP2154147B1/en active Active
- 2008-04-29 BR BRPI0811016-6A patent/BRPI0811016B1/pt active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008134934A1 (fr) | 2008-11-13 |
| DK2154147T3 (en) | 2015-12-07 |
| EP2154147B1 (en) | 2015-10-07 |
| EP2154147A4 (en) | 2011-11-02 |
| BRPI0811016B1 (pt) | 2021-09-21 |
| US9428555B2 (en) | 2016-08-30 |
| CN101293918B (zh) | 2013-03-27 |
| US20100255031A1 (en) | 2010-10-07 |
| CN101293918A (zh) | 2008-10-29 |
| EP2154147A1 (en) | 2010-02-17 |
| HK1124868A1 (en) | 2009-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: XIAMEN UNIVERSITY (CN) ; XIAMEN INNOVAX BIOTECH CO., LTD. (CN) |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/04/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |