BRPI0811065A2 - 5-HETEROARYL INDAZOES REPLACED AS KINASE INHIBITORS - Google Patents
5-HETEROARYL INDAZOES REPLACED AS KINASE INHIBITORSInfo
- Publication number
- BRPI0811065A2 BRPI0811065A2 BRPI0811065-4A2A BRPI0811065A BRPI0811065A2 BR PI0811065 A2 BRPI0811065 A2 BR PI0811065A2 BR PI0811065 A BRPI0811065 A BR PI0811065A BR PI0811065 A2 BRPI0811065 A2 BR PI0811065A2
- Authority
- BR
- Brazil
- Prior art keywords
- indazoes
- heteroaryl
- replaced
- kinase inhibitors
- kinase
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93396007P | 2007-06-08 | 2007-06-08 | |
| PCT/US2008/065727 WO2008154241A1 (en) | 2007-06-08 | 2008-06-04 | 5-heteroaryl substituted indazoles as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0811065A2 true BRPI0811065A2 (en) | 2014-12-02 |
Family
ID=39951673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0811065-4A2A BRPI0811065A2 (en) | 2007-06-08 | 2008-06-04 | 5-HETEROARYL INDAZOES REPLACED AS KINASE INHIBITORS |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2167491A1 (en) |
| JP (2) | JP5451602B2 (en) |
| KR (1) | KR20100032886A (en) |
| CN (1) | CN101790526A (en) |
| AU (1) | AU2008262038A1 (en) |
| BR (1) | BRPI0811065A2 (en) |
| CA (1) | CA2689117A1 (en) |
| IL (1) | IL202318A0 (en) |
| MX (1) | MX2009013213A (en) |
| RU (1) | RU2487873C2 (en) |
| SG (1) | SG182187A1 (en) |
| WO (1) | WO2008154241A1 (en) |
| ZA (1) | ZA200908624B (en) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
| EP1984331B1 (en) | 2006-02-16 | 2010-10-20 | Schering Corporation | Pyrrolidine derivatives as erk inhibitors |
| US8648069B2 (en) * | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| EP2157859A4 (en) * | 2007-06-19 | 2011-01-12 | Takeda Pharmaceutical | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE |
| AU2008276521B2 (en) | 2007-07-17 | 2011-11-03 | Amgen Inc. | Heterocyclic modulators of PKB |
| WO2009011871A2 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of pkb |
| AR068813A1 (en) * | 2007-08-30 | 2009-12-09 | Takeda Pharmaceutical | DERIVATIVES OF PIRAZOL REPLACED AS ANTAGONISTS OF THE ANDROGEN RECEIVER (AR), A PHARMACEUTICAL AGENT THAT UNDERSTANDS AND USES THEMSELVES IN THE TREATMENT OF PROSTATE CANCER |
| RU2525389C2 (en) | 2008-02-21 | 2014-08-10 | Мерк Шарп И Доум Корп. | Compounds which are erk inhibitors |
| CL2009001158A1 (en) | 2008-05-15 | 2009-10-23 | Nerviano Medical Sciences Srl | Compounds derived from carboxylic acids, such as 5,6-dihiro-4h-pyrrolo [3,4-c] pyrazole, furo [3,2-c] pyrazole, thieno [2,3-c] pyrazole, 4,5 , 6,7-tetrahydropyrazole [4,3-c] pyridine and indazole; pharmaceutical composition; and its use in the treatment of cell proliferative disorders associated with altered protein kinase activity, such as cancer. |
| US8697685B2 (en) * | 2008-11-20 | 2014-04-15 | Glaxosmithkline Llc | Chemical compounds |
| EP2464232B1 (en) | 2009-08-10 | 2015-10-07 | Samumed, LLC | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| SMT201700581T1 (en) | 2009-12-21 | 2018-01-11 | Samumed Llc | 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| UY33213A (en) * | 2010-02-18 | 2011-09-30 | Almirall Sa | PIRAZOL DERIVATIVES AS JAK INHIBITORS |
| KR101233082B1 (en) | 2010-02-25 | 2013-02-14 | 주식회사 이큐스앤자루 | A composition containing of novel imidazole pyrazine compound having Influenza virus activity for treating antivirus |
| JP6026284B2 (en) * | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | Inhibitors of glutaminyl cyclase |
| CA2791020A1 (en) * | 2010-04-28 | 2011-11-03 | Daiichi Sankyo Company, Limited | [5,6] heterocyclic compound |
| WO2011140333A1 (en) | 2010-05-07 | 2011-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of stabilizers of multimeric proteins |
| WO2012084704A1 (en) | 2010-12-20 | 2012-06-28 | Merck Serono S.A. | Indazolyl triazole derivatives as irak inhibitors |
| CN106986862A (en) | 2010-12-22 | 2017-07-28 | Abbvie 公司 | Hepatitis c inhibitor and application thereof |
| US9090592B2 (en) * | 2010-12-30 | 2015-07-28 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
| CN102675286B (en) * | 2011-03-07 | 2015-08-19 | 中国科学院上海药物研究所 | Indazole compounds, preparation method, application and pharmaceutical composition thereof |
| EA024890B1 (en) * | 2011-04-07 | 2016-10-31 | Байер Интеллектчуал Проперти Гмбх | IMIDAZOPIRIDAZINES AS AKT KINASE INHIBITORS |
| KR20140071361A (en) * | 2011-08-12 | 2014-06-11 | 에프. 호프만-라 로슈 아게 | PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE |
| AU2012308570B2 (en) | 2011-09-14 | 2016-11-10 | Samumed, Llc | Indazole-3-carboxamides and their use as Wnt/b-catenin signaling pathway inhibitors |
| DK2921495T3 (en) | 2011-12-27 | 2018-07-16 | Bayer Ip Gmbh | HETEROARYLPIPERIDINE AND PIPERAZINE DERIVATIVES AS FUNGICIDES |
| AU2013224302B2 (en) * | 2012-02-21 | 2017-03-30 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| ME03573B (en) | 2012-05-04 | 2020-07-20 | Samumed Llc | 1H-PYRAZOLO [3,4-B] PYRIDINES AND THEIR THERAPEUTIC USES |
| TW201406758A (en) * | 2012-06-28 | 2014-02-16 | Daiichi Sankyo Co Ltd | Tricyclic compounds |
| CN105120862A (en) | 2013-01-08 | 2015-12-02 | 萨穆梅德有限公司 | 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof |
| US9440952B2 (en) | 2013-03-04 | 2016-09-13 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134772A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134776A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134774A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| JO3383B1 (en) * | 2013-03-14 | 2019-03-13 | Lilly Co Eli | CDC7 Inhibitors |
| WO2015004533A2 (en) * | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| KR102421235B1 (en) | 2014-02-13 | 2022-07-15 | 인사이트 코포레이션 | Cyclopropylamines as lsd1 inhibitors |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| NZ723203A (en) | 2014-02-13 | 2020-08-28 | Incyte Corp | Cyclopropylamines as lsd1 inhibitors |
| EP3392244A1 (en) | 2014-02-13 | 2018-10-24 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| PE20170127A1 (en) | 2014-03-20 | 2017-03-30 | Samumed Llc | INDAZOL-3-CARBOXAMIDES 5-SUBSTITUTED AND THE PREPARATION AND USE OF THE SAME |
| WO2015143652A1 (en) * | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
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