BRPI0811069A2 - Derivados de amida para inibir o crescimento de células cancerosas - Google Patents

Derivados de amida para inibir o crescimento de células cancerosas

Info

Publication number
BRPI0811069A2
BRPI0811069A2 BRPI0811069-7A2A BRPI0811069A BRPI0811069A2 BR PI0811069 A2 BRPI0811069 A2 BR PI0811069A2 BR PI0811069 A BRPI0811069 A BR PI0811069A BR PI0811069 A2 BRPI0811069 A2 BR PI0811069A2
Authority
BR
Brazil
Prior art keywords
cancer cell
cell growth
inhibit cancer
amida
derivatives
Prior art date
Application number
BRPI0811069-7A2A
Other languages
English (en)
Inventor
Kwang-Ok Lee
Mi Young Cha
Mi Ra Kim
Young Hee Jung
Chang Gon Lee
Se Young Kim
Keukchan Bang
Bum Woo Park
Bo Im Choi
Yun Jung Chae
Mi Young Ko
Han Kyong Kim
Young-Gil Ahn
Maeng Sup Kim
Gwan Sun Lee
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of BRPI0811069A2 publication Critical patent/BRPI0811069A2/pt
Publication of BRPI0811069B1 publication Critical patent/BRPI0811069B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0811069-7A 2007-06-05 2008-06-05 Derivado de amida e composição farmacêutica para inibir o crescimento de células cancerosas compreendendo o mesmo BRPI0811069B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2007-0054997 2007-06-05
KR20070054997 2007-06-05
PCT/KR2008/003162 WO2008150118A2 (en) 2007-06-05 2008-06-05 Novel amide derivative for inhibiting the growth of cancer cells

Publications (2)

Publication Number Publication Date
BRPI0811069A2 true BRPI0811069A2 (pt) 2014-12-09
BRPI0811069B1 BRPI0811069B1 (pt) 2022-08-30

Family

ID=40094307

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0811069-7A BRPI0811069B1 (pt) 2007-06-05 2008-06-05 Derivado de amida e composição farmacêutica para inibir o crescimento de células cancerosas compreendendo o mesmo

Country Status (24)

Country Link
US (1) US8188102B2 (pt)
EP (1) EP2167492B1 (pt)
JP (1) JP5155391B2 (pt)
KR (1) KR101013319B1 (pt)
CN (1) CN101679384B (pt)
AR (2) AR066876A1 (pt)
AU (1) AU2008260772B2 (pt)
BR (1) BRPI0811069B1 (pt)
CA (1) CA2687180C (pt)
DK (1) DK2167492T3 (pt)
ES (1) ES2558623T3 (pt)
HR (1) HRP20160007T1 (pt)
HU (1) HUE028243T2 (pt)
IL (1) IL202154A (pt)
MX (1) MX2009012772A (pt)
MY (1) MY144972A (pt)
NZ (1) NZ582412A (pt)
PL (1) PL2167492T3 (pt)
PT (1) PT2167492E (pt)
RU (1) RU2434010C2 (pt)
TW (1) TWI377944B (pt)
UA (1) UA96045C2 (pt)
WO (1) WO2008150118A2 (pt)
ZA (1) ZA201000022B (pt)

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US8119616B2 (en) 2007-09-10 2012-02-21 Curis, Inc. Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety
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US8828391B2 (en) 2011-05-17 2014-09-09 Boehringer Ingelheim International Gmbh Method for EGFR directed combination treatment of non-small cell lung cancer
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CN106068262B (zh) * 2014-04-11 2019-10-29 海思科医药集团股份有限公司 喹唑啉衍生物及其制备方法和在医药上的应用
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JP7036798B2 (ja) * 2016-08-25 2022-03-15 正大天晴▲藥▼▲業▼集▲団▼股▲フン▼有限公司 キナゾリン誘導体の塩の結晶
CN108069946B (zh) * 2016-11-08 2020-06-05 威尚（上海）生物医药有限公司 具有穿过血脑屏障能力的取代的喹唑啉化合物
US11446302B2 (en) 2016-11-17 2022-09-20 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing EGFR or HER2 exon 20 mutations
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TWI808958B (zh) 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
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TWI870922B (zh) 2017-12-21 2025-01-21 德商百靈佳殷格翰國際股份有限公司 作為sos1抑制劑之新穎芐胺基取代吡啶并嘧啶酮及衍生物
WO2019191279A2 (en) 2018-03-27 2019-10-03 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing her2 exon 19 mutations
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Also Published As

Publication number Publication date
MY144972A (en) 2011-11-30
RU2434010C2 (ru) 2011-11-20
PT2167492E (pt) 2016-02-04
WO2008150118A3 (en) 2009-01-29
AR066876A1 (es) 2009-09-16
RU2009149307A (ru) 2011-07-20
US20100179120A1 (en) 2010-07-15
KR101013319B1 (ko) 2011-02-09
CA2687180C (en) 2012-07-24
DK2167492T3 (en) 2016-01-11
IL202154A (en) 2014-05-28
MX2009012772A (es) 2009-12-15
JP2010529115A (ja) 2010-08-26
CA2687180A1 (en) 2008-12-11
EP2167492B1 (en) 2015-10-14
AR110003A2 (es) 2019-02-13
CN101679384A (zh) 2010-03-24
NZ582412A (en) 2011-12-22
ZA201000022B (en) 2011-04-28
ES2558623T3 (es) 2016-02-05
TW200906414A (en) 2009-02-16
US8188102B2 (en) 2012-05-29
IL202154A0 (en) 2010-06-16
KR20080107294A (ko) 2008-12-10
EP2167492A2 (en) 2010-03-31
HUE028243T2 (en) 2016-12-28
HK1142591A1 (en) 2010-12-10
WO2008150118A2 (en) 2008-12-11
HRP20160007T1 (hr) 2016-02-12
PL2167492T3 (pl) 2016-03-31
AU2008260772A1 (en) 2008-12-11
EP2167492A4 (en) 2010-12-15
AU2008260772B2 (en) 2011-06-02
JP5155391B2 (ja) 2013-03-06
CN101679384B (zh) 2013-10-16
BRPI0811069B1 (pt) 2022-08-30
UA96045C2 (ru) 2011-09-26
TWI377944B (en) 2012-12-01

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